PREGASIA NT TABLET 10'S

How PREGASIA NT TABLET 10'S Works

• PREGASIA NT TABLET 10'S is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic condition that results from damage to or dysfunction of the nerves. It's often described as a shooting, burning, or stabbing pain. This medication effectively targets different pathways involved in the generation and transmission of neuropathic pain signals, offering a comprehensive approach to pain management.
• Pregabalin, one of the active ingredients, is a structural analogue of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve excitability in the brain. Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. By binding to this subunit, pregabalin modulates calcium influx at nerve terminals, reducing the release of several excitatory neurotransmitters, including glutamate, noradrenaline, and substance P. This reduction in neurotransmitter release helps to calm overexcited nerves and reduces pain signals.
• Nortriptyline, the other key ingredient, is a tricyclic antidepressant. It primarily works by inhibiting the reuptake of norepinephrine and serotonin in the brain. These neurotransmitters play a crucial role in mood regulation and pain modulation. By preventing their reuptake, nortriptyline increases the concentration of norepinephrine and serotonin in the synaptic cleft, allowing them to bind to their receptors for a more extended period. This enhanced neurotransmitter activity helps to elevate mood, reduce pain perception, and improve sleep.
• The synergistic action of pregabalin and nortriptyline results in effective pain relief for neuropathic pain. Pregabalin directly addresses the overactivity of nerves by modulating calcium channel activity and reducing excitatory neurotransmitter release. Nortriptyline enhances the activity of pain-modulating neurotransmitters, providing additional pain relief and improving mood. Together, they tackle the multiple facets of neuropathic pain, helping to improve the patient's overall quality of life.
• In summary, PREGASIA NT TABLET 10'S reduces neuropathic pain through a dual mechanism. Pregabalin reduces nerve excitability by affecting calcium channels and reducing the release of excitatory neurotransmitters. Nortriptyline increases the availability of norepinephrine and serotonin, which helps to modulate pain and improve mood. This combined action provides comprehensive pain relief and improved quality of life for individuals suffering from neuropathic pain.

Common side effects of Pregasia NT Tablet may include: Dizziness, Sleepiness, Headache, Nausea, Vomiting, Diarrhea, Constipation, Dry mouth, Blurred vision, Difficulty in concentrating, Weight gain, Swelling of extremities, Increased appetite, Tremors, Peripheral neuropathy, Memory impairment, Confusion, Anxiety, Irritability, Depression, Fatigue, Weakness, Uncoordinated movements, Speech disorder. Less common or rare side effects may include: Muscle pain or cramps, Joint pain, Back pain, Skin rash, Itching, Hair loss, Changes in libido, Erectile dysfunction, Decreased platelet count, Liver problems (indicated by jaundice, dark urine, abdominal pain), Allergic reactions (swelling of face, lips, tongue, or throat, difficulty breathing), Suicidal thoughts, Serotonin syndrome (agitation, hallucinations, rapid heart rate, fever, sweating, muscle stiffness, loss of coordination, nausea, vomiting, diarrhea). This is not an exhaustive list. If you experience any unusual or severe side effects, consult your doctor immediately.

• If you miss a dose of Pregasia NT Tablet 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep PREGASIA NT TAB 1X10 away from the reach of children and pets.
• Store PREGASIA NT TAB 1X10 at room temperature.

• Take PREGASIA NT TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or frequency without consulting your healthcare provider. This ensures optimal effectiveness and minimizes the risk of side effects.
• PREGASIA NT TABLET 10'S can be taken with or without food, but maintaining a consistent routine can help you remember to take it regularly. If you experience stomach upset, taking it with food may be beneficial.
• Be patient and consistent with your treatment. It may take several weeks to months to experience the full benefits of PREGASIA NT TABLET 10'S. Continue taking the medication as directed, even if you start feeling better.
• Inform your doctor about all other medications, supplements, and herbal products you are taking. This is crucial to avoid potential drug interactions that could affect the efficacy of PREGASIA NT TABLET 10'S or increase the risk of adverse effects. Pay special attention to other medications for nerve pain, depression, or anxiety.
• If you experience any concerning side effects, such as severe drowsiness, dizziness, swelling, or allergic reactions (rash, itching, difficulty breathing), contact your doctor immediately. Do not discontinue the medication abruptly without medical advice, as this may lead to withdrawal symptoms or a worsening of your condition. Regular monitoring and open communication with your healthcare provider are essential for a safe and effective treatment experience.

• PREGASIA NT TABLET 10'S can be taken with or without food, but it is important to take it at the same time each day to maintain a consistent level of medication in your body.
• Avoid alcohol consumption while taking this medication, as it can increase the risk of side effects such as drowsiness and dizziness.
• There are no specific food restrictions while taking PREGASIA NT TABLET 10'S unless otherwise directed by your doctor.