DAPAVEL S 10/100MG TABLET 10'S
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DAPAVEL S 10/100MG TABLET 10'SDAPAVEL S 10/100MG TABLET 10'SDAPAVEL S 10/100MG TABLET 10'S
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DAPAVEL S 10/100MG TABLET 10'S

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DAPAVEL S 10/100MG TABLET 10'S

By INTAS PHARMACEUTICALS LIMITED

MRP

217.75

₹185.09

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Product DetailsArrow

About DAPAVEL S 10/100MG TABLET 10'S

  • DAPAVEL S 10/100MG TABLET is a combination medication designed to effectively manage blood sugar levels in adults with type 2 diabetes. It combines two powerful active ingredients: Dapagliflozin and Sitagliptin. Dapagliflozin belongs to a class of drugs known as sodium-glucose cotransporter 2 (SGLT2) inhibitors, while Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. This dual-action approach helps to control blood sugar through different mechanisms, providing comprehensive glycemic control.
  • Dapagliflozin works by preventing the kidneys from reabsorbing glucose back into the bloodstream. Instead, the excess glucose is eliminated from the body through urine. This process not only lowers blood sugar levels but can also contribute to modest weight loss and blood pressure reduction. Sitagliptin, on the other hand, enhances the levels of incretin hormones in the body. These hormones stimulate the release of insulin after a meal and reduce the secretion of glucagon, a hormone that raises blood sugar levels. By increasing insulin and decreasing glucagon, Sitagliptin helps to regulate blood sugar after food intake.
  • DAPAVEL S 10/100MG TABLET is typically taken once daily, as directed by your healthcare provider. It is important to take the medication at the same time each day to maintain consistent blood sugar control. This medication is most effective when used in conjunction with a healthy diet and regular exercise. It is not recommended for use in patients with type 1 diabetes or diabetic ketoacidosis. Common side effects may include urinary tract infections, genital infections, and changes in urination. It's essential to discuss any existing medical conditions and other medications you are taking with your doctor before starting DAPAVEL S 10/100MG TABLET to avoid potential interactions and ensure it is safe for you.
  • This medicine is a prescription drug, and it's important to consult with a healthcare professional before starting this medication. They can evaluate your specific health needs and determine if DAPAVEL S 10/100MG TABLET is the right choice for you. Self-medicating can be harmful to your health. The information provided here is for informational purposes only and does not constitute medical advice. Always follow the guidance of your physician or qualified healthcare provider.

Uses of DAPAVEL S 10/100MG TABLET 10'S

  • Treatment of type 2 diabetes mellitus
  • Lowering high blood sugar levels
  • Reducing cardiovascular risk (in patients with type 2 diabetes)
  • Slowing the progression of kidney disease (in patients with type 2 diabetes)
  • Management of heart failure (in certain patients)

How DAPAVEL S 10/100MG TABLET 10'S Works

  • DAPAVEL S 10/100MG TABLET 10'S is a combination medication designed to manage blood sugar levels in individuals with type 2 diabetes. It contains two active ingredients: Dapagliflozin and Sitagliptin. These components work through different mechanisms to achieve better glycemic control.
  • Dapagliflozin belongs to a class of drugs called Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitors. The kidneys filter glucose from the blood, and SGLT2 is responsible for reabsorbing glucose back into the bloodstream. Dapagliflozin inhibits SGLT2, reducing the reabsorption of glucose and increasing glucose excretion in the urine. This process lowers blood sugar levels and can also lead to modest weight loss and blood pressure reduction in some patients. By removing excess glucose through urine, Dapagliflozin helps to reduce the overall glucose burden on the body.
  • Sitagliptin, on the other hand, is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor. DPP-4 is an enzyme that breaks down incretin hormones. Incretins, such as GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-dependent Insulinotropic Polypeptide), are released by the gut in response to food intake. These hormones stimulate insulin release from the pancreas and decrease glucagon secretion from the alpha cells of the pancreas, both of which help lower blood sugar levels. Sitagliptin inhibits DPP-4, thereby increasing the levels of active incretin hormones in the body. This leads to increased insulin secretion and decreased glucagon secretion in a glucose-dependent manner, meaning these effects are more pronounced when blood sugar is high.
  • The combination of Dapagliflozin and Sitagliptin in DAPAVEL S 10/100MG TABLET 10'S provides a dual mechanism of action to control blood sugar levels. Dapagliflozin reduces glucose reabsorption in the kidneys, while Sitagliptin enhances the body's own ability to regulate blood sugar through incretin hormones. This synergistic effect can result in more effective blood sugar control compared to using either medication alone. The medication is most effective when used in conjunction with a healthy diet and regular exercise. Patients should consult their healthcare provider for proper dosage and usage instructions.
  • In summary, DAPAVEL S 10/100MG TABLET 10'S works by utilizing Dapagliflozin to decrease glucose reabsorption in the kidneys and Sitagliptin to enhance incretin hormone activity, ultimately resulting in improved blood sugar control in patients with type 2 diabetes.

Side Effects of DAPAVEL S 10/100MG TABLET 10'SArrow

Possible side effects of DAPAVEL S 10/100MG Tablet may include: * **Common:** Hypoglycemia (low blood sugar), headache, nausea, frequent urination, urinary tract infections (UTIs), genital infections (thrush), increased thirst. * **Less Common:** Dizziness, constipation, skin rash, back pain, changes in cholesterol levels. * **Rare:** Diabetic ketoacidosis (DKA), Fournier's gangrene (a serious infection of the genitals), severe allergic reactions (anaphylaxis), kidney problems. **Note:** This is not an exhaustive list. If you experience any unusual or severe side effects, consult your doctor immediately.

Safety Advice for DAPAVEL S 10/100MG TABLET 10'SArrow

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Allergies

Allergies

Do not consume DAPAVEL S 10/100MG TABLET 10'S if you are allergic to it.

Dosage of DAPAVEL S 10/100MG TABLET 10'SArrow

  • The recommended dosage of 'DAPAVEL S 10/100MG TABLET 10'S' varies depending on individual patient factors, including the severity of your condition, kidney function, and other medications you may be taking. It is crucial to strictly adhere to your doctor's instructions regarding dosage and administration. Typically, the starting dose is one tablet daily, taken orally. Your doctor may adjust the dosage based on your response to the medication and your individual needs.
  • It is important to take 'DAPAVEL S 10/100MG TABLET 10'S' at the same time each day to maintain a consistent level of medication in your body. This helps ensure optimal effectiveness. You can take it with or without food, but consistency is key. If you experience any gastrointestinal upset, taking it with food might be helpful.
  • If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. Doubling the dose can increase the risk of side effects. Regular monitoring by your physician is important while taking 'DAPAVEL S 10/100MG TABLET 10'S' to assess its effectiveness and to monitor for any potential side effects. Do not abruptly stop taking this medication without consulting your doctor, as this could lead to undesirable consequences. Take 'DAPAVEL S 10/100MG TABLET 10'S' only as per the prescription by your physician only

What if I miss my dose of DAPAVEL S 10/100MG TABLET 10'S?Arrow

  • If you miss a dose of DAPAVEL S 10/100MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How to store DAPAVEL S 10/100MG TABLET 10'S?Arrow

  • Keep DAPAVEL S 10/100MG TAB 1X10 away from the reach of children and pets.
  • Store DAPAVEL S 10/100MG TAB 1X10 at room temperature.

Benefits of DAPAVEL S 10/100MG TABLET 10'SArrow

  • DAPAVEL S 10/100MG TABLET 10'S offers a dual-action approach to managing blood sugar levels in individuals with type 2 diabetes. This combination medication harnesses the power of two distinct active ingredients to provide comprehensive glycemic control. Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, works by preventing the kidneys from reabsorbing glucose back into the bloodstream. This excess glucose is then eliminated through urine, effectively lowering blood sugar levels. By reducing glucose reabsorption, Dapagliflozin not only improves glycemic control but also offers the potential for weight loss due to the caloric expenditure associated with glucose excretion.
  • Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, functions by enhancing the body's own ability to regulate blood sugar. DPP-4 enzymes naturally break down incretin hormones, which play a crucial role in stimulating insulin release and suppressing glucagon secretion after meals. Sitagliptin inhibits the action of DPP-4, leading to increased levels of active incretin hormones. This, in turn, promotes insulin release when blood sugar is high and reduces glucagon secretion, which helps prevent excessive glucose production by the liver.
  • The combined action of Dapagliflozin and Sitagliptin in DAPAVEL S 10/100MG TABLET 10'S provides several key benefits. Firstly, it delivers significant improvements in HbA1c levels, a measure of long-term blood sugar control. This reduction in HbA1c translates to a decreased risk of diabetes-related complications, such as nerve damage, kidney disease, eye problems, and cardiovascular issues. Secondly, this medication helps to reduce fasting plasma glucose (FPG) and postprandial glucose (PPG) levels, leading to more stable blood sugar control throughout the day.
  • Beyond glycemic control, DAPAVEL S 10/100MG TABLET 10'S may offer additional advantages. Dapagliflozin's mechanism of action can contribute to modest weight loss in some individuals. Furthermore, SGLT2 inhibitors like Dapagliflozin have shown potential benefits for cardiovascular health, including reducing the risk of heart failure hospitalization in certain patient populations. This combination medication is typically well-tolerated, with common side effects being generally mild and manageable. The convenience of a single tablet formulation improves adherence to treatment, making it easier for patients to manage their diabetes effectively.

How to use DAPAVEL S 10/100MG TABLET 10'SArrow

  • DAPAVEL S 10/100MG TABLET 10'S should be taken orally, usually once daily, preferably in the morning. This helps maintain consistent drug levels in your body throughout the day. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medication is released and absorbed.
  • It's crucial to adhere to your doctor's prescribed dosage and treatment duration. Do not alter the dosage or discontinue the medication without consulting your physician, even if you feel better. Sudden discontinuation can lead to undesirable side effects or a worsening of your condition.
  • DAPAVEL S 10/100MG TABLET 10'S can be taken with or without food. However, taking it at the same time each day will help you remember to take it. If you experience any stomach upset, try taking it with a small meal.
  • While taking this medication, it's important to maintain a healthy lifestyle, including a balanced diet and regular exercise. Monitor your blood sugar levels regularly, as directed by your doctor, and report any significant changes.
  • Inform your doctor about all other medications, supplements, and herbal products you are taking, as they may interact with DAPAVEL S 10/100MG TABLET 10'S. Be especially cautious about medications that can affect blood sugar levels.
  • If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • Store DAPAVEL S 10/100MG TABLET 10'S at room temperature, away from heat, light, and moisture. Keep it out of reach of children and pets.

Quick Tips for DAPAVEL S 10/100MG TABLET 10'SArrow

  • **Take DAPAVEL S 10/100MG Tablet as prescribed by your doctor:** Always follow your doctor's instructions regarding dosage and timing. Do not self-medicate or adjust the dosage without consulting your healthcare provider, even if you feel better or worse. Consistency is key for optimal results.
  • **Maintain a healthy lifestyle:** DAPAVEL S works best when combined with a balanced diet and regular exercise. Focus on consuming fiber-rich foods, lean proteins, and healthy fats while limiting processed foods, sugary drinks, and excessive alcohol intake. Aim for at least 30 minutes of moderate-intensity exercise most days of the week to help manage blood sugar levels.
  • **Monitor your blood sugar levels regularly:** Regular monitoring is crucial to assess how well DAPAVEL S is working for you. Keep a log of your blood sugar readings and share it with your doctor during appointments. This information helps them fine-tune your treatment plan and address any potential issues promptly. Use a reliable glucose meter and testing strips for accurate results.
  • **Stay hydrated:** Drink plenty of water throughout the day. Proper hydration helps your kidneys function efficiently, which is important when taking medications like DAPAVEL S. It also aids in maintaining overall health and well-being. Aim for at least 8 glasses of water daily, and increase your intake if you are physically active or live in a hot climate.
  • **Be aware of potential side effects and interactions:** Familiarize yourself with the possible side effects of DAPAVEL S, such as urinary tract infections or dehydration. Also, inform your doctor about all other medications, supplements, and herbal remedies you are taking to avoid potential drug interactions. Report any unusual symptoms or concerns to your healthcare provider immediately.

Food Interactions with DAPAVEL S 10/100MG TABLET 10'SArrow

  • DAPAVEL S 10/100MG TABLET 10'S can be taken with or without food. However, it is important to take it at the same time each day to maintain consistent blood levels of the medication. Avoid excessive alcohol consumption while taking this medicine, as it may increase the risk of side effects such as low blood sugar.

FAQs

What is DAPAVEL S 10/100MG TABLET 10'S?Arrow

DAPAVEL S 10/100MG TABLET 10'S is a combination of two medicines: Dapagliflozin and Sitagliptin. It is used to lower high blood sugar levels in adults with type 2 diabetes mellitus.

How to use DAPAVEL S 10/100MG TABLET 10'S?Arrow

Take DAPAVEL S 10/100MG TABLET 10'S as prescribed by your doctor. It can be taken with or without food.

What are the common side effects of DAPAVEL S 10/100MG TABLET 10'S?Arrow

Common side effects of DAPAVEL S 10/100MG TABLET 10'S include nausea, vomiting, diarrhea, abdominal pain, and headache.

Is DAPAVEL S 10/100MG TABLET 10'S safe for people with kidney problems?Arrow

DAPAVEL S 10/100MG TABLET 10'S should be used with caution in people with kidney problems. Dosage adjustments may be necessary.

Is DAPAVEL S 10/100MG TABLET 10'S safe during pregnancy?Arrow

The safety of DAPAVEL S 10/100MG TABLET 10'S during pregnancy has not been established. Therefore, pregnant women should consult their doctor before using it.

Is DAPAVEL S 10/100MG TABLET 10'S safe during breastfeeding?Arrow

The safety of DAPAVEL S 10/100MG TABLET 10'S during breastfeeding has not been established. Therefore, breastfeeding women should consult their doctor before using it.

Does DAPAVEL S 10/100MG TABLET 10'S interact with other medications?Arrow

DAPAVEL S 10/100MG TABLET 10'S can interact with certain other medications. Inform your doctor about all the medications you are taking.

How to store DAPAVEL S 10/100MG TABLET 10'S?Arrow

Store DAPAVEL S 10/100MG TABLET 10'S at room temperature, away from heat and moisture.

Can I drink alcohol with DAPAVEL S 10/100MG TABLET 10'S?Arrow

Avoid drinking alcohol with DAPAVEL S 10/100MG TABLET 10'S, as it may lower blood sugar levels.

What happens if I miss a dose of DAPAVEL S 10/100MG TABLET 10'S?Arrow

If you miss a dose of DAPAVEL S 10/100MG TABLET 10'S, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule.

What are the symptoms of an overdose of DAPAVEL S 10/100MG TABLET 10'S?Arrow

Symptoms of an overdose of DAPAVEL S 10/100MG TABLET 10'S may include nausea, vomiting, diarrhea, abdominal pain, dizziness, and fainting.

Can DAPAVEL S 10/100 be used for Type 1 Diabetes?Arrow

No, DAPAVEL S 10/100 is not suitable for treating Type 1 Diabetes. It is intended for use only in patients with Type 2 Diabetes.

Does DAPAVEL S 10/100 help in weight loss?Arrow

Some studies have shown that Dapagliflozin (present in DAPAVEL S) may lead to weight loss in some patients, but the drug is not primarily intended for weight loss.

Can DAPAVEL S 10/100 cause yeast infections?Arrow

Yes, Dapagliflozin (a component of DAPAVEL S) can increase the risk of yeast infections in the genital area. Maintaining good hygiene and watching for symptoms is important.

Can I take DAPAVEL S 10/100 with Metformin?Arrow

DAPAVEL S 10/100 contains Sitagliptin and Dapagliflozin. Consult with your doctor before taking it with Metformin to ensure it is safe for you.

References

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FDA - QTERN (dapagliflozin and saxagliptin) tablets, for oral use. Full prescribing information including clinical pharmacology, mechanism of action, pharmacokinetics and clinical studies.

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DrugBank - Dapagliflozin: A detailed overview of dapagliflozin, including its mechanism of action, absorption, metabolism, and potential drug interactions. It provides chemical structure information and relevant scientific literature.

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DrugBank - Saxagliptin: Information about saxagliptin's mechanism of action, pharmacokinetics, and potential drug interactions, including its chemical structure.

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European Medicines Agency (EMA) - Onglyza (saxagliptin) EPAR: European public assessment report providing detailed information about Onglyza, including clinical trials, safety data, and efficacy.

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National Center for Biotechnology Information (NCBI) - Efficacy and safety of saxagliptin added to dapagliflozin in patients with inadequately controlled type 2 diabetes mellitus. A clinical study evaluating the combined use of dapagliflozin and saxagliptin.

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National Center for Biotechnology Information (NCBI) - Dapagliflozin: A review of its pharmacology, pharmacokinetics and clinical use. A comprehensive review article on dapagliflozin, covering its pharmacological properties, pharmacokinetics, and clinical applications.

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Marketer / Manufacturer Details

INTAS PHARMACEUTICALS LIMITED

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