PREGABID D 75/20 CAPSULE 10'S

How PREGABID D 75/20 CAPSULE 10'S Works

• PREGABID D 75/20 Capsule is a combination medication containing Pregabalin and Duloxetine, both of which work through different mechanisms to alleviate nerve pain and improve mood. Pregabalin primarily targets neuropathic pain, while Duloxetine addresses both pain and mood disorders like anxiety and depression, often co-occurring conditions with chronic pain.
• Pregabalin is an anticonvulsant and analgesic. It binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. By binding to this subunit, Pregabalin modulates calcium influx at nerve terminals, which subsequently reduces the release of several neurotransmitters, including glutamate, noradrenaline, and substance P. These neurotransmitters are involved in the transmission of pain signals. By reducing their release, Pregabalin effectively decreases the excitability of neurons and dampens the pain signals sent to the brain. This mechanism helps in alleviating neuropathic pain, such as that experienced in diabetic neuropathy, postherpetic neuralgia, and fibromyalgia. Its action is primarily focused on reducing the intensity of pain signals, rather than eliminating the source of the pain.
• Duloxetine, on the other hand, is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by inhibiting the reuptake of serotonin and norepinephrine in the synaptic cleft, the space between nerve cells. By preventing the reuptake of these neurotransmitters, Duloxetine increases their concentration in the synaptic cleft, allowing them to bind to receptors on the receiving nerve cell for a longer duration. Serotonin and norepinephrine are crucial neurotransmitters involved in mood regulation and pain modulation. Increasing their levels in the brain helps to improve mood, reduce anxiety, and alleviate pain. Duloxetine's pain-relieving effects are thought to be mediated through its action on descending pain pathways in the spinal cord, where increased serotonin and norepinephrine levels help to inhibit the transmission of pain signals. This dual action on both mood and pain makes Duloxetine particularly useful in treating conditions where pain is accompanied by mood disturbances, such as fibromyalgia and depression-related chronic pain.
• In combination, Pregabalin and Duloxetine offer a synergistic effect in managing pain and mood disorders. Pregabalin reduces the intensity of pain signals, while Duloxetine enhances the body's natural pain-inhibiting mechanisms and improves mood. This comprehensive approach addresses both the physical and psychological aspects of chronic pain, leading to improved overall well-being and quality of life for patients. The combination allows for a more effective management strategy compared to using either medication alone, particularly in cases where neuropathic pain is accompanied by symptoms of anxiety or depression. Patients should always take PREGABID D 75/20 Capsule as prescribed by their healthcare provider, as individual responses to the medication can vary, and dosage adjustments may be necessary to achieve optimal therapeutic effects.
• It's important to note that while PREGABID D 75/20 Capsule can significantly improve pain management and mood, it does not cure the underlying conditions causing the pain. Consistent adherence to the prescribed dosage and regular follow-up with a healthcare professional are essential for long-term management and to monitor for any potential side effects.

Common side effects of Pregabid D 75/20 Capsule may include: Dizziness, Sleepiness, Tiredness, Difficulty in concentrating, Blurred vision, Dry mouth, Weight gain, Swelling of hands and feet, Uncoordinated body movements. Less common or rare side effects may include: Mood changes, Memory problems, Confusion, Anxiety, Reduced sexual drive, Erectile dysfunction, Muscle pain or cramps, Numbness or tingling, Vomiting, Constipation, Diarrhea, Flatulence, Changes in appetite, Increased sweating, Tremor, Speech disorder.

• If you miss a dose of PREGABID D 75/20 CAPSULE 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep PREGABID D 75/20MG CAP 1X10 away from the reach of children and pets.
• Store PREGABID D 75/20MG CAP 1X10 at room temperature.

• Take PREGABID D 75/20 exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting them, as this can worsen your condition or cause withdrawal symptoms.
• PREGABID D 75/20 can be taken with or without food. However, taking it at the same time each day helps maintain a consistent level of medication in your body, improving its effectiveness. Consistency is key!
• Be aware that PREGABID D 75/20 may cause drowsiness or dizziness. Avoid driving, operating machinery, or performing other tasks that require alertness until you know how this medication affects you. Your safety is important.
• Inform your doctor about all other medications, supplements, and herbal products you are taking. Some medications can interact with PREGABID D 75/20, potentially reducing its effectiveness or increasing the risk of side effects. A complete medication list helps your doctor ensure your safety.
• If you experience any unusual or severe side effects while taking PREGABID D 75/20, such as changes in mood or behavior, swelling, or vision problems, contact your doctor immediately. Prompt reporting of side effects allows for timely management and care.
• Store PREGABID D 75/20 at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Proper storage maintains the medication's integrity and prevents accidental ingestion.
• If you miss a dose of PREGABID D 75/20, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one.
• Regularly monitor your blood sugar levels if you have diabetes, as PREGABID D 75/20 can affect blood sugar control. Discuss any concerns about blood sugar fluctuations with your doctor. Proactive monitoring helps manage your health effectively.

• PREGABID D 75/20 Capsule can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent medicine levels in your body. There are no specific food restrictions while taking this medicine.