SITABITE M 50/500MG TABLET 10'S

How SITABITE M 50/500MG TABLET 10'S Works

• SITABITE M 50/500MG TABLET is a combination medication containing Sitagliptin and Metformin, designed to manage blood sugar levels in individuals with type 2 diabetes. To understand how SITABITE M works, it's crucial to look at the individual roles of its active ingredients.
• Sitagliptin belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). DPP-4 inhibitors work by increasing the amount of incretin hormones released in the body. Incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), play a crucial role in regulating blood sugar levels. They are released by the intestine in response to food intake. Specifically, incretins stimulate the pancreas to release insulin after a meal and also reduce the amount of glucagon released by the liver. Glucagon is a hormone that raises blood sugar levels. By inhibiting the DPP-4 enzyme, Sitagliptin effectively prolongs the activity of these incretin hormones, enhancing insulin secretion and reducing glucagon secretion in a glucose-dependent manner. This means it helps lower blood sugar levels specifically when they are elevated, reducing the risk of hypoglycemia (low blood sugar).
• Metformin, on the other hand, is a biguanide antihyperglycemic agent. It works through several mechanisms to lower blood sugar levels. Primarily, Metformin reduces glucose production in the liver. It does this by suppressing hepatic gluconeogenesis (the production of glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, Metformin improves insulin sensitivity in peripheral tissues, such as muscles, allowing cells to uptake and utilize glucose more efficiently. It also slows down the absorption of glucose from the intestines after a meal. Unlike some other diabetes medications, Metformin does not stimulate insulin secretion, which minimizes the risk of hypoglycemia when used alone.
• When Sitagliptin and Metformin are combined in SITABITE M, they offer complementary mechanisms of action to improve glycemic control. Sitagliptin enhances insulin secretion and reduces glucagon levels in a glucose-dependent manner, while Metformin reduces glucose production in the liver, improves insulin sensitivity, and reduces glucose absorption. This synergistic effect results in more effective blood sugar management compared to either drug used alone. It helps to lower both fasting and postprandial (after-meal) blood sugar levels.
• In summary, SITABITE M 50/500MG TABLET works by: 1. Increasing incretin hormone levels (Sitagliptin), which stimulates insulin release and reduces glucagon secretion. 2. Reducing glucose production in the liver (Metformin). 3. Improving insulin sensitivity in peripheral tissues (Metformin). 4. Reducing glucose absorption from the intestines (Metformin).
• It is essential to take SITABITE M as prescribed by your doctor, usually with meals to minimize gastrointestinal side effects associated with Metformin. Regular monitoring of blood sugar levels and kidney function is also important while taking this medication.

Common side effects of Sitabite M 50/500mg Tablet may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar). Other possible side effects are headache, dizziness, constipation, upper respiratory tract infection, and skin reactions like rash or itching. In rare cases, it can cause lactic acidosis (build-up of lactic acid in the body), pancreatitis (inflammation of the pancreas), and allergic reactions. Consult your doctor if you experience any persistent or severe side effects.

• If you miss a dose of SITABITE M 50/500MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep SITABITE M 50/500MG TAB 1X10 away from the reach of children and pets.
• Store SITABITE M 50/500MG TAB 1X10 at room temperature.

• Take SITABITE M 50/500MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as this can affect your blood sugar control.
• SITABITE M 50/500MG TABLET 10'S is typically taken with meals to help reduce the risk of stomach upset. Swallow the tablet whole with a glass of water, and do not crush, chew, or break it.
• Regularly monitor your blood sugar levels as directed by your doctor while taking SITABITE M 50/500MG TABLET 10'S. Keep a record of your blood sugar readings to share with your healthcare provider during check-ups. This helps in assessing the effectiveness of the medication and making necessary adjustments.
• Inform your doctor about all other medications, supplements, and herbal products you are taking before starting SITABITE M 50/500MG TABLET 10'S. Certain medications can interact with sitagliptin and metformin, affecting their efficacy or increasing the risk of side effects. It’s crucial to provide a complete medical history to your doctor.
• Follow a healthy diet and exercise regularly while taking SITABITE M 50/500MG TABLET 10'S. This medication works best when combined with lifestyle modifications to manage blood sugar levels effectively. Consult a dietitian or healthcare provider for guidance on a suitable diet and exercise plan.

• SITABITE M 50/500MG TABLET 10'S should be taken with food to decrease the chance of an upset stomach.
• Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis and hypoglycemia.