GLUCRETA SM 10/100/1000MG TABLET 10'S

How GLUCRETA SM 10/100/1000MG TABLET 10'S Works

• GLUCRETA SM 10/100/1000MG TABLET 10'S is a combination medicine designed to manage type 2 diabetes effectively. It combines three active ingredients: Teneligliptin, Metformin, and Sulphonylurea (often Gliclazide or Glimepiride), each addressing different aspects of blood sugar control.
• Teneligliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 inhibitors work by increasing the amount of incretin hormones in the body. Incretins are released by the intestine throughout the day and in response to a meal. These hormones increase insulin release from the pancreas and decrease glucagon secretion from the alpha cells of the pancreas. By inhibiting the DPP-4 enzyme, teneligliptin prolongs the action of incretin hormones, leading to better glucose control. This mechanism is glucose-dependent, meaning it primarily works when blood sugar levels are high, reducing the risk of hypoglycemia.
• Metformin is a biguanide that works primarily by reducing glucose production in the liver. It decreases hepatic glucose output by suppressing gluconeogenesis (the process of creating glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Metformin also improves insulin sensitivity in peripheral tissues, such as muscle and fat, allowing cells to utilize glucose more effectively. Additionally, it slows down the absorption of glucose from the intestines, further contributing to lower post-meal blood sugar spikes. Metformin does not typically cause hypoglycemia when used alone but can increase the risk when combined with other antidiabetic medications.
• Sulphonylureas, such as Gliclazide or Glimepiride, stimulate the beta cells in the pancreas to release more insulin. They work by binding to specific receptors on the beta cells, leading to an influx of calcium ions, which triggers insulin secretion. This action is independent of glucose levels, meaning they can lower blood sugar even when it's already within a normal range. This characteristic makes them effective at reducing blood sugar but also carries a higher risk of hypoglycemia, especially if meals are skipped or delayed.
• In combination, these three medications provide a multi-pronged approach to managing blood sugar levels. Teneligliptin enhances the incretin effect, improving insulin release and reducing glucagon secretion in a glucose-dependent manner. Metformin reduces glucose production in the liver and enhances insulin sensitivity. The Sulphonylurea component increases insulin secretion from the pancreas. This combination helps to maintain better glycemic control throughout the day, reducing both fasting and post-meal blood sugar levels. It's crucial to take GLUCRETA SM 10/100/1000MG TABLET 10'S as directed by your healthcare provider, along with following a healthy diet and exercise plan, to maximize its effectiveness and minimize potential side effects.
• The synergistic action of these three components targets different pathways involved in glucose metabolism, providing comprehensive glycemic control for individuals with type 2 diabetes. Regular monitoring of blood glucose levels is essential to ensure the medication is working effectively and to adjust the dosage as needed, under the guidance of a healthcare professional.

Common side effects of GLUCRETA SM 10/100/1000MG TABLET may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, hypoglycemia (low blood sugar), headache, dizziness, and weakness. Less common but potentially serious side effects can include lactic acidosis (build-up of lactic acid in the body), allergic reactions (rash, itching, swelling), liver problems (jaundice, dark urine), and blood disorders (anemia, thrombocytopenia). Other reported side effects are constipation, flatulence, heartburn, and skin reactions. This is not an exhaustive list, and it's important to consult with your doctor or pharmacist if you experience any unusual or concerning symptoms while taking this medication.

• If you miss a dose of GLUCRETA SM 10/100/1000MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep GLUCRETA SM 10/100/1000MG TAB 1X10 away from the reach of children and pets.
• Store GLUCRETA SM 10/100/1000MG TAB 1X10 at room temperature.

• Take GLUCRETA SM 10/100/1000MG TABLET 10'S as prescribed by your doctor. Follow the dosage instructions carefully and do not exceed the recommended dose. Typically, it is taken orally with meals to minimize stomach upset and maximize absorption of the medicine. Consistency is key; take it at the same time each day for optimal results in managing blood sugar levels.
• Monitor your blood sugar levels regularly. GLUCRETA SM 10/100/1000MG TABLET 10'S helps control blood sugar, but regular monitoring is essential to ensure the medication is working effectively and to adjust the treatment plan as needed. Keep a log of your readings and share it with your doctor during appointments.
• Maintain a healthy diet. While taking GLUCRETA SM 10/100/1000MG TABLET 10'S, focus on a balanced diet that includes plenty of fruits, vegetables, whole grains, and lean protein. Limit your intake of sugary foods and drinks, as these can counteract the effects of the medication. Consult with a dietician or nutritionist for personalized dietary advice.
• Engage in regular physical activity. Exercise helps improve insulin sensitivity and lowers blood sugar levels. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Activities like brisk walking, swimming, or cycling can be beneficial. Always consult your doctor before starting a new exercise program.
• Be aware of potential side effects. Common side effects of GLUCRETA SM 10/100/1000MG TABLET 10'S may include nausea, diarrhea, or stomach upset. If you experience any severe or persistent side effects, such as signs of liver problems (e.g., jaundice, dark urine), severe abdominal pain, or symptoms of lactic acidosis (e.g., muscle cramps, rapid breathing), seek immediate medical attention. Also, be cautious of hypoglycemia (low blood sugar), which can occur if you skip meals or take too much medication; always carry a source of quick-acting sugar with you.

• GLUCRETA SM 10/100/1000MG TABLET 10'S should be taken orally as directed by your doctor. To minimize the risk of gastrointestinal side effects, it is best to take this medication with food. Avoid consuming large amounts of alcohol while taking this medicine, as it may increase the risk of lactic acidosis or hypoglycemia. Consult your doctor for personalized dietary advice.