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Composition
Content Reviewed By:
Dr. Amit Patel
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
In most instances, side effects are temporary and diminish as your body adapts to the medication. However, if these effects persist or cause concern, it is important to seek advice from your doctor.

General precautions and administration
Use under medical supervisionHuminsulin R should be used only as prescribed, with the dose and timing individualized by a healthcare professional.
If you are a type 1 diabetes patient, then yes, you have to take HUMINSULIN R PENFILL 3 ML for the rest of your life because your body is unable to produce sufficient insulin. Therefore, you would need HUMINSULIN R PENFILL 3 ML as an external source of insulin. However, if you are a type 2 diabetes patient, sometimes your doctor may ask you to stop HUMINSULIN R PENFILL 3 ML if you are able to manage your diabetes with proper exercise, diet and oral medicines.
Yes, HUMINSULIN R PENFILL 3 ML can be used alone or in combination with other diabetes medicines like long-acting insulin or oral diabetes medicines, along with proper diet and exercise. Follow your doctor’s advice and treatment plan to get the maximum benefit.
HUMINSULIN R PENFILL 3 ML is injected under the skin (subcutaneously). Your doctor will show you the area of your skin where you should inject it. Try not to inject on the same spot every time. Rotate between the typical injection sites, such as abdomen, buttocks, upper legs or upper arms. Never inject Humalog into a muscle or vein. Move to a new injection site every week or two. Inject in the same area of the body, making sure to move around within that area with each injection, for one or two weeks. You can then move to another area of your body and repeat the process. Use the same area for at least a week to avoid extreme blood sugar variations.
Yes. HUMINSULIN R PENFILL 3 ML is safe to use in pregnancy if prescribed by a doctor. However, please inform your doctor if you are pregnant, planning pregnancy or breastfeeding before using HUMINSULIN R PENFILL 3 ML. You may require dose modifications and your doctor will advise you to monitor your blood sugar levels regularly. You must follow the instructions of your doctor to get maximum benefits.
Yes, insulin is safe to use in type 2 diabetes if used according to your doctor's advice. Keep monitoring your blood sugar levels regularly as advised. Your dosage may need to be adjusted as per your needs. Follow the lifestyle changes as advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.
The side effects of HUMINSULIN R PENFILL 3 ML are injection site reactions such as redness, itching, pain and swelling. However, these are temporary and usually resolve on their own. Rarely, it can also cause lipodystrophy, which means abnormal changes in the fat tissues due to repeated insulin injections in the same area of the skin. It includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption. Rotate insulin injection or infusion sites within the same region to reduce the risk of lipodystrophy.
Yes, the most common side effect of HUMINSULIN R PENFILL 3 ML is hypoglycemia. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, do not skip meals and be consistent in the timing and amount of your meals. Take some snacks as per your requirement if you over exercise. Regular monitoring of the blood sugar level is important. Always carry some sugary candies, glucose/glucon-D or fruit juice with you. Take all the medicines prescribed by the doctor on time and consult your doctor if you notice any fluctuations in your blood sugar levels.
Yes, sometimes, in specific situations like diabetic ketoacidosis, severe hyperglycemia etc, HUMINSULIN R PENFILL 3 ML may be given as an injection into a vein (intravenous). However, in such cases, it is only given by a doctor, under continuous monitoring of blood sugar levels in a hospital setting.
You should consult your doctor for dose adjustment if you experience weight gain or loss, increased stress, illness, changes in diet such as missed meals or if you are taking alcohol. Your dose may also change if you have recently changed your exercise regime or are taking any medicines. Also, you must be vigilant for certain side effects that you may experience while using HUMINSULIN R PENFILL 3 ML. Your doctor will tell you ways to prevent them. These side effects are usually temporary but if they are very severe, you may need dose modifications.
HUMINSULIN R PENFILL 3 ML needs to be refrigerated before its first use. Unopened cartridges and unused pre-filled pens of Humalog must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use HUMINSULIN R PENFILL 3 ML if it has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain HUMINSULIN R PENFILL 3 ML.
HUMINSULIN R PENFILL 3 ML is a man-made version of human insulin, produced by the process of biotechnology called recombinant DNA technology. It is sold as a sterile, aqueous, clear, and colorless solution that contains insulin aspart along with other constituents like glycerin, phenol, metacresol, zinc, sodium chloride etc.
Huminsulin R is a preparation of regular human insulin used to control high blood glucose in people with diabetes mellitus. It is a short-acting insulin that helps glucose enter cells and reduces glucose production by the liver. It is used in type 1 diabetes and in some cases of type 2 diabetes when oral medicines are not sufficient, and may also be used in acute situations such as diabetic ketoacidosis or during surgery under medical supervision.
Huminsulin R works by replacing or supplementing the insulin that the body either does not produce at all or does not use effectively. After injection, it binds to insulin receptors on cells, promoting the uptake of glucose from the bloodstream into muscle and fat tissue and inhibiting glucose production by the liver. This leads to a reduction in blood glucose levels and helps maintain them within a target range when used as part of a comprehensive diabetes management plan.
Huminsulin R is a short-acting insulin that typically starts working within about 30 minutes after subcutaneous injection. It is usually administered approximately 30 minutes before a meal, as directed by a healthcare professional, so that its peak action coincides with the rise in blood glucose after eating. The exact timing may vary based on individual response and the overall insulin regimen, and should be confirmed with the treating physician.
The most common side effect of Huminsulin R is hypoglycaemia, or low blood sugar, which may cause symptoms such as sweating, shakiness, hunger, palpitations, headache, irritability, confusion, or dizziness. Other possible side effects include local injection site reactions like redness, swelling, or itching, and changes in the fatty tissue under the skin (lipohypertrophy or lipoatrophy) if injection sites are not rotated. Allergic reactions are less common but can occur. Any persistent or severe symptoms should be discussed with a healthcare professional.
If you miss a scheduled dose of Huminsulin R, do not inject an extra dose without medical advice. The appropriate action depends on how much time has passed, your current blood glucose level, and when you will eat next. Check your blood glucose and contact your healthcare provider or diabetes educator for individualized instructions. In general, avoid taking a double dose to make up for a missed one, as this may increase the risk of hypoglycaemia.
Yes, Huminsulin R can cause hypoglycaemia, especially if you inject too much insulin, delay or skip meals, exercise more than usual, or consume alcohol. If you experience symptoms of low blood sugar and are conscious, you should take fast-acting carbohydrates such as glucose tablets, sugar, or sweet juice according to your diabetes care plan, then recheck your blood glucose. If symptoms are severe, if you are unable to swallow, or if you do not improve, emergency medical help is required. Your healthcare provider may also advise that a caregiver be trained to use glucagon for severe hypoglycaemia.
Dose adjustments for Huminsulin R should be made under the guidance of a healthcare professional. While self-monitoring of blood glucose is essential, changes in dose require clinical judgment that takes into account patterns of readings, diet, physical activity, other medications, and overall health status. Some patients may be given individualized written algorithms for minor adjustments, but these should be followed exactly as prescribed and reviewed regularly with the treating clinician.
Yes, many medicines and medical conditions can influence insulin requirements. Drugs such as corticosteroids, some diuretics, oral contraceptives, thyroid hormones, and certain antipsychotics may increase blood glucose and raise insulin needs. Others, including some oral antidiabetics, ACE inhibitors, salicylates, and beta-blockers, may enhance the glucose-lowering effect and increase the risk of hypoglycaemia. Illness, infection, stress, changes in kidney or liver function, and hormonal changes can also alter insulin requirements. Always inform your healthcare provider about all medicines and supplements you are taking.
Unopened Huminsulin R cartridges or vials are generally stored in a refrigerator at the temperature range specified in the product information, and should not be frozen. Once in use, they are usually kept at room temperature for a limited period as recommended by the manufacturer, away from direct heat and light. The solution should be clear and colorless; do not use it if it appears cloudy, thickened, or contains particles. Always check the expiry date and follow the storage instructions provided with the specific product you are using.
Insulin is the preferred treatment for managing diabetes during pregnancy, and regular human insulin such as Huminsulin R is commonly used when clinically appropriate. Good glycaemic control before and during pregnancy is important to reduce risks to both mother and baby. Dose requirements often change during pregnancy and after delivery, so close monitoring and frequent consultation with the healthcare team are essential. Insulin is generally considered compatible with breastfeeding, as it is a peptide that is broken down in the infant’s digestive tract and is not expected to harm the nursing infant. Individual assessment by the treating physician is still necessary.
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