TRIOLMEZEST 40MG TABLET 10'S

How TRIOLMEZEST 40MG TABLET 10'S Works

• TRIOLMEZEST 40MG TABLET is a combination medication designed to manage high blood pressure (hypertension). It combines three active ingredients: Olmesartan, Amlodipine, and Hydrochlorothiazide, each working through different mechanisms to lower blood pressure effectively.
• Olmesartan belongs to a class of drugs called angiotensin II receptor blockers (ARBs). Angiotensin II is a hormone that causes blood vessels to constrict, leading to increased blood pressure. Olmesartan blocks the action of angiotensin II, allowing blood vessels to relax and widen. This reduces the resistance against which the heart has to pump, thereby lowering blood pressure.
• Amlodipine is a calcium channel blocker. It works by preventing calcium from entering the muscle cells of the heart and blood vessels. This relaxation of the blood vessels improves blood flow and reduces the workload on the heart, contributing to lower blood pressure. Amlodipine primarily affects the arteries, causing them to dilate and reducing peripheral vascular resistance.
• Hydrochlorothiazide is a thiazide diuretic, often referred to as a 'water pill.' It works by increasing the excretion of sodium and chloride (salts) and water from the body through urine. This reduces the volume of fluid in the blood, which in turn lowers blood pressure. Hydrochlorothiazide also has a relaxing effect on blood vessels, further contributing to its blood pressure-lowering effect. It helps to remove excess water, reducing the strain on heart.
• The combination of these three medications provides a synergistic effect, meaning they work together to lower blood pressure more effectively than any single medication alone. By targeting different pathways involved in blood pressure regulation, TRIOLMEZEST 40MG TABLET provides comprehensive control of hypertension.
• Specifically, Olmesartan helps in vasodilation by blocking the effects of Angiotensin II. Amlodipine also helps in vasodilation by inhibiting calcium influx into the arterial muscle cells. Hydrochlorothiazide reduces blood volume by acting on kidneys, increasing excretion of water and electrolytes, and also contributes to vasodilation over prolonged usage. This triple mechanism effectively tackles high blood pressure where single-drug therapies might not be sufficient.
• The coordinated action of these three components makes TRIOLMEZEST 40MG TABLET a powerful tool in managing hypertension and reducing the risk of cardiovascular complications such as heart attack, stroke, and kidney disease. It is crucial to take this medication as prescribed by your doctor and to follow their recommendations regarding diet, exercise, and lifestyle modifications to maximize its benefits.

Possible side effects of TRIOLMEZEST 40MG TABLET may include: * Dizziness * Lightheadedness * Headache * Nausea * Vomiting * Diarrhea * Abdominal pain * Fatigue * Weakness * Muscle cramps * Cough * Upper respiratory tract infection * Increased blood uric acid * Increased blood creatinine * Hypotension (low blood pressure) * Hyperkalemia (high potassium levels) * Rash * Pruritus (itching) * Angioedema (swelling of the face, lips, tongue, or throat) * Renal impairment * Elevated liver enzymes * Changes in heart rhythm (arrhythmia) * Insomnia * Anxiety * Erectile dysfunction This is not an exhaustive list. If you experience any unusual symptoms, consult your doctor.

• If you miss a dose of TRIOLMEZEST 40MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep TRIOLMEZEST 40MG TAB 1X10 away from the reach of children and pets.
• Store TRIOLMEZEST 40MG TAB 1X10 at room temperature.

• **Take consistently at the same time daily:** For optimal blood pressure control, take TRIOLMEZEST 40MG TABLET 10'S at the same time each day. Consistency is key to maintaining stable medication levels in your body.
• **Monitor blood pressure regularly:** While taking TRIOLMEZEST 40MG TABLET 10'S, regularly monitor your blood pressure, especially during the first few weeks of treatment or after any dosage adjustments. Keep a log of your readings to share with your doctor.
• **Inform your doctor of all medications and supplements:** Before starting TRIOLMEZEST 40MG TABLET 10'S, inform your doctor about all other medications, over-the-counter drugs, herbal supplements, and vitamins you're taking. This helps prevent potential drug interactions.
• **Stay hydrated:** Drink plenty of water throughout the day while taking TRIOLMEZEST 40MG TABLET 10'S. Proper hydration supports healthy blood pressure and overall kidney function. If you experience excessive thirst, contact your doctor.
• **Be aware of potential side effects:** Be aware of common side effects like dizziness, lightheadedness, or fatigue. If you experience any persistent or severe side effects, especially swelling, difficulty breathing, or signs of an allergic reaction, seek immediate medical attention. Dizziness is more common when standing up quickly, so rise slowly from sitting or lying down. Avoid driving or operating machinery if you feel dizzy.
• **Lifestyle modifications are crucial:** TRIOLMEZEST 40MG TABLET 10'S works best when combined with lifestyle changes. Adopt a heart-healthy diet low in sodium and saturated fats, engage in regular physical activity, maintain a healthy weight, and limit alcohol consumption. Smoking cessation is also highly recommended.
• **Do not stop abruptly:** Do not suddenly stop taking TRIOLMEZEST 40MG TABLET 10'S without consulting your doctor. Abruptly discontinuing the medication can cause a sudden increase in blood pressure, which could be dangerous. Your doctor will guide you on how to safely taper off the medication if necessary.
• **Potassium levels:** TRIOLMEZEST can affect potassium levels. Consult your doctor about whether you need to adjust your diet, and if any blood tests are required to check your potassium levels.
• **Limit Alcohol Consumption:** Alcohol can further lower blood pressure and may increase the dizziness side effect of this medicine. So, it is better to limit or avoid alcohol consumption.

• TRIOLMEZEST 40MG TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood levels. While food doesn't significantly alter its absorption, avoid consuming large amounts of grapefruit or grapefruit juice, as it may interact with the medication.