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Composition
Content Reviewed By:
Dr. Rajesh Sharma
, (MBBS)
Written By:
Ms. Priyanka Shah
, (B.Pharm)
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Other Medical Conditions and Drug Interactions
Use under medical supervisionZapiz 0.25 should be used cautiously in patients with respiratory disorders such as chronic obstructive pulmonary disease, sleep apnea, or severe asthma, as benzodiazepines can depress respiratory drive.
ZAPIZ 0.25MG TABLET 20'S belongs to a class of medicines called benzodiazepines and is used to treat anxiety, stop seizures (fits) or relax tense muscles. This can also help relieve difficulty sleeping (insomnia), and is usually prescribed for a short period of time, if used to treat sleeping problems. You should take it in the dose and duration advised by the doctor.
Yes, ZAPIZ 0.25MG TABLET 20'S causes drowsiness very commonly. It also causes forgetfulness and affects muscular function which may adversely affect your ability to drive. Sometimes, drowsiness persists even on the following day. So, in case ZAPIZ 0.25MG TABLET 20'S makes you sleepy and affects your alertness, you should avoid driving.
The duration of treatment with ZAPIZ 0.25MG TABLET 20'S is mainly as short as possible. Your doctor will evaluate you after 4 weeks of treatment in order to assess the need for continuation of treatment, especially if you do not have any symptoms. Before taking you off this medicine, your doctor may gradually decrease your dose to prevent any withdrawal side effects. Follow your doctor’s instructions carefully to get the most benefit.
No, it is not at all recommended to take alcohol with ZAPIZ 0.25MG TABLET 20'S since it can cause breathing problems, sleepiness and heart problems. Taking ZAPIZ 0.25MG TABLET 20'S with alcohol may make you sleepy and your breathing may become so shallow that you may not wake up. This may even lead to death.
People taking ZAPIZ 0.25MG TABLET 20'S in high doses or for a long term may become addicted to it. Also, people with a history of alcoholism and drug abuse are more likely to become addicted to ZAPIZ 0.25MG TABLET 20'S. Therefore, ZAPIZ 0.25MG TABLET 20'S should be taken for the shortest possible time and in the lowest effective dose.
No, do not stop taking ZAPIZ 0.25MG TABLET 20'S suddenly as you may experience withdrawal effects like depression, nervousness, difficulty in sleeping, irritability, sweating, upset stomach or diarrhea. Stopping it suddenly may even bring back the symptoms and make them harder to treat. You may also experience mood changes, anxiety, restlessness and changes in sleep patterns. These effects may occur even after taking low doses for a short period of time.
Yes, you should avoid taking foods containing caffeine such as tea, coffee, chocolates etc., while taking ZAPIZ 0.25MG TABLET 20'S. This is because caffeine stimulates your brain and ZAPIZ 0.25MG TABLET 20'S calms the brain. So, taking too much caffeine can affect the calming ability of this medicine and worsen your condition. Also, you should avoid taking alcohol while on treatment with ZAPIZ 0.25MG TABLET 20'S. Alcohol can cause excessive sleepiness and make you more drowsy and inattentive. Talk to your doctor if you have any other doubts regarding your diet while taking ZAPIZ 0.25MG TABLET 20'S.
Zapiz 0.25 is a prescription medicine that contains clonazepam 0.25 mg as its active ingredient. Clonazepam is a benzodiazepine used for the management of certain anxiety disorders, panic disorder, and some types of seizures. It works by enhancing the effect of the inhibitory neurotransmitter GABA in the brain, which helps reduce abnormal electrical activity and produces a calming effect.
Zapiz 0.25 is commonly prescribed for anxiety disorders, panic disorder, and as an adjunct in the treatment of certain seizure disorders, such as absence seizures, myoclonic seizures, or partial seizures, depending on the clinician’s assessment. The exact indication for an individual patient is determined by the treating doctor after a thorough clinical evaluation.
Zapiz 0.25 should be taken exactly as prescribed by your doctor. It is usually taken by mouth with water, with or without food, at the same time each day to maintain consistent levels in the body. Do not change the dose, frequency, or duration of use on your own. If you have any doubt about how to take it, consult your prescribing physician or pharmacist rather than guessing or copying another person’s regimen.
You should not stop Zapiz 0.25 abruptly without medical advice, especially if you have been taking it regularly for more than a short period. Sudden discontinuation can lead to withdrawal symptoms such as anxiety, restlessness, insomnia, irritability, tremors, sweating, and, in some cases, seizures. Your doctor may recommend a gradual dose reduction (tapering) to minimize withdrawal risks.
Common side effects of Zapiz 0.25 include drowsiness, dizziness, fatigue, muscle weakness, impaired coordination, slowed reaction time, and difficulty concentrating. Some people may experience confusion, memory problems, or mood changes. These effects are often more pronounced when treatment is started or when the dose is increased. If side effects are severe, persistent, or interfere with daily activities, contact your doctor.
Clonazepam, the active ingredient in Zapiz 0.25, has the potential to cause physical and psychological dependence, particularly with prolonged use, higher doses, or in individuals with a history of substance use disorder. Misuse can lead to tolerance, where higher doses are needed to achieve the same effect, and withdrawal symptoms on stopping. Therefore, it should be used strictly under medical supervision and only for the duration recommended by your doctor.
Alcohol should be avoided while taking Zapiz 0.25. Both alcohol and clonazepam depress the central nervous system, and their combined use can lead to excessive drowsiness, impaired coordination, confusion, and, in severe cases, respiratory depression, coma, or death. Even small amounts of alcohol can significantly enhance these effects, so it is safest to abstain completely during treatment.
Use of Zapiz 0.25 during pregnancy is generally not recommended unless the potential benefit to the mother clearly outweighs the potential risk to the fetus. Benzodiazepines have been associated with risks such as neonatal respiratory depression, floppy infant syndrome, and withdrawal symptoms in the newborn when used in late pregnancy. If you are pregnant, planning pregnancy, or become pregnant while taking Zapiz 0.25, discuss the risks and alternatives with your doctor promptly.
Clonazepam passes into breast milk and may cause sedation, poor feeding, or weight gain issues in the breastfed infant. Use of Zapiz 0.25 while breastfeeding requires careful consideration of the risks and benefits. Your doctor may advise avoiding breastfeeding, using the lowest effective dose for the shortest duration, or choosing an alternative treatment. Monitor the baby for unusual sleepiness, poor sucking, or breathing difficulties and seek medical advice if these occur.
Older adults are more sensitive to the effects of benzodiazepines, including Zapiz 0.25. They have an increased risk of excessive sedation, confusion, falls, fractures, and cognitive impairment. Lower starting doses, close monitoring, and regular review of the ongoing need for therapy are essential in this age group. Any new confusion, unsteadiness, or change in behavior should be reported to the doctor immediately.
If you miss a dose of Zapiz 0.25, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects such as excessive drowsiness or impaired coordination. If you frequently forget doses, speak with your doctor or pharmacist about strategies to improve adherence.
Zapiz 0.25 should generally be avoided in individuals with a known allergy to clonazepam or other benzodiazepines, those with severe respiratory insufficiency, significant liver impairment, or a history of acute narrow‑angle glaucoma. It should also be used with great caution, or avoided, in people with a history of substance use disorder, severe depression, or suicidal tendencies. Your doctor will evaluate your medical history and current medicines to determine whether Zapiz 0.25 is appropriate for you.
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INTAS PHARMACEUTICALS LIMITED
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India
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