ZEVTAXEL 60MG/1.5ML INJECTION
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ZEVTAXEL 60MG/1.5ML INJECTION
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ZEVTAXEL 60MG/1.5ML INJECTION

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ZEVTAXEL 60MG/1.5ML INJECTION

By ZEE LABORATORIES LTD

MRP

11718.75

₹11718.75

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Product DetailsArrow

Content Reviewed By:

Dr. Neha Patel

, (MBBS)

Written By:

Mr. Ankit Jain

, (B.Pharm)

About ZEVTAXEL 60MG/1.5ML INJECTION

  • ZEVTAXEL 60MG/1.5ML INJECTION contains cabazitaxel as its active ingredient. It is a medication used in cancer treatment, specifically prescribed alongside steroid medications like prednisone or prednisolone. This combination therapy is indicated for individuals with hormone-refractory metastatic prostate cancer, particularly when the cancer has continued to progress despite prior treatment with other anticancer drugs, including docetaxel. Cancer, at its core, involves the abnormal and uncontrolled proliferation of cells within the body.
  • Many prostate cancers in their early stages rely on normal levels of testosterone (a male hormone) to fuel their growth. However, in hormone-refractory metastatic prostate cancer, this dependency shifts, and the cancer persists in growing even when testosterone levels in the body are significantly reduced. It's important to note that ZEVTAXEL 60MG/1.5ML INJECTION is contraindicated in individuals with severe liver function abnormalities or those who have recently received a yellow fever vaccination. Patients with hypersensitivity or allergy to cabazitaxel or polysorbate 80 should also avoid this medication.
  • The major potential toxicities associated with ZEVTAXEL 60MG/1.5ML INJECTION include myelosuppression (bone marrow suppression), neurotoxicity (nerve damage), and the possibility of allergic reactions. Neutropenia, a condition characterized by a low count of neutrophils (a type of white blood cell), is the most commonly observed adverse reaction to this medication. Regular monitoring of complete blood counts is crucial, ideally on a weekly basis during the first cycle of treatment and before each subsequent treatment cycle. This allows for timely dose adjustments as needed to manage neutropenia and other potential hematological toxicities. Vaccination with live attenuated vaccines should be avoided while receiving ZEVTAXEL 60MG/1.5ML INJECTION; instead, killed or inactivated vaccines can be considered.
  • If you are pregnant, planning to conceive, or breastfeeding, it is imperative to consult your doctor before starting ZEVTAXEL 60MG/1.5ML INJECTION treatment. This drug is considered unsafe for use during pregnancy due to the potential for harm to the developing fetus. Your healthcare provider will typically perform a pregnancy test before initiating treatment with ZEVTAXEL 60MG/1.5ML INJECTION. It is essential to discuss effective birth control methods with your doctor and consistently use them throughout treatment and for at least two weeks after the final dose. It is also advised to avoid breastfeeding during treatment, as it is currently unknown whether ZEVTAXEL 60MG/1.5ML INJECTION passes into breast milk.

Uses of ZEVTAXEL 60MG/1.5ML INJECTION

  • Advanced prostate cancer refers to a stage where the cancer has spread beyond the prostate gland to other parts of the body. This advanced stage requires specialized treatment approaches.

Side Effects of ZEVTAXEL 60MG/1.5ML INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious side effects include low white blood cells, infection (fever, cough, muscle aches, burning on urination), severe allergic reactions (rash, itching, breathing problems, swelling of face, chest, or throat tightness), kidney damage, and severe stomach pain. Common side effects include low red blood cell count, low blood platelet count, constipation, back pain, joint pain, decreased appetite, hair loss, numbness, burning, tingling, or decreased sensation in your feet or hands, taste change, headache, dizziness, inflammation of the mouth, and blood in urine.

  • Low white blood cells
  • Infection (fever, cough, muscle aches, burning on urination)
  • Severe allergic reactions (rash, itching, breathing problems, swelling of face, chest, or throat tightness)
  • Kidney damage
  • Severe stomach pain
  • Low red blood cell count
  • Low blood platelet count
  • Constipation
  • Back pain, joint pain
  • Decreased appetite
  • Hair loss
  • Numbness, burning, tingling, or decreased sensation in your feet or hands
  • Taste change
  • Headache, dizziness
  • Inflammation of the mouth
  • Blood in urine

Safety Advice for ZEVTAXEL 60MG/1.5ML INJECTIONArrow

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Pregnancy

UNSAFE

It is unsafe to use during pregnancy whether ZEVTAXEL 60MG/1.5ML INJECTION can be taken during pregnancy. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.

Dosage of ZEVTAXEL 60MG/1.5ML INJECTIONArrow

  • A trained healthcare professional will administer ZEVTAXEL 60MG/1.5ML INJECTION to you within a hospital environment, ensuring your safety and proper monitoring. The standard recommended dosage involves a 25mg dose, delivered via intravenous infusion, slowly, over a period of one hour. This treatment is typically repeated every three weeks. During this treatment, you'll also take oral prednisone, at a dosage of 10mg daily, as it complements the effects of ZEVTAXEL 60MG/1.5ML INJECTION.
  • It's important to understand that your doctor may adjust the dosage of ZEVTAXEL 60MG/1.5ML INJECTION based on your unique medical profile. Factors like your age, overall body weight, and any pre-existing medical conditions you might have will all play a role in determining the most appropriate and effective dose for you. This personalized approach ensures you receive the optimal therapeutic benefit while minimizing potential side effects. Always discuss any concerns you have with your healthcare provider.

How to store ZEVTAXEL 60MG/1.5ML INJECTION?Arrow

  • Keep ZEVTAXEL 60MG INJ 1.5ML away from the reach of children and pets.
  • Store ZEVTAXEL 60MG INJ 1.5ML at room temperature.

Benefits of ZEVTAXEL 60MG/1.5ML INJECTIONArrow

  • ZEVTAXEL 60MG/1.5ML INJECTION is a medication that targets and disrupts the rapid division of cancer cells. It achieves this by interfering with the crucial process of mitosis, a fundamental step in cell division. Specifically, this injection impacts the microtubules, which are vital components of the cell's cytoskeleton. These microtubules play a critical role in mitosis, ensuring the accurate separation of chromosomes during cell division.
  • By inhibiting the function of microtubules, ZEVTAXEL 60MG/1.5ML INJECTION effectively prevents cancer cells from dividing in a normal and controlled manner. This disruption leads to an inability of the cancer cells to replicate properly, halting their growth and proliferation. The ultimate outcome of this interference is the death of the affected cancer cells, contributing to the therapeutic effect of the injection.
  • This mechanism of action makes ZEVTAXEL 60MG/1.5ML INJECTION a valuable tool in cancer treatment. By selectively targeting the rapid cell division characteristic of cancerous growth, it helps to control and eliminate cancer cells while minimizing damage to healthy cells. The disruption of microtubules is a key step in achieving this therapeutic effect, offering a targeted approach to combatting cancer.

How to use ZEVTAXEL 60MG/1.5ML INJECTIONArrow

  • ZEVTAXEL 60MG/1.5ML INJECTION will be administered to you by a qualified healthcare professional within a hospital environment, ensuring proper monitoring and immediate access to supportive care. This medication is delivered via intravenous infusion, a method where the drug is slowly dripped into your vein over a specific period.
  • The standard recommended dose for ZEVTAXEL 60MG/1.5ML INJECTION is 25mg, given as an intravenous infusion lasting one hour. This treatment is typically repeated every three weeks. Simultaneously, you will also be prescribed oral prednisone, taken daily at a dose of 10mg. Prednisone helps manage potential side effects and enhances the effectiveness of ZEVTAXEL 60MG/1.5ML INJECTION.
  • It's important to understand that the dosage of ZEVTAXEL 60MG/1.5ML INJECTION can be tailored to your individual needs. Your doctor will consider factors such as your age, body weight, pre-existing medical conditions, and your body's response to the treatment to determine the most appropriate dose for you. This personalized approach ensures the best possible outcome while minimizing potential risks.
  • Strict adherence to the prescribed schedule and dosage is crucial for the success of your treatment. Any deviations or concerns should be immediately discussed with your healthcare provider.

FAQs

Why is prednisone given with ZEVTAXEL 60MG/1.5ML INJECTION?Arrow

This drug is designed to kill cancer cells by decreasing their ability to divide into more cells. Prednisone is taken with ZEVTAXEL 60MG/1.5ML INJECTION as part of the chemotherapy regimen to possibly slow the growth of cancer cells and reduce side effects from chemotherapy.

How does ZEVTAXEL 60MG/1.5ML INJECTION work?Arrow

This drug shrinks tumors by attacking rapidly dividing cells, including cancer cells, so they can no longer grow and divide.

Who should not use ZEVTAXEL 60MG/1.5ML INJECTIONs?Arrow

ZEVTAXEL 60MG/1.5ML INJECTION is not indicated for children and adolescents under the age of 18. It should not be used in people who are allergic to this drug, as well as pregnant or breastfeeding women.

Is it safe for women of reproductive potential to use ZEVTAXEL 60MG/1.5ML INJECTIONs?Arrow

ZEVTAXEL 60MG/1.5ML INJECTIONs are not recommended for use during pregnancy and breastfeeding. Tell your healthcare provider before starting this treatment if you are pregnant, think you might be pregnant, breastfeeding, or planning to have a baby.

What should I avoid while taking ZEVTAXEL 60MG/1.5ML INJECTIONs?Arrow

It is advised to avoid eating grapefruit or drinking grapefruit juice as it may increase the concentration of drugs in your blood, leading to a higher risk of side effects.

Does ZEVTAXEL 60MG/1.5ML INJECTION interact with other drugs?Arrow

There are no known interactions of ZEVTAXEL 60MG/1.5ML INJECTION with other drugs.

What advice should I follow during ZEVTAXEL 60MG/1.5ML INJECTION treatment?Arrow

Drink at least two litres of fluids every day when you are having diarrhoea. Avoid milk, dairy products, high fibre food or spicy food while you are having diarrhoea. Rinsing your mouth with an alcohol-free mouth gargle or salt water may help reduce chances of infections like mouth ulcers. Risk of infection can occur as this drug can reduce the WBC count in your blood, so it is advised to avoid crowds and people who are sick, wash your hands after toileting. You must not become pregnant during treatment and must use an effective method of contraception. If pregnancy occurs during your treatment, you must inform your doctor immediately. This drug may make you dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. If you are addicted to alcohol, have liver disease or epilepsy, talk to your doctor before taking this medicine.

Which molecule/combination is used for making ZEVTAXEL 60MG/1.5ML INJECTION?Arrow

CABAZITAXEL is the molecule/combination used for making ZEVTAXEL 60MG/1.5ML INJECTION.

For which ailments/diseases/conditions is ZEVTAXEL 60MG/1.5ML INJECTION prescribed?Arrow

ZEVTAXEL 60MG/1.5ML INJECTION is prescribed for ailments/diseases/conditions related to Oncology.

References

Book Icon

Sanofi-aventis Groupe, Electronic medicines compendium (EMC)

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Annex I summary of Product Characteristics - European Medicines Agency. Available at:

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Package leaflet: Information for the user. www.hpra.ie.

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Ratings & Review

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Best generic alternative. Great quality, great prices

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Find the medicine which was quite hard to find in the vicinity

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(4/5)


Marketer / Manufacturer Details

ZEE LABORATORIES LTD

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India

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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