human actrapid penfill 3 ml
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HUMAN ACTRAPID PENFILL 3 ML

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HUMAN ACTRAPID PENFILL 3 ML

By NOVO NORDISK INDIA PVT LTD

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424.59

₹382.13

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Product DetailsArrow

Content Reviewed By:

Dr. Amit Patel

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About HUMAN ACTRAPID PENFILL 3 ML

  • Human Actrapid insulin is a short-acting human insulin preparation used for the management of diabetes mellitus, primarily type 1 diabetes and, in many cases, type 2 diabetes when oral medicines are insufficient. It contains soluble human insulin produced by recombinant DNA technology and is designed to mimic the body’s natural prandial (mealtime) insulin response. After subcutaneous injection, Human Actrapid insulin typically starts to act within approximately 30 minutes, reaches peak effect in about 1.5–3.5 hours, and its glucose-lowering effect may last for up to 7–8 hours. Because of this onset and duration profile, it is usually administered shortly before a meal, in combination with intermediate- or long-acting basal insulin as part of an individualized insulin regimen. Human Actrapid insulin helps lower blood glucose by facilitating the uptake of glucose into skeletal muscle and adipose tissue and by inhibiting hepatic glucose production. It also influences protein and lipid metabolism. The dose and timing must always be individualized based on blood glucose monitoring, dietary intake, physical activity, and concomitant medications. It is commonly supplied in vials or cartridges (such as Penfill) for use with insulin syringes or compatible insulin pens. Patients and caregivers must be trained in correct injection technique, rotation of injection sites, and recognition and management of hypoglycaemia. The most frequent adverse effect of Human Actrapid insulin is hypoglycaemia, which can be serious and potentially life-threatening if not recognized and treated promptly. Symptoms may include sweating, tremor, palpitations, hunger, headache, confusion, and, in severe cases, seizures or loss of consciousness. Local injection-site reactions such as redness, swelling, or itching can occur, usually mild and transient. Long-term use without proper rotation of injection sites may lead to lipodystrophy (lipoatrophy or lipohypertrophy), which can alter insulin absorption. Rarely, systemic allergic reactions may occur. Human Actrapid insulin is generally safe when used under medical supervision, including in special populations such as pregnant or breastfeeding women, but dose adjustments and close monitoring are often required. Renal or hepatic impairment, changes in diet or physical activity, intercurrent illness, and the use of other glucose-lowering drugs or certain concomitant medicines can significantly alter insulin requirements. Patients should be advised not to change insulin type, brand, strength, or administration schedule without consulting their healthcare provider. Regular follow-up, self-monitoring of blood glucose, and education on sick-day rules and hypoglycaemia management are essential components of safe and effective therapy with Human Actrapid insulin.

Uses of HUMAN ACTRAPID PENFILL 3 ML

  • Diabetes: Diabetes is a chronic condition that affects how your body regulates blood glucose (sugar) levels.

How HUMAN ACTRAPID PENFILL 3 ML Works

  • HUMAN ACTRAPID PENFILL 3 ML is a rapid-acting insulin that begins to lower blood sugar levels approximately 30 minutes after injection. It is designed to mimic the action of naturally produced insulin in the body, helping to regulate glucose metabolism. Essentially, HUMAN ACTRAPID PENFILL 3 ML enables the body to use sugar (glucose) from the blood for energy.
  • This medication works primarily by facilitating the reuptake of glucose from the bloodstream into muscle and fat cells. When insulin binds to receptors on these cells, it signals them to open channels that allow glucose to enter. This process lowers the amount of glucose circulating in the blood.
  • In addition to promoting glucose uptake by cells, HUMAN ACTRAPID PENFILL 3 ML also plays a crucial role in suppressing the liver's production of glucose. The liver can release stored glucose into the bloodstream, especially during periods of fasting or stress. Insulin signals the liver to reduce this glucose output, further contributing to blood sugar control. By mimicking the body's own insulin, HUMAN ACTRAPID PENFILL 3 ML helps maintain stable and healthy blood glucose levels, particularly after meals.

Side Effects of HUMAN ACTRAPID PENFILL 3 MLArrow

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.Common side effects of HUMAN ACTRAPID PENFILL 3 ML

  • Hypoglycemia (low blood glucose level)
  • Weight gain
  • Injection site reactions (pain, swelling, redness)
  • Cold sweat
  • Anxiety
  • Shakiness
  • Hunger pangs
  • Fast heart rate
  • Headache
  • Nervousness

Safety Advice for HUMAN ACTRAPID PENFILL 3 MLArrow

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General precautions and dose changes

Monitor closely during any change in regimen or health status

Any change in insulin type, brand, strength, injection site, or administration schedule involving Human Actrapid insulin should be made only under medical supervision, as it may require dose adjustment.

Dosage of HUMAN ACTRAPID PENFILL 3 MLArrow

  • Dosage for children: The use of HUMAN ACTRAPID PENFILL 3 ML in children is not recommended without proper medical consultation and guidance.
  • Dosage for adults: The recommended dosage of HUMAN ACTRAPID PENFILL 3 ML for adults is one program cycle per day, adhering to the prescribed regimen and instructions provided.

How to store HUMAN ACTRAPID PENFILL 3 ML?Arrow

  • Keep HUMAN ACTRAPID PENFILL 3ML away from the reach of children and pets.
  • Store HUMAN ACTRAPID PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of HUMAN ACTRAPID PENFILL 3 MLArrow

  • <b>Diabetes Management with HUMAN ACTRAPID PENFILL 3 ML</b><br>HUMAN ACTRAPID PENFILL 3 ML is a fast-acting insulin designed to help manage blood sugar levels, typically used in conjunction with other diabetes medications. It serves as a replacement for the insulin that your body should be producing, facilitating the movement of glucose from the bloodstream into your muscle and fat cells. This allows your body to use glucose effectively for energy, while also reducing glucose production in the liver. This dual action helps maintain healthy blood sugar levels.
  • Effective blood sugar control is vital in preventing serious long-term complications associated with diabetes. These complications can include kidney damage (nephropathy), eye damage (retinopathy), nerve problems (neuropathy), and even the potential loss of limbs. By consistently using HUMAN ACTRAPID PENFILL 3 ML as prescribed, you can significantly reduce your risk of developing these issues and maintain a better quality of life.
  • To maximize the effectiveness of HUMAN ACTRAPID PENFILL 3 ML, it's crucial to understand the correct injection technique, including where and when to inject it. Consistent use, combined with a balanced diet and regular exercise, is essential for living a normal, healthy life while managing diabetes. Always follow your doctor's instructions and consult with them if you have any questions or concerns about your treatment plan.

How to use HUMAN ACTRAPID PENFILL 3 MLArrow

  • Your doctor or nurse will provide detailed instructions on how to use HUMAN ACTRAPID PENFILL 3 ML. It is crucial to follow their guidance precisely. This medication is typically administered via subcutaneous injection, meaning it's injected under the skin.
  • Before each injection, carefully inspect the cartridge for any signs of damage or leakage. Ensure the solution is clear and colorless. If you notice any cloudiness, discoloration, or particles, do not use the cartridge. Always use a new needle for each injection to prevent contamination and ensure proper dosage.
  • Your healthcare provider will determine the appropriate dosage and timing of injections based on your individual needs and blood sugar levels. It's essential to monitor your blood sugar regularly as directed by your doctor and adjust your insulin dosage accordingly. Never share your insulin pen or needles with others, as this can spread infections.
  • Proper injection technique is essential for optimal absorption of insulin. Your doctor or nurse will demonstrate the correct technique, including how to pinch the skin, insert the needle, and release the skin after injection. Rotate injection sites to prevent skin thickening or pitting (lipodystrophy). Choose a different injection site each time, such as your abdomen, thigh, or upper arm.
  • If you have any questions or concerns about using HUMAN ACTRAPID PENFILL 3 ML, don't hesitate to contact your doctor, nurse, or pharmacist. They can provide additional guidance and support to ensure you're using the medication safely and effectively.

Quick Tips for HUMAN ACTRAPID PENFILL 3 MLArrow

  • Administer HUMAN ACTRAPID PENFILL 3 ML 20 to 30 minutes before a meal to ensure optimal glucose control. This timing allows the insulin to start working as your body begins to process the food you're about to eat, helping to prevent post-meal blood sugar spikes.
  • Be vigilant about hypoglycemia, a common side effect characterized by low blood sugar levels. Familiarize yourself with the symptoms, including sweating, rapid heartbeat, weakness, blurry vision, and headache. Educate your family and close contacts on how to recognize these signs and respond appropriately, such as by administering a quick-acting source of glucose.
  • The abdomen offers the fastest absorption rate when injecting HUMAN ACTRAPID PENFILL 3 ML beneath the skin. However, it's crucial to rotate injection sites within the abdomen or other recommended areas to prevent lipohypertrophy, which are hard lumps that can develop from repeated injections in the same spot. Consistent rotation ensures even absorption and maintains skin health.
  • Proper storage is essential to maintain the efficacy of HUMAN ACTRAPID PENFILL 3 ML. Opened vials or cartridges can be stored at room temperature for up to 4 weeks, making them convenient for daily use. Unopened vials, however, must be stored in the refrigerator between 2°C and 8°C to preserve their stability and potency. Always check the expiration date before use.
  • To optimize the use of HUMAN ACTRAPID PENFILL 3 ML, always ensure that you are using the correct dose as prescribed by your healthcare provider. Monitor your blood sugar levels regularly, especially before meals and at bedtime, to understand how the insulin is affecting your glucose control. Discuss any concerns or adjustments with your doctor or diabetes educator.

FAQs

Will I need HUMAN ACTRAPID PENFILL 3 ML for the rest of my life?Arrow

If you are a type 1 diabetes patient, then yes, you have to take HUMAN ACTRAPID PENFILL 3 ML for the rest of your life because your body is unable to produce sufficient insulin. Therefore, you would need HUMAN ACTRAPID PENFILL 3 ML as an external source of insulin. However, if you are a type 2 diabetes patient, sometimes your doctor may ask you to stop HUMAN ACTRAPID PENFILL 3 ML if you are able to manage your diabetes with proper exercise, diet and oral medicines.

Can HUMAN ACTRAPID PENFILL 3 ML be used with other diabetes medicine?Arrow

Yes, HUMAN ACTRAPID PENFILL 3 ML can be used alone or in combination with other diabetes medicines like long-acting insulin or oral diabetes medicines, along with proper diet and exercise. Follow your doctor’s advice and treatment plan to get the maximum benefit.

How should HUMAN ACTRAPID PENFILL 3 ML be used?Arrow

HUMAN ACTRAPID PENFILL 3 ML is injected under the skin (subcutaneously). Your doctor will show you the area of your skin where you should inject it. Try not to inject on the same spot every time. Rotate between the typical injection sites, such as abdomen, buttocks, upper legs or upper arms. Never inject HUMAN ACTRAPID PENFILL 3 ML into a muscle or vein. Move to a new injection site every week or two. Inject in the same area of the body, making sure to move around within that area with each injection, for one or two weeks. You can then move to another area of your body and repeat the process. Use the same area for at least a week to avoid extreme blood sugar variations.

Is HUMAN ACTRAPID PENFILL 3 ML safe to use in pregnancy?Arrow

Yes. HUMAN ACTRAPID PENFILL 3 ML is safe to use in pregnancy if prescribed by a doctor. However, please inform your doctor if you are pregnant, planning pregnancy or breastfeeding before using HUMAN ACTRAPID PENFILL 3 ML. You may require dose modifications and your doctor will advise you to monitor your blood sugar levels regularly. You must follow the instructions of your doctor to get maximum benefits.

Is HUMAN ACTRAPID PENFILL 3 ML safe to use in type 2 diabetes?Arrow

Yes, insulin is safe to use in type 2 diabetes if used according to your doctor's advice. Keep monitoring your blood sugar levels regularly as advised. Your dosage may need to be adjusted as per your needs. Follow the lifestyle changes as advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.

What are the side effects of HUMAN ACTRAPID PENFILL 3 ML? How to prevent them?Arrow

The side effects of HUMAN ACTRAPID PENFILL 3 ML are injection site reactions such as redness, itching, pain and swelling. However, these are temporary and usually resolve on their own. Rarely, it can also cause lipodystrophy, which means abnormal changes in the fat tissues due to repeated insulin injections in the same area of the skin. It includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption. Rotate insulin injection or infusion sites within the same region to reduce the risk of lipodystrophy.

Can HUMAN ACTRAPID PENFILL 3 ML cause hypoglycemia? How do I prevent it?Arrow

Yes, the most common side effect of HUMAN ACTRAPID PENFILL 3 ML is hypoglycemia. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, do not skip meals and be consistent in the timing and amount of your meals. Take some snacks as per your requirement if you over exercise. Regular monitoring of the blood sugar level is important. Always carry some sugary candies, glucose/glucon-D or fruit juice with you. Take all the medicines prescribed by the doctor on time and consult your doctor if you notice any fluctuations in your blood sugar levels.

Is HUMAN ACTRAPID PENFILL 3 ML given as an injection into a vein (intravenous)?Arrow

Yes, sometimes, in specific situations like diabetic ketoacidosis, severe hyperglycemia etc, HUMAN ACTRAPID PENFILL 3 ML may be given as an injection into a vein (intravenous). However, in such cases, it is only given by a doctor, under continuous monitoring of blood sugar levels in a hospital setting.

When does the dosage of HUMAN ACTRAPID PENFILL 3 ML need to be changed?Arrow

You should consult your doctor for dose adjustment if you experience weight gain or loss, increased stress, illness, changes in diet such as missed meals or if you are taking alcohol. Your dose may also change if you have recently changed your exercise regime or are taking any medicines. Also, you must be vigilant for certain side effects that you may experience while using HUMAN ACTRAPID PENFILL 3 ML. Your doctor will tell you ways to prevent them. These side effects are usually temporary but if they are very severe, you may need dose modifications.

Does HUMAN ACTRAPID PENFILL 3 ML need to be refrigerated?Arrow

HUMAN ACTRAPID PENFILL 3 ML needs to be refrigerated before its first use. Unopened cartridges and unused pre-filled pens of HUMAN ACTRAPID PENFILL 3 ML must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use HUMAN ACTRAPID PENFILL 3 ML if it has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain HUMAN ACTRAPID PENFILL 3 ML.

What is HUMAN ACTRAPID PENFILL 3 ML? How is it made?Arrow

HUMAN ACTRAPID PENFILL 3 ML is a man-made version of human insulin, produced by the process of biotechnology called recombinant DNA technology. It is sold as a sterile, aqueous, clear, and colorless solution that contains insulin aspart along with other constituents like glycerin, phenol, metacresol, zinc, sodium chloride etc.

What is Human Actrapid insulin and what is it used for?Arrow

Human Actrapid insulin is a short-acting, soluble human insulin used to control blood glucose levels in people with diabetes mellitus, particularly type 1 diabetes and in some patients with type 2 diabetes when oral medicines are inadequate. It is usually given before meals to cover the rise in blood glucose that occurs after eating and is often combined with an intermediate- or long-acting insulin as part of a basal–bolus regimen.

How does Human Actrapid insulin work in the body?Arrow

Human Actrapid insulin works by replacing or supplementing the insulin that the body either does not produce or does not use effectively. It promotes the uptake of glucose into muscle and fat cells, reduces glucose production by the liver, and influences protein and fat metabolism. This combined effect lowers blood glucose levels and helps prevent both acute and long-term complications of diabetes when used appropriately.

When does Human Actrapid insulin start working and how long does it last?Arrow

After subcutaneous injection, Human Actrapid insulin usually begins to act within about 30 minutes. Its maximum glucose-lowering effect typically occurs between 1.5 and 3.5 hours after injection, and the total duration of action can extend up to approximately 7–8 hours. Because of this profile, it is generally administered shortly before a meal, according to the timing advised by the treating clinician.

How should Human Actrapid insulin be administered?Arrow

Human Actrapid insulin is given by subcutaneous injection, usually into the abdominal wall, thigh, upper arm, or buttock. Injection sites should be rotated within the same region to reduce the risk of lipodystrophy. It must not be injected into a vein or muscle unless specifically directed by a healthcare professional. Patients should receive training on correct injection technique, use of syringes or insulin pens, and safe disposal of needles and cartridges.

Can I adjust my dose of Human Actrapid insulin on my own?Arrow

Dose adjustments should always be guided by your healthcare provider, based on blood glucose monitoring, dietary patterns, physical activity, and other medications. Some patients may be given individualized instructions on how to make small dose changes in response to blood glucose readings, but unsupervised major changes or frequent dose alterations can increase the risk of hypoglycaemia or poor control. Never change the type or brand of insulin without medical advice.

What are the common side effects of Human Actrapid insulin?Arrow

The most common side effect is hypoglycaemia, which may present with sweating, shakiness, palpitations, hunger, headache, irritability, confusion, or visual disturbances. Local injection-site reactions such as redness, swelling, or itching can occur, usually mild and transient. Long-term use without proper site rotation may cause lipodystrophy. Rarely, generalized allergic reactions, including rash, angioedema, or breathing difficulty, may occur and require urgent medical attention.

What should I do if I miss a dose of Human Actrapid insulin before a meal?Arrow

If you forget to take Human Actrapid insulin before a meal, follow the advice provided by your healthcare team. In general, if you realize soon after eating, you may be instructed to take the dose promptly, but taking it much later than recommended can increase the risk of hypoglycaemia or hyperglycaemia. Do not double the next dose to compensate. Monitor your blood glucose and contact your healthcare provider for individualized guidance if you are unsure.

Can Human Actrapid insulin be used during pregnancy?Arrow

Human Actrapid insulin is commonly used during pregnancy for women with pre-existing diabetes or gestational diabetes when insulin therapy is required. Human insulin is generally considered the standard of care in this setting. However, insulin requirements often change throughout pregnancy and after delivery, so close monitoring, frequent blood glucose checks, and regular follow-up with the obstetric and diabetes care team are essential.

How should Human Actrapid insulin be stored?Arrow

Unopened vials or cartridges of Human Actrapid insulin should be stored in a refrigerator at the temperature range specified in the product information, protected from freezing and direct light. Once in use, storage recommendations may allow room temperature use for a limited period, as indicated in the official package leaflet. Insulin that has been frozen, exposed to extreme temperatures, or appears cloudy, discoloured, or contains particles should not be used. Always check the manufacturer’s instructions for specific storage conditions and shelf-life after first use.

Can I drink alcohol while using Human Actrapid insulin?Arrow

Alcohol can unpredictably affect blood glucose levels and may increase the risk of both hypoglycaemia and hyperglycaemia in people using Human Actrapid insulin. If you drink alcohol, it should be in moderation and preferably with food, and you should monitor your blood glucose more frequently. Patients with a history of severe hypoglycaemia or poor awareness of hypoglycaemia should be particularly cautious. Discuss alcohol use with your healthcare provider for personalized advice.

What medicines or conditions can affect my insulin requirements with Human Actrapid insulin?Arrow

Many factors can alter insulin requirements, including changes in diet, physical activity, acute illness, stress, surgery, and organ function (especially kidney and liver). Certain medicines, such as corticosteroids, some diuretics, beta-blockers, oral antidiabetic drugs, and others, may increase or decrease insulin needs or mask hypoglycaemia symptoms. Always inform your healthcare provider about all prescription, over-the-counter, and herbal products you are taking so that your insulin regimen can be adjusted safely.

References

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Human Insulin. Bagsvaerd, Denmark: Novo Nordisk A/S; 2012. (online) Available from:

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Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98. (online) Available from:

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Actrapid [Summary of Product Characteristics]. Bagsværd, Denmark; Novo Nordisk A/S, Novo Allé; 2007. (online) Available from:

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Humulin [Product monograph]. Toronto, Ontario; Eli Lilly Canada Inc.; 2011. (online) Available from:

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American Diabetes Association (ADA). Insulin administration (Position statement). Diabetes Care. 2004;27(Suppl 1): S106-S109. (online) Available from:

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Insulin [Package Insert]. Bengaluru, India: Biocon Biologics India Limited; 2019. (online) Available from:

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human actrapid penfill 3 ml

HUMAN ACTRAPID PENFILL 3 ML

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