ZITA PIO 20/15MG TABLET 10'S
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ZITA PIO 20/15MG TABLET 10'S

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ZITA PIO 20/15MG TABLET 10'S

By GLENMARK PHARMACEUTICALS LIMITED

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Content Reviewed By:

Dr. Rajesh Sharma

, (MBBS)

Written By:

Ms. Priyanka Shah

, (B.Pharm)

About ZITA PIO 20/15MG TABLET 10'S

  • ZITA PIO 20/15MG TABLET is a powerful and effective medication specifically designed for the comprehensive management of Type 2 Diabetes Mellitus in adults. This advanced combination therapy brings together two potent active ingredients, Sitagliptin and Pioglitazone, to offer a multi-faceted approach to blood sugar control. Developed to help millions manage their condition, ZITA PIO 20/15MG assists in achieving optimal glycemic control, which is crucial for preventing the long-term complications associated with diabetes. This medication is a vital tool for patients whose blood sugar levels are not adequately controlled by diet and exercise alone, or by single-agent therapy.
  • At the heart of ZITA PIO 20/15MG TABLET are its two key components: Sitagliptin (20mg) and Pioglitazone (15mg). Sitagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, works by increasing the body's natural incretin hormones. These incretins play a crucial role in regulating glucose homeostasis by enhancing insulin release from the pancreas when blood sugar levels are high and by decreasing the production of glucose by the liver. On the other hand, Pioglitazone, belonging to the thiazolidinedione (TZD) class, addresses insulin resistance, a common underlying issue in Type 2 Diabetes. It achieves this by making the body's cells, particularly in muscle, fat, and liver, more sensitive to insulin, thereby allowing more glucose to be taken up from the bloodstream and utilized for energy.
  • The synergistic action of Sitagliptin and Pioglitazone in ZITA PIO 20/15MG provides superior glycemic control compared to individual therapies. By targeting both impaired insulin secretion and insulin resistance, this tablet helps maintain stable blood sugar levels throughout the day. Regular use, as prescribed by a healthcare professional, alongside a balanced diet and regular exercise, can significantly improve your quality of life and reduce the risk of serious diabetes-related health issues such as kidney disease, nerve damage, and cardiovascular complications. ZITA PIO 20/15MG TABLET is an easy-to-take option, designed to support you in your journey towards better health and effective diabetes management. Always consult your doctor for personalized advice and dosage instructions.

Uses of ZITA PIO 20/15MG TABLET 10'S

  • Type 2 Diabetes management
  • High blood sugar control
  • Improved blood sugar levels
  • Glycemic control in adults
  • Used with diet and exercise for diabetes

How ZITA PIO 20/15MG TABLET 10'S Works

  • Unlock better blood sugar control with ZITA PIO 20/15MG TABLET, a powerful combination medicine designed to help individuals with Type 2 Diabetes manage their condition effectively. This advanced formulation brings together two distinct yet complementary active ingredients: Sitagliptin and Pioglitazone, each playing a crucial role in lowering elevated blood glucose levels.
  • Let's delve into how ZITA PIO works its magic. The 'Zita' in ZITA PIO refers to Sitagliptin, an innovative medication belonging to a class known as Dipeptidyl Peptidase-4 (DPP-4) inhibitors. Sitagliptin works by targeting specific natural hormones in your body called incretins – Glucagon-Like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP). These incretin hormones are released from your gut throughout the day, and their levels increase after a meal. Their primary job is to signal your pancreas to release more insulin when blood sugar levels are high and to reduce the amount of glucose produced by your liver.
  • However, these incretins are quickly broken down by the DPP-4 enzyme. Sitagliptin stops this enzyme from working, thereby increasing and prolonging the activity of incretin hormones. This leads to a more effective, glucose-dependent insulin release and a decrease in glucagon, ultimately helping to lower blood sugar without causing low blood sugar (hypoglycemia) when levels are already normal.
  • Then comes the 'Pio' – Pioglitazone, a highly effective medication from the thiazolidinedione (TZD) class. Pioglitazone addresses a fundamental problem in Type 2 Diabetes: insulin resistance. Insulin resistance means your body's cells (in muscles, fat, and liver) don't respond properly to insulin, making it harder for glucose to enter them from the bloodstream. Pioglitazone works by activating specific receptors within your cells called Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma).
  • When activated, these PPAR-gamma receptors improve the sensitivity of your cells to insulin. This allows more glucose to be absorbed from the blood into the cells, where it can be used for energy or stored. By tackling insulin resistance directly, Pioglitazone helps your body make better use of the insulin it produces, leading to lower blood glucose levels and improved long-term glycemic control.
  • Together, Sitagliptin and Pioglitazone in ZITA PIO offer a comprehensive approach to managing Type 2 Diabetes. While Sitagliptin enhances insulin secretion and reduces glucose production in a glucose-dependent manner, Pioglitazone tackles the root cause of insulin resistance. This dual action means that ZITA PIO not only helps your pancreas work more efficiently but also ensures your body's cells are more responsive to the insulin available. The result is a more stable and controlled blood sugar profile, reducing the risk of complications associated with diabetes and helping you lead a healthier life. This synergistic combination provides a robust solution for achieving and maintaining optimal blood glucose levels, making ZITA PIO 20/15MG TABLET a vital tool in your diabetes management plan.

Side Effects of ZITA PIO 20/15MG TABLET 10'SArrow

Like all medicines, ZITA PIO 20/15MG TABLET can cause side effects, though not everybody gets them. It's important to be aware of both common and less common but serious side effects. **Common Side Effects (may affect up to 1 in 10 people):** * **Hypoglycemia (low blood sugar):** Especially if taken with other diabetes medicines. Symptoms include dizziness, sweating, shaking, confusion, hunger. * **Fluid Retention/Edema:** Swelling, particularly in the ankles or feet, leading to weight gain. * **Weight Gain:** Due to fluid retention or other factors. * **Headache:** Mild to moderate. * **Upper Respiratory Tract Infections:** Such as the common cold, stuffy or runny nose, sore throat. * **Nausea/Vomiting:** Feeling sick to your stomach. * **Diarrhea:** Loose stools. * **Muscle Pain (Myalgia):** Aches or discomfort in muscles. **Less Common or Serious Side Effects (seek medical attention immediately if you experience these):** * **Heart Failure:** Symptoms include unusual tiredness, shortness of breath, sudden weight gain, and swelling in your legs or feet. This risk is higher if you already have heart problems. * **Bone Fractures:** Increased risk of fractures, especially in women, affecting arms, hands, feet, or spine. * **Vision Changes (Macular Edema):** Blurred vision or other changes in your eyesight. * **Pancreatitis:** Severe and persistent stomach pain that may radiate to your back, with or without vomiting. This is a serious condition. * **Severe Allergic Reactions:** Rash, hives, swelling of your face, lips, tongue, or throat that may cause difficulty breathing or swallowing. * **Liver Problems:** Symptoms like yellowing of your skin or the whites of your eyes (jaundice), dark urine, persistent nausea, vomiting, or stomach pain. Regular liver function tests may be required. * **Bladder Cancer:** While rare, there's a potential increased risk, especially with long-term use. Report any blood in your urine, painful urination, or new/worsening urge to urinate immediately.

Safety Advice for ZITA PIO 20/15MG TABLET 10'SArrow

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Allergies

Unsafe

Do not take this medication if you are allergic to Sitagliptin, Pioglitazone, or any other ingredients.

Dosage of ZITA PIO 20/15MG TABLET 10'SArrow

  • Take 'ZITA PIO 20/15MG TABLET 10'S' only as per the prescription by your physician only.
  • ZITA PIO 20/15MG TABLET is a powerful combination medication designed to manage blood sugar levels in adults with type 2 diabetes mellitus. It combines Sitagliptin, a DPP-4 inhibitor, and Pioglitazone, a thiazolidinedione, working together to improve glycemic control. The recommended dosage for ZITA PIO 20/15MG TABLET is highly individualized, meaning it will be precisely determined by your healthcare provider based on several critical factors.
  • Your physician will consider your current blood sugar levels, your overall health condition, kidney and liver function, and any other medications you might be taking. This comprehensive assessment ensures that the dosage prescribed is both effective and safe for you. Typically, ZITA PIO 20/15MG TABLET is prescribed to be taken once daily. It can be consumed with or without food, but maintaining a consistent time each day is crucial for optimal efficacy and to establish a routine. This helps ensure a steady level of the medication in your body, contributing to better blood sugar management throughout the day.
  • It is paramount to strictly follow your doctor's instructions regarding the frequency and duration of your ZITA PIO 20/15MG TABLET dosage. Do not alter your dosage, stop taking the medication, or increase/decrease the number of tablets without consulting your physician. Abruptly stopping this medication can lead to a dangerous increase in blood sugar levels, potentially resulting in serious health complications. If you happen to miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Never double the dose to compensate for a missed one.
  • Regular monitoring of your blood sugar levels is an integral part of your treatment plan with ZITA PIO 20/15MG TABLET. Your doctor may also recommend periodic blood tests to assess your kidney and liver function, ensuring the medication is well-tolerated. Remember, ZITA PIO 20/15MG TABLET is most effective when combined with a balanced diet and a regular exercise regimen. These lifestyle modifications play a significant role in managing type 2 diabetes and enhancing the benefits of your medication. Always discuss any concerns or side effects with your healthcare provider to ensure your treatment plan remains appropriate for your evolving health needs. Your doctor is your primary resource for managing your diabetes effectively and safely.

What if I miss my dose of ZITA PIO 20/15MG TABLET 10'S?Arrow

  • If you miss a dose of ZITA PIO 20/15MG TABLET, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Consult your doctor or pharmacist if you have any concerns.

How to store ZITA PIO 20/15MG TABLET 10'S?Arrow

  • Keep ZITA PIO 20/15MG TAB 1X10 away from the reach of children and pets.
  • Store ZITA PIO 20/15MG TAB 1X10 at room temperature.

Benefits of ZITA PIO 20/15MG TABLET 10'SArrow

  • ZITA PIO 20/15MG TABLET 10'S offers a powerful and convenient solution for individuals living with Type 2 Diabetes. This innovative medication combines two highly effective active ingredients – Sitagliptin and Pioglitazone – to provide a multi-pronged approach to blood sugar management. For those seeking enhanced control over their glucose levels, ZITA PIO stands out by addressing key underlying issues of Type 2 diabetes, making it easier to achieve and maintain healthy blood sugar targets. Its unique formulation is designed to simplify daily diabetes care, reducing the pill burden and promoting better adherence to treatment, ultimately leading to improved patient outcomes and a better quality of life.
  • One of the core benefits of ZITA PIO lies in the action of Sitagliptin. As a DPP-4 inhibitor, Sitagliptin works by increasing the levels of natural substances in the body called incretins. These incretins play a crucial role in regulating blood sugar by stimulating the pancreas to produce more insulin when blood sugar levels are high, especially after meals. Simultaneously, Sitagliptin helps to reduce the amount of sugar produced by the liver, preventing excess glucose from entering the bloodstream. This targeted action ensures that your body responds more effectively to the food you eat, helping to keep post-meal blood sugar spikes under control and contributing to more stable glucose levels throughout the day.
  • Complementing Sitagliptin's action is Pioglitazone, a highly effective Thiazolidinedione (TZD). Pioglitazone directly addresses one of the fundamental problems in Type 2 diabetes: insulin resistance. It works by making the body's cells – particularly in muscle and fat tissues – more sensitive to the insulin that your pancreas produces. When cells are more sensitive to insulin, they can absorb glucose from the blood more efficiently, using it for energy or storing it. Furthermore, Pioglitazone also helps to decrease the liver's production of glucose, adding another layer of control. By tackling insulin resistance, Pioglitazone not only helps lower blood sugar but also works on a deeper physiological level to improve overall metabolic health.
  • The synergy between Sitagliptin and Pioglitazone in ZITA PIO is what truly sets it apart. While Sitagliptin enhances insulin secretion and reduces hepatic glucose output, Pioglitazone improves insulin sensitivity and also reduces liver glucose production. This dual mechanism means ZITA PIO provides comprehensive control by targeting both the production and utilization of glucose in the body. This leads to a significant reduction in HbA1c levels, a key indicator of long-term blood sugar control, and helps patients achieve their individualized glycemic goals more effectively. The combined power helps in managing blood sugar fluctuations more robustly than single-agent therapies might.
  • Beyond just numbers, effective blood sugar management with ZITA PIO translates into significant long-term health benefits. By consistently keeping blood glucose within a healthy range, patients can substantially reduce their risk of developing or worsening serious diabetes-related complications. This includes debilitating conditions like nerve damage (neuropathy), kidney disease (nephropathy), vision impairment (retinopathy), and cardiovascular events such as heart attacks and strokes. Controlling diabetes effectively empowers individuals to lead fuller, more active lives, enjoying better overall well-being and a greater sense of confidence in managing their condition.
  • Choosing ZITA PIO 20/15MG TABLET 10'S means opting for an advanced, patient-friendly approach to Type 2 diabetes care. It's particularly beneficial for patients who have not achieved adequate glycemic control with other medications or who have significant insulin resistance. The convenience of a single tablet that combines these two powerful agents simplifies the treatment regimen, making it easier for patients to adhere to their prescribed medication schedule. This commitment to ease of use, coupled with its robust efficacy, positions ZITA PIO as an excellent choice for healthcare providers and patients alike in the ongoing battle against Type 2 diabetes, helping to pave the way for a healthier future.

How to use ZITA PIO 20/15MG TABLET 10'SArrow

  • ZITA PIO 20/15MG TABLET is a prescribed medication specifically designed for the effective management of Type 2 Diabetes Mellitus. It combines two powerful agents, Sitagliptin and Pioglitazone, to help lower blood sugar levels when diet and exercise alone aren't enough. It is crucial to take this medicine exactly as directed by your healthcare provider. Your doctor will determine the appropriate dosage and duration of treatment based on your individual condition, response to therapy, and other medications you may be taking. Do not adjust your dose or stop taking the medication without consulting your doctor, as this could lead to uncontrolled blood sugar levels and potential health complications.
  • For optimal results, ZITA PIO 20/15MG TABLET should be swallowed whole with a glass of water, usually once daily. You can take it either with or without food, but try to take it at the same time each day to help you remember and maintain consistent levels of the medication in your body. Consistency is key for effective blood sugar control. Remember, this tablet is meant to be swallowed whole; do not chew, crush, or break it, as this may alter its efficacy. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Never double your dose to make up for a missed one.
  • Beyond just taking your medication, incorporating lifestyle changes such as a balanced diet, regular physical activity, and maintaining a healthy weight are vital components of your diabetes management plan and significantly enhance the effectiveness of ZITA PIO 20/15MG TABLET. Regular monitoring of your blood sugar levels, as advised by your doctor, is essential to track your progress and ensure the medication is working effectively. Your doctor may also conduct periodic tests to monitor your liver function, kidney health, and heart condition. Store ZITA PIO 20/15MG TABLET at room temperature, away from direct light and moisture, and always keep it out of reach of children and pets. Always consult your healthcare professional for any concerns or questions regarding your medication.

Quick Tips for ZITA PIO 20/15MG TABLET 10'SArrow

  • For optimal control of your Type 2 Diabetes, it is crucial to take ZITA PIO 20/15MG TABLET exactly as prescribed by your doctor. This usually means taking it at the same time each day, with or without food, to maintain steady levels of the medication in your system. Do not skip doses, even if you feel well, as consistent intake is vital for effective blood sugar management. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose, in which case skip the missed one. Never double your dose. Adherence ensures the combined action of Sitagliptin and Pioglitazone works synergistically to improve insulin sensitivity and regulate glucose production.
  • ZITA PIO 20/15MG TABLET is most effective when paired with a balanced diet and regular physical activity. Focus on consuming whole grains, lean proteins, and plenty of fruits and vegetables, while limiting processed foods, sugary drinks, and unhealthy fats. Regular exercise, even a brisk 30-minute walk most days of the week, can significantly enhance the medication's ability to lower blood sugar and improve your overall health. These lifestyle changes not only support the medication's efficacy but also contribute to weight management and reduce the risk of diabetes-related complications.
  • Regular monitoring of your blood glucose levels is essential to understand how well ZITA PIO 20/15MG TABLET is working for you and to identify any potential fluctuations. Your doctor will advise you on how often and when to check your sugar levels. Keep a detailed record of your readings to share with your healthcare provider during your appointments. This information helps your doctor adjust your treatment plan if necessary, ensuring your blood sugar remains within a healthy target range and preventing both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar), especially if you are on other diabetes medications.
  • Like all medications, ZITA PIO 20/15MG TABLET may cause side effects. Common ones can include mild stomach upset, headache, or respiratory infections. More importantly, Pioglitazone, one of its components, can lead to fluid retention, which might manifest as swelling in the ankles or feet, and in rare cases, worsen heart failure. Be vigilant for symptoms like unusual weight gain, shortness of breath, or sudden swelling, and report them to your doctor immediately. Also, discuss any concerns about bone fractures or liver problems. Never hesitate to discuss any new or worsening symptoms with your healthcare provider.
  • Maintain adequate hydration by drinking plenty of water throughout the day, unless advised otherwise by your doctor, especially since Pioglitazone can sometimes influence fluid balance. It's vital to inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential drug interactions. Do not stop taking ZITA PIO 20/15MG TABLET abruptly without consulting your doctor, as this could lead to a sudden increase in blood sugar levels. Regular follow-ups with your healthcare team are crucial for ongoing diabetes management and to ensure the medication remains safe and effective for you.

FAQs

What is ZITA PIO 20/15MG Tablet used for?Arrow

ZITA PIO 20/15MG Tablet is used to treat Type 2 Diabetes Mellitus in adults. It helps to control high blood sugar levels when diet and exercise alone are not enough.

What are the active ingredients in ZITA PIO 20/15MG Tablet?Arrow

The active ingredients are Sitagliptin (20mg) and Pioglitazone (15mg). Sitagliptin belongs to the DPP-4 inhibitor class, and Pioglitazone is a thiazolidinedione (TZD).

How does ZITA PIO work to control blood sugar?Arrow

Sitagliptin works by increasing the levels of natural substances called incretins, which help control blood sugar by increasing insulin release and decreasing sugar production by the liver. Pioglitazone works by increasing the body's sensitivity to insulin, allowing cells to absorb more sugar from the blood.

What is the recommended dosage of ZITA PIO 20/15MG Tablet?Arrow

The dosage is typically once daily, as prescribed by your doctor. It's crucial to follow your doctor's instructions precisely.

Can I take ZITA PIO with or without food?Arrow

ZITA PIO can be taken with or without food. However, taking it at the same time each day is recommended for better consistency.

What are the common side effects of ZITA PIO?Arrow

Common side effects may include upper respiratory tract infection, headache, nausea, diarrhea, and mild swelling (edema). Consult your doctor if these persist or worsen.

Are there any serious side effects associated with ZITA PIO?Arrow

Serious side effects can include heart failure (especially with Pioglitazone), bone fractures, liver problems, bladder cancer (rare, long-term use of Pioglitazone), and severe allergic reactions. Seek immediate medical attention if you experience severe symptoms.

Does ZITA PIO cause weight gain?Arrow

Yes, Pioglitazone, one of the components of ZITA PIO, can sometimes cause weight gain, primarily due to fluid retention.

Who should not take ZITA PIO 20/15MG Tablet?Arrow

It should not be taken by patients with Type 1 Diabetes, diabetic ketoacidosis, severe heart failure, active bladder cancer, severe liver disease, or a history of allergic reactions to sitagliptin or pioglitazone.

Can ZITA PIO be used during pregnancy or breastfeeding?Arrow

ZITA PIO is generally not recommended during pregnancy or breastfeeding. Always consult your doctor before taking any medication if you are pregnant, planning to become pregnant, or breastfeeding.

What should I do if I miss a dose of ZITA PIO?Arrow

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

How should I store ZITA PIO 20/15MG Tablet?Arrow

Store ZITA PIO at room temperature, away from moisture and heat. Keep it out of reach of children and pets.

Can ZITA PIO interact with other medications?Arrow

Yes, it can interact with certain medications, including gemfibrozil (for high cholesterol), rifampin (antibiotic), and other diabetes medications. Always inform your doctor about all medicines, supplements, and herbal products you are taking.

Is ZITA PIO a cure for Type 2 Diabetes?Arrow

No, ZITA PIO helps manage Type 2 Diabetes by controlling blood sugar levels, but it is not a cure. It is an ongoing treatment, and lifestyle modifications (diet, exercise) are also crucial.

Are there other medicines with Sitagliptin and Pioglitazone as active ingredients?Arrow

Yes, several pharmaceutical companies manufacture medicines containing Sitagliptin and Pioglitazone in combination, often under different brand names. The specific strengths and availability may vary by region and manufacturer. Your doctor can guide you on suitable alternatives if needed.

Does ZITA PIO affect kidney or liver function?Arrow

ZITA PIO should be used with caution in patients with kidney impairment, and it is contraindicated in severe liver disease. Your doctor will assess your kidney and liver function before prescribing this medication and monitor it during treatment.

References

Book Icon

Sitagliptin: a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus

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Pioglitazone: a review of its therapeutic use in type 2 diabetes mellitus

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Dipeptidyl peptidase-4 (DPP-4) inhibitors: a new class of oral antidiabetic drugs

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Peroxisome proliferator-activated receptor-γ agonists in the treatment of type 2 diabetes mellitus: mechanisms of action and effects on cardiovascular risk

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ZITA PIO 20/15MG TABLET 10'S

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