SENIZO VIAL 4.5GM INJECTION
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SENIZO VIAL 4.5GM INJECTION
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SENIZO VIAL 4.5GM INJECTION

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SENIZO VIAL 4.5GM INJECTION

By BIOLOGICAL E LIMITED

MRP

546

₹464.1

15 % OFF

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Product DetailsArrow

About SENIZO VIAL 4.5GM INJECTION

  • SENIZO VIAL 4.5GM INJECTION is a potent antibiotic combination designed to combat a wide range of bacterial infections. This injectable formulation contains two active ingredients: Piperacillin and Tazobactam. Piperacillin is a broad-spectrum penicillin antibiotic that works by interfering with the bacteria's ability to build cell walls, ultimately leading to bacterial cell death. However, some bacteria produce an enzyme called beta-lactamase, which can inactivate Piperacillin, rendering it ineffective.
  • To overcome this resistance mechanism, SENIZO VIAL 4.5GM INJECTION includes Tazobactam, a beta-lactamase inhibitor. Tazobactam binds to and inhibits the beta-lactamase enzyme, preventing it from breaking down Piperacillin. This allows Piperacillin to effectively target and kill the bacteria, even those that are resistant to other penicillin-based antibiotics. This synergistic combination makes SENIZO VIAL 4.5GM INJECTION a powerful tool in the treatment of various infections.
  • SENIZO VIAL 4.5GM INJECTION is typically administered intravenously or intramuscularly by a healthcare professional. It is used to treat a variety of bacterial infections, including pneumonia, skin and soft tissue infections, intra-abdominal infections, and urinary tract infections. The specific dosage and duration of treatment will depend on the type and severity of the infection, as well as the patient's overall health and response to treatment. As with all medications, SENIZO VIAL 4.5GM INJECTION may cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions. It is crucial to inform your doctor of any existing medical conditions or allergies before starting treatment.
  • SENIZO VIAL 4.5GM INJECTION is a prescription medication and should only be used under the supervision of a qualified healthcare provider. It's important to complete the full course of treatment, even if you start to feel better, to ensure that the infection is completely eradicated and to prevent the development of antibiotic resistance. Always consult with your doctor or pharmacist if you have any questions or concerns about SENIZO VIAL 4.5GM INJECTION or its use. This medicine is not intended for self-administration.

Uses of SENIZO VIAL 4.5GM INJECTION

  • Treatment of Pneumonia
  • Treatment of Skin and Soft Tissue Infections
  • Treatment of Intra-abdominal Infections
  • Treatment of Urinary Tract Infections
  • Treatment of Septicemia (Blood Infection)
  • Treatment of Meningitis
  • Prevention of Surgical Site Infections
  • Treatment of Gynecological Infections
  • Treatment of Bone and Joint Infections
  • Treatment of Respiratory Tract Infections

How SENIZO VIAL 4.5GM INJECTION Works

  • SENIZO VIAL 4.5GM INJECTION is a powerful antibiotic combination containing Cefoperazone and Sulbactam. Cefoperazone is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis. Bacteria need to build cell walls to survive. Cefoperazone blocks the enzymes that build this wall, leading to a weakened cell wall and bacterial death. Specifically, it binds to penicillin-binding proteins (PBPs), which are essential for cell wall construction. By interfering with PBPs, Cefoperazone effectively stops the bacteria from growing and multiplying.
  • Sulbactam, on the other hand, is a beta-lactamase inhibitor. Many bacteria develop resistance to antibiotics like Cefoperazone by producing enzymes called beta-lactamases. These enzymes break down the antibiotic, rendering it ineffective. Sulbactam cleverly binds to these beta-lactamase enzymes, preventing them from deactivating Cefoperazone. This allows Cefoperazone to reach its target – the bacterial cell wall – and effectively kill the bacteria.
  • The combination of Cefoperazone and Sulbactam in SENIZO VIAL 4.5GM INJECTION provides a synergistic effect. Sulbactam not only protects Cefoperazone from degradation but also exhibits some antibacterial activity of its own. This dual action broadens the spectrum of bacteria that the injection can effectively combat. This makes SENIZO VIAL 4.5GM INJECTION effective against a wide range of bacterial infections, including those resistant to Cefoperazone alone. By inhibiting cell wall synthesis and neutralizing resistance mechanisms, SENIZO VIAL 4.5GM INJECTION effectively eliminates susceptible bacteria, helping to resolve the infection and alleviate symptoms. The combination ensures that even bacteria that have developed defense mechanisms against beta-lactam antibiotics are still vulnerable to the effects of Cefoperazone.

Side Effects of SENIZO VIAL 4.5GM INJECTIONArrow

Like all medicines, SENIZO VIAL 4.5GM INJECTION can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Diarrhea * Nausea * Vomiting * Rash * Injection site reactions (pain, swelling, redness) * Abnormal liver function tests **Uncommon Side Effects (may affect up to 1 in 100 people):** * Headache * Dizziness * Itching * Hives * Fungal infections (Candidiasis) * Blood disorders (changes in blood cell counts) **Rare Side Effects (may affect up to 1 in 1,000 people):** * Severe allergic reactions (anaphylaxis) - symptoms may include sudden wheezing, difficulty breathing, swelling of the face, lips, tongue or throat. * Inflammation of the colon (Colitis) * Kidney problems * Seizures **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) **Other Possible Side Effects:** * Clostridium difficile-associated diarrhea * Drug reaction with eosinophilia and systemic symptoms (DRESS)

Safety Advice for SENIZO VIAL 4.5GM INJECTIONArrow

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Allergies

Allergies

Consult your Doctor

Dosage of SENIZO VIAL 4.5GM INJECTIONArrow

  • The recommended dosage of SENIZO VIAL 4.5GM INJECTION varies significantly based on several factors, including the type and severity of the infection being treated, the patient's renal function, and their overall health status. It's crucial to adhere strictly to the dosage prescribed by your healthcare provider. Dosage adjustments are often necessary for patients with impaired kidney function to prevent drug accumulation and potential toxicity. The typical adult dosage for many susceptible infections is 4.5 grams (comprising piperacillin and tazobactam) administered intravenously every 6 to 8 hours.
  • For more severe infections, or those caused by less susceptible organisms, your doctor may increase the frequency of administration or adjust the dose accordingly. The infusion should be administered slowly over a period of approximately 30 minutes. Prolonged infusion times may be recommended in certain situations to optimize drug concentrations at the site of infection. Pediatric dosing is weight-based and determined by the child's physician, considering factors such as age, weight, and the severity of the infection.
  • It is essential to complete the full course of treatment, even if you start feeling better, to ensure that the infection is completely eradicated and to prevent the development of antibiotic resistance. If you experience any adverse reactions or have any concerns regarding your treatment, consult your healthcare provider immediately. Always remember, self-medication can be dangerous. Take 'SENIZO VIAL 4.5GM INJECTION' only as per the prescription by your physician only.

What if I miss my dose of SENIZO VIAL 4.5GM INJECTION?Arrow

  • If you miss a dose of Senizo Vial 4.5GM Injection, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How to store SENIZO VIAL 4.5GM INJECTION?Arrow

  • Keep SENIZO VIAL 4.5GM away from the reach of children and pets.
  • Store SENIZO VIAL 4.5GM at room temperature.

Benefits of SENIZO VIAL 4.5GM INJECTIONArrow

  • SENIZO VIAL 4.5GM INJECTION is a powerful antibiotic combination containing Piperacillin and Tazobactam, working synergistically to combat a wide range of bacterial infections. Piperacillin, a penicillin-derivative antibiotic, disrupts the formation of bacterial cell walls, leading to bacterial cell death. Tazobactam, a beta-lactamase inhibitor, enhances Piperacillin's effectiveness by preventing bacteria from inactivating it. This combination expands the spectrum of bacteria that SENIZO can target.
  • This injection is highly effective against various infections, including severe pneumonia (both hospital-acquired and community-acquired), complicated intra-abdominal infections (such as appendicitis, peritonitis, and gallbladder infections), skin and soft tissue infections (including cellulitis, abscesses, and surgical site infections), and bloodstream infections (bacteremia) when suspected or confirmed to be caused by susceptible bacteria. Its broad-spectrum activity makes it a valuable asset in treating polymicrobial infections, where multiple types of bacteria are involved.
  • SENIZO is also indicated for treating gynecological infections such as postpartum endometritis (uterine lining infection after childbirth) and pelvic inflammatory disease. In addition, it may be used in managing infections in immunocompromised patients, such as those undergoing chemotherapy or those with HIV/AIDS, who are more susceptible to opportunistic infections.
  • A significant benefit of SENIZO is its ability to overcome antibiotic resistance. Beta-lactamase enzymes produced by certain bacteria can degrade beta-lactam antibiotics like Piperacillin, rendering them ineffective. Tazobactam inhibits these enzymes, restoring Piperacillin's activity and enabling it to kill resistant bacteria. This feature is particularly crucial in settings where antibiotic resistance is prevalent.
  • The injectable formulation allows for rapid and direct delivery of the medication into the bloodstream, ensuring quick therapeutic action. This is especially important in severe and life-threatening infections where timely intervention is critical. SENIZO provides a reliable and effective treatment option for patients requiring hospitalization and intravenous antibiotic therapy.
  • SENIZO VIAL 4.5GM INJECTION's targeted action minimizes disruption to the body's normal flora compared to some broad-spectrum antibiotics. It reduces the risk of secondary infections, such as Clostridium difficile-associated diarrhea, which can occur when beneficial bacteria in the gut are eliminated.
  • Furthermore, SENIZO's established safety profile and extensive clinical use provide clinicians with confidence in its efficacy and tolerability. While side effects can occur, they are generally manageable, and the benefits of treatment often outweigh the risks in serious infections. Regular monitoring by healthcare professionals is crucial to ensure optimal outcomes and minimize potential adverse events.
  • In summary, SENIZO VIAL 4.5GM INJECTION offers a comprehensive and reliable solution for treating a wide spectrum of bacterial infections, including those caused by resistant organisms. Its combination of Piperacillin and Tazobactam provides enhanced efficacy, rapid action, and a favorable safety profile, making it a valuable tool in the fight against infectious diseases.

How to use SENIZO VIAL 4.5GM INJECTIONArrow

  • SENIZO VIAL 4.5GM INJECTION is administered intravenously, meaning it's given directly into a vein by a healthcare professional. Self-administration is strongly discouraged. The dosage and duration of treatment depend on the type and severity of your infection, as well as your kidney function. Your doctor will determine the appropriate dose for you.
  • Before administration, the SENIZO VIAL 4.5GM INJECTION powder needs to be reconstituted with a compatible solution, such as sterile water for injection or sodium chloride injection. The healthcare professional will carefully follow the instructions on the vial and package insert to ensure proper reconstitution and dilution. The reconstituted solution should be clear and free from particulate matter. If any discoloration or particles are observed, the solution should not be used.
  • The intravenous infusion is typically administered slowly over a period of 30 minutes to several hours, depending on the dose and the patient's tolerance. During the infusion, you'll be closely monitored for any signs of adverse reactions, such as allergic reactions, skin rashes, itching, difficulty breathing, or swelling of the face, lips, or tongue. If any of these symptoms occur, inform your healthcare provider immediately.
  • It's crucial to complete the full course of treatment, even if you start feeling better after a few days. Stopping the medication prematurely can lead to incomplete eradication of the infection and the development of antibiotic-resistant bacteria. If you miss a dose, contact your doctor or pharmacist as soon as possible to determine when you should receive the next dose. Do not double the dose to make up for a missed one.
  • To minimize the risk of phlebitis (inflammation of the vein) at the injection site, the healthcare professional may rotate the injection site or use a larger vein for infusion. After the infusion, the injection site will be monitored for any signs of redness, swelling, or pain. Inform your healthcare provider if you experience any discomfort or irritation at the injection site.
  • Inform your doctor about all other medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins, as some medications may interact with SENIZO VIAL 4.5GM INJECTION. It’s especially important to mention any blood thinners (anticoagulants) or medications that affect kidney function. Regular blood tests may be required to monitor your kidney function and blood cell counts during treatment.
  • This medicine is a potent antibiotic and should be used judiciously. Do not use it for viral infections like the common cold or flu. Unnecessary use of antibiotics can contribute to antibiotic resistance. Always consult your healthcare provider for proper diagnosis and treatment of infections.
  • If you experience any unexpected side effects or have any concerns about your treatment, contact your doctor or pharmacist immediately. They can provide you with appropriate medical advice and guidance. Remember to keep all your scheduled appointments with your doctor to monitor your progress and ensure the effectiveness of the treatment.

Quick Tips for SENIZO VIAL 4.5GM INJECTIONArrow

  • Complete the Full Course: Even if you start feeling better, it's crucial to finish the entire course of SENIZO VIAL 4.5GM INJECTION as prescribed by your doctor. Prematurely stopping the medication can lead to the infection returning and developing resistance to the antibiotic.
  • Inform Your Doctor About Allergies: Before starting SENIZO VIAL 4.5GM INJECTION, inform your doctor about any allergies you have, especially to penicillins, cephalosporins, or other beta-lactam antibiotics. Allergic reactions can be severe and require immediate medical attention. Watch for signs like rash, itching, swelling, or difficulty breathing.
  • Stay Hydrated: Drink plenty of fluids while receiving SENIZO VIAL 4.5GM INJECTION. This helps to flush out the kidneys and reduces the risk of kidney-related side effects associated with some antibiotics. Water, clear broths, and herbal teas are good choices.
  • Report Any Unusual Symptoms: While on SENIZO VIAL 4.5GM INJECTION, promptly report any unusual symptoms to your doctor, such as severe diarrhea, stomach cramps, signs of a new infection (like fever or persistent cough), or any other concerning changes in your health. These symptoms could indicate a side effect or a superinfection requiring treatment.
  • Understand Potential Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking, including over-the-counter medications. SENIZO VIAL 4.5GM INJECTION can interact with certain drugs, potentially affecting their effectiveness or increasing the risk of side effects. Probenecid, a medication used for gout, is a notable example of a drug that can interact with this injection.

Food Interactions with SENIZO VIAL 4.5GM INJECTIONArrow

  • While taking SENIZO VIAL 4.5GM INJECTION, there are no specific food restrictions. It can be taken without regard to food.

FAQs

What is the use of Senizo 4.5GM Injection?Arrow

Senizo 4.5GM Injection is used to treat bacterial infections. It is used to treat various types of infections such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, and abdominal infections.

How does Senizo 4.5GM Injection work?Arrow

Senizo 4.5GM Injection is a combination of two antibiotics, Ceftriaxone and Sulbactam. Ceftriaxone works by inhibiting the synthesis of the bacterial cell wall, while Sulbactam works by blocking enzymes that inactivate Ceftriaxone.

What are the common side effects of Senizo 4.5GM Injection?Arrow

Common side effects of Senizo 4.5GM Injection include pain, swelling, and redness at the injection site, nausea, vomiting, diarrhea, and allergic reactions.

What is the dosage of Senizo 4.5GM Injection?Arrow

The dosage of Senizo 4.5GM Injection depends on the severity of the infection and the patient's condition. It is usually injected intravenously by a healthcare professional.

Is Senizo 4.5GM Injection safe for pregnant or breastfeeding women?Arrow

Senizo 4.5GM Injection should be used during pregnancy and breastfeeding only if the benefits outweigh the risks. Consult your doctor before using this medication.

Does Senizo 4.5GM Injection interact with other medications?Arrow

Senizo 4.5GM Injection may interact with certain medications, such as aminoglycoside antibiotics and diuretics. Inform your doctor if you are taking any other medications.

What happens if I miss a dose of Senizo 4.5GM Injection?Arrow

If you miss a dose of Senizo 4.5GM Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Can Senizo 4.5GM Injection cause allergies?Arrow

Yes, Senizo 4.5GM Injection can cause allergies in some individuals. Seek immediate medical attention if you experience any symptoms of an allergic reaction such as skin rash, itching, swelling, dizziness, or difficulty breathing.

How to store Senizo 4.5GM Injection?Arrow

Store Senizo 4.5GM Injection at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.

What are the other brands of Ceftriaxone and Sulbactam?Arrow

Some other brands of Ceftriaxone and Sulbactam are Monocef-SB, Kefact-S, and Sulbacef.

Is Senizo 4.5GM Injection effective for viral infections?Arrow

No, Senizo 4.5GM Injection is not effective against viral infections. It is only effective for treating bacterial infections.

Can I drink alcohol with Senizo 4.5GM Injection?Arrow

Drinking alcohol with Senizo 4.5GM Injection can increase the risk of side effects such as dizziness, drowsiness, and stomach upset. It is advisable to avoid drinking alcohol with this medication.

Can Senizo 4.5GM Injection cause resistance?Arrow

Overuse of antibiotics can lead to antibiotic resistance. Senizo 4.5GM Injection should only be used when necessary and for the duration prescribed by the doctor.

Is Senizo 4.5GM Injection safe for children?Arrow

Senizo 4.5GM Injection should be used with caution in children and only under the supervision of a doctor. The dosage depends on the child's weight and the severity of the infection.

Is Senizo 4.5GM Injection safe for people with kidney problems?Arrow

Senizo 4.5GM Injection should be used with caution in people with kidney problems. The dosage may need to be adjusted according to kidney function. Consult your doctor.

References

Book Icon

DrugBank: Ceftolozane. Provides detailed information on ceftolozane, including its mechanism of action, pharmacokinetics, and indications.

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FDA Prescribing Information: ZERBAXA (ceftolozane and tazobactam) for injection. This is the official prescribing information document for ceftolozane/tazobactam, detailing usage, dosage, side effects, and clinical trial data.

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European Medicines Agency (EMA): Zerbaxa. Provides the European regulatory perspective on ceftolozane/tazobactam, including assessment reports and public summaries.

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Clinical Infectious Diseases: Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination for the Treatment of Gram-Negative Infections. This article reviews the clinical development and efficacy of ceftolozane/tazobactam.

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National Center for Biotechnology Information (NCBI) Bookshelf: Ceftolozane-Tazobactam. This resource offers a summary of ceftolozane-tazobactam's properties, indications, and potential adverse effects.

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ScienceDirect: Ceftolozane. This page provides a concise overview of ceftolozane, its pharmacology, and its role in treating bacterial infections.

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FDA Pharmacology Review: Ceftolozane/Tazobactam. Provides a detailed pharmacological review submitted to the FDA during the drug approval process.

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BIOLOGICAL E LIMITED

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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