TRIOLVANCE 40MG TABLET 10'S

How TRIOLVANCE 40MG TABLET 10'S Works

• TRIOLVANCE 40MG TABLET 10'S is a combination medication designed to manage hypertension and reduce the risk of cardiovascular events. It contains three active ingredients: Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide. Each component works through a different mechanism to achieve a synergistic effect in lowering blood pressure.
• Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB). Angiotensin II is a hormone that causes blood vessels to constrict, leading to increased blood pressure. Olmesartan blocks the action of angiotensin II by binding to the angiotensin II receptors in blood vessel walls, preventing the hormone from exerting its constricting effects. This results in vasodilation (widening of blood vessels) and a decrease in blood pressure. By blocking angiotensin II, olmesartan also helps reduce the release of aldosterone, a hormone that causes the kidneys to retain sodium and water, further contributing to blood pressure reduction.
• Amlodipine is a calcium channel blocker. It works by blocking the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. In vascular smooth muscle, this reduces the ability of the muscles to contract, leading to vasodilation and a decrease in blood pressure. In cardiac muscle, amlodipine has a negative chronotropic effect (reducing heart rate) and a negative inotropic effect (reducing the force of heart contractions), which also contributes to lowering blood pressure. Amlodipine is particularly effective in treating hypertension because it has a long duration of action, providing sustained blood pressure control throughout the day.
• Hydrochlorothiazide is a thiazide diuretic. It works by inhibiting the reabsorption of sodium and chloride ions in the kidneys, specifically in the distal convoluted tubule. This increases the excretion of sodium and chloride in the urine, leading to increased water excretion. As the body loses water, the volume of blood decreases, resulting in a lower blood pressure. Hydrochlorothiazide also has a vasodilatory effect on blood vessels, which further contributes to its blood pressure-lowering effects. The diuretic action of hydrochlorothiazide also helps reduce edema (swelling) associated with hypertension and other conditions.
• In combination, these three medications address hypertension from multiple angles. Olmesartan blocks the vasoconstricting effects of angiotensin II, Amlodipine promotes vasodilation by blocking calcium channels, and Hydrochlorothiazide reduces blood volume through its diuretic action. This triple-action approach is often more effective than using a single medication to manage hypertension, especially in patients who require more aggressive blood pressure control. The combined effect helps to relax blood vessels, reduce the workload on the heart, and lower blood pressure, thereby decreasing the risk of cardiovascular complications such as heart attack, stroke, and kidney disease. It is important to take TRIOLVANCE 40MG TABLET 10'S as prescribed by your healthcare provider and to monitor your blood pressure regularly.

Like all medicines, TRIOLVANCE 40MG TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Dizziness * Headache * Fatigue * Nausea * Diarrhea * Muscle pain * Increased blood sugar levels (hyperglycemia) * Upper respiratory tract infection, like common cold **Uncommon Side Effects (may affect up to 1 in 100 people):** * Low blood pressure (hypotension) * Increased heart rate (tachycardia) * Palpitations * Skin rash * Itching (pruritus) * Upset stomach * Vomiting * Anxiety * Sleep disturbances * Elevated liver enzymes * Muscle weakness **Rare Side Effects (may affect up to 1 in 1,000 people):** * Kidney problems * Nerve damage (peripheral neuropathy) * Depression * Hair loss * Impotence **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Liver failure **Other Potential Side Effects:** * Allergic reactions (swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing) * Severe muscle pain, tenderness, or weakness (rhabdomyolysis) * Confusion * Memory loss **Important Note:** This is not an exhaustive list. If you experience any unusual symptoms while taking TRIOLVANCE 40MG TABLET 10'S, consult your doctor or pharmacist immediately.

• If you miss a dose of TRIOLVANCE 40MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep TRIOLVANCE 40MG TAB 1X10 away from the reach of children and pets.
• Store TRIOLVANCE 40MG TAB 1X10 at room temperature.

• **Take consistently, as prescribed:** For optimal results, take TRIOLVANCE 40MG TABLET 10'S exactly as your doctor prescribes, at the same time each day. Consistency is key to managing your blood pressure and cholesterol effectively. Don't alter the dosage or stop taking the medication without consulting your healthcare provider, even if you feel well.
• **Monitor your blood pressure and cholesterol regularly:** While TRIOLVANCE 40MG TABLET 10'S helps manage these levels, regular monitoring is crucial. Keep track of your blood pressure readings at home and attend scheduled lab appointments to check your cholesterol. Share this information with your doctor to optimize your treatment plan.
• **Lifestyle modifications are crucial:** TRIOLVANCE 40MG TABLET 10'S works best when combined with a healthy lifestyle. This includes adopting a balanced diet low in saturated and trans fats, cholesterol, and sodium. Regular physical activity, such as brisk walking for at least 30 minutes most days of the week, is also highly beneficial. Quitting smoking and managing stress can further improve your cardiovascular health.
• **Be aware of potential side effects:** Like all medications, TRIOLVANCE 40MG TABLET 10'S can cause side effects. Common side effects may include muscle pain or weakness, headache, dizziness, or gastrointestinal issues. Contact your doctor if you experience severe or persistent side effects. Be especially vigilant for signs of muscle problems, as this medication can rarely cause a serious muscle condition.
• **Inform your doctor about other medications and health conditions:** Before starting TRIOLVANCE 40MG TABLET 10'S, inform your doctor about all other medications you are taking, including over-the-counter drugs, supplements, and herbal remedies. Also, disclose any existing health conditions, such as liver or kidney problems, thyroid disorders, or diabetes. This information will help your doctor ensure the medication is safe and effective for you.

• TRIOLVANCE 40MG TABLET 10'S can be taken with or without food. However, it is important to take it consistently, either always with food or always without food, to maintain consistent absorption of the medication. Consult your doctor or pharmacist for further guidance based on your specific health condition and other medications you may be taking.