PEGADRIA 50 INJECTION
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PEGADRIA 50 INJECTION
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PEGADRIA 50 INJECTION

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PEGADRIA 50 INJECTION

By INTAS PHARMACEUTICALS LIMITED

MRP

8600

₹6949

19.2 % OFF

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Product DetailsArrow

About PEGADRIA 50 INJECTION

  • PEGADRIA 50 INJECTION is an anticancer medication containing doxorubicin, an active ingredient encapsulated in a liposome (a closed lipid sphere). Cancer is characterized by the uncontrolled and abnormal multiplication of cells. This medication is used to treat various cancers, including breast cancer, ovarian cancer, multiple myeloma (a cancer of plasma cells, a type of white blood cell), and AIDS-related Kaposi’s sarcoma.
  • Individuals with HIV infection are at the highest risk of developing Kaposi’s sarcoma, a cancer that originates in the lining of the lymph and blood vessels. PEGADRIA 50 INJECTION can be administered as a standalone treatment or in conjunction with other anticancer medications. It is generally not recommended for use in adolescents and children due to the lack of sufficient safety and efficacy data in these age groups. Therefore, its use is restricted to adults unless specifically indicated by a healthcare professional.
  • It is crucial to use effective birth control methods during the treatment period and for at least six months following the final dose of PEGADRIA 50 INJECTION to prevent potential harm to the fetus. Before starting PEGADRIA 50 INJECTION, inform your doctor if you have any allergies, especially to peanuts or soya, or if you are currently taking medications for heart or liver conditions. Also, disclose any pre-existing conditions such as diabetes, Kaposi’s sarcoma, or any oral health issues. This information will help your doctor assess the risks and benefits of the treatment and make necessary adjustments to ensure your safety.

Uses of PEGADRIA 50 INJECTION

  • Breast cancer: This injection helps to stop or slow down the growth of breast cancer cells.
  • Ovarian cancer: This injection is used in the treatment of ovarian cancer by targeting and disrupting the growth of cancer cells.
  • Multiple myeloma: This injection may be used in the treatment of multiple myeloma, a type of blood cancer that affects plasma cells.
  • AIDS-related Kaposi’s sarcoma: PEGADRIA 50 INJECTION is used to treat AIDS-related Kaposi’s sarcoma, a cancer that occurs in people with HIV/AIDS.

Side Effects of PEGADRIA 50 INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. If you experience any of the following serious side effects, seek immediate medical attention: Common side effects include:

  • Fever, tiredness, bruising or bleeding
  • Severe diarrhea, sores in mouth, nausea, vomiting
  • Lung infections, shortness of breath
  • Severe stomach pain
  • Severe weakness
  • Low blood cell counts
  • Hair loss
  • Decreased appetite
  • Skin rashes
  • Pain in the muscles and joints
  • Constipation
  • Feeling confused, difficulty sleeping
  • Headache, dizziness, sleepiness
  • Change in taste
  • High or low blood pressure
  • Excessive sweating
  • Pain when passing urine
  • Weight loss
  • Muscle spasms
  • Fast heartbeat

Safety Advice for PEGADRIA 50 INJECTIONArrow

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Pregnancy

UNSAFE

PEGADRIA 50 INJECTION may harm the unborn baby. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine.

Dosage of PEGADRIA 50 INJECTIONArrow

  • PEGADRIA 50 INJECTION should only be administered by doctors experienced in cancer chemotherapy. Your doctor will decide the appropriate dosage and how often you receive it, based on the type and severity of your cancer.
  • For breast and ovarian cancer, the typical dose is 50 mg/m2 of body surface, given intravenously once every 4 weeks. This treatment is usually continued for at least 4 cycles. Your doctor will monitor your response to the medication and adjust the treatment plan accordingly.
  • For AIDS-related Kaposi Sarcoma, PEGADRIA 50 INJECTION is used at a dose of 20 mg/m2 of body surface, given intravenously every two to three weeks. This is generally only considered after other systemic chemotherapy options have failed or if you experienced significant intolerance to those treatments. The decision to use this medication will be based on careful consideration of your overall health and treatment history.
  • In the treatment of multiple myeloma, the protocol involves two drugs: First, bortezomib is given at a dose of 1.3 mg/m2 as an intravenous bolus on days 1, 4, 8, and 11 of a three-week cycle. Then, on day 4 following the bortezomib administration, PEGADRIA 50 INJECTION 30 mg/m2 is given as a 1-hour intravenous infusion. The sequence and timing of these medications are critical for effective treatment.

How to store PEGADRIA 50 INJECTION?Arrow

  • Keep PEGADRIA 50MG INJ 25ML away from the reach of children and pets.
  • Store PEGADRIA 50MG INJ 25ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of PEGADRIA 50 INJECTIONArrow

  • PEGADRIA 50 INJECTION represents a significant advancement in drug delivery, utilizing liposomes to encapsulate and transport doxorubicin HCl. This innovative formulation enhances the drug's effectiveness by improving its targeted delivery to cancer cells and minimizing exposure to healthy tissues. Doxorubicin HCl, the active ingredient, is a potent anti-cancer agent that works by interfering with DNA replication and repair processes within cancer cells. Specifically, it binds to DNA, inhibiting the synthesis of nucleic acids, which are essential for cell division and growth. This disruption ultimately leads to the death of rapidly dividing cancer cells.
  • The liposomal formulation of PEGADRIA 50 INJECTION offers several advantages over traditional doxorubicin formulations. Liposomes protect the drug from degradation in the bloodstream, prolonging its circulation time and allowing for greater accumulation in tumor tissues. This targeted delivery reduces the risk of side effects commonly associated with chemotherapy, such as hair loss, nausea, and cardiac toxicity. By selectively targeting cancer cells, PEGADRIA 50 INJECTION maximizes its therapeutic effect while minimizing damage to healthy cells.
  • Furthermore, studies have shown that PEGADRIA 50 INJECTION can effectively penetrate cancer cells, binding to specific proteins within the DNA and disrupting the cell's ability to divide and replicate. This mechanism of action makes it a valuable treatment option for a variety of cancers. The ability to precisely target and disrupt cancer cell function contributes to the overall effectiveness of PEGADRIA 50 INJECTION in combating cancerous growth.

How to use PEGADRIA 50 INJECTIONArrow

  • PEGADRIA 50 INJECTION should only be administered by physicians who are highly experienced in cancer chemotherapy. The specific dosage and frequency of administration will be determined by your physician, taking into account the type of cancer you have and the severity of your condition. It's crucial to adhere strictly to their guidance.
  • For breast and ovarian cancer, the typical protocol involves intravenous administration of the medicine at a dose of 50 mg/m2 of body surface area. This is usually done once every 4 weeks, and the treatment plan generally includes at least 4 courses to achieve the desired therapeutic effect. The exact duration of the treatment will be determined by your healthcare provider based on your response to the medication and overall health.
  • In the treatment of AIDS-related Kaposi Sarcoma, PEGADRIA 50 INJECTION is administered intravenously at a dose of 20 mg/m2 of body surface area. This is typically done once every two to three weeks. However, this treatment is generally reserved for cases where prior systemic chemotherapy has failed or if the patient has experienced significant intolerance to previous therapies. Your doctor will carefully evaluate your medical history before initiating this treatment.
  • For multiple myeloma treatment, a combination therapy is used. Initially, bortezomib is administered intravenously at a dose of 1.3 mg/m2 as an intravenous bolus on days 1, 4, 8, and 11 of a three-week cycle. Following the bortezomib treatment, PEGADRIA 50 INJECTION at a dose of 30 mg/m2 is administered as a 1-hour intravenous infusion on day 4 after the bortezomib administration. This combined approach aims to maximize the effectiveness of the treatment.

FAQs

What is the use of PEGADRIA 50 INJECTION?Arrow

This medication is used to treat breast cancer, ovarian cancer, multiple myeloma (cancer of white blood cells called plasma cells) and AIDS-related Kaposi’s sarcoma.

Is it safe to use PEGADRIA 50 INJECTION while driving?Arrow

No, it is unsafe to use this medication while driving and handling heavy machinery as it causes lack of concentration and alertness.

How does PEGADRIA 50 INJECTION work?Arrow

It damages the genetic material (DNA) of the cancer cells and stops their growth and multiplication

What are the side effects of PEGADRIA 50 INJECTION?Arrow

The common side effects of these medications are nausea, vomiting, rash, weakness, low blood platelets, Fatigue, Fever, Loss of appetite, Anemia, and Constipation.

Is it safe to use PEGADRIA 50 INJECTION during pregnancy?Arrow

It is unsafe to use this medication in patients planning for pregnancy or during pregnancy and breastfeeding mothers as it causes harmful effects for the baby.

Does PEGADRIA 50 INJECTION interact with other drugs?Arrow

No known drug interactions with PEGADRIA 50 INJECTION.

What advice should I follow while using PEGADRIA 50 INJECTION?Arrow

Avoid prolonged sun exposure and unnecessary heat exposure (such as hot dishwater and long hot baths). Avoid pressure on elbows, knees, and soles of feet (such as leaning on elbows, kneeling, and long walks). Wear loose clothing. Keep this medicine out of sight and reach of children. Store the tablets at room temperature. Avoid keeping the tablet in direct sunlight or excessive moisture. This drug may cause dizziness. If you are affected by this side effect, do not drive, use machinery, or do anything that needs alert until you can do it safely.

What molecule/combination is used for making PEGADRIA 50 INJECTION?Arrow

PEGYLATED LIPOSOMAL DOXORUBICIN is molecule/combination used for making PEGADRIA 50 INJECTION.

For what type of cancer is PEGADRIA 50 INJECTION prescribed?Arrow

PEGADRIA 50 INJECTION is prescribed for ailments/diseases/conditions related to Oncology.

References

Book Icon

Baxter Holding BV, European medicines agency (ema), https://www.ema.europa.eu/en/documents/product-information/caelyx-pegylated-liposomal-epar-product-information_en.pdf

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Ben Venue Laboratories, Inc, US Food and Drug Administration, https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050718s029lbl.pdf

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Reviewed on 15-01-2024

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(5/5)


Marketer / Manufacturer Details

INTAS PHARMACEUTICALS LIMITED

Country of Origin -

India

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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