PERINDOSYL PLUS TABLET 10'S

How PERINDOSYL PLUS TABLET 10'S Works

• PERINDOSYL PLUS TABLET 10'S is a combination medicine containing two active ingredients: Perindopril and Indapamide. Each component contributes to lowering blood pressure through different mechanisms, providing a synergistic effect for enhanced efficacy.
• Perindopril belongs to a class of drugs called ACE inhibitors (Angiotensin-Converting Enzyme inhibitors). ACE is an enzyme in the body that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, leading to increased blood pressure. Perindopril works by inhibiting ACE, thereby reducing the production of angiotensin II. This leads to vasodilation (widening of blood vessels), which lowers blood pressure. Additionally, decreased angiotensin II levels reduce the release of aldosterone, a hormone that causes the kidneys to retain sodium and water. By reducing aldosterone, Perindopril promotes sodium and water excretion, further contributing to blood pressure reduction. In simpler terms, Perindopril relaxes the blood vessels and helps the body get rid of excess salt and water.
• Indapamide is a thiazide-like diuretic, often referred to as a 'water pill.' It works primarily by acting on the kidneys to increase the excretion of sodium and chloride, along with water. This reduces the volume of fluid in the bloodstream, thereby lowering blood pressure. Indapamide achieves this by inhibiting the reabsorption of sodium in the distal convoluted tubule of the nephron (the functional unit of the kidney). Less sodium is reabsorbed back into the blood; more is excreted in the urine, taking water along with it. Beyond its diuretic effect, Indapamide also has a direct vasodilatory effect on blood vessels, which contributes to further reducing blood pressure. This dual action makes Indapamide effective in managing hypertension. It is important to understand that while Indapamide helps the body get rid of excess fluid, it also helps in relaxing the blood vessels directly.
• The combined action of Perindopril and Indapamide in PERINDOSYL PLUS TABLET 10'S offers a comprehensive approach to managing hypertension. Perindopril reduces the production of a substance that narrows blood vessels, while Indapamide helps the body get rid of excess salt and water and also relaxes blood vessels directly. This dual mechanism is particularly beneficial for individuals who require more than one medication to control their blood pressure effectively. By working together, these components provide a more potent and sustained reduction in blood pressure compared to either medication used alone. As with all medications, it's important to use PERINDOSYL PLUS TABLET 10'S exactly as prescribed by your doctor and to attend regular check-ups to monitor your blood pressure and overall health.

Common side effects of Perindosyl Plus may include cough, dizziness, headache, fatigue, and gastrointestinal disturbances like nausea or diarrhea. Some patients might experience hypotension (low blood pressure), especially when starting the medication. Less common side effects can involve skin rashes, taste disturbances, sleep disorders, muscle cramps, and mood changes. Rare but potentially serious side effects include angioedema (swelling of the face, lips, tongue, or throat), kidney problems, and changes in blood cell counts. If you experience any unusual or severe symptoms, it's crucial to contact your doctor immediately.

• If you miss a dose of PERINDOSYL PLUS TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep PERINDOSYL PLUS TAB 1X10 away from the reach of children and pets.
• Store PERINDOSYL PLUS TAB 1X10 at room temperature.

• Take Perindosyl Plus Tablet 10'S exactly as prescribed by your doctor. Do not change the dose or stop taking the medication without consulting them, as this can affect your blood pressure control.
• If you experience persistent dry cough, a common side effect of ACE inhibitors like perindopril (one of the components of Perindosyl Plus), inform your doctor. They may consider alternative medications or strategies to manage the cough.
• Monitor your blood pressure regularly, especially during the first few weeks of taking Perindosyl Plus. Keep a record of your readings and share them with your doctor during your check-ups. This helps in assessing the effectiveness of the medication and adjusting the dosage if needed.
• Stay hydrated while taking Perindosyl Plus, especially if you are physically active or live in a hot climate. Adequate fluid intake helps prevent dehydration, which can sometimes lead to dizziness or lightheadedness, particularly when combined with blood pressure-lowering medications.
• Inform your doctor about all other medications, supplements, and herbal products you are taking, including over-the-counter drugs. Certain medications can interact with Perindosyl Plus, potentially affecting its efficacy or increasing the risk of side effects. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Perindosyl Plus.
• Be cautious when driving or operating machinery until you know how Perindosyl Plus affects you. Some people may experience dizziness or fatigue, especially when starting the medication or increasing the dose. If you experience these side effects, avoid activities that require alertness until they subside.
• Limit your alcohol consumption while taking Perindosyl Plus, as alcohol can further lower your blood pressure and increase the risk of dizziness or lightheadedness. If you choose to drink alcohol, do so in moderation and monitor your blood pressure closely.
• Follow a heart-healthy lifestyle while taking Perindosyl Plus, including a balanced diet low in sodium and saturated fat, regular physical activity, and smoking cessation. These lifestyle modifications can complement the effects of the medication and improve your overall cardiovascular health.

• It is recommended to take PERINDOSYL PLUS TABLET 10'S preferably at the same time each day, with or without food, to maintain consistent blood levels and maximize its effectiveness. However, it is advisable to avoid excessive intake of potassium-rich foods or potassium supplements while on this medication, as it can increase the risk of hyperkalemia (high potassium levels in the blood). Consult your doctor or pharmacist for specific dietary recommendations.