TAZCAN 4.5GM INJECTION 30 ML
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TAZCAN 4.5GM INJECTION 30 ML
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TAZCAN 4.5GM INJECTION 30 ML

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TAZCAN 4.5GM INJECTION 30 ML

By CIPLA PHARMACEUTICAL COMPANY LIMITED

MRP

290

₹246.5

15 % OFF


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Product DetailsArrow

About TAZCAN 4.5GM INJECTION 30 ML

  • TAZCAN 4.5GM Injection is a potent antibiotic combination designed to combat a wide range of bacterial infections. This injectable solution contains two active ingredients: Piperacillin and Tazobactam. Piperacillin is a penicillin-derived antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death. However, some bacteria produce enzymes called beta-lactamases, which can inactivate Piperacillin.
  • Tazobactam steps in as a beta-lactamase inhibitor. It binds to and inactivates these enzymes, preventing them from breaking down Piperacillin. This synergistic action allows Piperacillin to remain effective against a broader spectrum of bacteria, including those that are resistant to penicillin alone. Each vial of TAZCAN 4.5GM Injection contains 4g of Piperacillin and 0.5g of Tazobactam.
  • TAZCAN 4.5GM Injection is typically administered intravenously by a healthcare professional. It is crucial to follow the prescribed dosage and administration guidelines provided by the physician or healthcare provider. This medication is commonly used to treat infections such as pneumonia, skin infections, intra-abdominal infections, and gynecological infections. It's efficacy against susceptible bacteria makes it a valuable asset in combating severe infections.
  • Before using TAZCAN 4.5GM Injection, it's important to inform your doctor about any allergies, especially to penicillin or other beta-lactam antibiotics. Common side effects may include nausea, diarrhea, and injection site reactions. Serious side effects are rare but can occur. It is crucial to seek immediate medical attention if you experience any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing. TAZCAN 4.5GM Injection should only be used under the supervision of a qualified healthcare professional.

Uses of TAZCAN 4.5GM INJECTION 30 ML

  • Treatment of Pneumonia
  • Treatment of Skin and Soft Tissue Infections
  • Treatment of Intra-abdominal Infections
  • Treatment of Female Pelvic Infections
  • Treatment of Bacterial Septicemia
  • Empirical Therapy in Neutropenic Patients
  • Surgical Prophylaxis
  • Treatment of Complicated Urinary Tract Infections
  • Treatment of Pyelonephritis
  • Treatment of Post-partum Sepsis

How TAZCAN 4.5GM INJECTION 30 ML Works

  • TAZCAN 4.5GM INJECTION 30 ML is a powerful antibiotic combination containing Piperacillin and Tazobactam. It is specifically formulated to combat a wide range of bacterial infections. Understanding how this injection works involves examining the individual roles of its two active ingredients: Piperacillin and Tazobactam.
  • Piperacillin is a broad-spectrum penicillin antibiotic. It functions by interfering with the bacteria's ability to build and maintain its cell wall. Bacterial cell walls are crucial for their survival, providing structural integrity and protection. Piperacillin inhibits the synthesis of peptidoglycans, which are essential components of the bacterial cell wall. By disrupting this process, Piperacillin weakens the cell wall, eventually leading to cell lysis (rupture) and bacterial death. Piperacillin's effectiveness stems from its ability to bind to specific proteins, called penicillin-binding proteins (PBPs), located inside the bacterial cell wall. This binding action prevents the bacteria from properly constructing its cell wall, making it vulnerable and ultimately causing its demise.
  • However, many bacteria have developed resistance mechanisms to penicillin antibiotics like Piperacillin. One common resistance mechanism is the production of enzymes called beta-lactamases. These enzymes can break down the beta-lactam ring, a crucial structural component of penicillin antibiotics, rendering them ineffective. This is where Tazobactam plays a vital role.
  • Tazobactam is a beta-lactamase inhibitor. It works by binding to and inactivating beta-lactamase enzymes produced by bacteria. By inhibiting these enzymes, Tazobactam prevents them from breaking down Piperacillin. This allows Piperacillin to reach its target PBPs and effectively inhibit bacterial cell wall synthesis. In essence, Tazobactam protects Piperacillin from degradation, enhancing its antibacterial activity and broadening its spectrum of activity to include bacteria that would otherwise be resistant.
  • The combination of Piperacillin and Tazobactam in TAZCAN 4.5GM INJECTION 30 ML provides a synergistic effect. Piperacillin directly targets bacterial cell wall synthesis, while Tazobactam protects Piperacillin from inactivation by bacterial enzymes. This combination effectively combats a wide variety of bacteria, including many that are resistant to other antibiotics. This makes TAZCAN 4.5GM INJECTION 30 ML a valuable tool in treating serious infections, such as pneumonia, bloodstream infections, intra-abdominal infections, and skin and soft tissue infections. It is typically administered intravenously by a healthcare professional to ensure proper dosage and administration.
  • In summary, TAZCAN 4.5GM INJECTION 30 ML works by a dual mechanism: Piperacillin inhibits bacterial cell wall synthesis, leading to bacterial cell death, and Tazobactam inhibits beta-lactamase enzymes, protecting Piperacillin from degradation and enhancing its effectiveness. This synergistic action makes it a potent antibiotic combination for treating a wide range of bacterial infections.

Side Effects of TAZCAN 4.5GM INJECTION 30 MLArrow

Like all medicines, TAZCAN 4.5GM INJECTION 30 ML can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Diarrhea * Nausea * Vomiting * Rash * Itching * Injection site reactions (pain, redness, swelling) * Elevated liver enzymes * Headache **Uncommon Side Effects (may affect up to 1 in 100 people):** * Oral thrush (fungal infection in the mouth) * Vaginal thrush * Dizziness * Muscle pain * Joint pain * Abdominal pain * Loss of appetite * Fatigue * Fever * Inflammation of the vein (phlebitis) * Low blood potassium **Rare Side Effects (may affect up to 1 in 1,000 people):** * Allergic reactions (including anaphylaxis, characterized by difficulty breathing, swelling of the face and throat, and a drop in blood pressure) * Seizures * Kidney problems * Blood disorders (such as decreased white blood cells, red blood cells, or platelets) * Severe skin reactions (such as Stevens-Johnson syndrome or toxic epidermal necrolysis) * Clostridium difficile-associated diarrhea (symptoms include watery or bloody stools, stomach cramps, and fever)

Safety Advice for TAZCAN 4.5GM INJECTION 30 MLArrow

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Allergies

Allergies

Do not take TAZCAN 4.5GM INJECTION 30 ML if you are allergic to it.

Dosage of TAZCAN 4.5GM INJECTION 30 MLArrow

  • The recommended dosage of TAZCAN 4.5GM INJECTION 30 ML varies significantly depending on the severity and type of infection being treated, as well as the patient's renal function. Therefore, it's crucial to adhere strictly to your physician's prescribed dosage regimen. Typical adult dosages generally fall within the range of 3.375 grams to 4.5 grams administered intravenously every 6 to 8 hours. For patients with impaired kidney function, dosage adjustments are essential to prevent drug accumulation and potential toxicity. Your doctor will carefully assess your creatinine clearance to determine the appropriate dosage reduction.
  • In cases of severe infections, such as hospital-acquired pneumonia or complicated intra-abdominal infections, the higher end of the dosage range (4.5 grams every 6 hours) may be necessary. Conversely, for less severe infections or in patients with mild renal impairment, a lower dosage (e.g., 3.375 grams every 8 hours) might be sufficient. The duration of treatment also varies depending on the infection type and patient response, typically ranging from 7 to 14 days. It is important to complete the full course of treatment as prescribed, even if you start feeling better, to ensure complete eradication of the infection and prevent the development of antibiotic resistance.
  • For pediatric patients, the dosage is calculated based on body weight and renal function. The typical dosage range is 90 mg/kg every 6 to 8 hours, with adjustments necessary for renal impairment. The injection should be administered slowly over 30 minutes to minimize the risk of infusion-related reactions. Regular monitoring of renal function and clinical response is essential throughout the treatment course.
  • Take 'TAZCAN 4.5GM INJECTION 30 ML' only as per the prescription by your physician only.

What if I miss my dose of TAZCAN 4.5GM INJECTION 30 ML?Arrow

  • As TAZCAN 4.5GM INJECTION 30 ML is administered by a healthcare professional, the chances of missing a dose are low. However, if you believe you have missed a dose, inform your healthcare provider immediately. Do not self-administer a double dose to compensate for the missed one.

How to store TAZCAN 4.5GM INJECTION 30 ML?Arrow

  • Keep TAZCAN 4.5GM INJ 30ML away from the reach of children and pets.
  • Store TAZCAN 4.5GM INJ 30ML at room temperature.

Benefits of TAZCAN 4.5GM INJECTION 30 MLArrow

  • TAZCAN 4.5GM INJECTION 30 ML is a powerful antibiotic medication primarily used to treat a wide range of bacterial infections. Its formulation combines two active ingredients: piperacillin and tazobactam. Piperacillin, a broad-spectrum penicillin antibiotic, works by interfering with the bacteria's ability to build cell walls, ultimately leading to bacterial cell death. However, some bacteria produce enzymes called beta-lactamases, which can inactivate piperacillin. This is where tazobactam comes in; it's a beta-lactamase inhibitor that blocks these enzymes, allowing piperacillin to effectively target and destroy bacteria. This synergistic action significantly broadens the spectrum of bacteria that TAZCAN can combat.
  • One of the key benefits of TAZCAN 4.5GM INJECTION is its effectiveness against a diverse array of infections. It is commonly prescribed for serious infections affecting the lower respiratory tract, such as pneumonia, particularly hospital-acquired pneumonia or ventilator-associated pneumonia. TAZCAN is also highly effective in treating complicated intra-abdominal infections, including those involving appendicitis, peritonitis, and abscesses. Furthermore, it is a valuable treatment option for skin and soft tissue infections, especially those that are severe or complicated, such as cellulitis, abscesses, and diabetic foot infections.
  • In addition to these common uses, TAZCAN 4.5GM INJECTION also plays a crucial role in managing gynecological infections, including postpartum endometritis and pelvic inflammatory disease (PID). It is also indicated for treating bacterial septicemia, a severe bloodstream infection that can be life-threatening. Because of its broad spectrum of activity, TAZCAN is often used in empirical therapy, where treatment is initiated before the specific causative bacteria has been identified. This is particularly important in critical care settings where rapid treatment is essential.
  • Another significant advantage of TAZCAN 4.5GM INJECTION is its ability to combat infections caused by multi-drug resistant bacteria. The combination of piperacillin and tazobactam is often effective against bacteria that have developed resistance to other antibiotics, making it a valuable tool in combating antibiotic resistance. The intravenous administration of TAZCAN ensures rapid and complete absorption of the medication, resulting in quicker onset of action compared to oral antibiotics. This is especially important in severe infections where a fast response is needed to prevent further complications.
  • The safety profile of TAZCAN 4.5GM INJECTION is also noteworthy. While, like all medications, it can cause side effects, these are typically mild and manageable. Common side effects include nausea, vomiting, diarrhea, and injection site reactions. Serious side effects are rare but can include allergic reactions, seizures, and blood disorders. Healthcare professionals carefully monitor patients receiving TAZCAN to minimize the risk of adverse events. Overall, TAZCAN 4.5GM INJECTION is a highly effective and versatile antibiotic that plays a critical role in treating a wide range of bacterial infections, especially in severe or complicated cases and those involving antibiotic-resistant bacteria.

How to use TAZCAN 4.5GM INJECTION 30 MLArrow

  • TAZCAN 4.5GM Injection is administered intravenously, meaning it's injected directly into a vein. This should always be done by a qualified healthcare professional, such as a doctor or nurse. Self-administration is strongly discouraged.
  • The dosage and frequency of TAZCAN 4.5GM Injection will depend on several factors, including the severity of the infection, the location of the infection, your kidney function, and your overall health. Your doctor will determine the appropriate dose for you.
  • Before administration, TAZCAN 4.5GM Injection needs to be reconstituted. This involves mixing the powder in the vial with a compatible solution, such as sterile water for injection or sodium chloride injection. The healthcare professional will follow specific guidelines for reconstitution to ensure the correct concentration.
  • The reconstituted solution is then further diluted in an appropriate intravenous fluid. The infusion is typically administered over a period of 30 minutes to several hours, depending on the prescribed dosage and the patient's condition. The healthcare professional will monitor you during the infusion for any signs of adverse reactions.
  • It's crucial to complete the full course of TAZCAN 4.5GM Injection, even if you start feeling better after a few days. Stopping the medication prematurely can allow the infection to persist or recur, and it may also contribute to the development of antibiotic resistance.
  • TAZCAN 4.5GM Injection may interact with other medications you are taking. Therefore, it's essential to inform your doctor about all prescription drugs, over-the-counter medications, vitamins, and herbal supplements you are using before starting treatment with TAZCAN 4.5GM Injection.
  • If you experience any side effects during or after the infusion, such as rash, itching, swelling, difficulty breathing, or dizziness, notify your healthcare professional immediately. These could be signs of an allergic reaction or other serious adverse effect.
  • During treatment with TAZCAN 4.5GM Injection, your doctor may order blood tests to monitor your kidney function and blood cell counts. This is to ensure that the medication is not causing any harm to your organs or blood.
  • Ensure to store TAZCAN 4.5GM Injection as per the recommendations by your pharmacist or doctor. Typically it needs to be stored in a cool and dry place. Keep away from children.
  • Discard any unused portion of the reconstituted solution. Do not save it for later use. Follow proper disposal procedures for used needles and syringes.

Quick Tips for TAZCAN 4.5GM INJECTION 30 MLArrow

  • Always inform your doctor about any existing allergies you have, especially to penicillin or other beta-lactam antibiotics, before receiving TAZCAN. This injection contains piperacillin and tazobactam, and allergic reactions can be severe.
  • TAZCAN is administered intravenously by a healthcare professional. Ensure the injection site is monitored for any signs of irritation, swelling, or pain. Report any unusual sensations to the nurse or doctor immediately.
  • Complete the full course of TAZCAN as prescribed by your doctor, even if you start feeling better. Stopping the medication prematurely can lead to antibiotic resistance and recurrence of the infection. This is crucial for effective treatment.
  • Maintain adequate hydration while receiving TAZCAN. Drinking plenty of fluids helps your kidneys function properly and assists in flushing out the medication from your system, reducing the risk of kidney-related side effects. Staying hydrated is key.
  • Inform your doctor about all other medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins, before starting TAZCAN. Some medications can interact with TAZCAN, affecting its effectiveness or increasing the risk of side effects. A complete medication list ensures safe usage.

Food Interactions with TAZCAN 4.5GM INJECTION 30 MLArrow

  • There are no known significant food interactions with TAZCAN 4.5GM INJECTION 30 ML. It is administered intravenously and does not require specific dietary adjustments.

FAQs

What is TAZCAN 4.5GM INJECTION 30 ML used for?Arrow

TAZCAN 4.5GM INJECTION 30 ML is an antibiotic used to treat a variety of bacterial infections, such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, and infections inside the abdomen.

How does TAZCAN 4.5GM INJECTION 30 ML work?Arrow

TAZCAN 4.5GM INJECTION 30 ML is a combination of two medicines: Piperacillin and Tazobactam. Piperacillin is an antibiotic that works by preventing the formation of the bacterial cell wall, while Tazobactam is a beta-lactamase inhibitor that prevents Piperacillin from being inactivated.

What are the common side effects of TAZCAN 4.5GM INJECTION 30 ML?Arrow

Common side effects of TAZCAN 4.5GM INJECTION 30 ML include nausea, vomiting, diarrhea, headache, and pain at the injection site.

Is TAZCAN 4.5GM INJECTION 30 ML safe for pregnant women?Arrow

The safety of TAZCAN 4.5GM INJECTION 30 ML during pregnancy has not been established. It should only be used when clearly needed and prescribed by a doctor.

Is TAZCAN 4.5GM INJECTION 30 ML safe for breastfeeding women?Arrow

TAZCAN 4.5GM INJECTION 30 ML may be excreted in breast milk. Breastfeeding women should consult their doctor before using this medicine.

What is the dosage of TAZCAN 4.5GM INJECTION 30 ML?Arrow

The dosage of TAZCAN 4.5GM INJECTION 30 ML depends on the severity of the infection and the patient's condition. Your doctor will determine the correct dosage.

Can TAZCAN 4.5GM INJECTION 30 ML interact with other medications?Arrow

TAZCAN 4.5GM INJECTION 30 ML can interact with certain medications, such as anticoagulants (blood thinners) and probenecid. Inform your doctor if you are taking any other medications.

How to store TAZCAN 4.5GM INJECTION 30 ML?Arrow

Store TAZCAN 4.5GM INJECTION 30 ML at room temperature, away from direct sunlight and moisture.

Is TAZCAN 4.5GM INJECTION 30 ML safe for patients with penicillin allergy?Arrow

TAZCAN 4.5GM INJECTION 30 ML contains Piperacillin, which is an antibiotic from the penicillin family. Patients with penicillin allergy should not use this medicine.

What happens if I miss a dose of TAZCAN 4.5GM INJECTION 30 ML?Arrow

If you miss a dose of TAZCAN 4.5GM INJECTION 30 ML, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

Can I drink alcohol with TAZCAN 4.5GM INJECTION 30 ML?Arrow

It is not recommended to drink alcohol with TAZCAN 4.5GM INJECTION 30 ML, as it can increase the side effects.

Is TAZCAN 4.5GM INJECTION 30 ML effective for viral infections?Arrow

No, TAZCAN 4.5GM INJECTION 30 ML is not effective against viral infections. It is only used to treat bacterial infections.

How is TAZCAN 4.5GM INJECTION 30 ML administered?Arrow

TAZCAN 4.5GM INJECTION 30 ML is usually administered by a healthcare professional via injection into a vein.

Can TAZCAN 4.5GM INJECTION 30 ML cause antibiotic resistance?Arrow

Overuse of antibiotics can lead to antibiotic resistance. TAZCAN 4.5GM INJECTION 30 ML should only be used when prescribed by a doctor, and it's important to complete the prescribed course, even if you feel better.

Can TAZCAN 4.5GM INJECTION 30 ML cause diarrhea?Arrow

Yes, TAZCAN 4.5GM INJECTION 30 ML can cause diarrhea. Consult your doctor if you experience severe diarrhea.

References

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DailyMed - PIPERACILLIN AND TAZOBACTAM injection, powder, for solution. This provides label information including composition, usage, and warnings.

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DrugBank - Piperacillin. This entry offers detailed chemical information, pharmacology, and therapeutic uses of piperacillin, one of the active ingredients.

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DrugBank - Tazobactam. Provides chemical and pharmaceutical data regarding tazobactam, the beta-lactamase inhibitor component.

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National Center for Biotechnology Information (NCBI) - Piperacillin/tazobactam: a comprehensive review of its use in serious infections globally. This is a research paper evaluating the clinical efficacy and safety.

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FDA (Food and Drug Administration) - ZOSYN (piperacillin and tazobactam) injection, for intravenous use. Full prescribing information.

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