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Introduction to generic medicines
A branded drug possesses 20 years of patent protection from the original maker. Only the firm in possession of a patent is permitted to manufacture and promote the drug during this time. They are also permitted to set the price to recoup their costs for the new drug’s development, production, and marketing.
When the patent on the drug expires, other pharmaceutical companies are free to begin manufacturing and distributing the generic equivalent. The drug’s generic equivalent must adhere to the same safety and quality requirements as per WHO-GMP, and must have the same active ingredient. Since other businesses can create generic versions and do not need to engage in R&D, generic medications are less expensive.
Are Generics Available for Cancer Treatment?
Cancer is a major problem in terms of public health all around the world. Cancer has a multiple disease profile and consists of a “cluster” of diseases with vastly different syndromes and progression. Millions of individuals are diagnosed with cancer every year throughout the globe.
The International Agency for Research on Cancer (IARC) forecasts that by 2040 there will be 29.5 million cases of cancer and 16.4 million deaths due to cancer globally , an increase of around 1.6–1.7 times over 2018 predictions.
Different countries have different laws regarding marketing exclusivity for medications, such as orphan drugs (for uncommon disorders), creating biosimilar medicines, etc. Drug patents have been directly challenged in India, with Imatinib being India’s most noteworthy example of generic drug medicine. Its branded version was named Glivec.
The following studies concluded that switching from brand-name to generic Imatinib was typically safe and did not compromise effectiveness.
A larger sample size with a longer follow-up period is needed to confirm these conclusions further.
Developing generics for cancer
The price of generating generics is another factor. One of the causes of the well-publicized shortages of cancer medications in recent years is that incentives to continue production can diminish when costs for some therapies are dropped to only a few cents per dose.
Small-molecule medications, such as tyrosine kinase inhibitors (TKIs) like imatinib and chemotherapy, such as cisplatin, differ from large-molecule “biologics,” like monoclonal antibodies. The latter is part of a developing industry for “biosimilars,” which have stricter regulatory requirements and cannot be reproduced similarly to small-molecule drugs.
Are Generics available for cancer?
A developing subcategory of medications, complicated non-biological pharmaceuticals (NBCDs), cannot be regulated like traditional generic medications. Doxil, a 1995-released nanotechnology-based doxorubicin formulation used in chemotherapy, is a suitable illustration in the context of Cancer.
Here, the medicine is contained in nano-sized liposomes, making it difficult to determine how well a generic version would compare in terms of particle size and behavior.
Top available generic medicine for cancer treatment
1) Cisplatin
The chemotherapy medication cisplatin is used to treat a variety of cancers, including blood cancer, cervix and uterine cancer, bladder cancer, ovarian Cancer, testicular Cancer, breast cancer, Cancer of the lip and oral cavity, and lung, oesophageal, stomach, and lip cancer. It is administered intravenously, alone or in conjunction with other drugs. This medicine inhibits the growth of cancer cells by altering their genetic makeup.
2) Docetaxel
Docetaxel is used to treat malignancies of the lungs, esophagus, uterus, cervix, oral cavity, stomach, ovary, prostate, head, and neck, among other cancers. It is administered intravenously and may be combined with anti-cancer medications. The cellular microtubules are suppressed by docetaxel. Tumor cell proliferation is slowed by the suppression of microtubule structures, which aid in the division and multiplication of tumor cells.
3) Carboplatin
Cancers of the breast, cervix, uterus, lungs, esophagus, ovaries, blood, lips and oral cavity can all be treated with carboplatin, a chemotherapy medication. Although often administered intravenously, this medicine can also be administered intraperitoneally (into the peritoneal cavity of the abdomen). Carboplatin creates reactive compounds that alter the structure of DNA (genetic material), prevent DNA synthesis, and halt the growth of tumor cells.
4) Cyclophosphamide
Breast cancer, blood cancer, ovarian cancer, eye cancer, and blood cancer are all treated with cyclophosphamide. Depending on the dosage and illness being treated, this medicine can be administered through various methods. It is typically administered intravenously or as tablets. Cyclophosphamide stops the growth of cancer cells by harming their RNA and DNA genetic makeup.
5) Paclitaxel
In addition to Kaposi’s sarcoma, paclitaxel is used to treat stomach, ovarian, oesophageal, lung, cervix-uterine, breast, and oral Cancer. Paclitaxel, like docetaxel, inhibits the cell’s microtubule structures to retard the growth of cancer cells. It may be taken along with other cancer medications and is administered as an injection or infusion into the vein.
6) Irinotecan
Colorectal cancer, uterine Cancer, cervix cancer, lung cancer, and stomach and esophageal Cancer are among the conditions for which irinotecan is prescribed. It can be given alone or along with other medications and is given intravenously. Irinotecan inhibits the enzyme topoisomerase, which prevents cancer cells from multiplying and spreading. Enzymes called topoisomerases regulate the modification of the DNA structure required for replication.
7) 5-Fluorouracil
This anti-cancer drug is used to treat a variety of cancers, including oesophageal, colorectal, stomach, oral, and breast cancers and many other common tumors. Depending on the disease and diagnosis, this drug may be administered as a topical ointment or as an injection into a vein. After being administered, the drug 5-fluorouracil creates a compound that obstructs the synthesis and operation of genetic material. This prevents the spread of cancer cells, which multiply quickly.
Conclusion
You can deal better and choose the best solutions if you understand the disease and the available treatments.
At Medkart, we offer generic cancer medicines that benefit patients with reduced costs. We recommend bringing in the prescription of your cancer drug to avail its generic version unless recommended by the doctor — “Not to Substitute”.
Our pharmacists will help you with generic drugs for cancer treatment that will be as effective as branded drugs. Once you are satisfied, order generic drugs for cancer online from medkart.inor download our applications — iOS and Android.
