ZITA DM 20/500MG TABLET 15'S
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ZITA DM 20/500MG TABLET 15'S
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ZITA DM 20/500MG TABLET 15'S

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ZITA DM 20/500MG TABLET 15'S

By GLENMARK PHARMACEUTICALS LIMITED

MRP

136.08

₹115.67

15 % OFF

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About ZITA DM 20/500MG TABLET 15'S

  • ZITA DM 20/500MG TABLET is a combination medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels in adults when diet and exercise alone are not enough. This medication combines two active ingredients, Sitagliptin and Metformin, to provide comprehensive glycemic control.
  • Sitagliptin belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). It works by increasing the amount of incretin hormones in the body. These hormones help to regulate blood sugar levels by increasing insulin release after a meal and decreasing the amount of sugar your liver makes. Metformin, on the other hand, is a biguanide. It works by decreasing glucose production in the liver, improving insulin sensitivity, and decreasing the absorption of glucose from the intestines.
  • By combining these two medications, ZITA DM 20/500MG TABLET addresses multiple pathways involved in blood sugar control. It effectively lowers both fasting and postprandial (after-meal) blood glucose levels. This can lead to better overall glycemic control, reduced risk of diabetes-related complications, and improved quality of life for individuals with type 2 diabetes.
  • This medication is typically taken orally, once or twice daily, with meals to reduce gastrointestinal side effects. The dosage is usually individualized based on the patient's response to treatment and kidney function. It is important to follow your doctor's instructions carefully and to monitor your blood sugar levels regularly while taking ZITA DM 20/500MG TABLET. Common side effects may include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, more serious side effects such as lactic acidosis can occur, particularly in individuals with kidney problems.
  • ZITA DM 20/500MG TABLET should be used as part of a comprehensive diabetes management plan that includes diet, exercise, and regular medical check-ups. It is not a substitute for a healthy lifestyle. Consult your doctor or healthcare provider for personalized advice and to determine if ZITA DM 20/500MG TABLET is right for you.

Uses of ZITA DM 20/500MG TABLET 15'S

  • Treatment of Type 2 Diabetes Mellitus
  • Lowering blood sugar levels
  • Control of high blood sugar
  • Improving insulin sensitivity
  • Reducing post-meal blood sugar levels
  • Reducing glycated hemoglobin (HbA1c) levels
  • Management of complications associated with Type 2 diabetes

How ZITA DM 20/500MG TABLET 15'S Works

  • ZITA DM 20/500MG TABLET 15'S is a combination medicine designed to manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients: Sitagliptin and Metformin. Each component works through different mechanisms to achieve optimal glycemic control.
  • Sitagliptin belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). DPP-4 is an enzyme that inactivates incretin hormones. Incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), are released by the intestine throughout the day and in response to meals. These hormones increase insulin release from the pancreas and decrease glucagon secretion from the pancreas. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones in the body. This results in: 1) Increased Insulin Release: When blood sugar is high, incretin hormones stimulate the pancreas to release more insulin, helping to lower blood glucose levels. 2) Decreased Glucagon Secretion: Incretin hormones also reduce the secretion of glucagon, a hormone that raises blood sugar levels. By decreasing glucagon, Sitagliptin helps prevent the liver from producing excess glucose.
  • Metformin, on the other hand, is a biguanide. It works primarily by: 1) Reducing Hepatic Glucose Production: Metformin decreases the amount of glucose produced by the liver. This is a major source of elevated blood sugar in people with type 2 diabetes. 2) Improving Insulin Sensitivity: Metformin enhances the sensitivity of body tissues to insulin. This means that cells are better able to take up and use glucose from the bloodstream. 3) Slowing Glucose Absorption: To a lesser extent, Metformin can also slow down the absorption of glucose from the intestines after a meal.
  • The combination of Sitagliptin and Metformin in ZITA DM 20/500MG TABLET 15'S provides a dual approach to managing blood sugar. Sitagliptin enhances the body's own ability to regulate blood sugar by increasing incretin hormone activity, while Metformin reduces glucose production by the liver and improves insulin sensitivity. Together, they help to lower both fasting and postprandial (after-meal) blood sugar levels. This synergistic effect makes ZITA DM 20/500MG TABLET 15'S an effective option for many individuals with type 2 diabetes, especially when diet and exercise alone are not sufficient to achieve adequate glycemic control. It is important to use this medication as directed by a healthcare professional, in conjunction with a healthy lifestyle, for optimal results. Always consult your doctor or pharmacist if you have any questions.
  • In summary, ZITA DM 20/500MG TABLET 15'S works by: Increasing insulin release when blood sugar is high, Decreasing glucagon secretion, Reducing glucose production by the liver and Improving the body's sensitivity to insulin, ultimately lowering blood sugar levels in individuals with type 2 diabetes.

Side Effects of ZITA DM 20/500MG TABLET 15'SArrow

The following side effects may occur while using ZITA DM 20/500MG TABLET 15'S. This is not an exhaustive list, and it is important to consult with your doctor if you experience any unusual or concerning symptoms. **Common Side Effects:** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Metallic taste * Headache * Hypoglycemia (low blood sugar), especially when used with other diabetes medications * Upper respiratory tract infection **Uncommon Side Effects:** * Skin rash or itching * Constipation * Dizziness * Fatigue * Edema (swelling) of the legs and ankles * Joint pain * Muscle pain * Pancreatitis (inflammation of the pancreas) * Vitamin B12 deficiency * Lactic acidosis (rare but serious complication with metformin) **Rare Side Effects:** * Severe allergic reactions (anaphylaxis) * Liver problems * Kidney problems * Blood disorders **Important Considerations:** * This is not a complete list of side effects. * If you experience any severe or persistent side effects, stop taking ZITA DM 20/500MG TABLET 15'S and consult your doctor immediately. * Inform your doctor about all other medications you are taking, as they may interact with ZITA DM 20/500MG TABLET 15'S. * Regular monitoring of blood sugar levels, kidney function, and liver function is recommended while taking this medication.

Safety Advice for ZITA DM 20/500MG TABLET 15'SArrow

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Dosage of ZITA DM 20/500MG TABLET 15'SArrow

  • The recommended dosage of 'ZITA DM 20/500MG TABLET 15'S' varies significantly depending on individual patient factors, including the severity of diabetes, kidney function, other medications being taken, and individual response to treatment. Your doctor will determine the most appropriate dosage for you.
  • Typically, 'ZITA DM 20/500MG TABLET 15'S' is administered once or twice daily, usually with meals. This helps to reduce the likelihood of gastrointestinal side effects and ensures optimal absorption of the medication. It is crucial to take the medication at the same time(s) each day to maintain consistent blood glucose levels.
  • It is essential to adhere strictly to the dosage prescribed by your physician. Do not increase or decrease the dosage without consulting your doctor. Altering the dosage on your own can lead to either uncontrolled blood sugar levels or an increased risk of side effects.
  • If you miss a dose of 'ZITA DM 20/500MG TABLET 15'S', take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
  • Regular monitoring of blood glucose levels is important while taking 'ZITA DM 20/500MG TABLET 15'S'. Your doctor may also recommend periodic kidney function tests and other blood tests to assess your response to the medication and monitor for any potential side effects. Take 'ZITA DM 20/500MG TABLET 15'S' only as per the prescription by your physician only.

What if I miss my dose of ZITA DM 20/500MG TABLET 15'S?Arrow

  • If you miss a dose of ZITA DM 20/500MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to catch up.

How to store ZITA DM 20/500MG TABLET 15'S?Arrow

  • Keep ZITA DM 20/500MG TAB 1X15 away from the reach of children and pets.
  • Store ZITA DM 20/500MG TAB 1X15 at room temperature.

Benefits of ZITA DM 20/500MG TABLET 15'SArrow

  • ZITA DM 20/500MG TABLET 15'S is a combination medication specifically formulated to manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients, a dipeptidyl peptidase-4 (DPP-4) inhibitor (Sitagliptin) and a biguanide (Metformin), working synergistically to achieve optimal glycemic control. One of the primary benefits of ZITA DM is its dual-action mechanism. Sitagliptin enhances the incretin system, increasing insulin release after meals and decreasing glucagon secretion, which lowers blood sugar levels. Metformin, on the other hand, reduces glucose production in the liver and improves insulin sensitivity in peripheral tissues. This combination effectively addresses multiple facets of type 2 diabetes.
  • Improved Glycemic Control: By targeting different pathways involved in blood sugar regulation, ZITA DM provides superior glycemic control compared to monotherapy with either Sitagliptin or Metformin alone. This helps in maintaining stable blood sugar levels throughout the day, reducing the risk of hyperglycemic spikes and related complications.
  • Reduced Risk of Hypoglycemia: Compared to some other diabetes medications like sulfonylureas, ZITA DM has a lower risk of causing hypoglycemia (low blood sugar). Sitagliptin's action is glucose-dependent, meaning it primarily works when blood sugar levels are elevated. Metformin, by itself, rarely causes hypoglycemia.
  • Weight Management: Metformin, a component of ZITA DM, is often associated with modest weight loss or weight neutrality. This can be particularly beneficial for individuals with type 2 diabetes who are also struggling with overweight or obesity, as weight management plays a crucial role in diabetes management.
  • Cardiovascular Benefits: Studies have suggested that both Sitagliptin and Metformin may have potential cardiovascular benefits. Metformin has been shown to reduce the risk of cardiovascular events in some patient populations, while Sitagliptin has demonstrated cardiovascular safety in clinical trials. However, more research is ongoing to fully elucidate these effects.
  • Convenient Dosage: ZITA DM is available as a fixed-dose combination tablet, which simplifies the treatment regimen for patients. This can improve adherence to medication, as patients only need to take one tablet instead of multiple medications.
  • Improved Insulin Sensitivity: Metformin, one of the key ingredients, enhances the body's response to insulin. This is vital, as insulin resistance is a hallmark of type 2 diabetes. By improving insulin sensitivity, ZITA DM helps the body use insulin more effectively to lower blood sugar levels.
  • Reduced Hepatic Glucose Production: Metformin's action in the liver to reduce glucose production further aids in lowering overall blood sugar levels. This is especially beneficial for individuals whose livers are overproducing glucose, contributing to hyperglycemia.
  • Complementary Action: The combination of Sitagliptin and Metformin works in a complementary manner, addressing different aspects of glucose metabolism. This synergistic effect provides a more comprehensive approach to managing type 2 diabetes.
  • Reduced Risk of Diabetic Complications: By maintaining stable blood sugar levels, ZITA DM helps reduce the risk of long-term complications associated with diabetes, such as nerve damage (neuropathy), kidney damage (nephropathy), eye damage (retinopathy), and cardiovascular disease.

How to use ZITA DM 20/500MG TABLET 15'SArrow

  • ZITA DM 20/500MG TABLET 15'S is an oral medication and should be taken exactly as prescribed by your doctor. Adhere strictly to the dosage and duration of treatment recommended by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your doctor, even if you feel better. This medicine is usually taken once or twice daily, preferably with meals, to minimize the risk of stomach upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
  • Consistency is key for optimal results. Try to take ZITA DM 20/500MG TABLET 15'S at the same time(s) each day to help you remember. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one.
  • Before starting ZITA DM 20/500MG TABLET 15'S, inform your doctor about all other medications you are taking, including prescription drugs, over-the-counter medicines, and herbal supplements, as well as any existing medical conditions, particularly kidney or liver problems. It's also important to discuss your diet and exercise habits with your doctor, as these factors can significantly impact your blood sugar levels and the effectiveness of the medication. Regular monitoring of your blood sugar levels is crucial while taking this medication. Follow your doctor’s instructions regarding blood sugar monitoring and report any unusual or concerning symptoms to your healthcare provider promptly. Store ZITA DM 20/500MG TABLET 15'S at room temperature, away from moisture and heat, and out of reach of children.

Quick Tips for ZITA DM 20/500MG TABLET 15'SArrow

  • **Take Consistently for Best Results:** Adhere to your doctor's prescribed dosage and timing for ZITA DM 20/500mg Tablet. Consistent intake helps maintain stable blood sugar levels throughout the day, maximizing the medication's effectiveness in managing your diabetes.
  • **Monitor Blood Sugar Regularly:** While taking ZITA DM, it’s essential to monitor your blood sugar levels regularly, as directed by your healthcare provider. This helps you and your doctor understand how well the medication is working and if any adjustments to the dosage or treatment plan are needed. Keep a record of your readings to share with your doctor during check-ups.
  • **Be Aware of Hypoglycemia Symptoms:** ZITA DM can sometimes cause hypoglycemia (low blood sugar). Be familiar with the symptoms, which include shakiness, sweating, anxiety, blurred vision, rapid heartbeat, and confusion. If you experience these symptoms, consume a fast-acting source of sugar, such as glucose tablets, fruit juice, or hard candy, and inform your doctor.
  • **Inform Your Doctor About Other Medications:** Before starting ZITA DM, inform your doctor about all other medications, supplements, and herbal products you are taking. Some medications can interact with ZITA DM, affecting its efficacy or increasing the risk of side effects. This includes over-the-counter drugs, as well as prescription medications for other conditions.
  • **Follow Dietary and Exercise Recommendations:** ZITA DM works best when combined with a healthy diet and regular exercise. Follow the dietary guidelines provided by your doctor or a registered dietitian, focusing on balanced meals with controlled carbohydrate intake. Engage in regular physical activity, such as brisk walking or cycling, to improve insulin sensitivity and overall health.

Food Interactions with ZITA DM 20/500MG TABLET 15'SArrow

  • ZITA DM 20/500MG TABLET 15'S can be taken with or without food. However, it is advisable to take it at a fixed time to ensure consistent blood sugar control. If you experience stomach upset, taking it with food may help.

FAQs

What is ZITA DM 20/500MG TABLET 15'S?Arrow

ZITA DM 20/500MG TABLET 15'S is a combination of two medicines: Sitagliptin and Metformin. It is used to control high blood sugar levels in people with type 2 diabetes mellitus.

How to use ZITA DM 20/500MG TABLET 15'S?Arrow

Take ZITA DM 20/500MG TABLET 15'S with or after food. Take it in the dose and duration prescribed by your doctor.

What are the common side effects of ZITA DM 20/500MG TABLET 15'S?Arrow

Common side effects of ZITA DM 20/500MG TABLET 15'S include nausea, vomiting, diarrhea, stomach pain, and loss of appetite.

Is ZITA DM 20/500MG TABLET 15'S safe for people with kidney disease?Arrow

People with kidney disease should use ZITA DM 20/500MG TABLET 15'S with caution. Dosage adjustments may be necessary. Consult your doctor.

Is ZITA DM 20/500MG TABLET 15'S safe during pregnancy?Arrow

The safety of ZITA DM 20/500MG TABLET 15'S during pregnancy is not established. It should be used only when clearly needed and under the supervision of a doctor.

How to store ZITA DM 20/500MG TABLET 15'S?Arrow

Store ZITA DM 20/500MG TABLET 15'S at room temperature, away from direct sunlight and moisture. Keep out of reach of children and pets.

What happens if I miss a dose of ZITA DM 20/500MG TABLET 15'S?Arrow

If you miss a dose of ZITA DM 20/500MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Does ZITA DM 20/500MG TABLET 15'S cause weight gain?Arrow

ZITA DM 20/500MG TABLET 15'S does not typically cause weight gain. However, it may increase appetite in some individuals, leading to indirect weight gain.

Can ZITA DM 20/500MG TABLET 15'S be taken with alcohol?Arrow

Avoid taking ZITA DM 20/500MG TABLET 15'S with alcohol, as it can cause very low blood sugar levels and other side effects.

What are other brands of Sitagliptin and Metformin?Arrow

Other brands of Sitagliptin and Metformin include Janumet, Velmet, and Metglip.

Can ZITA DM 20/500MG TABLET 15'S be taken on an empty stomach?Arrow

It is not recommended to take ZITA DM 20/500MG TABLET 15'S on an empty stomach, as it can cause stomach upset. It is best to take it with or after food.

Who should not take ZITA DM 20/500MG TABLET 15'S?Arrow

ZITA DM 20/500MG TABLET 15'S should not be taken by people who are allergic to sitagliptin or metformin, have severe kidney disease, or have uncontrolled diabetes.

How does ZITA DM 20/500MG TABLET 15'S work?Arrow

ZITA DM 20/500MG TABLET 15'S works in two ways: sitagliptin lowers blood sugar by increasing insulin production, and metformin works by decreasing glucose production by the liver and increasing the body's sensitivity to insulin.

What are the symptoms of an overdose of ZITA DM 20/500MG TABLET 15'S?Arrow

Symptoms of an overdose of ZITA DM 20/500MG TABLET 15'S may include nausea, vomiting, abdominal pain, diarrhea, and in severe cases, lactic acidosis.

Can ZITA DM 20/500MG TABLET 15'S interact with other medications?Arrow

ZITA DM 20/500MG TABLET 15'S can interact with certain other medications, such as insulin, sulfonylureas, and some antibiotics. Tell your doctor about all the medications you are taking.

References

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FDA application for sitagliptin/metformin combination product (likely relevant to Zita DM given ingredients)

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DrugBank entry for Sitagliptin, detailing pharmacology, interactions, and chemical properties.

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DrugBank entry for Metformin, detailing pharmacology, interactions, and chemical properties.

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Efficacy and safety of sitagliptin and metformin as initial combination therapy in patients with type 2 diabetes mellitus: A systematic review and meta-analysis

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European Medicines Agency assessment report for a sitagliptin/metformin combination product (Janumet). Contains detailed scientific information.

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ScienceDirect page about Sitagliptin

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