SIGLYN D 100/10MG TABLET 10'S

How SIGLYN D 100/10MG TABLET 10'S Works

• SIGLYN D 100/10MG TABLET 10'S is a combination medicine containing two active ingredients: Sitagliptin and Dapagliflozin. These medications work through different but complementary mechanisms to lower blood sugar levels in individuals with type 2 diabetes mellitus. Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, while Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. Understanding how each component works is crucial to appreciating the overall effectiveness of this combination therapy.
• Sitagliptin primarily works by enhancing the incretin system. Incretins are hormones released by the gut in response to food intake. These hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), stimulate the release of insulin from the pancreas and reduce the secretion of glucagon. Glucagon is a hormone that raises blood sugar levels by promoting glucose production in the liver. However, DPP-4, an enzyme in the body, rapidly inactivates GLP-1 and GIP, limiting their beneficial effects. Sitagliptin inhibits DPP-4, thereby increasing the levels of active GLP-1 and GIP. This results in increased insulin secretion in response to elevated blood glucose and decreased glucagon secretion, both of which contribute to lowering blood sugar levels. Sitagliptin's action is glucose-dependent, meaning it primarily works when blood sugar is high, reducing the risk of hypoglycemia (low blood sugar).
• Dapagliflozin, on the other hand, works independently of insulin. It inhibits SGLT2, a protein in the kidneys responsible for reabsorbing glucose back into the bloodstream. By blocking SGLT2, Dapagliflozin reduces the reabsorption of glucose, causing excess glucose to be excreted in the urine. This process effectively lowers blood sugar levels. Furthermore, the excretion of glucose via urine leads to a loss of calories, which can contribute to weight loss. Dapagliflozin may also have a mild diuretic effect, potentially lowering blood pressure in some individuals. The mechanism of action of Dapagliflozin complements that of Sitagliptin, as it provides an insulin-independent pathway for glucose control.
• In summary, SIGLYN D 100/10MG TABLET 10'S leverages the complementary actions of Sitagliptin and Dapagliflozin to provide comprehensive glycemic control. Sitagliptin enhances the incretin system, increasing insulin secretion and decreasing glucagon secretion in a glucose-dependent manner. Dapagliflozin inhibits glucose reabsorption in the kidneys, leading to glucose excretion in the urine. This dual mechanism of action effectively lowers blood sugar levels, improves glycemic control, and may offer additional benefits such as weight loss and blood pressure reduction. As always, it is important to take this medication as prescribed by your healthcare provider and to monitor blood sugar levels regularly.
• It's also important to note that while this medication effectively manages blood sugar, lifestyle modifications such as diet and exercise are crucial for overall diabetes management.

Common side effects of SIGLYN D 100/10MG TABLET may include nausea, vomiting, diarrhea, stomach pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar). Some patients may also experience headache, dizziness, weakness, and upper respiratory tract infection symptoms like a sore throat or runny nose. Less common but potentially serious side effects consist of pancreatitis, severe allergic reactions (rash, itching, swelling), liver problems (indicated by jaundice or dark urine), lactic acidosis (muscle cramps, rapid breathing), and vitamin B12 deficiency. Report any persistent or severe side effects to your doctor immediately.

• If you miss a dose of SIGLYN D 100/10MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep SIGLYN D 100/10MG TAB 1X10 away from the reach of children and pets.
• Store SIGLYN D 100/10MG TAB 1X10 at room temperature.

• **Take SIGLYN D 100/10MG Tablet as Prescribed:** Always follow your doctor's instructions regarding dosage and timing. Do not alter the dosage without consulting your healthcare provider, as this can impact its effectiveness and safety.
• **Administer Before Meals:** For optimal results, take SIGLYN D 100/10MG Tablet before your meals. This helps in better absorption of the medication and synchronization with your body's natural processes.
• **Maintain Consistent Timing:** Try to take SIGLYN D 100/10MG Tablet at the same time each day. Consistency in timing maximizes the therapeutic benefits and minimizes the chance of missed doses. Set a daily reminder if needed.
• **Monitor Blood Sugar Levels Regularly:** While taking SIGLYN D 100/10MG Tablet, regularly monitor your blood sugar levels. This helps you and your doctor assess how well the medication is working and adjust your treatment plan if necessary. Keep a log of your readings to share with your healthcare provider during check-ups.
• **Stay Hydrated and Maintain a Healthy Lifestyle:** Drink plenty of water throughout the day and maintain a balanced diet along with regular physical activity. These habits support the effectiveness of SIGLYN D 100/10MG Tablet and contribute to overall health and well-being. Consult with your dietician for personalized dietary advice.

• SIGLYN D 100/10MG TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent blood sugar levels. Consult your doctor for specific dietary advice while taking this medication.