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Composition
Content Reviewed By:
Dr. Amit Patel
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Most side effects are temporary and disappear as your body adapts to the medicine. If they continue or cause you concern, speak with your doctor.

Heart and Blood Pressure
Use with extreme cautionPatients with significant cardiovascular disease, recent heart attack or stroke, uncontrolled high or low blood pressure, or severe heart failure must consult a cardiologist before using Megalis 20.
No, using MEGALIS 20MG TABLET 4'S does not affect fertility. It works by relaxing the muscles of penile blood vessels and has no effect on fertility.
Alcohol in small amounts may not cause any discomfort to you. However, drinking too much alcohol (5 units or greater) can increase your chances of getting a headache or feeling dizzy, increased heart rate or low blood pressure.
No, MEGALIS 20MG TABLET 4'S is not known to affect ejaculation. It is used for the treatment of erectile dysfunction.
You should immediately consult your doctor if you experience sudden vision loss in one or both eyes, sudden decrease in hearing or hearing loss, ringing in ears and dizziness. Also, contact your doctor if you experience prolonged erections greater than 4 hours and painful erections greater than 6 hours in duration.
Megalis 20 is primarily used to treat erectile dysfunction (ED) in adult men. It contains tadalafil, which helps increase blood flow to the penis during sexual stimulation, improving the ability to achieve and maintain an erection. It does not cure ED permanently and does not increase sexual desire; it works only when you are sexually aroused. It should be taken only on medical advice.
Megalis 20 contains tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor. During sexual stimulation, nitric oxide is released in the penis, leading to increased levels of cyclic guanosine monophosphate (cGMP), which relaxes blood vessels and allows more blood to enter the erectile tissue. PDE5 breaks down cGMP. By inhibiting PDE5, tadalafil helps maintain higher cGMP levels, promoting better erections in response to sexual stimulation.
If you have liver disease or a history of liver problems, you must inform your doctor before taking Megalis 20. In mild to moderate liver impairment, your doctor may decide whether tadalafil is appropriate and may adjust the treatment plan or monitor you more closely. In severe liver disease, tadalafil may not be recommended due to reduced drug clearance and increased risk of side effects. Never start or continue Megalis 20 without medical supervision if you have liver issues.
Kidney function affects how tadalafil is removed from the body. In mild to moderate kidney impairment, your doctor may still prescribe Megalis 20 but could adjust the regimen or advise less frequent use. In severe kidney disease or patients on dialysis, tadalafil may not be suitable or may require very careful specialist supervision. Always tell your doctor about any kidney problems, past or present, before using Megalis 20, and do not change how often you take it without medical advice.
Megalis 20 is intended for use in adult men with erectile dysfunction and is not indicated for women. There is limited safety data regarding tadalafil use in pregnant women, and it is not prescribed for pregnancy-related conditions. If a woman is pregnant or planning pregnancy, Megalis 20 should not be used. Any off‑label or experimental use must only be under strict specialist supervision, but for routine care, this medicine is not recommended for women.
Megalis 20 is not intended for use in women, including those who are breastfeeding. It is not known whether tadalafil passes into human breast milk, and potential effects on a nursing infant have not been well studied. Therefore, Megalis 20 should not be used by breastfeeding women. If a breastfeeding mother has taken tadalafil accidentally, she should contact a healthcare professional for advice and monitoring.
Megalis 20 can cause side effects such as dizziness, light‑headedness, blurred vision, or changes in blood pressure in some individuals. If you experience any of these effects, your ability to drive or operate machinery may be impaired. You should first see how the medicine affects you before engaging in activities that require alertness. If you feel dizzy, tired, or have visual disturbances after taking Megalis 20, avoid driving or using heavy machines and contact your doctor if symptoms persist.
Alcohol can enhance some of the blood pressure‑lowering effects of Megalis 20 and may increase the likelihood of dizziness, fainting, rapid heartbeat, or headache. Heavy alcohol intake can also worsen erectile dysfunction. It is advisable to limit or avoid alcohol when taking Megalis 20. If you choose to drink, keep the amount low and monitor how you feel. Do not drive or perform risky activities if you feel light‑headed after combining alcohol with this medicine.
If you have a known allergy to tadalafil or any other component of Megalis 20, you must not take this medicine. Signs of an allergic reaction can include rash, itching, swelling of the face, lips, tongue, or throat, severe dizziness, or difficulty breathing. If you develop any of these symptoms after taking Megalis 20, seek emergency medical help immediately. Inform your doctor about any previous reactions to ED medicines or other drugs before starting treatment.
Megalis 20 must never be taken with nitrates (such as nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate) or certain nitric oxide donors, because the combination can cause a severe and dangerous drop in blood pressure. Caution is also needed with some blood pressure medicines and alpha‑blockers used for prostate problems. Always provide your doctor with a complete list of your medicines, including over‑the‑counter drugs and herbal supplements, so they can assess interactions and decide whether Megalis 20 is safe for you.
Seek immediate medical attention if you experience chest pain, severe dizziness or fainting, a sudden loss of vision in one or both eyes, sudden decrease or loss of hearing, ringing in the ears, or an erection that lasts more than 4 hours and is painful (priapism). These events are rare but can be serious and may lead to permanent damage if not treated promptly. Also contact your doctor if you notice severe allergic reactions, shortness of breath, or swelling of the face or limbs after taking Megalis 20.
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MACLEODS PHARMACEUTICALS PRIVATE LIMITED
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India
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