TRI GLYCLAZAR 60MG SR TABLET 10'S

How TRI GLYCLAZAR 60MG SR TABLET 10'S Works

• TRI GLYCLAZAR 60MG SR TABLET 10'S is an oral hypoglycemic (anti-diabetic) medicine used to treat type 2 diabetes mellitus, especially in people whose blood sugar levels cannot be controlled by diet and exercise alone. Its active ingredient, gliclazide, belongs to a class of drugs called sulfonylureas. These medications work primarily by stimulating the beta cells in the pancreas to release more insulin. Insulin is a hormone that helps glucose (sugar) from the blood enter cells to be used for energy. In type 2 diabetes, either the pancreas doesn't produce enough insulin, or the body's cells become resistant to insulin's effects (insulin resistance).
• Gliclazide's mechanism of action involves several steps. First, it binds to specific receptors on the beta cells of the pancreas. This binding stimulates the closure of ATP-sensitive potassium (KATP) channels on the beta cell membrane. These KATP channels normally help to regulate the cell's resting membrane potential. When these channels close, it causes the beta cell membrane to depolarize. This depolarization, in turn, opens voltage-gated calcium channels, allowing calcium ions to enter the beta cells. The increase in intracellular calcium triggers the release of insulin granules, which contain insulin, into the bloodstream.
• In addition to stimulating insulin release, gliclazide may also have some other beneficial effects. Some studies suggest that it can improve insulin sensitivity in peripheral tissues (such as muscle and fat), helping the body to use insulin more effectively. It also possesses antioxidant properties, which could potentially protect pancreatic beta cells from damage caused by oxidative stress. Furthermore, gliclazide may help to reduce the risk of microvascular complications associated with diabetes, such as damage to the eyes (retinopathy) and kidneys (nephropathy). This is thought to be due to its effects on platelet aggregation and vascular endothelial function.
• The 'SR' in TRI GLYCLAZAR 60MG SR TABLET 10'S stands for sustained release. This means that the gliclazide is released slowly into the body over a longer period, typically 24 hours. This sustained release helps to provide a more consistent blood sugar control throughout the day, reducing the risk of both high and low blood sugar levels. Taking it once daily, usually with breakfast, is useful for better compliance and a steady therapeutic effect. However, it is important to note that TRI GLYCLAZAR 60MG SR TABLET 10'S is most effective when used in conjunction with a healthy diet and regular exercise. It is also crucial to follow your doctor's instructions carefully and monitor your blood sugar levels regularly.

The following side effects have been reported with Gliclazide (the active ingredient in TRI GLYCLAZAR 60MG SR TABLET 10'S). While not everyone will experience them, be aware of the possibilities: * **Common Side Effects:** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms can include sweating, shakiness, dizziness, hunger, rapid heartbeat, headache, confusion, and blurred vision. Severe hypoglycemia can lead to loss of consciousness and seizures. * Gastrointestinal disturbances: Nausea, vomiting, indigestion, diarrhea, constipation, and abdominal pain. * **Uncommon Side Effects:** * Skin reactions: Rash, itching, hives, and other allergic skin reactions. * Changes in blood counts: In rare cases, gliclazide can cause a decrease in white blood cells (leukopenia), red blood cells (anemia), or platelets (thrombocytopenia). This can increase the risk of infection, fatigue, and bleeding. * Liver problems: Elevated liver enzymes, hepatitis (inflammation of the liver), and jaundice (yellowing of the skin and eyes) are rare but serious side effects. * Visual disturbances: Temporary visual disturbances may occur, especially at the beginning of treatment. * **Very Rare Side Effects:** * Severe skin reactions: Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare, but serious, skin reactions that require immediate medical attention. * Blood disorders: Agranulocytosis (a severe deficiency of white blood cells) and hemolytic anemia (destruction of red blood cells) are very rare. **Important Note:** This is not an exhaustive list. If you experience any unusual or concerning symptoms while taking TRI GLYCLAZAR 60MG SR TABLET 10'S, contact your doctor immediately.

• If you miss a dose of TRI GLYCLAZAR 60MG SR TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to catch up.

• Keep TRI GLYCLAZAR 60MG SR TAB 1X10 away from the reach of children and pets.
• Store TRI GLYCLAZAR 60MG SR TAB 1X10 at room temperature.

• Take TRI GLYCLAZAR 60MG SR TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as this can affect your blood sugar control. Consistency is key for optimal results.
• TRI GLYCLAZAR 60MG SR TABLET 10'S is designed to be taken once daily, usually with breakfast. Taking it at the same time each day helps maintain a steady level of the medication in your bloodstream, maximizing its effectiveness in managing your blood sugar levels. Always follow your doctor's specific instructions.
• Monitor your blood sugar levels regularly as directed by your doctor or diabetes educator. Keeping a log of your blood sugar readings helps you and your doctor understand how well the medication is working and allows for timely adjustments to your treatment plan. Share these records during your regular check-ups.
• While taking TRI GLYCLAZAR 60MG SR TABLET 10'S, pay close attention to your diet. A balanced diet that is low in sugars and refined carbohydrates is crucial. Consult with a registered dietitian or nutritionist to create a meal plan that supports your blood sugar control and overall health. Combine with regular exercise, as advised by your healthcare provider.
• Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, dizziness, and confusion. Always carry a quick source of sugar, like glucose tablets or juice, to treat a hypoglycemic episode promptly. Inform your family and friends about recognizing and managing hypoglycemia. Consult with your doctor about what to do during such episodes.

• TRI GLYCLAZAR 60MG SR TABLET 10'S is generally recommended to be taken with food to help prevent low blood sugar (hypoglycemia).
• Consistent timing with meals is important to maintain stable blood sugar levels. Follow your doctor's instructions regarding when to take this medication in relation to your meals.
• Avoid skipping meals while taking this medication, as this can increase the risk of hypoglycemia.
• Be mindful of alcohol consumption, as it can interact with TRI GLYCLAZAR 60MG SR TABLET 10'S and increase the risk of low blood sugar. Consult your doctor about safe alcohol consumption limits.