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Composition
Content Reviewed By:
Dr. Sanjay Mehta
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Common side effects of OLEANZ PLUS TABLET may include drowsiness, weight gain, increased appetite, dizziness, lightheadedness, weakness, dry mouth, constipation, and blurred vision. Some people may also experience restlessness, tremors, muscle stiffness, or difficulty with movement. Less common side effects can involve changes in blood sugar and cholesterol levels, swelling in the hands or feet, breast enlargement or discharge, decreased sexual desire, and menstrual irregularities. Rarely, more serious side effects such as neuroleptic malignant syndrome (NMS), tardive dyskinesia, seizures, severe allergic reactions, and blood disorders may occur. Contact your doctor immediately if you experience any severe or persistent side effects.

Other Medical Conditions and Interactions
Use under close supervisionCaution is required in patients with a history of seizures, cardiovascular disease, stroke, low blood pressure, glaucoma, urinary retention, or low white blood cell counts.
Oleanz Plus Tablet 10'S is a medication used to treat certain mental health conditions.
This medication helps in treating mental disorders such as schizophrenia and bipolar disorder.
It works by affecting the balance of certain natural chemicals in the brain.
Common side effects may include drowsiness, weight gain, dizziness, and dry mouth.
No, Oleanz Plus Tablet 10'S is not addictive.
It is not recommended to drink alcohol with Oleanz Plus Tablet 10'S, as it can increase side effects.
If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
It is important to consult a doctor before using Oleanz Plus Tablet 10'S during pregnancy.
Store it at room temperature, away from moisture and heat.
Oleanz Plus Tablet 10'S should be used in children only under the advice of a doctor.
Symptoms of an overdose may include drowsiness, confusion, rapid heartbeat, and fainting.
Oleanz Plus Tablet 10'S can interact with certain medications. Tell your doctor about all the medications you are taking.
Yes, Oleanz Plus Tablet 10'S can cause weight gain.
There are several alternatives available. Please consult your doctor.
It is advisable to monitor blood sugar levels, cholesterol levels, and weight.
Oleanz Plus is a fixed-dose combination of olanzapine (an atypical antipsychotic) and fluoxetine (an SSRI antidepressant). It is generally prescribed for treatment-resistant major depressive disorder and for depressive episodes associated with bipolar disorder when other treatments have not provided adequate benefit. The decision to use this combination is made by a psychiatrist or specialist after careful evaluation.
Olanzapine in Oleanz Plus blocks certain dopamine and serotonin receptors, helping to stabilise mood, reduce agitation, and control psychotic-like symptoms. Fluoxetine increases serotonin levels in the brain by inhibiting its reuptake, which can improve mood, energy, and anxiety symptoms. Together, they provide both antipsychotic and antidepressant effects, which may be useful in complex or resistant depressive conditions.
Some people may notice improvements in sleep, appetite, or anxiety within 1–2 weeks, but significant improvement in mood and overall functioning often takes several weeks. Full therapeutic effects may require 4–6 weeks or longer. Response time varies between individuals. Treatment should not be stopped early without consulting the prescribing doctor, even if improvement seems slow.
No. Stopping Oleanz Plus abruptly can lead to withdrawal symptoms such as nausea, dizziness, irritability, sleep disturbance, anxiety, and a rapid return or worsening of depressive or mood symptoms. Any change in dose, including discontinuation, should be done gradually and only under medical supervision, following a tapering plan provided by your doctor.
Common side effects include weight gain, increased appetite, drowsiness, dizziness, dry mouth, constipation, fatigue, tremor, restlessness, and changes in sleep pattern. Some people may experience sexual dysfunction, sweating, or gastrointestinal discomfort. Many side effects are dose-related and may lessen over time, but persistent or troublesome symptoms should be discussed with the treating physician.
Yes, Oleanz Plus, mainly due to olanzapine, is associated with weight gain and metabolic changes. It can increase appetite and may raise blood sugar, cholesterol, and triglyceride levels. Patients should have regular monitoring of weight, waist circumference, fasting blood glucose, and lipid profile. Lifestyle measures such as a balanced diet and regular physical activity are important, and any significant changes should be reported to the doctor.
Oleanz Plus is not considered addictive in the way that substances of abuse are, and it does not produce a typical drug "high." However, the body can adapt to its presence, and sudden discontinuation may cause withdrawal-like symptoms or relapse of the underlying condition. This is why it must be started, adjusted, and stopped only under medical guidance.
Antidepressant-containing medicines, including those with fluoxetine, can increase the risk of suicidal thoughts and behaviour in some adolescents and young adults, particularly in the early stages of treatment or after dose changes. Close monitoring by family members and healthcare professionals is essential. Any new or worsening suicidal thoughts, self-harm behaviour, severe agitation, or sudden mood changes should be reported immediately and treated as an emergency if needed.
Alcohol is generally not recommended while taking Oleanz Plus. Both alcohol and this medicine act on the central nervous system and can increase drowsiness, dizziness, impaired judgment, and risk of accidents. Alcohol may also worsen mood symptoms and interfere with treatment response. If you consume alcohol, discuss this openly with your doctor so that individual advice can be given.
Use of Oleanz Plus during pregnancy requires careful risk–benefit assessment by a specialist. Both olanzapine and fluoxetine can cross the placenta. Exposure, especially in late pregnancy, may be associated with neonatal adaptation symptoms such as irritability, feeding difficulties, respiratory problems, or altered muscle tone in the newborn. The medicine should be used in pregnancy only if the potential benefit to the mother clearly outweighs the potential risks to the fetus, and alternative options have been considered.
Both olanzapine and fluoxetine can pass into breast milk. There is a potential risk of side effects in the breastfed infant, such as sedation, poor feeding, irritability, or developmental concerns. The decision to use Oleanz Plus while breastfeeding should be made by the treating physician after weighing the benefits of treatment for the mother against the potential risks for the infant. In some cases, an alternative medicine or avoidance of breastfeeding may be recommended.
People with diabetes, prediabetes, obesity, or high cholesterol require particular caution with Oleanz Plus because olanzapine can worsen blood sugar and lipid levels and promote weight gain. Before starting treatment, baseline measurements of weight, waist circumference, fasting blood glucose, and lipid profile are advisable, with regular follow-up monitoring. Dose adjustments of antidiabetic medicines, dietary changes, and increased physical activity may be needed. Any signs of excessive thirst, frequent urination, or unexplained fatigue should be reported promptly.
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