TOZAAR AT TABLET 10'S

How TOZAAR AT TABLET 10'S Works

• TOZAAR AT TABLET 10'S is a combination medication containing two active ingredients: Losartan and Amlodipine. These components work synergistically to effectively manage hypertension (high blood pressure) and reduce the risk of cardiovascular events.
• Losartan belongs to a class of drugs known as Angiotensin II Receptor Blockers (ARBs). Angiotensin II is a hormone that causes blood vessels to constrict, leading to increased blood pressure. Losartan works by selectively blocking the binding of Angiotensin II to its receptors in various tissues, including blood vessels and the adrenal glands. This blockage prevents the vasoconstrictive effects of Angiotensin II, allowing blood vessels to relax and widen. As a result, blood pressure decreases, and blood flow to the heart and other organs improves. Additionally, Losartan helps reduce the release of aldosterone, a hormone that promotes sodium and water retention, further contributing to blood pressure reduction. Losartan also has a protective effect on the kidneys, making it particularly beneficial for patients with hypertension and kidney disease.
• Amlodipine is a calcium channel blocker that primarily affects the blood vessels. Calcium plays a crucial role in muscle contraction, including the muscles in the walls of blood vessels. Amlodipine works by blocking the entry of calcium ions into these muscle cells. This action causes the smooth muscles in the blood vessel walls to relax, leading to vasodilation (widening of blood vessels). The vasodilation effect of Amlodipine reduces peripheral vascular resistance, which is the resistance the heart must overcome to pump blood. By reducing this resistance, Amlodipine lowers blood pressure and decreases the workload on the heart. Amlodipine is particularly effective in treating hypertension and angina (chest pain) because it improves blood flow to the heart muscle.
• The combination of Losartan and Amlodipine in TOZAAR AT TABLET 10'S provides a complementary mechanism of action to effectively lower blood pressure. Losartan blocks the effects of Angiotensin II, while Amlodipine relaxes blood vessels by blocking calcium channels. This dual action helps to achieve better blood pressure control compared to using either medication alone. The synergistic effect also minimizes the potential side effects associated with higher doses of each individual drug.
• Furthermore, TOZAAR AT TABLET 10'S provides round-the-clock blood pressure control with a single daily dose, making it a convenient option for patients. Regular monitoring of blood pressure and adherence to prescribed lifestyle modifications, such as a healthy diet and regular exercise, are essential for maximizing the benefits of TOZAAR AT TABLET 10'S.
• In summary, TOZAAR AT TABLET 10'S works by combining the actions of Losartan and Amlodipine to relax blood vessels, reduce peripheral vascular resistance, and ultimately lower blood pressure. This comprehensive approach helps protect the heart, kidneys, and other vital organs from the harmful effects of hypertension.

Like all medicines, TOZAAR AT Tablet can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Dizziness * Cough * Headache * Low blood pressure * Diarrhea * Nausea * Vomiting * Muscle cramps * Fatigue * Weakness * Increased blood potassium * Increased uric acid in the blood **Uncommon side effects (may affect up to 1 in 100 people):** * Anemia * Skin rash * Urticaria (hives) * Pruritus (itching) * Angioedema (swelling of the face, lips, tongue, and/or throat) * Chest pain * Palpitations * Orthostatic hypotension (low blood pressure upon standing) * Abdominal pain * Constipation * Liver dysfunction * Increased blood creatinine * Impotence **Rare side effects (may affect up to 1 in 1,000 people):** * Hepatitis (inflammation of the liver) * Hyperkalemia (very high blood potassium) **Very rare side effects (may affect up to 1 in 10,000 people):** * Acute renal failure **Not known (frequency cannot be estimated from the available data):** * Flu-like symptoms * Back pain * Urinary tract infection * Sinusitis * Insomnia * Depression * Stroke * Myocardial infarction (heart attack) * Vasculitis (inflammation of blood vessels) * Pancreatitis (inflammation of the pancreas) * Muscle pain * Arthralgia (joint pain) * Photosensitivity (increased sensitivity to sunlight) * Erectile dysfunction * Tinnitus (ringing in the ears) * Blurred vision

• If you miss a dose of TOZAAR AT TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep TOZAAR AT TAB 1X10 away from the reach of children and pets.
• Store TOZAAR AT TAB 1X10 at room temperature.

• TOZAAR AT TABLET 10'S can be taken with or without food. Food does not significantly affect the absorption of this medication.