niftran 100mg capsule 10's
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NIFTRAN 100MG CAPSULE 10'S

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NIFTRAN 100MG CAPSULE 10'S

By SUN PHARMACEUTICAL INDUSTRIES LTD

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92.29

₹78.45

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Product DetailsArrow

Content Reviewed By:

Dr. Sanjay Mehta

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About NIFTRAN 100MG CAPSULE 10'S

  • Niftran 100 is a branded formulation of nitrofurantoin 100 mg, an antibacterial medicine used primarily for the treatment and prevention of uncomplicated urinary tract infections (UTIs), especially infections of the lower urinary tract such as cystitis. It acts by inhibiting bacterial enzymes and damaging bacterial DNA, which stops the growth of susceptible bacteria in the urine. Niftran 100 is generally effective against common UTI-causing organisms such as Escherichia coli and some other Gram-negative and Gram-positive bacteria, but it is not active against all urinary pathogens. It is not suitable for treating kidney infections (pyelonephritis), prostatitis, or systemic infections because it achieves therapeutic concentrations mainly in the urine rather than in blood or kidney tissue. Niftran 100 is usually prescribed as part of short-course therapy for acute uncomplicated cystitis or as long-term low-dose prophylaxis in selected patients with recurrent UTIs, according to a physician’s judgment and local guidelines. The exact dose, frequency, and duration must be determined by a healthcare professional based on age, kidney function, severity of infection, and individual risk factors. Patients should not self-medicate or adjust the dose without medical advice. The capsule is typically taken by mouth with food or milk to improve absorption and reduce stomach upset. Common adverse effects include nausea, loss of appetite, abdominal discomfort, and headache. Urine may become dark yellow or brown; this is usually harmless but should be distinguished from blood in the urine. Less common but clinically important adverse reactions include allergic skin rashes, liver injury, lung reactions (acute or chronic pulmonary hypersensitivity), peripheral neuropathy, and blood disorders such as hemolytic anemia, particularly in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Niftran 100 is contraindicated in patients with significantly reduced kidney function, in late pregnancy (near term), and in neonates because of the risk of hemolytic anemia. Caution is required in patients with pre-existing liver disease, lung disease, peripheral neuropathy, anemia, diabetes, or electrolyte imbalances. Long-term use requires periodic monitoring of liver function, kidney function, and pulmonary symptoms. Patients should complete the full prescribed course even if symptoms improve early, to reduce the risk of treatment failure and bacterial resistance. If symptoms persist, worsen, or are accompanied by fever, flank pain, or systemic signs of infection, prompt medical reassessment is necessary.

Uses of NIFTRAN 100MG CAPSULE 10'S

  • Treatment of Bacterial infections of the urinary tract involves addressing the infection with appropriate medication, often antibiotics, to eliminate the bacteria causing the issue and alleviate symptoms.

How NIFTRAN 100MG CAPSULE 10'S Works

  • NIFTRAN 100MG CAPSULE 10'S is an antibiotic medication primarily used to treat urinary tract infections (UTIs). It contains an active ingredient that specifically targets bacteria present in the urine, responsible for causing the infection. This medication works by interfering with essential bacterial processes, ultimately leading to the death of the bacteria and clearing the infection. Specifically, it disrupts bacterial cell wall formation and inhibits certain enzymes necessary for bacterial survival and replication.
  • NIFTRAN 100MG CAPSULE 10'S concentrates in the urine, ensuring high levels of the drug reach the site of infection. The sustained-release (SR) formulation allows for a gradual release of the medication, providing a prolonged effect and potentially reducing the frequency of administration. This helps maintain a consistent level of the antibiotic in the urinary tract over a longer period, maximizing its effectiveness against the bacteria.
  • By directly targeting and eliminating the bacteria causing the UTI, NIFTRAN 100MG CAPSULE 10'S helps to relieve symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain. It is crucial to complete the full course of treatment as prescribed by your doctor, even if symptoms improve before the medication is finished, to ensure the complete eradication of the infection and prevent the development of antibiotic resistance.

Side Effects of NIFTRAN 100MG CAPSULE 10'SArrow

Most side effects are temporary and generally disappear as your body adapts to the medication. If any side effects persist or cause concern, it's important to seek advice from your doctor.

  • Nausea
  • Vomiting
  • Diarrhea

Safety Advice for NIFTRAN 100MG CAPSULE 10'SArrow

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Other medical conditions

Special precautions

Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at increased risk of hemolytic anemia when exposed to nitrofurantoin and should generally avoid Niftran 100 unless the benefit clearly outweighs the risk and close monitoring is feasible.

Dosage of NIFTRAN 100MG CAPSULE 10'SArrow

  • Dosage for children: The dosage of NIFTRAN 100MG CAPSULE 10'S for children varies based on their age, weight, and the specific condition being treated. It is important to follow the prescribing physician's instructions and the dosage guidelines provided with the medication.
  • Dosage for adults: The recommended adult dosage of NIFTRAN 100MG CAPSULE 10'S for treating urinary tract infections is typically 50 to 100 mg taken orally four times a day, with food or milk. However, the dosage may vary depending on the severity of the infection and individual patient factors. It is important to consult a healthcare professional for an accurate dosage recommendation.

How to store NIFTRAN 100MG CAPSULE 10'S?Arrow

  • Keep NIFTRAN 100MG CAP 1X10 away from the reach of children and pets.
  • Store NIFTRAN 100MG CAP 1X10 at room temperature.

Benefits of NIFTRAN 100MG CAPSULE 10'SArrow

  • NIFTRAN 100MG CAPSULE 10'S is a medication specifically designed to combat bacterial infections within the urinary tract. It functions by inhibiting the proliferation of bacteria responsible for causing these infections, effectively halting their growth and spread. This targeted action helps to alleviate the symptoms associated with urinary tract infections, such as frequent urination, burning sensations, and lower abdominal pain.
  • Typically, patients experience noticeable relief and improvement in their condition relatively quickly after commencing treatment with NIFTRAN 100MG CAPSULE 10'S. However, it is crucial to adhere strictly to the prescribed dosage and duration of treatment, even if you start feeling better before the course is completed. This is to ensure that all the bacteria are eradicated completely from the urinary tract.
  • Completing the full course of NIFTRAN 100MG CAPSULE 10'S is essential to prevent the recurrence of the infection and to minimize the risk of bacteria developing resistance to the medication. By ensuring that all bacteria are eliminated, the likelihood of a future infection is significantly reduced, and the effectiveness of the antibiotic is preserved for future use.

How to use NIFTRAN 100MG CAPSULE 10'SArrow

  • It's crucial to take NIFTRAN 100MG CAPSULE 10'S exactly as your doctor has prescribed. This ensures you receive the maximum benefit from the medication and minimizes the risk of side effects. Pay close attention to the dosage instructions and the duration of treatment recommended by your physician.
  • Administering the medicine is simple: swallow the capsule whole with a glass of water. Avoid chewing, crushing, or breaking the capsule, as this could alter the way the medication is absorbed into your body and potentially affect its effectiveness. The capsule is designed to release the medication in a specific manner, so maintaining its integrity is important.
  • For optimal absorption and to reduce the possibility of stomach upset, NIFTRAN 100MG CAPSULE 10'S is best taken with food. This helps your body process the medication more efficiently and can contribute to a more comfortable experience. If you experience any discomfort or have concerns about taking it with food, consult your doctor or pharmacist for further guidance.

FAQs

<h3 class=bodySemiBold>How long does NIFTRAN 100MG CAPSULE 10'S take to work on a UTI?</h3>Arrow

NIFTRAN 100MG CAPSULE 10'S starts acting quickly, but you will not start feeling better immediately after taking it. It may take a few days (2-3 days) before you see any improvement in your symptoms. If you do not start feeling better within 3 days of starting NIFTRAN 100MG CAPSULE 10'S or your condition worsens, contact your doctor. It is important to complete the full course of NIFTRAN 100MG CAPSULE 10'S as advised by your doctor, even if you start feeling better.

<h3 class=bodySemiBold>What happens if you take NIFTRAN 100MG CAPSULE 10'S without food?</h3>Arrow

You should take NIFTRAN 100MG CAPSULE 10'S with your meal or straightaway after the meal. Taking with food helps in absorption of medicine so that it works better. If you take it without food, you are likely to get an upset stomach. The symptoms include nausea, vomiting, diarrhoea, and loss of appetite may also occur. Therefore, to avoid unpleasant side effects, take it exactly as prescribed by your doctor.

<h3 class=bodySemiBold>Does NIFTRAN 100MG CAPSULE 10'S make your urine orange?</h3>Arrow

NIFTRAN 100MG CAPSULE 10'S may turn your urine brown or dark yellow in colour. However, you need not worry as this is usually temporary and completely harmless effect. It will disappear once you stop taking NIFTRAN 100MG CAPSULE 10'S. Consult your doctor if you are not sure or still have any concern, but do not stop taking NIFTRAN 100MG CAPSULE 10'S.

<h3 class=bodySemiBold>Can NIFTRAN 100MG CAPSULE 10'S give you a yeast infection?</h3>Arrow

Yes, some people may get a fungal or yeast infection known as ‘thrush’ after taking NIFTRAN 100MG CAPSULE 10'S. This is because antibiotics kill the ‘good bacteria’ which help in preventing thrush. You should inform your doctor if you get vaginal itching or discharge after taking NIFTRAN 100MG CAPSULE 10'S or soon after stopping it.

<h3 class=bodySemiBold>Is NIFTRAN 100MG CAPSULE 10'S a strong antibiotic?</h3>Arrow

Yes, NIFTRAN 100MG CAPSULE 10'S is a strong antibiotic (or broad spectrum antibiotic), which means that it is effective against a wide variety of urinary bacteria. It is important that NIFTRAN 100MG CAPSULE 10'S should be given to treat or prevent infections that are proven to be caused by susceptible bacteria. This is usually evaluated by a culture test which demonstrates a range of bacteria which cannot grow in the prence of an antibiotic. NIFTRAN 100MG CAPSULE 10'S has seen to be effective against UTI caused by Escherichia coli, Enteroccus faecalis, Klebsiella species, Enterobacter species, Staphylococcus species: (eg S. aureus, S. saprophyticus, S. epidermidis). Some strains of Enterobacter and Klebsiella are resistant to NIFTRAN 100MG CAPSULE 10'S.

What is Niftran 100 and what is it used for?Arrow

Niftran 100 is a capsule containing nitrofurantoin 100 mg, an antibacterial agent used mainly to treat and prevent uncomplicated urinary tract infections, particularly infections of the bladder (cystitis) caused by susceptible bacteria. It is not appropriate for treating kidney infections, prostatitis, or infections outside the urinary tract.

How does Niftran 100 work against urinary tract infections?Arrow

Nitrofurantoin in Niftran 100 is rapidly excreted into the urine, where it reaches concentrations high enough to inhibit bacterial enzymes and damage bacterial DNA. This interferes with vital metabolic processes of susceptible bacteria, leading to inhibition of growth and eventual bacterial death. Its activity is largely confined to the urinary tract because systemic blood levels remain relatively low.

How should I take Niftran 100 capsules?Arrow

Niftran 100 should be taken exactly as prescribed by your doctor. The capsule is usually swallowed whole with a glass of water, preferably with food or milk to enhance absorption and reduce stomach upset. Do not crush or chew the capsule unless your healthcare provider specifically advises otherwise. Do not change the dose or duration on your own.

How long does it take for Niftran 100 to start working?Arrow

Niftran 100 begins to exert antibacterial activity soon after it is absorbed and excreted into the urine, typically within a few hours of the first dose. Many patients notice improvement in urinary symptoms such as burning, urgency, and frequency within 24 to 48 hours. However, you should continue the full prescribed course even if you feel better earlier, unless your doctor tells you to stop.

What are the common side effects of Niftran 100?Arrow

Common side effects include nausea, vomiting, loss of appetite, abdominal discomfort, diarrhea, and headache. Urine discoloration to a dark yellow or brown shade can occur and is usually harmless. Mild dizziness or drowsiness may also be experienced. If these effects are persistent, troublesome, or worsen, you should inform your healthcare provider.

What serious side effects should I watch for while taking Niftran 100?Arrow

Seek medical attention immediately if you develop difficulty breathing, chest pain, persistent cough, or shortness of breath, which may indicate lung reactions. Other serious signs include yellowing of the skin or eyes, dark urine, severe fatigue, unusual bruising or bleeding, numbness or tingling in hands or feet, severe skin rash, peeling, fever with chills, or joint pains. These may signal liver injury, blood disorders, peripheral neuropathy, or severe hypersensitivity reactions.

Can Niftran 100 be used in patients with kidney problems?Arrow

Niftran 100 is not recommended in patients with significantly impaired kidney function because inadequate drug excretion into the urine reduces effectiveness and increases the risk of toxicity. In mild to moderate renal impairment, use may be considered only under close medical supervision with appropriate dose adjustment if indicated. Kidney function should be assessed before starting therapy, especially in older adults.

Is Niftran 100 safe during pregnancy?Arrow

Nitrofurantoin may be used during certain stages of pregnancy when clearly needed and when potential benefits outweigh risks, but it is generally avoided at term (late third trimester) because of the risk of hemolytic anemia in the newborn. Pregnant patients should not take Niftran 100 without medical evaluation. The prescribing clinician will consider gestational age, maternal kidney function, and alternative options before recommending this medicine.

Can I take Niftran 100 while breastfeeding?Arrow

Nitrofurantoin passes into breast milk in small amounts. It is usually considered compatible with breastfeeding for healthy, full-term infants, but it should be avoided if the infant is premature, has jaundice, or is suspected to have glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of hemolytic anemia. Breastfeeding mothers should use Niftran 100 only on medical advice and should report any unusual symptoms in the infant, such as poor feeding, pallor, or jaundice.

Does Niftran 100 interact with other medicines?Arrow

Yes, Niftran 100 can interact with certain medicines. Antacids containing magnesium trisilicate may reduce nitrofurantoin absorption. Some drugs that affect kidney function or urine pH can alter its effectiveness. Probenecid and sulfinpyrazone can reduce renal excretion of nitrofurantoin, increasing blood levels and toxicity risk. It may also interfere with some laboratory tests, such as urine glucose tests using certain methods. Always inform your doctor and pharmacist about all prescription medicines, over-the-counter products, and supplements you are taking.

What should I do if I miss a dose of Niftran 100?Arrow

If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose, as this may increase the risk of side effects without improving efficacy. If you frequently forget doses, discuss strategies with your healthcare provider to improve adherence.

Can I drink alcohol while taking Niftran 100?Arrow

There is no well-established direct interaction between nitrofurantoin and moderate alcohol intake, but alcohol can worsen side effects such as dizziness, drowsiness, and stomach upset. Alcohol may also impair immune function and hydration, which can hinder recovery from infection. It is generally advisable to limit or avoid alcohol while being treated for a urinary tract infection and while taking Niftran 100.

References

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Nitrofurantoin. North Norwich, New York: Norwich Pharmaceuticals, Inc.; 2008.

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Central Drugs Standard Control Organisation (CDSCO).

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Nitrofurantoin monohydrate/macrocrystals [Prescribing Information]. North Norwich, NY: Norwich Pharmaceuticals, Inc.; 2008.

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SUN PHARMACEUTICAL INDUSTRIES LTD

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