huminsulin r penfill 3 ml
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HUMINSULIN R PENFILL 3 ML

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HUMINSULIN R PENFILL 3 ML

By ELI LILLY AND COMPANY INDIA PRIVATE LIMITED

MRP

515.9

₹438.52

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Product DetailsArrow

Content Reviewed By:

Dr. Amit Patel

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About HUMINSULIN R PENFILL 3 ML

  • Huminsulin R is a brand of regular human insulin used to control blood glucose levels in people with diabetes mellitus. It is a short-acting insulin preparation that helps lower blood sugar by facilitating the uptake of glucose into cells and reducing glucose production by the liver. Huminsulin R is typically used in individuals with type 1 diabetes who require lifelong insulin therapy, and in some people with type 2 diabetes when oral antidiabetic medicines alone are insufficient to achieve adequate glycaemic control. It may also be used in certain acute situations such as diabetic ketoacidosis or during surgery and severe illness, under close medical supervision. Huminsulin R is usually administered by subcutaneous injection, commonly in the abdomen, thigh, buttock, or upper arm. The injection site should be rotated to reduce the risk of lipodystrophy (local changes in fat tissue). In some clinical settings, regular human insulin may be given intravenously, but this must only be done by healthcare professionals with appropriate monitoring. The onset of action of regular insulin is typically within 30 minutes after subcutaneous injection, with peak effect around 2 to 4 hours and duration of action up to about 6 to 8 hours. Because of this profile, Huminsulin R is often given approximately 30 minutes before a meal, as directed by a physician. The dose and timing of Huminsulin R are highly individualized and must be determined by a healthcare provider based on blood glucose monitoring, diet, physical activity, and concomitant medications. Patients should not adjust their dose on their own without medical advice. Regular self-monitoring of blood glucose and, when indicated, HbA1c testing are essential to evaluate the effectiveness of therapy and to minimize the risk of both hyperglycaemia and hypoglycaemia. Common side effects of Huminsulin R include hypoglycaemia (low blood sugar), local injection site reactions such as redness, swelling, or itching, and, less commonly, lipohypertrophy or lipoatrophy at injection sites. Hypoglycaemia is the most clinically significant adverse effect and may present with symptoms such as sweating, tremor, palpitations, hunger, headache, confusion, or, in severe cases, seizures and loss of consciousness. Patients and caregivers should be educated on recognizing and treating hypoglycaemia promptly, usually with fast-acting carbohydrates, and on when to seek emergency medical help. Huminsulin R may interact with various medicines, including other antidiabetic agents, beta-blockers, corticosteroids, diuretics, and certain antidepressants, which can either increase or decrease insulin requirements. Illness, stress, changes in diet, weight, or physical activity, and hormonal changes (such as during pregnancy) can also alter insulin needs. Regular follow-up with a healthcare professional is important to review blood glucose records, adjust therapy, and address any concerns. Huminsulin R should be stored and handled according to the manufacturer’s instructions, typically refrigerated before first use and protected from extreme temperatures and direct sunlight. In-use cartridges or vials are usually kept at room temperature for a limited period as specified in the product information, to reduce injection discomfort. Patients should always check the label, appearance of the solution, and expiry date before use, and must not use the insulin if it appears cloudy, thickened, or contains particles, as regular human insulin should be clear and colorless. This medicine should only be used under medical supervision as part of a comprehensive diabetes management plan that includes diet, exercise, and regular monitoring.

Uses of HUMINSULIN R PENFILL 3 ML

  • Diabetes: This medication is used to help manage diabetes, assisting in controlling blood sugar levels and promoting a healthier lifestyle.

How HUMINSULIN R PENFILL 3 ML Works

  • HUMINSULIN R PENFILL 3 ML is a rapid-acting insulin designed to help manage blood sugar levels. As a short-acting insulin, it begins to take effect approximately 30 minutes after being injected, providing a quick response to elevated glucose levels in the bloodstream. This medication works by essentially mimicking the function of naturally produced insulin in your body. Insulin's primary role is to enable the absorption of sugar (glucose) from the blood into cells, particularly muscle and fat cells, where it can be used for energy.
  • By facilitating this reuptake of glucose, HUMINSULIN R PENFILL 3 ML helps to lower blood sugar levels. In addition to aiding glucose uptake by cells, this insulin also plays a crucial role in the liver. It actively suppresses the liver's production of sugar, further contributing to the overall reduction of glucose in the bloodstream. This dual action – promoting glucose uptake and inhibiting glucose production – makes HUMINSULIN R PENFILL 3 ML an effective tool in managing diabetes and maintaining healthy blood sugar levels throughout the day, especially around mealtimes.
  • This carefully balanced mechanism helps to prevent hyperglycemia (high blood sugar) and ensures that the body's cells receive the energy they need to function properly. Individuals using HUMINSULIN R PENFILL 3 ML should carefully follow their doctor's instructions regarding dosage and timing to achieve optimal blood sugar control.

Side Effects of HUMINSULIN R PENFILL 3 MLArrow

In most instances, side effects are temporary and diminish as your body adapts to the medication. However, if these effects persist or cause concern, it is important to seek advice from your doctor.

  • Hypoglycemia (low blood glucose level)
  • Weight gain
  • Injection site reactions (pain, swelling, redness)
  • Cold sweat
  • Anxiety
  • Shakiness
  • Hunger pangs
  • Fast heart rate
  • Headache
  • Nervousness

Safety Advice for HUMINSULIN R PENFILL 3 MLArrow

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General precautions and administration

Use under medical supervision

Huminsulin R should be used only as prescribed, with the dose and timing individualized by a healthcare professional.

Dosage of HUMINSULIN R PENFILL 3 MLArrow

  • Dosage for children: The use of HUMINSULIN R PENFILL 3 ML in children is not recommended without proper medical consultation and guidance.
  • Dosage for adults: The recommended dosage of HUMINSULIN R PENFILL 3 ML for adults is one program cycle per day, adhering to the prescribed regimen and instructions provided.

How to store HUMINSULIN R PENFILL 3 ML?Arrow

  • Keep HUMINSULIN R 100IU PENFILL 3ML away from the reach of children and pets.
  • Store HUMINSULIN R 100IU PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of HUMINSULIN R PENFILL 3 MLArrow

  • <b>Diabetes Management with HUMINSULIN R PENFILL 3 ML</b><br>HUMINSULIN R PENFILL 3 ML is a rapid-acting insulin designed to help manage blood sugar levels, typically used in conjunction with other diabetes medications. It serves as a replacement for the insulin your body should naturally produce, facilitating the movement of glucose into your muscle and fat cells, where it can be utilized for energy. Furthermore, it aids in reducing glucose production in the liver, contributing to overall blood sugar control.
  • Maintaining optimal blood sugar levels is crucial in minimizing the risk of severe diabetes-related complications, including kidney damage, vision impairment, nerve issues, and potential limb loss. Proper usage of this insulin is paramount for its effectiveness. It is important to understand the correct injection technique, the appropriate injection sites, and the ideal timing for administration.
  • For a healthy and fulfilling life, consistent and regular use of HUMINSULIN R PENFILL 3 ML is essential, alongside a balanced diet and regular physical activity. This comprehensive approach to diabetes management will help you achieve and maintain stable blood sugar levels, reducing the risk of long-term health problems and improving your overall well-being.
  • This medication starts working quickly, which allows for flexible mealtime dosing. Always follow your doctor's instructions carefully regarding dosage and timing. Regular monitoring of your blood sugar levels is crucial to ensure the medication is working effectively and to make any necessary adjustments to your treatment plan.
  • Remember to store HUMINSULIN R PENFILL 3 ML as directed by the manufacturer and your healthcare provider to maintain its effectiveness. Never share your insulin pen with others, even if they have diabetes. Used needles and syringes should be disposed of safely and responsibly, following local guidelines for sharps disposal.

How to use HUMINSULIN R PENFILL 3 MLArrow

  • Your doctor or nurse will provide detailed instructions on how to properly use HUMINSULIN R PENFILL 3 ML. It is crucial to follow their guidance precisely. They will explain the correct dosage, timing of injections, and injection technique specific to your needs. Do not adjust the dosage without consulting your healthcare provider, as this can lead to dangerous fluctuations in blood sugar levels.
  • Before each injection, carefully inspect the HUMINSULIN R PENFILL 3 ML solution. It should appear clear and colorless. Do not use the solution if it is cloudy, discolored, or contains any particles. Always use a new needle for each injection to prevent contamination and ensure proper insulin delivery. The injection site should be rotated regularly to avoid lipodystrophy (thickening or pitting of the skin).
  • Your healthcare provider will also teach you how to properly dispose of used needles and syringes. It is essential to follow safe disposal practices to prevent accidental needle sticks and the spread of infection. If you have any questions or concerns about using HUMINSULIN R PENFILL 3 ML, do not hesitate to ask your doctor or nurse for clarification. They are your best resource for ensuring safe and effective insulin therapy.

Quick Tips for HUMINSULIN R PENFILL 3 MLArrow

  • Administer HUMINSULIN R PENFILL 3 ML 20 to 30 minutes before a meal to ensure optimal blood sugar control.
  • Be vigilant for signs of hypoglycemia, a common side effect characterized by symptoms like sweating, rapid heartbeat, weakness, blurry vision, and headache. Educate yourself and your family on how to recognize and effectively manage these symptoms to prevent complications. Keep a source of fast-acting sugar readily available.
  • For quickest absorption, inject HUMINSULIN R PENFILL 3 ML into the abdomen. Absorption rates can vary depending on the injection site.
  • To prevent lipohypertrophy (hard lumps under the skin), consistently rotate injection sites. This practice ensures proper insulin absorption and maintains skin health.
  • Opened HUMINSULIN R PENFILL 3 ML vials or cartridges can be stored at room temperature for up to 4 weeks. Unopened vials should be refrigerated between 2°C and 8°C to maintain their potency and effectiveness. Always check the expiration date before use.
  • Regularly monitor your blood glucose levels as directed by your healthcare provider to ensure HUMINSULIN R PENFILL 3 ML is effectively managing your diabetes. Keep a log of your readings to share with your doctor.
  • If you experience any persistent or severe side effects, consult your doctor or pharmacist immediately. Do not adjust your dosage without professional medical advice.
  • Always use a new needle for each injection to prevent contamination and ensure proper dosage. Dispose of used needles safely in a sharps container.
  • Ensure you understand how to properly use the HUMINSULIN R PENFILL 3 ML device. If you are unsure, ask your healthcare provider for a demonstration or refer to the product instructions.
  • Carry identification indicating that you have diabetes and are taking insulin, especially when traveling.

FAQs

<h3 class=bodySemiBold>Will I need HUMINSULIN R PENFILL 3 ML for the rest of my life?</h3>Arrow

If you are a type 1 diabetes patient, then yes, you have to take HUMINSULIN R PENFILL 3 ML for the rest of your life because your body is unable to produce sufficient insulin. Therefore, you would need HUMINSULIN R PENFILL 3 ML as an external source of insulin. However, if you are a type 2 diabetes patient, sometimes your doctor may ask you to stop HUMINSULIN R PENFILL 3 ML if you are able to manage your diabetes with proper exercise, diet and oral medicines.

<h3 class=bodySemiBold>Can HUMINSULIN R PENFILL 3 ML be used with other diabetes medicine?</h3>Arrow

Yes, HUMINSULIN R PENFILL 3 ML can be used alone or in combination with other diabetes medicines like long-acting insulin or oral diabetes medicines, along with proper diet and exercise. Follow your doctor’s advice and treatment plan to get the maximum benefit.

<h3 class=bodySemiBold>How should HUMINSULIN R PENFILL 3 ML be used?</h3>Arrow

HUMINSULIN R PENFILL 3 ML is injected under the skin (subcutaneously). Your doctor will show you the area of your skin where you should inject it. Try not to inject on the same spot every time. Rotate between the typical injection sites, such as abdomen, buttocks, upper legs or upper arms. Never inject Humalog into a muscle or vein. Move to a new injection site every week or two. Inject in the same area of the body, making sure to move around within that area with each injection, for one or two weeks. You can then move to another area of your body and repeat the process. Use the same area for at least a week to avoid extreme blood sugar variations.

<h3 class=bodySemiBold>Is HUMINSULIN R PENFILL 3 ML safe to use in pregnancy?</h3>Arrow

Yes. HUMINSULIN R PENFILL 3 ML is safe to use in pregnancy if prescribed by a doctor. However, please inform your doctor if you are pregnant, planning pregnancy or breastfeeding before using HUMINSULIN R PENFILL 3 ML. You may require dose modifications and your doctor will advise you to monitor your blood sugar levels regularly. You must follow the instructions of your doctor to get maximum benefits.

<h3 class=bodySemiBold>Is HUMINSULIN R PENFILL 3 ML safe to use in type 2 diabetes?</h3>Arrow

Yes, insulin is safe to use in type 2 diabetes if used according to your doctor's advice. Keep monitoring your blood sugar levels regularly as advised. Your dosage may need to be adjusted as per your needs. Follow the lifestyle changes as advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.

<h3 class=bodySemiBold>What are the side effects of HUMINSULIN R PENFILL 3 ML? How to prevent them?</h3>Arrow

The side effects of HUMINSULIN R PENFILL 3 ML are injection site reactions such as redness, itching, pain and swelling. However, these are temporary and usually resolve on their own. Rarely, it can also cause lipodystrophy, which means abnormal changes in the fat tissues due to repeated insulin injections in the same area of the skin. It includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption. Rotate insulin injection or infusion sites within the same region to reduce the risk of lipodystrophy.

<h3 class=bodySemiBold>Can HUMINSULIN R PENFILL 3 ML cause hypoglycemia? How do I prevent it?</h3>Arrow

Yes, the most common side effect of HUMINSULIN R PENFILL 3 ML is hypoglycemia. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, do not skip meals and be consistent in the timing and amount of your meals. Take some snacks as per your requirement if you over exercise. Regular monitoring of the blood sugar level is important. Always carry some sugary candies, glucose/glucon-D or fruit juice with you. Take all the medicines prescribed by the doctor on time and consult your doctor if you notice any fluctuations in your blood sugar levels.

<h3 class=bodySemiBold>Is HUMINSULIN R PENFILL 3 ML given as an injection into a vein (intravenous)?</h3>Arrow

Yes, sometimes, in specific situations like diabetic ketoacidosis, severe hyperglycemia etc, HUMINSULIN R PENFILL 3 ML may be given as an injection into a vein (intravenous). However, in such cases, it is only given by a doctor, under continuous monitoring of blood sugar levels in a hospital setting.

<h3 class=bodySemiBold>When does the dosage of HUMINSULIN R PENFILL 3 ML need to be changed?</h3>Arrow

You should consult your doctor for dose adjustment if you experience weight gain or loss, increased stress, illness, changes in diet such as missed meals or if you are taking alcohol. Your dose may also change if you have recently changed your exercise regime or are taking any medicines. Also, you must be vigilant for certain side effects that you may experience while using HUMINSULIN R PENFILL 3 ML. Your doctor will tell you ways to prevent them. These side effects are usually temporary but if they are very severe, you may need dose modifications.

<h3 class=bodySemiBold>Does HUMINSULIN R PENFILL 3 ML need to be refrigerated?</h3>Arrow

HUMINSULIN R PENFILL 3 ML needs to be refrigerated before its first use. Unopened cartridges and unused pre-filled pens of Humalog must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use HUMINSULIN R PENFILL 3 ML if it has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain HUMINSULIN R PENFILL 3 ML.

<h3 class=bodySemiBold>What is HUMINSULIN R PENFILL 3 ML? How is it made?</h3>Arrow

HUMINSULIN R PENFILL 3 ML is a man-made version of human insulin, produced by the process of biotechnology called recombinant DNA technology. It is sold as a sterile, aqueous, clear, and colorless solution that contains insulin aspart along with other constituents like glycerin, phenol, metacresol, zinc, sodium chloride etc.

What is Huminsulin R and what is it used for?Arrow

Huminsulin R is a preparation of regular human insulin used to control high blood glucose in people with diabetes mellitus. It is a short-acting insulin that helps glucose enter cells and reduces glucose production by the liver. It is used in type 1 diabetes and in some cases of type 2 diabetes when oral medicines are not sufficient, and may also be used in acute situations such as diabetic ketoacidosis or during surgery under medical supervision.

How does Huminsulin R work in the body?Arrow

Huminsulin R works by replacing or supplementing the insulin that the body either does not produce at all or does not use effectively. After injection, it binds to insulin receptors on cells, promoting the uptake of glucose from the bloodstream into muscle and fat tissue and inhibiting glucose production by the liver. This leads to a reduction in blood glucose levels and helps maintain them within a target range when used as part of a comprehensive diabetes management plan.

When should Huminsulin R be injected in relation to meals?Arrow

Huminsulin R is a short-acting insulin that typically starts working within about 30 minutes after subcutaneous injection. It is usually administered approximately 30 minutes before a meal, as directed by a healthcare professional, so that its peak action coincides with the rise in blood glucose after eating. The exact timing may vary based on individual response and the overall insulin regimen, and should be confirmed with the treating physician.

What are the common side effects of Huminsulin R?Arrow

The most common side effect of Huminsulin R is hypoglycaemia, or low blood sugar, which may cause symptoms such as sweating, shakiness, hunger, palpitations, headache, irritability, confusion, or dizziness. Other possible side effects include local injection site reactions like redness, swelling, or itching, and changes in the fatty tissue under the skin (lipohypertrophy or lipoatrophy) if injection sites are not rotated. Allergic reactions are less common but can occur. Any persistent or severe symptoms should be discussed with a healthcare professional.

What should I do if I miss a dose of Huminsulin R?Arrow

If you miss a scheduled dose of Huminsulin R, do not inject an extra dose without medical advice. The appropriate action depends on how much time has passed, your current blood glucose level, and when you will eat next. Check your blood glucose and contact your healthcare provider or diabetes educator for individualized instructions. In general, avoid taking a double dose to make up for a missed one, as this may increase the risk of hypoglycaemia.

Can Huminsulin R cause low blood sugar and how should I manage it?Arrow

Yes, Huminsulin R can cause hypoglycaemia, especially if you inject too much insulin, delay or skip meals, exercise more than usual, or consume alcohol. If you experience symptoms of low blood sugar and are conscious, you should take fast-acting carbohydrates such as glucose tablets, sugar, or sweet juice according to your diabetes care plan, then recheck your blood glucose. If symptoms are severe, if you are unable to swallow, or if you do not improve, emergency medical help is required. Your healthcare provider may also advise that a caregiver be trained to use glucagon for severe hypoglycaemia.

Can I adjust my Huminsulin R dose on my own based on blood sugar readings?Arrow

Dose adjustments for Huminsulin R should be made under the guidance of a healthcare professional. While self-monitoring of blood glucose is essential, changes in dose require clinical judgment that takes into account patterns of readings, diet, physical activity, other medications, and overall health status. Some patients may be given individualized written algorithms for minor adjustments, but these should be followed exactly as prescribed and reviewed regularly with the treating clinician.

Are there any medicines or conditions that can affect how Huminsulin R works?Arrow

Yes, many medicines and medical conditions can influence insulin requirements. Drugs such as corticosteroids, some diuretics, oral contraceptives, thyroid hormones, and certain antipsychotics may increase blood glucose and raise insulin needs. Others, including some oral antidiabetics, ACE inhibitors, salicylates, and beta-blockers, may enhance the glucose-lowering effect and increase the risk of hypoglycaemia. Illness, infection, stress, changes in kidney or liver function, and hormonal changes can also alter insulin requirements. Always inform your healthcare provider about all medicines and supplements you are taking.

How should Huminsulin R be stored and handled?Arrow

Unopened Huminsulin R cartridges or vials are generally stored in a refrigerator at the temperature range specified in the product information, and should not be frozen. Once in use, they are usually kept at room temperature for a limited period as recommended by the manufacturer, away from direct heat and light. The solution should be clear and colorless; do not use it if it appears cloudy, thickened, or contains particles. Always check the expiry date and follow the storage instructions provided with the specific product you are using.

Can Huminsulin R be used during pregnancy and breastfeeding?Arrow

Insulin is the preferred treatment for managing diabetes during pregnancy, and regular human insulin such as Huminsulin R is commonly used when clinically appropriate. Good glycaemic control before and during pregnancy is important to reduce risks to both mother and baby. Dose requirements often change during pregnancy and after delivery, so close monitoring and frequent consultation with the healthcare team are essential. Insulin is generally considered compatible with breastfeeding, as it is a peptide that is broken down in the infant’s digestive tract and is not expected to harm the nursing infant. Individual assessment by the treating physician is still necessary.

References

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Human Insulin. Bagsvaerd, Denmark: Novo Nordisk A/S; 2012. (online) Available from:

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Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98. (online) Available from:

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Actrapid [Summary of Product Characteristics]. Bagsværd, Denmark; Novo Nordisk A/S, Novo Allé; 2007. (online) Available from:

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Humulin [Product monograph]. Toronto, Ontario; Eli Lilly Canada Inc.; 2011. (online) Available from:

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American Diabetes Association (ADA). Insulin administration (Position statement). Diabetes Care. 2004;27(Suppl 1): S106-S109. (online) Available from:

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Insulin [Package Insert]. Bengaluru, India: Biocon Biologics India Limited; 2019. (online) Available from:

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