oleanz plus tablet 10's
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OLEANZ PLUS TABLET 10'S

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OLEANZ PLUS TABLET 10'S

By SUN PHARMACEUTICAL INDUSTRIES LTD

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135.94

₹115.55

15 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Sanjay Mehta

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About OLEANZ PLUS TABLET 10'S

  • Oleanz Plus is a branded fixed-dose combination medicine that contains olanzapine and fluoxetine. Olanzapine is an atypical antipsychotic, and fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. This combination is generally used under specialist supervision for treatment-resistant major depressive disorder and for depressive episodes associated with bipolar disorder, when monotherapy with an antidepressant or mood stabiliser has not been sufficient. It acts on multiple neurotransmitter systems in the brain, including serotonin, dopamine, and norepinephrine pathways, to help stabilise mood, reduce depressive symptoms, and control associated anxiety or agitation. Olanzapine works mainly by blocking dopamine D2 and serotonin 5-HT2A receptors, which helps in reducing psychotic symptoms, mood swings, and agitation. Fluoxetine increases serotonin levels in the synaptic cleft by inhibiting its reuptake, which can improve mood, sleep, appetite, and energy in people with depression. The combination may be chosen when there is a need for both antipsychotic and antidepressant actions in a single tablet, but it is not a first-line treatment and is usually reserved for patients who have not responded adequately to other regimens. Oleanz Plus should only be used on the prescription of a psychiatrist or qualified physician, after a detailed assessment of mental health history, physical health, and concurrent medications. The dose and duration are individualised and must not be altered, started, or stopped without medical advice. Abrupt discontinuation can lead to withdrawal symptoms, relapse, or worsening of mood and behaviour. Commonly reported adverse effects include weight gain, increased appetite, drowsiness, dizziness, dry mouth, constipation, tremor, restlessness, and changes in sleep pattern. Metabolic changes such as increased blood sugar, cholesterol, and triglycerides can occur, particularly with longer-term use. Some patients may experience sexual dysfunction, sweating, or gastrointestinal discomfort. Serious but less common risks include neuroleptic malignant syndrome, serotonin syndrome, severe extrapyramidal symptoms, seizures, significant changes in blood pressure, and abnormalities in heart rhythm (including QT prolongation). Oleanz Plus can increase suicidal thoughts or behaviour in some adolescents and young adults, especially in the early phase of treatment or after dose changes. Close monitoring by caregivers and clinicians is essential. It may also impair judgment, thinking, and motor skills, so caution is required with activities that need alertness. The medicine can interact with many other drugs, including other antidepressants, antipsychotics, mood stabilisers, benzodiazepines, certain antibiotics, antiarrhythmics, and medicines that affect liver enzymes. Alcohol use can enhance sedation and other central nervous system effects and is generally discouraged. Patients with diabetes, obesity, high cholesterol, liver or kidney impairment, cardiovascular disease, seizure disorders, glaucoma, or a history of low white blood cell counts require careful evaluation and regular monitoring. Periodic checks of weight, waist circumference, fasting blood glucose, lipid profile, and, when indicated, liver function and complete blood counts are recommended. Oleanz Plus is not suitable for everyone, and risk–benefit assessment must be individualised. It should be kept out of reach of children and never shared with others, even if they have similar symptoms.

Uses of OLEANZ PLUS TABLET 10'S

  • Treatment of Schizophrenia
  • Treatment of Bipolar disorder
  • Treatment of Mental disorders
  • Treatment of Mood swings
  • Treatment of Anxiety
  • Treatment of Depression
  • Treatment of Mania

How OLEANZ PLUS TABLET 10'S Works

  • OLEANZ PLUS TABLET 10'S is a combination medicine designed to address mental health conditions, primarily schizophrenia and bipolar disorder. It combines the therapeutic actions of olanzapine and fluoxetine to provide comprehensive symptom management.
  • Olanzapine, an atypical antipsychotic, works by affecting several neurotransmitters in the brain. It primarily blocks dopamine and serotonin receptors. By blocking dopamine receptors, olanzapine helps to reduce psychotic symptoms such as hallucinations, delusions, and disorganized thinking, which are commonly associated with schizophrenia. The blockade of serotonin receptors contributes to its mood-stabilizing effects, making it useful in managing bipolar disorder. Olanzapine's action on these receptors helps to normalize brain activity and reduce the severity of psychotic and manic episodes.
  • Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), primarily works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that plays a crucial role in regulating mood, emotions, and sleep. Fluoxetine inhibits the reabsorption (reuptake) of serotonin in the brain, which means more serotonin is available to bind to receptors on nerve cells. This increased serotonin activity helps to improve mood, reduce symptoms of depression, and alleviate anxiety. In the context of OLEANZ PLUS, fluoxetine complements olanzapine by addressing the depressive aspects of bipolar disorder and improving overall mood stability.
  • The combined action of olanzapine and fluoxetine in OLEANZ PLUS provides a synergistic effect. Olanzapine targets the psychotic and manic symptoms, while fluoxetine addresses the depressive components. This combination can lead to more effective symptom control than using either medication alone. By modulating dopamine and serotonin levels, OLEANZ PLUS helps to restore chemical balance in the brain, reducing the frequency and intensity of mood swings and psychotic episodes. This comprehensive approach allows individuals to experience improved mental clarity, emotional stability, and overall quality of life.
  • It is important to note that OLEANZ PLUS should be taken as prescribed by a healthcare professional. The dosage and duration of treatment will depend on the individual's specific condition and response to the medication. Regular monitoring by a doctor is essential to ensure the medication's effectiveness and to manage any potential side effects. Individuals should also be aware that it may take several weeks to experience the full therapeutic benefits of OLEANZ PLUS.

Side Effects of OLEANZ PLUS TABLET 10'SArrow

Common side effects of OLEANZ PLUS TABLET may include drowsiness, weight gain, increased appetite, dizziness, lightheadedness, weakness, dry mouth, constipation, and blurred vision. Some people may also experience restlessness, tremors, muscle stiffness, or difficulty with movement. Less common side effects can involve changes in blood sugar and cholesterol levels, swelling in the hands or feet, breast enlargement or discharge, decreased sexual desire, and menstrual irregularities. Rarely, more serious side effects such as neuroleptic malignant syndrome (NMS), tardive dyskinesia, seizures, severe allergic reactions, and blood disorders may occur. Contact your doctor immediately if you experience any severe or persistent side effects.

Safety Advice for OLEANZ PLUS TABLET 10'SArrow

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Other Medical Conditions and Interactions

Use under close supervision

Caution is required in patients with a history of seizures, cardiovascular disease, stroke, low blood pressure, glaucoma, urinary retention, or low white blood cell counts.

Dosage of OLEANZ PLUS TABLET 10'SArrow

  • The recommended dosage of OLEANZ PLUS TABLET 10'S varies significantly depending on the individual's condition, severity of symptoms, and response to treatment. It is crucial to adhere strictly to the dosage prescribed by your physician. Typically, the starting dose may range from a low dose, gradually increasing as needed and tolerated. This titration approach helps minimize potential side effects and optimize therapeutic benefits.
  • OLEANZ PLUS TABLET 10'S is usually taken once daily, with or without food. Consistency in timing is important for maintaining stable blood levels of the medication. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • Your doctor may adjust your dosage over time based on your progress and any side effects you experience. It is important to attend all scheduled follow-up appointments and communicate openly with your doctor about any concerns or changes in your health. Suddenly discontinuing OLEANZ PLUS TABLET 10'S can lead to withdrawal symptoms or a worsening of your condition, so always consult your doctor before making any changes to your medication regimen.
  • Factors such as age, weight, kidney function, liver function, and other medical conditions can influence the appropriate dosage. Individuals with certain medical conditions may require lower doses or more careful monitoring. Always inform your doctor about all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, as drug interactions can affect the effectiveness and safety of OLEANZ PLUS TABLET 10'S.
  • Take 'OLEANZ PLUS TABLET 10'S' only as per the prescription by your physician only

What if I miss my dose of OLEANZ PLUS TABLET 10'S?Arrow

  • If you miss a dose of Oleanz Plus Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store OLEANZ PLUS TABLET 10'S?Arrow

  • Keep OLEANZ PLUS TAB 1X10 away from the reach of children and pets.
  • Store OLEANZ PLUS TAB 1X10 at room temperature.

Benefits of OLEANZ PLUS TABLET 10'SArrow

  • OLEANZ PLUS TABLET 10'S offers a comprehensive approach to managing mental health conditions by combining the therapeutic effects of two active ingredients. This combination provides a multi-faceted strategy to alleviate symptoms and improve the overall well-being of individuals suffering from conditions such as schizophrenia, bipolar disorder, and related mood disorders.
  • One of the primary benefits of OLEANZ PLUS TABLET 10'S is its efficacy in reducing psychotic symptoms. The medication helps to alleviate hallucinations, delusions, and disorganized thinking, enabling patients to regain a clearer perception of reality. By targeting specific neurotransmitter pathways in the brain, OLEANZ PLUS TABLET 10'S helps stabilize mood and reduce the frequency and intensity of psychotic episodes.
  • In addition to its antipsychotic properties, OLEANZ PLUS TABLET 10'S also demonstrates mood-stabilizing effects. This is particularly beneficial for individuals with bipolar disorder, where extreme shifts in mood can significantly impair daily functioning. The medication helps to regulate mood swings, preventing both manic and depressive episodes. This allows patients to maintain a more balanced emotional state and lead more productive lives.
  • Furthermore, OLEANZ PLUS TABLET 10'S can improve cognitive function in some individuals. Mental health conditions can often impair cognitive abilities such as attention, memory, and executive function. By reducing the severity of symptoms, OLEANZ PLUS TABLET 10'S can indirectly improve cognitive performance, allowing patients to think more clearly and concentrate more effectively.
  • OLEANZ PLUS TABLET 10'S also promotes better sleep quality. Sleep disturbances are common in individuals with mental health conditions, further exacerbating symptoms and impairing overall well-being. By regulating neurotransmitter activity, OLEANZ PLUS TABLET 10'S can promote more restful sleep, leading to improved mood, energy levels, and cognitive function.
  • Another significant benefit of OLEANZ PLUS TABLET 10'S is its ability to reduce anxiety and agitation. Many individuals with mental health conditions experience heightened levels of anxiety and restlessness. The medication helps to calm the nervous system, reducing feelings of anxiety and promoting a sense of relaxation. This can significantly improve the patient's ability to cope with daily stressors and engage in social activities.
  • Finally, OLEANZ PLUS TABLET 10'S can improve overall quality of life. By effectively managing symptoms such as psychosis, mood swings, cognitive impairment, sleep disturbances, and anxiety, the medication allows patients to regain control over their lives. This leads to improved social relationships, increased productivity, and a greater sense of fulfillment. OLEANZ PLUS TABLET 10'S is a valuable tool in the management of mental health conditions, empowering individuals to live more fulfilling and meaningful lives. It is crucial to consult with a healthcare professional to determine if OLEANZ PLUS TABLET 10'S is the right medication for your specific needs and to discuss any potential risks and benefits.

How to use OLEANZ PLUS TABLET 10'SArrow

  • OLEANZ PLUS TABLET 10'S is an oral medication and should be taken exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as this could lead to a worsening of your condition or withdrawal symptoms. Typically, it is taken once daily, with or without food, but it is best to take it at the same time each day to maintain a consistent level of medication in your body.
  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can affect how the medication is absorbed. If you have difficulty swallowing pills, discuss it with your doctor or pharmacist; they may be able to offer alternative formulations or strategies.
  • It is important to adhere to the full course of treatment, even if you start feeling better. The medication may take several weeks to reach its full effect. Be patient and continue taking the medication as prescribed. Regular follow-up appointments with your doctor are necessary to monitor your progress and adjust the dosage if needed.
  • Avoid consuming alcohol while taking OLEANZ PLUS TABLET 10'S, as it can increase the risk of side effects, such as drowsiness and dizziness. Also, be cautious when driving or operating heavy machinery until you know how the medication affects you. If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • Store OLEANZ PLUS TABLET 10'S at room temperature, away from heat, light, and moisture. Keep the medication out of reach of children and pets. If you have any questions or concerns about how to take this medication, or if you experience any unusual side effects, contact your doctor or pharmacist immediately.

Quick Tips for OLEANZ PLUS TABLET 10'SArrow

  • Take OLEANZ PLUS TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as this can lead to a relapse of your symptoms. It's crucial to adhere to the prescribed treatment plan for optimal results.
  • OLEANZ PLUS TABLET 10'S can cause drowsiness. Avoid driving or operating heavy machinery until you know how the medication affects you. If you experience excessive sleepiness, discuss it with your doctor, who may adjust your dosage or suggest alternative strategies.
  • Be aware of potential side effects, such as weight gain, increased appetite, and changes in blood sugar levels. Maintain a healthy diet and exercise regularly to manage these side effects. Regular monitoring of your weight and blood sugar is advisable while taking OLEANZ PLUS TABLET 10'S.
  • Inform your doctor about all other medications, supplements, and herbal products you are taking. OLEANZ PLUS TABLET 10'S can interact with other substances, potentially leading to adverse effects or reduced efficacy. A comprehensive medication history ensures safer and more effective treatment.
  • If you experience any unusual or severe side effects, such as muscle stiffness, fever, confusion, or irregular heartbeat, seek immediate medical attention. These could be signs of a serious adverse reaction. Prompt medical intervention can prevent complications and ensure your well-being.
  • Store OLEANZ PLUS TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage maintains the medication's effectiveness and prevents accidental ingestion.
  • Regular follow-up appointments with your doctor are essential while taking OLEANZ PLUS TABLET 10'S. These visits allow your doctor to monitor your progress, assess for any side effects, and make necessary adjustments to your treatment plan. Consistent communication with your healthcare provider ensures the best possible outcome.
  • Avoid alcohol consumption while taking OLEANZ PLUS TABLET 10'S, as it can increase the risk of drowsiness and other side effects. Alcohol can also interfere with the medication's effectiveness. Abstaining from alcohol promotes safer and more predictable treatment results.

Food Interactions with OLEANZ PLUS TABLET 10'SArrow

  • OLEANZ PLUS TABLET 10'S can be taken with or without food. However, consistent timing with meals is recommended to maintain a steady level of medication in your body. While there are no specific food restrictions, it's advisable to avoid excessive alcohol consumption as it may increase the risk of side effects such as drowsiness and dizziness. Consult your doctor for personalized advice based on your specific health condition and other medications you may be taking.

FAQs

What is Oleanz Plus Tablet 10'S?Arrow

Oleanz Plus Tablet 10'S is a medication used to treat certain mental health conditions.

What is Oleanz Plus Tablet 10'S used for?Arrow

This medication helps in treating mental disorders such as schizophrenia and bipolar disorder.

How does Oleanz Plus Tablet 10'S work?Arrow

It works by affecting the balance of certain natural chemicals in the brain.

What are the common side effects of Oleanz Plus Tablet 10'S?Arrow

Common side effects may include drowsiness, weight gain, dizziness, and dry mouth.

Is Oleanz Plus Tablet 10'S addictive?Arrow

No, Oleanz Plus Tablet 10'S is not addictive.

Can I drink alcohol with Oleanz Plus Tablet 10'S?Arrow

It is not recommended to drink alcohol with Oleanz Plus Tablet 10'S, as it can increase side effects.

What happens if I miss a dose of Oleanz Plus Tablet 10'S?Arrow

If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Is Oleanz Plus Tablet 10'S safe for pregnant women?Arrow

It is important to consult a doctor before using Oleanz Plus Tablet 10'S during pregnancy.

How to store Oleanz Plus Tablet 10'S?Arrow

Store it at room temperature, away from moisture and heat.

Is Oleanz Plus Tablet 10'S safe for children?Arrow

Oleanz Plus Tablet 10'S should be used in children only under the advice of a doctor.

What are the symptoms of an overdose of Oleanz Plus Tablet 10'S?Arrow

Symptoms of an overdose may include drowsiness, confusion, rapid heartbeat, and fainting.

Does Oleanz Plus Tablet 10'S interact with other medications?Arrow

Oleanz Plus Tablet 10'S can interact with certain medications. Tell your doctor about all the medications you are taking.

Can Oleanz Plus Tablet 10'S cause weight gain?Arrow

Yes, Oleanz Plus Tablet 10'S can cause weight gain.

What are the alternatives to Oleanz Plus Tablet 10'S?Arrow

There are several alternatives available. Please consult your doctor.

What should I monitor while taking Oleanz Plus Tablet 10'S?Arrow

It is advisable to monitor blood sugar levels, cholesterol levels, and weight.

What is Oleanz Plus used for?Arrow

Oleanz Plus is a fixed-dose combination of olanzapine (an atypical antipsychotic) and fluoxetine (an SSRI antidepressant). It is generally prescribed for treatment-resistant major depressive disorder and for depressive episodes associated with bipolar disorder when other treatments have not provided adequate benefit. The decision to use this combination is made by a psychiatrist or specialist after careful evaluation.

How does Oleanz Plus work in the body?Arrow

Olanzapine in Oleanz Plus blocks certain dopamine and serotonin receptors, helping to stabilise mood, reduce agitation, and control psychotic-like symptoms. Fluoxetine increases serotonin levels in the brain by inhibiting its reuptake, which can improve mood, energy, and anxiety symptoms. Together, they provide both antipsychotic and antidepressant effects, which may be useful in complex or resistant depressive conditions.

How long does it take for Oleanz Plus to start working?Arrow

Some people may notice improvements in sleep, appetite, or anxiety within 1–2 weeks, but significant improvement in mood and overall functioning often takes several weeks. Full therapeutic effects may require 4–6 weeks or longer. Response time varies between individuals. Treatment should not be stopped early without consulting the prescribing doctor, even if improvement seems slow.

Can I stop taking Oleanz Plus suddenly if I feel better?Arrow

No. Stopping Oleanz Plus abruptly can lead to withdrawal symptoms such as nausea, dizziness, irritability, sleep disturbance, anxiety, and a rapid return or worsening of depressive or mood symptoms. Any change in dose, including discontinuation, should be done gradually and only under medical supervision, following a tapering plan provided by your doctor.

What are the common side effects of Oleanz Plus?Arrow

Common side effects include weight gain, increased appetite, drowsiness, dizziness, dry mouth, constipation, fatigue, tremor, restlessness, and changes in sleep pattern. Some people may experience sexual dysfunction, sweating, or gastrointestinal discomfort. Many side effects are dose-related and may lessen over time, but persistent or troublesome symptoms should be discussed with the treating physician.

Does Oleanz Plus cause weight gain or metabolic problems?Arrow

Yes, Oleanz Plus, mainly due to olanzapine, is associated with weight gain and metabolic changes. It can increase appetite and may raise blood sugar, cholesterol, and triglyceride levels. Patients should have regular monitoring of weight, waist circumference, fasting blood glucose, and lipid profile. Lifestyle measures such as a balanced diet and regular physical activity are important, and any significant changes should be reported to the doctor.

Is Oleanz Plus addictive or habit-forming?Arrow

Oleanz Plus is not considered addictive in the way that substances of abuse are, and it does not produce a typical drug "high." However, the body can adapt to its presence, and sudden discontinuation may cause withdrawal-like symptoms or relapse of the underlying condition. This is why it must be started, adjusted, and stopped only under medical guidance.

Can Oleanz Plus increase suicidal thoughts?Arrow

Antidepressant-containing medicines, including those with fluoxetine, can increase the risk of suicidal thoughts and behaviour in some adolescents and young adults, particularly in the early stages of treatment or after dose changes. Close monitoring by family members and healthcare professionals is essential. Any new or worsening suicidal thoughts, self-harm behaviour, severe agitation, or sudden mood changes should be reported immediately and treated as an emergency if needed.

Can I drink alcohol while taking Oleanz Plus?Arrow

Alcohol is generally not recommended while taking Oleanz Plus. Both alcohol and this medicine act on the central nervous system and can increase drowsiness, dizziness, impaired judgment, and risk of accidents. Alcohol may also worsen mood symptoms and interfere with treatment response. If you consume alcohol, discuss this openly with your doctor so that individual advice can be given.

Is Oleanz Plus safe during pregnancy?Arrow

Use of Oleanz Plus during pregnancy requires careful risk–benefit assessment by a specialist. Both olanzapine and fluoxetine can cross the placenta. Exposure, especially in late pregnancy, may be associated with neonatal adaptation symptoms such as irritability, feeding difficulties, respiratory problems, or altered muscle tone in the newborn. The medicine should be used in pregnancy only if the potential benefit to the mother clearly outweighs the potential risks to the fetus, and alternative options have been considered.

Can I take Oleanz Plus while breastfeeding?Arrow

Both olanzapine and fluoxetine can pass into breast milk. There is a potential risk of side effects in the breastfed infant, such as sedation, poor feeding, irritability, or developmental concerns. The decision to use Oleanz Plus while breastfeeding should be made by the treating physician after weighing the benefits of treatment for the mother against the potential risks for the infant. In some cases, an alternative medicine or avoidance of breastfeeding may be recommended.

What precautions should be taken if I have diabetes or high cholesterol?Arrow

People with diabetes, prediabetes, obesity, or high cholesterol require particular caution with Oleanz Plus because olanzapine can worsen blood sugar and lipid levels and promote weight gain. Before starting treatment, baseline measurements of weight, waist circumference, fasting blood glucose, and lipid profile are advisable, with regular follow-up monitoring. Dose adjustments of antidiabetic medicines, dietary changes, and increased physical activity may be needed. Any signs of excessive thirst, frequent urination, or unexplained fatigue should be reported promptly.

References

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FDA prescribing information for olanzapine (one of the ingredients in Oleanz Plus) - provides detailed information on pharmacology, clinical studies, and safety.

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A systematic review of fluoxetine and olanzapine combination for treatment-resistant depression.

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A study evaluating the effectiveness and safety of olanzapine and fluoxetine combination therapy in patients with bipolar depression.

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DrugBank entry for Olanzapine, providing detailed chemical and pharmacological information.

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DrugBank entry for Fluoxetine, providing detailed chemical and pharmacological information.

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European Medicines Agency (EMA) assessment report for Zyprexa (Olanzapine), including details on clinical efficacy and safety data.

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Marketer / Manufacturer Details

SUN PHARMACEUTICAL INDUSTRIES LTD

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India

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