SYNCAPONE 100MG TABLET 10'S

How SYNCAPONE 100MG TABLET 10'S Works

• SYNCAPONE 100MG TABLET 10'S is a combination medicine used to treat Parkinson's disease, a progressive nervous system disorder that affects movement. It contains three active ingredients: Levodopa, Carbidopa, and Entacapone. Understanding how each of these components works is crucial to appreciating the overall mechanism of action of SYNCAPONE.
• Levodopa is a precursor to dopamine, a neurotransmitter that is deficient in the brains of people with Parkinson's disease. In Parkinson's disease, the dopamine-producing cells in the brain gradually deteriorate, leading to a shortage of dopamine. Dopamine is essential for controlling movement, coordination, and other neurological functions. Levodopa crosses the blood-brain barrier and is converted into dopamine in the brain, effectively replenishing the depleted dopamine levels. This helps to alleviate motor symptoms such as tremors, rigidity, slow movement (bradykinesia), and postural instability.
• Carbidopa is a dopa decarboxylase inhibitor. It works by inhibiting the enzyme dopa decarboxylase, which is responsible for converting levodopa into dopamine in the bloodstream and other tissues outside the brain. By preventing this premature conversion, carbidopa ensures that a greater proportion of levodopa reaches the brain, where it is needed most. This not only increases the effectiveness of levodopa but also reduces the side effects associated with peripheral dopamine production, such as nausea and vomiting.
• Entacapone is a catechol-O-methyltransferase (COMT) inhibitor. COMT is an enzyme that breaks down levodopa in the bloodstream. Entacapone blocks the action of COMT, further preventing the breakdown of levodopa and allowing more of it to reach the brain. By prolonging the availability of levodopa, entacapone helps to maintain more stable dopamine levels in the brain and extend the duration of symptom relief.
• In summary, SYNCAPONE works through a triple mechanism: levodopa replenishes dopamine levels in the brain, carbidopa prevents the premature breakdown of levodopa in the periphery, and entacapone inhibits the COMT enzyme to further extend levodopa's duration of action. This synergistic combination helps to improve motor control, reduce motor fluctuations (on-off phenomenon), and enhance the overall quality of life for individuals living with Parkinson's disease. It is important to take SYNCAPONE exactly as prescribed by your doctor to achieve optimal therapeutic benefits.

Common side effects of SYNCAPONE may include: nausea, vomiting, dizziness, lightheadedness, abnormal involuntary movements (dyskinesias), muscle cramps, confusion, hallucinations, insomnia, dry mouth, constipation, diarrhea, and changes in urine color. Less common but potentially serious side effects include: severe dyskinesias, mental/mood changes (e.g., depression, anxiety, psychosis), impulse control problems (e.g., gambling, compulsive shopping), orthostatic hypotension (low blood pressure upon standing), and signs of allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing). Rare but serious side effects include: neuroleptic malignant syndrome (NMS), rhabdomyolysis, and liver problems.

• If you miss a dose of SYNCAPONE 100MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep SYNCAPONE 100MG TAB 1X10 away from the reach of children and pets.
• Store SYNCAPONE 100MG TAB 1X10 at room temperature.

• Take SYNCAPONE 100MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or frequency without consulting them, as this can impact its effectiveness and your symptom management. Consistency is key in managing Parkinson's symptoms effectively.
• SYNCAPONE 100MG TABLET 10'S is most effective when taken at consistent intervals throughout the day. Try to take your doses at the same times each day to maintain a steady level of medication in your body. Using a timer or medication reminder app can be helpful.
• Be aware of potential side effects such as nausea, dizziness, or involuntary movements (dyskinesias). These side effects are usually manageable, but it’s important to inform your doctor if they become bothersome or interfere with your daily activities. They may adjust your dosage or provide other recommendations.
• Certain foods, especially high-protein meals, may interfere with the absorption of SYNCAPONE 100MG TABLET 10'S. Discuss with your doctor or pharmacist whether you need to adjust your diet or the timing of your meals in relation to your medication intake. It's generally advised to take the medication 30-60 minutes before or after meals.
• Do not stop taking SYNCAPONE 100MG TABLET 10'S abruptly. Sudden discontinuation can lead to withdrawal symptoms and a worsening of Parkinson's symptoms. Always consult your doctor before making any changes to your medication regimen. They will guide you on how to safely taper off the medication if necessary.
• Store SYNCAPONE 100MG TABLET 10'S at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Proper storage helps maintain the medication's efficacy.
• Inform all your healthcare providers, including your dentist, about your SYNCAPONE 100MG TABLET 10'S use. This is crucial for avoiding potential drug interactions and ensuring your overall safety, especially if you need any other medications or treatments.
• Pay attention to how SYNCAPONE 100MG TABLET 10'S affects you. Keep a journal to track your symptoms, medication timing, and any side effects you experience. This information will be valuable for your doctor to fine-tune your treatment plan and optimize your symptom control.
• If you miss a dose of SYNCAPONE 100MG TABLET 10'S, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
• Avoid driving or operating heavy machinery until you know how SYNCAPONE 100MG TABLET 10'S affects you. The medication can cause dizziness or drowsiness, which may impair your ability to perform these tasks safely. Prioritize your safety and adjust your activities accordingly.

• SYNCAPONE 100MG TABLET 10'S can be taken with or without food, but it is important to maintain a consistent diet.
• High-protein diets may reduce the effectiveness of SYNCAPONE 100MG TABLET 10'S. Consult your doctor or pharmacist for advice on dietary adjustments.
• Avoid taking SYNCAPONE 100MG TABLET 10'S with iron supplements or iron-rich foods, as iron can interfere with the absorption of the medication.
• Be cautious about consuming large amounts of vitamin B6, as it may decrease the efficacy of SYNCAPONE 100MG TABLET 10'S. Discuss this with your healthcare provider.