COVANCE AT TABLET 10'S

How COVANCE AT TABLET 10'S Works

• COVANCE AT TABLET 10'S is a combination medication designed to manage cardiovascular health by addressing two key risk factors: high cholesterol and high blood pressure. It contains two active ingredients: Atorvastatin and Ramipril. Atorvastatin belongs to a class of drugs called statins, while Ramipril is an ACE inhibitor.
• Atorvastatin primarily works by inhibiting an enzyme called HMG-CoA reductase. This enzyme is crucial in the synthesis of cholesterol in the liver. By blocking this enzyme, Atorvastatin reduces the production of LDL cholesterol (often referred to as 'bad' cholesterol). Lowering LDL cholesterol levels helps to prevent the buildup of plaque in the arteries, a process known as atherosclerosis. This, in turn, reduces the risk of heart attacks and strokes. Atorvastatin also modestly increases HDL cholesterol (the 'good' cholesterol), which helps to remove LDL cholesterol from the arteries.
• Ramipril, on the other hand, works by inhibiting angiotensin-converting enzyme (ACE). ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor (a substance that narrows blood vessels). By blocking ACE, Ramipril reduces the production of angiotensin II, leading to vasodilation (widening of blood vessels). This vasodilation lowers blood pressure, making it easier for the heart to pump blood. Ramipril also reduces the release of aldosterone, a hormone that causes the kidneys to retain sodium and water. By reducing aldosterone levels, Ramipril further helps to lower blood pressure and reduce fluid retention.
• The combined action of Atorvastatin and Ramipril provides a synergistic effect in protecting against cardiovascular events. Atorvastatin lowers cholesterol levels, preventing the progression of atherosclerosis, while Ramipril lowers blood pressure and improves blood vessel function. This combination is particularly beneficial for individuals who have both high cholesterol and high blood pressure, as it addresses both risk factors simultaneously. This reduces strain on heart and overall cardiovascular system function. The dual mechanism helps stabilize the plaques and prevent rupture.

Like all medicines, COVANCE AT TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Diarrhea * Headache * Dizziness * Muscle pain * Fatigue * Increased blood sugar levels * Elevated liver enzymes * Common cold symptoms (nasal congestion, sneezing, sore throat) **Uncommon Side Effects (may affect up to 1 in 100 people):** * Allergic reactions (rash, itching, hives) * Sleep disturbances (insomnia, nightmares) * Memory problems * Nerve pain (peripheral neuropathy) * Vomiting * Constipation * Heartburn * Hair loss * Blurred vision * Ringing in the ears (tinnitus) * Decreased libido **Rare Side Effects (may affect up to 1 in 1,000 people):** * Muscle damage (rhabdomyolysis) - Seek immediate medical attention if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine. * Liver problems (jaundice, hepatitis) * Pancreatitis * Severe allergic reaction (anaphylaxis) - Seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, or dizziness. **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Liver failure * Stevens-Johnson syndrome (a severe skin reaction) **Other Potential Side Effects (frequency not known):** * Erectile dysfunction * Depression **Important Note:** This is not a complete list of side effects. If you experience any unusual symptoms while taking COVANCE AT TABLET 10'S, talk to your doctor or pharmacist.

• If you miss a dose of Covance AT Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep COVANCE AT TAB 1X10 away from the reach of children and pets.
• Store COVANCE AT TAB 1X10 at room temperature.

• Take Covance AT Tablet 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them, as this medication is often tailored to individual needs and health conditions.
• Consistency is key! Take Covance AT Tablet 10'S at the same time each day to maintain a stable level of medication in your bloodstream. This helps ensure the medication works effectively.
• Be mindful of potential food and drug interactions. Discuss your current medications, including over-the-counter drugs and supplements, with your doctor to avoid any adverse reactions. Also, inquire about any specific dietary restrictions or recommendations while taking Covance AT.
• Monitor your blood pressure regularly while taking Covance AT Tablet 10'S, especially at the beginning of treatment or when there are dosage adjustments. Keep a log of your readings to share with your healthcare provider during check-ups.
• Report any unusual side effects or symptoms to your doctor promptly. Common side effects can include dizziness, headache, or fatigue. If you experience severe or persistent symptoms, seek immediate medical attention. Do not discontinue the medication abruptly without your doctor’s advice.

• COVANCE AT TABLET 10'S can be taken with or without food. However, it is important to take it at the same time each day to maintain consistent blood levels of the medication. Avoid consuming large amounts of grapefruit or grapefruit juice while taking this medicine, as it can significantly increase the blood levels of atorvastatin, potentially leading to increased side effects. If you have any concerns about food interactions, consult your doctor or pharmacist.