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Content Reviewed By:
Dr. Anil Gupta
, (MBBS)
Written By:
Mr. Ankit Jain
, (B.Pharm)
The most common side effects of LINANEXT M ER 5/500MG TABLET may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar). Other possible side effects are headache, dizziness, constipation, upper respiratory tract infection, weight gain, blurred vision, and increased sweating. Less common but potentially serious side effects include lactic acidosis, pancreatitis, allergic reactions (rash, itching, swelling), liver problems, and vitamin B12 deficiency. If you experience any unusual or severe symptoms, stop taking LINANEXT M ER 5/500MG TABLET and consult your doctor immediately.
Pregnancy
Consult your doctorSafety data for the combination of linagliptin and metformin in pregnancy are limited.
BreastFeeding
Use only if clearly neededMetformin passes into breast milk in small amounts, while data on linagliptin excretion into human milk are limited.
Alcohol
Limit intakeExcessive alcohol consumption increases the risk of metformin‑associated lactic acidosis, which is a rare but serious condition.

Pancreas and gastrointestinal conditions
Monitor closelyDPP‑4 inhibitors, including linagliptin, have been associated rarely with acute pancreatitis.
LINANEXT M ER 5/500MG TABLET 10'S is used to treat type 2 diabetes mellitus by helping to control blood sugar levels.
Take LINANEXT M ER 5/500MG TABLET 10'S as prescribed by your doctor, usually once or twice daily with meals.
Common side effects may include nausea, vomiting, diarrhea, stomach pain, and loss of appetite.
Do not stop taking LINANEXT M ER 5/500MG TABLET 10'S without consulting your doctor. Suddenly stopping the medication can cause your blood sugar to rise.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Consult your doctor before taking LINANEXT M ER 5/500MG TABLET 10'S during pregnancy. It is generally not recommended.
Follow a balanced diet, exercise regularly, and monitor your blood sugar levels regularly as advised by your doctor.
LINANEXT M ER 5/500MG TABLET 10'S can cause hypoglycemia, especially when taken with other diabetes medications. Be aware of the symptoms and know how to treat low blood sugar.
Inform your doctor about all the medications, supplements, and herbal products you are taking to avoid potential drug interactions.
LINANEXT M ER 5/500MG TABLET 10'S works by increasing the amount of insulin released by the pancreas and decreasing the amount of glucose produced by the liver, thereby lowering blood sugar levels.
In rare cases, LINANEXT M ER 5/500MG TABLET 10'S can affect kidney function. Your doctor may monitor your kidney function while you are taking this medication.
LINANEXT M ER is an extended-release formulation, which means it releases the medication slowly over time. This can help to control blood sugar levels more evenly throughout the day.
It is generally recommended to avoid alcohol while taking LINANEXT M ER 5/500MG TABLET 10'S, as it can increase the risk of side effects such as hypoglycemia and lactic acidosis.
Store LINANEXT M ER 5/500MG TABLET 10'S at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
In case of an overdose, seek immediate medical attention or contact a poison control center.
Linanext M 5/500 is used to improve blood sugar control in adults with type 2 diabetes mellitus. It is prescribed when diet and exercise alone are not sufficient, or when patients are already taking linagliptin and metformin separately. It is not indicated for type 1 diabetes or diabetic ketoacidosis.
Linanext M 5/500 contains linagliptin, a DPP‑4 inhibitor, and metformin, a biguanide. Linagliptin increases incretin hormone levels, which enhance insulin release and reduce liver glucose production in a glucose‑dependent manner. Metformin decreases hepatic glucose production and improves insulin sensitivity, helping the body use insulin more effectively. Together, they help lower fasting and post‑meal blood glucose levels.
When used alone, linagliptin and metformin have a low risk of causing hypoglycaemia. However, the risk of low blood sugar increases if Linanext M 5/500 is taken with other antidiabetic medicines such as sulfonylureas or insulin, or if meals are skipped, caloric intake is reduced drastically, or there is intense unaccustomed exercise. Symptoms of hypoglycaemia include sweating, tremor, hunger, palpitations, confusion, and dizziness. Patients should be educated on recognising and treating low blood sugar.
Common side effects are mainly related to metformin and include nausea, vomiting, diarrhoea, abdominal pain, bloating, and loss of appetite, especially when starting treatment or after dose escalation. These effects are often mild and may improve over time. Less common side effects include headache, respiratory infections, cough, and rash. Rare but serious adverse effects include lactic acidosis (with metformin) and pancreatitis or severe hypersensitivity reactions (with linagliptin). Any severe or persistent symptoms should be reported to a doctor immediately.
Linanext M 5/500 is generally contraindicated in patients with significant kidney impairment where metformin is not recommended, in those with acute conditions that can affect kidney function (such as severe dehydration, severe infection, or shock), in patients with known hypersensitivity to linagliptin, metformin, or any excipients, and in individuals with acute or chronic metabolic acidosis, including diabetic ketoacidosis. It is also not intended for use in type 1 diabetes. Suitability must always be assessed by a healthcare professional.
The use of linagliptin‑metformin combinations during pregnancy is not well established. Metformin is sometimes used in pregnancy under specialist supervision, but linagliptin has limited pregnancy safety data. Therefore, Linanext M 5/500 is generally not the first‑line choice in pregnant women. Insulin is usually preferred for blood glucose control in pregnancy. Any woman who is pregnant, planning pregnancy, or suspects she may be pregnant should consult her doctor promptly to review her diabetes treatment.
Metformin is excreted in small amounts into breast milk and is sometimes used during breastfeeding under medical supervision. Data on the excretion of linagliptin into human breast milk are limited, and potential effects on the breastfed infant are not fully known. Because of this uncertainty, the decision to use Linanext M 5/500 while breastfeeding should be made by a doctor after weighing the benefits of breastfeeding, the clinical need for the medicine, and any potential risk to the infant. Alternative regimens may be considered.
Yes. Regular monitoring is important. Your doctor will typically check fasting and post‑meal blood glucose and HbA1c to assess long‑term control. Kidney function tests (serum creatinine, estimated glomerular filtration rate) should be performed before starting therapy and periodically thereafter because metformin is cleared by the kidneys. Liver function tests may be done in selected patients. Long‑term metformin use may be associated with reduced vitamin B12 levels, so B12 may be checked in patients with anaemia or neuropathy.
Alcohol intake should be limited while taking Linanext M 5/500. Excessive or binge drinking increases the risk of metformin‑associated lactic acidosis, a rare but serious condition. Alcohol can also affect blood sugar levels, causing both high and low readings. Patients who consume alcohol should discuss safe limits with their doctor and avoid drinking on an empty stomach or in situations where food intake is reduced.
If you miss a dose, take it as soon as you remember, with food, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects such as gastrointestinal upset or hypoglycaemia, especially if you are on other antidiabetic medicines.
Stopping Linanext M 5/500 abruptly can lead to loss of blood glucose control and an increase in blood sugar levels. Any change in therapy, including discontinuation, should be done only under medical supervision. Your doctor may switch you to alternative medicines or adjust your regimen based on your blood glucose readings, kidney function, and overall health status.
Linanext M ER 5/500MG Tablet 10's contains Linagliptin 5 MG + Metformin Hydrochloride 500 MG Sustained Release. It is a DPP-4 inhibitor antidiabetic; and biguanide antidiabetic.
Commonly reported side effects of Linanext M ER 5/500MG Tablet 10's include nasal congestion, sore throat, cough; and diarrhoea, nausea, abdominal discomfort, metallic taste, loss of appetite — often improve with time or when taken with food. Not everyone gets side effects. Tell your doctor or pharmacist if any effect persists or worries you.
Linanext M ER 5/500MG Tablet 10's is listed at Rs. 130.13 on Medkart. Prices can change — check the product page for the current price and pack size.
Rare acute pancreatitis — stop and seek care for severe persistent abdominal pain; and Rare but serious risk of lactic acidosis, particularly with kidney impairment, dehydration, acute illness or excess alcohol. Tell your doctor about all other medicines you take before starting Linanext M ER 5/500MG Tablet 10's.
The dose of Linanext M ER 5/500MG Tablet 10's depends on your condition, age, weight and other medicines you take, so it must be decided by your doctor. Follow the dose and duration on your prescription and do not change it on your own.
A generic medicine is one with the same active composition as the branded product — for Linanext M ER 5/500MG Tablet 10's that is Linagliptin 5 MG + Metformin Hydrochloride 500 MG Sustained Release. Medkart lists generic options by composition so you can compare. Ask your doctor or pharmacist before switching from Linanext M ER 5/500MG Tablet 10's.
Yes. Linanext M ER 5/500MG Tablet 10's requires a valid doctor's prescription.
Linanext M ER 5/500MG Tablet 10's is manufactured by Msn Laboratories Private Limited.
Linanext M ER 5/500MG Tablet 10's is supplied as a tablet and is taken by the oral route.
Linanext M ER 5/500MG Tablet 10's contains Linagliptin 5 MG + Metformin Hydrochloride 500 MG Sustained Release. It is used for type 2 diabetes mellitus alongside diet and exercise, alone or with other antidiabetic medicines; and first-line management of type 2 diabetes mellitus, usually alongside diet and exercise. The benefit you get depends on the condition your doctor prescribed Linanext M ER 5/500MG Tablet 10's for.
Whether Linanext M ER 5/500MG Tablet 10's can be taken daily, and for how long, depends on your condition and must be decided by your doctor. Do not start, extend or repeat a course of Linanext M ER 5/500MG Tablet 10's on your own.
The timing of Linanext M ER 5/500MG Tablet 10's depends on the dose your doctor prescribes and on the other medicines you take. Follow the timing on your prescription or ask your pharmacist.
No. Linanext M ER 5/500MG Tablet 10's is a prescription medicine and should only be taken on a doctor's advice.
Do not take Linanext M ER 5/500MG Tablet 10's during pregnancy or while breastfeeding without asking your doctor. Safety depends on the medicine, the stage of pregnancy and your own health.
Linanext M ER 5/500MG Tablet 10's is marked discontinued on Medkart and cannot be ordered. Speak to your doctor or pharmacist about alternatives with the same composition.
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