GLIPACURE M 50/1000MG TABLET 10'S

How GLIPACURE M 50/1000MG TABLET 10'S Works

• GLIPACURE M 50/1000MG TABLET 10'S is a combination medicine designed to effectively manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients: Gliclazide and Metformin, each working through different mechanisms to achieve optimal glycemic control.
• Gliclazide, a sulfonylurea, primarily stimulates the pancreas to release more insulin. Insulin is a hormone that helps glucose (sugar) move from the blood into cells where it can be used for energy. By increasing insulin secretion, Gliclazide helps lower blood sugar levels, particularly after meals. This action is glucose-dependent, meaning it has a lower risk of causing hypoglycemia (low blood sugar) compared to older sulfonylureas. Gliclazide binds to specific receptors on pancreatic beta cells, leading to the closure of potassium channels. This, in turn, causes depolarization of the cell membrane and an influx of calcium ions. The increased calcium concentration triggers the release of insulin granules.
• Metformin, a biguanide, works in multiple ways to reduce blood sugar. Firstly, it decreases glucose production in the liver by suppressing hepatic gluconeogenesis (the process by which the liver makes glucose from non-carbohydrate sources). Secondly, it improves insulin sensitivity in peripheral tissues, such as muscle and fat, allowing cells to utilize glucose more effectively. This means that the body requires less insulin to achieve the same blood sugar control. Thirdly, Metformin slows down the absorption of glucose from the intestines, further reducing post-meal blood sugar spikes. Metformin activates an enzyme called AMP-activated protein kinase (AMPK), which plays a crucial role in regulating glucose metabolism. Activation of AMPK leads to decreased hepatic glucose production and increased glucose uptake in peripheral tissues.
• The combined action of Gliclazide and Metformin provides a synergistic effect, addressing different aspects of glucose regulation. Gliclazide boosts insulin secretion, while Metformin reduces glucose production and improves insulin sensitivity. This dual approach results in better blood sugar control compared to using either medication alone. GLIPACURE M 50/1000MG is typically taken with meals to minimize gastrointestinal side effects and to coincide with postprandial glucose elevation. Regular monitoring of blood sugar levels is essential while taking this medication to ensure optimal therapeutic effect and to adjust dosage as needed. Patients should also be aware of the potential side effects and interactions with other medications.
• In summary, GLIPACURE M 50/1000MG works by: 1) Stimulating the pancreas to release more insulin (Gliclazide). 2) Reducing glucose production in the liver (Metformin). 3) Improving insulin sensitivity in peripheral tissues (Metformin). 4) Slowing down glucose absorption from the intestines (Metformin). This multi-pronged approach effectively lowers blood sugar levels in individuals with type 2 diabetes, helping to prevent long-term complications associated with uncontrolled hyperglycemia.

Common side effects of GLIPACURE M 50/1000MG TABLET may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and hypoglycemia (low blood sugar). Less common but potentially serious side effects include: allergic reactions (rash, itching, swelling), liver problems (yellowing of skin/eyes, dark urine), kidney problems, lactic acidosis (muscle pain, weakness, trouble breathing), and decreased vitamin B12 levels. It is important to contact your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of GLIPACURE M 50/1000MG TABLET 10'S, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep GLIPACURE M 50/1000MG TAB 1X10 away from the reach of children and pets.
• Store GLIPACURE M 50/1000MG TAB 1X10 at room temperature.

• Take GLIPACURE M 50/1000MG TABLET 10'S as prescribed by your doctor, usually once or twice daily with meals. This helps to prevent stomach upset and ensures better absorption of the medication.
• Follow a consistent meal schedule and avoid skipping meals. This medication works best when taken in conjunction with a balanced diet and regular eating habits to maintain stable blood sugar levels.
• Monitor your blood sugar levels regularly as directed by your healthcare provider. Keeping a log of your readings can help your doctor adjust your dosage of GLIPACURE M 50/1000MG TABLET 10'S effectively.
• Be aware of the symptoms of hypoglycemia (low blood sugar), such as sweating, shaking, rapid heartbeat, and confusion. Carry a source of fast-acting sugar, like glucose tablets or juice, to treat it promptly. Inform your family and friends about these symptoms and how to assist you if needed.
• Inform your doctor about all other medications, supplements, and herbal products you are taking. Certain substances can interact with GLIPACURE M 50/1000MG TABLET 10'S, affecting its efficacy or increasing the risk of side effects. Do not start or stop any medication without consulting your doctor.

• It is advisable to take GLIPACURE M 50/1000MG TABLET 10'S with food to minimize the risk of stomach upset.
• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of hypoglycemia (low blood sugar).
• Maintain a consistent diet and meal schedule to help regulate blood sugar levels effectively.