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Content Reviewed By:
Dr. Amit Patel
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.Common side effects of HUMAN ACTRAPID PENFILL 3 ML

General precautions and dose changes
Monitor closely during any change in regimen or health statusAny change in insulin type, brand, strength, injection site, or administration schedule involving Human Actrapid insulin should be made only under medical supervision, as it may require dose adjustment.
If you are a type 1 diabetes patient, then yes, you have to take HUMAN ACTRAPID PENFILL 3 ML for the rest of your life because your body is unable to produce sufficient insulin. Therefore, you would need HUMAN ACTRAPID PENFILL 3 ML as an external source of insulin. However, if you are a type 2 diabetes patient, sometimes your doctor may ask you to stop HUMAN ACTRAPID PENFILL 3 ML if you are able to manage your diabetes with proper exercise, diet and oral medicines.
Yes, HUMAN ACTRAPID PENFILL 3 ML can be used alone or in combination with other diabetes medicines like long-acting insulin or oral diabetes medicines, along with proper diet and exercise. Follow your doctor’s advice and treatment plan to get the maximum benefit.
HUMAN ACTRAPID PENFILL 3 ML is injected under the skin (subcutaneously). Your doctor will show you the area of your skin where you should inject it. Try not to inject on the same spot every time. Rotate between the typical injection sites, such as abdomen, buttocks, upper legs or upper arms. Never inject HUMAN ACTRAPID PENFILL 3 ML into a muscle or vein. Move to a new injection site every week or two. Inject in the same area of the body, making sure to move around within that area with each injection, for one or two weeks. You can then move to another area of your body and repeat the process. Use the same area for at least a week to avoid extreme blood sugar variations.
Yes. HUMAN ACTRAPID PENFILL 3 ML is safe to use in pregnancy if prescribed by a doctor. However, please inform your doctor if you are pregnant, planning pregnancy or breastfeeding before using HUMAN ACTRAPID PENFILL 3 ML. You may require dose modifications and your doctor will advise you to monitor your blood sugar levels regularly. You must follow the instructions of your doctor to get maximum benefits.
Yes, insulin is safe to use in type 2 diabetes if used according to your doctor's advice. Keep monitoring your blood sugar levels regularly as advised. Your dosage may need to be adjusted as per your needs. Follow the lifestyle changes as advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.
The side effects of HUMAN ACTRAPID PENFILL 3 ML are injection site reactions such as redness, itching, pain and swelling. However, these are temporary and usually resolve on their own. Rarely, it can also cause lipodystrophy, which means abnormal changes in the fat tissues due to repeated insulin injections in the same area of the skin. It includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption. Rotate insulin injection or infusion sites within the same region to reduce the risk of lipodystrophy.
Yes, the most common side effect of HUMAN ACTRAPID PENFILL 3 ML is hypoglycemia. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, do not skip meals and be consistent in the timing and amount of your meals. Take some snacks as per your requirement if you over exercise. Regular monitoring of the blood sugar level is important. Always carry some sugary candies, glucose/glucon-D or fruit juice with you. Take all the medicines prescribed by the doctor on time and consult your doctor if you notice any fluctuations in your blood sugar levels.
Yes, sometimes, in specific situations like diabetic ketoacidosis, severe hyperglycemia etc, HUMAN ACTRAPID PENFILL 3 ML may be given as an injection into a vein (intravenous). However, in such cases, it is only given by a doctor, under continuous monitoring of blood sugar levels in a hospital setting.
You should consult your doctor for dose adjustment if you experience weight gain or loss, increased stress, illness, changes in diet such as missed meals or if you are taking alcohol. Your dose may also change if you have recently changed your exercise regime or are taking any medicines. Also, you must be vigilant for certain side effects that you may experience while using HUMAN ACTRAPID PENFILL 3 ML. Your doctor will tell you ways to prevent them. These side effects are usually temporary but if they are very severe, you may need dose modifications.
HUMAN ACTRAPID PENFILL 3 ML needs to be refrigerated before its first use. Unopened cartridges and unused pre-filled pens of HUMAN ACTRAPID PENFILL 3 ML must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use HUMAN ACTRAPID PENFILL 3 ML if it has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain HUMAN ACTRAPID PENFILL 3 ML.
HUMAN ACTRAPID PENFILL 3 ML is a man-made version of human insulin, produced by the process of biotechnology called recombinant DNA technology. It is sold as a sterile, aqueous, clear, and colorless solution that contains insulin aspart along with other constituents like glycerin, phenol, metacresol, zinc, sodium chloride etc.
Human Actrapid insulin is a short-acting, soluble human insulin used to control blood glucose levels in people with diabetes mellitus, particularly type 1 diabetes and in some patients with type 2 diabetes when oral medicines are inadequate. It is usually given before meals to cover the rise in blood glucose that occurs after eating and is often combined with an intermediate- or long-acting insulin as part of a basal–bolus regimen.
Human Actrapid insulin works by replacing or supplementing the insulin that the body either does not produce or does not use effectively. It promotes the uptake of glucose into muscle and fat cells, reduces glucose production by the liver, and influences protein and fat metabolism. This combined effect lowers blood glucose levels and helps prevent both acute and long-term complications of diabetes when used appropriately.
After subcutaneous injection, Human Actrapid insulin usually begins to act within about 30 minutes. Its maximum glucose-lowering effect typically occurs between 1.5 and 3.5 hours after injection, and the total duration of action can extend up to approximately 7–8 hours. Because of this profile, it is generally administered shortly before a meal, according to the timing advised by the treating clinician.
Human Actrapid insulin is given by subcutaneous injection, usually into the abdominal wall, thigh, upper arm, or buttock. Injection sites should be rotated within the same region to reduce the risk of lipodystrophy. It must not be injected into a vein or muscle unless specifically directed by a healthcare professional. Patients should receive training on correct injection technique, use of syringes or insulin pens, and safe disposal of needles and cartridges.
Dose adjustments should always be guided by your healthcare provider, based on blood glucose monitoring, dietary patterns, physical activity, and other medications. Some patients may be given individualized instructions on how to make small dose changes in response to blood glucose readings, but unsupervised major changes or frequent dose alterations can increase the risk of hypoglycaemia or poor control. Never change the type or brand of insulin without medical advice.
The most common side effect is hypoglycaemia, which may present with sweating, shakiness, palpitations, hunger, headache, irritability, confusion, or visual disturbances. Local injection-site reactions such as redness, swelling, or itching can occur, usually mild and transient. Long-term use without proper site rotation may cause lipodystrophy. Rarely, generalized allergic reactions, including rash, angioedema, or breathing difficulty, may occur and require urgent medical attention.
If you forget to take Human Actrapid insulin before a meal, follow the advice provided by your healthcare team. In general, if you realize soon after eating, you may be instructed to take the dose promptly, but taking it much later than recommended can increase the risk of hypoglycaemia or hyperglycaemia. Do not double the next dose to compensate. Monitor your blood glucose and contact your healthcare provider for individualized guidance if you are unsure.
Human Actrapid insulin is commonly used during pregnancy for women with pre-existing diabetes or gestational diabetes when insulin therapy is required. Human insulin is generally considered the standard of care in this setting. However, insulin requirements often change throughout pregnancy and after delivery, so close monitoring, frequent blood glucose checks, and regular follow-up with the obstetric and diabetes care team are essential.
Unopened vials or cartridges of Human Actrapid insulin should be stored in a refrigerator at the temperature range specified in the product information, protected from freezing and direct light. Once in use, storage recommendations may allow room temperature use for a limited period, as indicated in the official package leaflet. Insulin that has been frozen, exposed to extreme temperatures, or appears cloudy, discoloured, or contains particles should not be used. Always check the manufacturer’s instructions for specific storage conditions and shelf-life after first use.
Alcohol can unpredictably affect blood glucose levels and may increase the risk of both hypoglycaemia and hyperglycaemia in people using Human Actrapid insulin. If you drink alcohol, it should be in moderation and preferably with food, and you should monitor your blood glucose more frequently. Patients with a history of severe hypoglycaemia or poor awareness of hypoglycaemia should be particularly cautious. Discuss alcohol use with your healthcare provider for personalized advice.
Many factors can alter insulin requirements, including changes in diet, physical activity, acute illness, stress, surgery, and organ function (especially kidney and liver). Certain medicines, such as corticosteroids, some diuretics, beta-blockers, oral antidiabetic drugs, and others, may increase or decrease insulin needs or mask hypoglycaemia symptoms. Always inform your healthcare provider about all prescription, over-the-counter, and herbal products you are taking so that your insulin regimen can be adjusted safely.
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NOVO NORDISK INDIA PVT LTD
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India

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