NIOCLEAN GEL 20 GM

How NIOCLEAN GEL 20 GM Works

• NIOCLEAN GEL 20 GM is a topical medication primarily used to treat acne vulgaris. Its effectiveness stems from the synergistic action of its active ingredients: Clindamycin and Nicotinamide.
• Clindamycin is an antibiotic that works by inhibiting bacterial protein synthesis. Specifically, it binds to the 23S rRNA of the bacterial 50S ribosomal subunit, preventing the formation of peptide bonds. This action effectively stops the growth and reproduction of acne-causing bacteria, particularly *Cutibacterium acnes* (formerly known as *Propionibacterium acnes*). By reducing the bacterial population on the skin, Clindamycin helps to decrease inflammation and the formation of new acne lesions.
• Nicotinamide, also known as Niacinamide, is a form of vitamin B3. It possesses several beneficial properties for the treatment of acne. Firstly, it has anti-inflammatory effects, which help to reduce the redness, swelling, and pain associated with acne lesions. Nicotinamide achieves this by inhibiting the production of pro-inflammatory cytokines and mediators in the skin.
• Secondly, Nicotinamide can help to regulate sebum (oil) production. Excessive sebum production is a major contributing factor to acne development, as it can clog pores and create a favorable environment for bacterial growth. By controlling sebum production, Nicotinamide helps to prevent the formation of new comedones (blackheads and whiteheads).
• Thirdly, Nicotinamide has been shown to improve the skin's barrier function. A healthy skin barrier is essential for maintaining hydration and protecting against external irritants. By strengthening the skin barrier, Nicotinamide helps to reduce skin sensitivity and improve overall skin health. This also can reduce post inflammatory hyperpigmentation or PIH which is redness of skin after acne.
• In summary, NIOCLEAN GEL 20 GM works by targeting multiple factors involved in acne development. Clindamycin reduces the bacterial population, while Nicotinamide reduces inflammation, regulates sebum production, and improves the skin's barrier function. The combined effect of these ingredients leads to a reduction in acne lesions, improved skin clarity, and a healthier complexion.

Possible side effects of Nioclean Gel 20 GM may include: * Skin irritation (redness, itching, burning, stinging) * Dryness * Peeling or scaling of the skin * Photosensitivity (increased sensitivity to sunlight) * Contact dermatitis (allergic skin reaction) * Temporary skin discoloration * Acne flare-up (in some cases, initially) * Rarely, severe allergic reactions (rash, hives, swelling, difficulty breathing)

• If you forget to apply NioClean Gel at the usual time, apply it as soon as you remember. However, if it is almost time for your next application, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.

• Keep NIOCLEAN GEL 20GM away from the reach of children and pets.
• Store NIOCLEAN GEL 20GM at room temperature.

• **Cleanse the Affected Area:** Before applying Nioclean Gel, gently wash and pat dry the acne-prone or affected skin area. This removes excess oil, dirt, and debris, allowing the medication to penetrate effectively. Use a mild, non-comedogenic cleanser to avoid irritation.
• **Apply a Thin Layer:** Use a pea-sized amount of Nioclean Gel and spread it thinly over the entire affected area. Avoid spot treatment unless specifically instructed by your doctor. Applying too much can increase the risk of dryness, peeling, and irritation. A thin layer ensures even distribution of the active ingredient.
• **Use Consistently as Prescribed:** Nioclean Gel works best when used consistently as directed by your healthcare provider. Typically, it is applied once or twice daily. Missing applications can reduce its effectiveness. Set a reminder if needed to maintain a regular application schedule for optimal results. Improvement may take several weeks, so patience and adherence are key.
• **Moisturize Regularly:** Nioclean Gel can sometimes cause dryness. Combat this by using a non-comedogenic, oil-free moisturizer after the gel has fully absorbed into the skin. This will help maintain skin hydration, reduce irritation, and prevent excessive dryness or peeling, which can sometimes deter users from continuing treatment.
• **Sun Protection is Essential:** Nioclean Gel can make your skin more sensitive to the sun. Always apply a broad-spectrum sunscreen with an SPF of 30 or higher to all exposed skin areas, even on cloudy days. Reapply sunscreen every two hours, especially if you are sweating or swimming. Protecting your skin from the sun will prevent sunburn, hyperpigmentation, and potential skin damage.

• NIOCLEAN GEL 20 GM is for external use only and is unlikely to be affected by the food you consume.
• However, it's always a good practice to inform your doctor about your diet and any other medications you are taking.