SIMBRINZA EYE 5 ML DROPS 5 ML
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SIMBRINZA EYE 5 ML DROPS 5 MLSIMBRINZA EYE 5 ML DROPS 5 MLSIMBRINZA EYE 5 ML DROPS 5 MLSIMBRINZA EYE 5 ML DROPS 5 ML
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SIMBRINZA EYE 5 ML DROPS 5 ML

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SIMBRINZA EYE 5 ML DROPS 5 ML

By ALCON LABORATORIES INDIA PRIVATE LIMITED

MRP

780.64

₹663.54

15 % OFF

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Product DetailsArrow

About SIMBRINZA EYE 5 ML DROPS 5 ML

  • SIMBRINZA® Eye Drops offer a potent dual-action formula designed to effectively manage elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. This innovative combination medication provides a synergistic approach by combining two well-established IOP-lowering agents: brinzolamide and brimonidine.
  • Brinzolamide, a carbonic anhydrase inhibitor, works by reducing the production of aqueous humor within the eye. By inhibiting carbonic anhydrase, an enzyme crucial for aqueous humor secretion, brinzolamide helps to decrease the overall fluid volume in the eye, leading to a reduction in IOP.
  • Brimonidine, an alpha-2 adrenergic receptor agonist, complements brinzolamide's action through a dual mechanism. Firstly, it reduces aqueous humor production, further contributing to IOP reduction. Secondly, it enhances the outflow of aqueous humor from the eye, promoting fluid drainage and helping to maintain a healthy IOP level. SIMBRINZA® offers the convenience of a single eye drop formulation, simplifying the treatment regimen for patients requiring both a carbonic anhydrase inhibitor and an alpha-2 adrenergic receptor agonist. This can lead to improved adherence and better overall outcomes.
  • SIMBRINZA® is typically administered twice daily, as directed by your ophthalmologist. It is crucial to follow the prescribed dosage and administration instructions carefully. Before using SIMBRINZA®, inform your doctor about any pre-existing medical conditions, allergies, or medications you are currently taking. Common side effects may include blurred vision, eye irritation, dry mouth, and fatigue. If you experience any persistent or bothersome side effects, consult your doctor.
  • Store SIMBRINZA® Eye Drops in a cool, dry place, away from direct sunlight and heat. Keep the bottle tightly closed when not in use and out of reach of children. Do not use the eye drops if the seal is broken or the solution appears discolored. SIMBRINZA® is a valuable tool in the management of glaucoma and ocular hypertension, helping to preserve vision and improve the quality of life for affected individuals. Regular monitoring by an ophthalmologist is essential to ensure the effectiveness and safety of SIMBRINZA® therapy.

Uses of SIMBRINZA EYE 5 ML DROPS 5 ML

  • Lowering elevated eye pressure (ocular hypertension)
  • Treatment of glaucoma
  • Treatment of open-angle glaucoma
  • Treatment of pseudoexfoliation glaucoma
  • Combination therapy with other medications that treat glaucoma

How SIMBRINZA EYE 5 ML DROPS 5 ML Works

  • SIMBRINZA® Eye Drops are a combination medication designed to lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It achieves this pressure reduction through two distinct mechanisms of action provided by its active ingredients: brinzolamide and brimonidine tartrate.
  • Brinzolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase is an enzyme found in the eye, and it plays a crucial role in the production of aqueous humor. Aqueous humor is a clear fluid that fills the space between the lens and the cornea, providing nutrients and maintaining the eye's shape. By inhibiting carbonic anhydrase, brinzolamide reduces the production of aqueous humor. This decreased production leads to a lower overall volume of fluid within the eye, thereby reducing IOP.
  • Brimonidine tartrate is an alpha-2 adrenergic receptor agonist. It works through a dual mechanism. Firstly, it reduces the production of aqueous humor, similar to brinzolamide, but through a different pathway. Secondly, it increases the outflow of aqueous humor from the eye. By stimulating alpha-2 adrenergic receptors, brimonidine promotes the drainage of aqueous humor through the trabecular meshwork and uveoscleral pathways, the eye's natural drainage systems. This enhanced outflow further contributes to lowering IOP.
  • The combined effect of brinzolamide and brimonidine tartrate provides a synergistic IOP-lowering effect. By targeting both aqueous humor production and outflow, SIMBRINZA® offers a comprehensive approach to managing glaucoma and ocular hypertension. This dual mechanism helps to effectively control IOP and reduce the risk of optic nerve damage and vision loss associated with these conditions.
  • In summary, SIMBRINZA® works by reducing the amount of fluid produced in the eye (aqueous humor) and increasing the amount of fluid that drains out of the eye. This combined action effectively lowers the pressure inside the eye, helping to protect against glaucoma-related damage.

Side Effects of SIMBRINZA EYE 5 ML DROPS 5 MLArrow

Like all medicines, SIMBRINZA eye drops can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Eye-related: Allergic conjunctivitis, superficial punctate keratitis (damage to the surface of the eye), eye pain, eye discomfort, blurred vision. * General: Dry mouth. **Uncommon side effects (may affect up to 1 in 100 people):** * Eye-related: Corneal erosion, corneal inflammation, conjunctivitis, blepharitis, eye irritation, tearing, eye redness, visual disturbance, eyelid swelling, eyelid pain, conjunctival edema, foreign body sensation in the eye, dry eye. * General: Decreased heart rate, palpitations, decreased blood pressure, shortness of breath, nasal dryness, taste disturbances, dyspepsia, nausea, generalized weakness. * Nervous system related: Dizziness, headache. **Rare side effects (may affect up to 1 in 1,000 people):** * Eye-related: Iritis, miosis, closed-angle glaucoma * General: Memory impairment, insomnia. **Other side effects reported include:** * Eye-related: Increased lacrimation * General: Rash, Angioedema It is important to inform your doctor or pharmacist if you experience any side effects, even those not listed, while using SIMBRINZA.

Safety Advice for SIMBRINZA EYE 5 ML DROPS 5 MLArrow

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Allergies

Allergies

Do not use Simbrinza Eye Drops if you are allergic to it.

Dosage of SIMBRINZA EYE 5 ML DROPS 5 MLArrow

  • The recommended dosage of SIMBRINZA EYE 5 ML DROPS 5 ML is typically one drop in the affected eye(s) two times daily, approximately 12 hours apart. It is crucial to adhere strictly to your doctor's instructions regarding the dosage and frequency of administration. Do not exceed the prescribed dosage, as it will not improve the drug's efficacy and may increase the risk of side effects. Shake the bottle well before each use to ensure that the medication is properly mixed.
  • To administer the eye drops, tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above your eye, without touching it, and squeeze out one drop into the pocket. Close your eye gently for 1-2 minutes, and avoid blinking or rubbing your eye. This allows the medication to be absorbed properly. If you are using other eye drops, wait at least 5-10 minutes before administering them to prevent the dilution of either medication.
  • If you miss a dose of SIMBRINZA EYE 5 ML DROPS 5 ML, administer it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. Consistency in administering the medication is important for maintaining optimal control of your condition. If you experience any irritation, pain, or vision changes while using these eye drops, consult your doctor immediately.
  • Take 'SIMBRINZA EYE 5 ML DROPS 5 ML' only as per the prescription by your physician only

What if I miss my dose of SIMBRINZA EYE 5 ML DROPS 5 ML?Arrow

  • If you miss a dose of SIMBRINZA eye drops, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to catch up.

How to store SIMBRINZA EYE 5 ML DROPS 5 ML?Arrow

  • Keep SIMBRINZA EYE DROPS 5ML away from the reach of children and pets.
  • Store SIMBRINZA EYE DROPS 5ML at room temperature.

Benefits of SIMBRINZA EYE 5 ML DROPS 5 MLArrow

  • SIMBRINZA Eye Drops offer a dual-action approach to effectively lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. This combination therapy utilizes two active ingredients, brinzolamide and brimonidine, working synergistically to achieve greater IOP reduction compared to either medication used alone. Brinzolamide, a carbonic anhydrase inhibitor, reduces the production of aqueous humor, the fluid inside the eye, thereby decreasing pressure. Brimonidine, an alpha-adrenergic receptor agonist, both reduces aqueous humor production and increases its outflow, further contributing to IOP control.
  • By targeting both production and outflow of aqueous humor, SIMBRINZA provides a comprehensive approach to managing elevated IOP. This dual mechanism of action can be particularly beneficial for patients who have not achieved sufficient IOP control with a single medication. The combination of brinzolamide and brimonidine allows for a more significant and sustained reduction in IOP, helping to protect the optic nerve from damage associated with glaucoma.
  • SIMBRINZA offers a convenient and simplified treatment regimen for patients requiring both a carbonic anhydrase inhibitor and an alpha-adrenergic receptor agonist. The fixed-dose combination reduces the burden of administering multiple eye drops at different times of the day, improving adherence to the prescribed treatment plan. This ease of use can lead to better long-term outcomes and a reduced risk of vision loss due to uncontrolled glaucoma.
  • Clinical trials have demonstrated the efficacy and safety of SIMBRINZA in lowering IOP. Studies have shown that SIMBRINZA provides a statistically significant reduction in IOP compared to placebo and is non-inferior to the concomitant administration of brinzolamide and brimonidine. The safety profile of SIMBRINZA is well-established, with common side effects being generally mild and transient. These may include blurred vision, eye irritation, and dry mouth. However, serious side effects are rare.
  • SIMBRINZA can be considered as a first-line treatment option for patients newly diagnosed with open-angle glaucoma or ocular hypertension, as well as for those who require additional IOP lowering despite being on other medications. Its dual mechanism of action, convenient dosing, and proven efficacy make it a valuable tool in the management of glaucoma and the prevention of vision loss. Regular monitoring by an ophthalmologist is essential to assess the effectiveness of SIMBRINZA and to manage any potential side effects.
  • SIMBRINZA offers a sustained IOP reduction throughout the day, providing consistent control and minimizing fluctuations that can contribute to optic nerve damage. Its use contributes significantly to preserving visual field and preventing progression of glaucoma-related vision loss. This consistent IOP management helps maintain a better quality of life for patients with glaucoma or ocular hypertension.
  • Compared to using separate eye drops, SIMBRINZA reduces exposure to preservatives, which can cause ocular surface disease over the long term. This makes it a better option for patients requiring long-term glaucoma management, as it minimizes the risk of preservative-related irritation and discomfort, promoting better ocular surface health.

How to use SIMBRINZA EYE 5 ML DROPS 5 MLArrow

  • SIMBRINZA® is a prescription eye drop used to lower the pressure inside the eye in adults with open-angle glaucoma or ocular hypertension. It combines two medicines, brinzolamide and brimonidine, to help reduce fluid production and increase fluid drainage from the eye.
  • Before using SIMBRINZA®, wash your hands thoroughly. Shake the bottle well before each use. To avoid contamination, do not touch the dropper tip to any surface, including your eye or eyelids.
  • Tilt your head back slightly and gently pull down your lower eyelid to create a small pocket. Hold the SIMBRINZA® bottle upside down and position the dropper tip close to your eye. Squeeze the bottle gently to dispense one drop into the pocket you have created. Avoid blinking or squeezing your eye shut tightly after applying the drop.
  • Close your eye gently for 1 to 2 minutes. Press lightly on the inner corner of your eye near your nose to prevent the medication from draining into your tear duct. This helps the medicine stay in your eye longer and reduces the risk of side effects.
  • If you wear contact lenses, remove them before using SIMBRINZA®. Wait at least 15 minutes after using the drops before reinserting your contact lenses. This is because some eye drops contain preservatives that can be absorbed by contact lenses.
  • If you are using other eye drops, wait at least 5 minutes between applying SIMBRINZA® and any other eye drops. This helps to prevent the medications from washing each other out of your eye.
  • The usual dosage of SIMBRINZA® is one drop in the affected eye(s) two times daily, approximately 12 hours apart. Use SIMBRINZA® exactly as your doctor prescribes. Do not use more or less of it, or use it more often than prescribed.
  • If you miss a dose, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one.
  • Store SIMBRINZA® at room temperature, away from heat and light. Keep the bottle tightly closed when not in use. Keep out of reach of children. If the solution changes color or contains particles, do not use it.
  • It is important to use SIMBRINZA® regularly to control your eye pressure. Continue to use SIMBRINZA® even if you feel well. Glaucoma often has no symptoms, and you may not notice any change in your vision. Do not stop using SIMBRINZA® without talking to your doctor.
  • If you experience any side effects, such as eye redness, itching, or blurred vision, contact your doctor. Serious side effects are rare, but seek immediate medical attention if you experience chest pain, shortness of breath, or severe allergic reactions.

Quick Tips for SIMBRINZA EYE 5 ML DROPS 5 MLArrow

  • **Use as Prescribed:** Always use SIMBRINZA exactly as your doctor has instructed. The dosage and frequency are tailored to your specific condition. Do not alter the dosage without consulting your ophthalmologist, as this could affect the medication's effectiveness and potentially increase the risk of side effects. Typically, it's administered as one drop in the affected eye(s) twice daily, but adhere strictly to your doctor's instructions.
  • **Proper Administration Technique:** Ensure you administer the eye drops correctly to maximize their benefit and minimize contamination. Wash your hands thoroughly before use. Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above your eye without touching it to prevent contamination. Squeeze the bottle gently to release one drop into the pocket. Close your eye gently for 1-2 minutes without blinking or rubbing. This helps the medication to be absorbed properly. If you are using other eye drops, wait at least 5-10 minutes between applications.
  • **Storage Instructions:** Store SIMBRINZA eye drops properly to maintain their stability and effectiveness. Keep the bottle tightly closed when not in use. Store it at room temperature, away from direct sunlight and heat. Do not store it in the bathroom, where humidity levels are high. Ensure the medication is out of reach of children and pets. If the solution changes color or contains particles, discard the bottle and obtain a new one.
  • **Potential Side Effects Awareness:** Be aware of potential side effects and know when to seek medical advice. Common side effects include blurred vision, eye irritation, dry eyes, and a foreign body sensation. These are usually mild and temporary. However, if you experience more severe side effects such as eye pain, redness, swelling, vision changes, or signs of an allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing), seek immediate medical attention. Inform your doctor about any side effects you experience, even if they are not listed in the medication guide.
  • **Contact Lens Considerations:** If you wear contact lenses, remove them before administering SIMBRINZA eye drops. Wait at least 15 minutes after using the drops before reinserting your lenses. This is because SIMBRINZA contains a preservative that may be absorbed by soft contact lenses and cause irritation. Following this guideline will help prevent discomfort and potential damage to your eyes.

Food Interactions with SIMBRINZA EYE 5 ML DROPS 5 MLArrow

  • SIMBRINZA Eye Drops are administered topically and are unlikely to interact with food. You can use SIMBRINZA Eye Drops irrespective of your food intake.

FAQs

What is Simbrinza Eye Drops used for?Arrow

Simbrinza Eye Drops are used to lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

How should I store Simbrinza Eye Drops?Arrow

Store Simbrinza Eye Drops at room temperature, away from light and moisture. Keep the bottle tightly closed when not in use.

What are the common side effects of Simbrinza?Arrow

Common side effects include blurred vision, eye irritation, dry eyes, and a bad taste in the mouth.

Can I use Simbrinza with other eye drops?Arrow

Consult your doctor before using Simbrinza with other eye drops to avoid potential interactions. If using multiple eye drops, administer them at least 5 minutes apart.

What should I do if I miss a dose of Simbrinza?Arrow

If you miss a dose, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

What are the ingredients in Simbrinza Eye Drops?Arrow

Simbrinza contains brinzolamide and brimonidine tartrate as active ingredients.

Is Simbrinza safe to use during pregnancy?Arrow

Consult your doctor before using Simbrinza if you are pregnant or planning to become pregnant. It is not generally recommended unless clearly needed.

Can Simbrinza cause drowsiness?Arrow

Yes, Simbrinza can sometimes cause drowsiness or fatigue in some individuals. Use caution when driving or operating machinery until you know how the medication affects you.

What should I avoid while using Simbrinza?Arrow

Avoid wearing contact lenses while using Simbrinza, unless otherwise directed by your doctor. Also, avoid activities requiring alertness until you know how the medication affects you.

How long does it take for Simbrinza to start working?Arrow

Simbrinza starts to lower intraocular pressure within a few hours of the first dose, but it may take a few weeks to see the full effect.

Is there a generic alternative to Simbrinza?Arrow

Currently, there is no generic version of Simbrinza available. Brinzolamide and Brimonidine are available as individual generics, but not as a combination drop.

Can Simbrinza cause allergic reactions?Arrow

Yes, Simbrinza can cause allergic reactions in some individuals. Symptoms may include rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.

What is the dosage of Simbrinza?Arrow

The usual dosage is one drop in the affected eye(s) three times daily.

How to use Simbrinza Eye Drops?Arrow

Wash your hands, tilt your head back, gently pull down your lower eyelid to create a pouch. Position the dropper above your eye and squeeze out one drop. Close your eye for 1-2 minutes. Do not blink or rub your eye. Repeat for the other eye if needed.

What to do in case of overdose of Simbrinza?Arrow

In case of an overdose, immediately contact your doctor or local poison control center. Symptoms of an overdose may include decreased heart rate, low blood pressure, and difficulty breathing.

References

Book Icon

SIMBRINZA (brinzolamide and brimonidine tartrate) Ophthalmic Suspension, for topical Ophthalmic Use. Full Prescribing Information. Alcon Laboratories, Inc.

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Katz LJ, Grove DS, Schiffman RM, et al. Brinzolamide/brimonidine fixed combination versus brinzolamide or brimonidine in open-angle glaucoma or ocular hypertension. J Glaucoma. 2014 Oct-Nov;23(8):591-8.

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Simbrinza - European Medicines Agency (EMA) - Summary of Product Characteristics

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IMS Brookes. সিমব্রিনজা (ব্রিনজোলামাইড/ব্রিমোনিডিন)। নিবন্ধিত মেডিসিন নির্দেশিকা। 2014;2014:6.

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Simbrinza Professional Information. Drugs.com.

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Brinzolamide. DrugBank Online.

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Brimonidine. DrugBank Online.

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Reviewed on 03-04-2022

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ALCON LABORATORIES INDIA PRIVATE LIMITED

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SIMBRINZA EYE 5 ML DROPS 5 ML

SIMBRINZA EYE 5 ML DROPS 5 ML

MRP

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₹663.54

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