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Content Reviewed By:
Dr. Amit Patel
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
In most cases, side effects are temporary and subside as your body adapts to the medication. However, if these effects persist or cause concern, it is important to seek medical advice. INSUGEN R PENFILL 3 ML can cause side effects.

Allergies
Contraindicated in severe allergyDo not use Insugen R if you have a known severe allergy to human insulin or any component of the formulation.
If you are a type 1 diabetes patient, then yes, you have to take INSUGEN R PENFILL 3 ML for the rest of your life because your body is unable to produce sufficient insulin. Therefore, you would need INSUGEN R PENFILL 3 ML as an external source of insulin. However, if you are a type 2 diabetes patient, sometimes your doctor may ask you to stop INSUGEN R PENFILL 3 ML if you are able to manage your diabetes with proper exercise, diet and oral medicines.
Yes, INSUGEN R PENFILL 3 ML can be used alone or in combination with other diabetes medicines like long-acting insulin or oral diabetes medicines, along with proper diet and exercise. Follow your doctor’s advice and treatment plan to get the maximum benefit.
INSUGEN R PENFILL 3 ML is injected under the skin (subcutaneously). Your doctor will show you the area of your skin where you should inject it. Try not to inject on the same spot every time. Rotate between the typical injection sites, such as abdomen, buttocks, upper legs or upper arms. Never inject INSUGEN R PENFILL 3 ML into a muscle or vein. Move to a new injection site every week or two. Inject in the same area of the body, making sure to move around within that area with each injection, for one or two weeks. You can then move to another area of your body and repeat the process. Use the same area for at least a week to avoid extreme blood sugar variations.
Yes. INSUGEN R PENFILL 3 ML is safe to use in pregnancy if prescribed by a doctor. However, please inform your doctor if you are pregnant, planning pregnancy or breastfeeding before using INSUGEN R PENFILL 3 ML. You may require dose modifications and your doctor will advise you to monitor your blood sugar levels regularly. You must follow the instructions of your doctor to get maximum benefits.
Yes, insulin is safe to use in type 2 diabetes if used according to your doctor's advice. Keep monitoring your blood sugar levels regularly as advised. Your dosage may need to be adjusted as per your needs. Follow the lifestyle changes as advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.
The side effects of INSUGEN R PENFILL 3 ML are injection site reactions such as redness, itching, pain and swelling. However, these are temporary and usually resolve on their own. Rarely, it can also cause lipodystrophy, which means abnormal changes in the fat tissues due to repeated insulin injections in the same area of the skin. It includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption. Rotate insulin injection or infusion sites within the same region to reduce the risk of lipodystrophy.
Yes, the most common side effect of INSUGEN R PENFILL 3 ML is hypoglycemia. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, do not skip meals and be consistent in the timing and amount of your meals. Take some snacks as per your requirement if you over exercise. Regular monitoring of the blood sugar level is important. Always carry some sugary candies, glucose/glucon-D or fruit juice with you. Take all the medicines prescribed by the doctor on time and consult your doctor if you notice any fluctuations in your blood sugar levels.
Yes, sometimes, in specific situations like diabetic ketoacidosis, severe hyperglycemia etc, INSUGEN R PENFILL 3 ML may be given as an injection into a vein (intravenous). However, in such cases, it is only given by a doctor, under continuous monitoring of blood sugar levels in a hospital setting.
You should consult your doctor for dose adjustment if you experience weight gain or loss, increased stress, illness, changes in diet such as missed meals or if you are taking alcohol. Your dose may also change if you have recently changed your exercise regime or are taking any medicines. Also, you must be vigilant for certain side effects that you may experience while using INSUGEN R PENFILL 3 ML. Your doctor will tell you ways to prevent them. These side effects are usually temporary but if they are very severe, you may need dose modifications.
INSUGEN R PENFILL 3 ML needs to be refrigerated before its first use. Unopened cartridges and unused pre-filled pens of Humalog must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use INSUGEN R PENFILL 3 ML if it has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain INSUGEN R PENFILL 3 ML.
INSUGEN R PENFILL 3 ML is a man-made version of human insulin, produced by the process of biotechnology called recombinant DNA technology. It is sold as a sterile, aqueous, clear, and colorless solution that contains insulin aspart along with other constituents like glycerin, phenol, metacresol, zinc, sodium chloride etc.
Insugen R is a short-acting human insulin preparation used to control blood glucose levels in people with diabetes mellitus, including type 1 and type 2 diabetes, when insulin therapy is required. It helps lower blood sugar by facilitating the uptake of glucose into cells and reducing glucose production by the liver. It is usually given by subcutaneous injection and is often used around meal times as part of a comprehensive diabetes management plan prescribed by a healthcare professional.
Insugen R contains regular human insulin, which mimics the action of natural insulin produced by the pancreas. After injection, it binds to insulin receptors on cells, especially in muscle and fat tissue, promoting the uptake of glucose from the bloodstream into these cells for energy or storage. It also reduces glucose production by the liver. This combined effect lowers blood glucose levels and helps maintain them within the target range set by the treating physician.
The timing of Insugen R injections in relation to meals must be individualized and decided by a healthcare professional. Regular human insulin is generally administered shortly before a meal to control the post-meal rise in blood sugar, but the exact timing can vary depending on your blood glucose pattern, meal composition, and your doctor’s instructions. You should not change the timing of your injections on your own; always follow the schedule recommended by your diabetes care team.
Yes, Insugen R can be used in patients with liver disease, but it must be used with caution and under close medical supervision. Liver impairment can affect how your body processes insulin and glucose, which may change your insulin requirements and increase the risk of both low and high blood sugar. Dose adjustments may be necessary, and more frequent blood glucose monitoring is usually recommended. Any changes in liver function or medications affecting the liver should be promptly discussed with your doctor.
Insugen R can be used in patients with kidney impairment, but careful monitoring is essential. Reduced kidney function can decrease insulin clearance from the body, potentially increasing the risk of hypoglycemia. Your doctor may need to adjust your insulin dose and may recommend more frequent blood glucose checks. If your kidney function changes over time, your insulin requirements may also change, so regular follow-up with your healthcare provider is important.
Human insulin, including preparations like Insugen R, is commonly used to manage diabetes during pregnancy when insulin therapy is indicated. Good blood glucose control before and during pregnancy is important for the health of both mother and baby. However, insulin requirements often change throughout pregnancy and after delivery, so close medical supervision, frequent blood glucose monitoring, and regular dose adjustments by your doctor are essential. Do not start, stop, or change your insulin regimen during pregnancy without consulting your obstetrician and diabetes specialist.
Insugen R is generally considered safe to use while breastfeeding when prescribed by a healthcare professional. Human insulin is a natural hormone, and only very small amounts, if any, are expected to pass into breast milk and be absorbed by the infant. However, your insulin needs may change after delivery and during breastfeeding, so your doctor may adjust your dose. Regular blood glucose monitoring and follow-up with your healthcare provider are important during this period.
You can usually drive or operate machinery while using Insugen R, provided your blood glucose is well controlled and you are able to recognize and manage symptoms of low blood sugar. Hypoglycemia can impair concentration, reaction time, and judgment, which may make driving or operating machinery dangerous. Always carry a source of fast-acting carbohydrate, monitor your blood glucose as advised, and avoid driving if you have frequent hypoglycemic episodes, reduced awareness of hypoglycemia, or if your doctor has advised against it.
Alcohol can affect blood glucose levels and may increase the risk of hypoglycemia, especially in people using insulin such as Insugen R. If your doctor allows you to drink alcohol, do so in moderation, never on an empty stomach, and monitor your blood glucose more frequently. Be aware that the symptoms of hypoglycemia can be confused with the effects of alcohol. Discuss alcohol use with your healthcare provider so that you understand the risks and any necessary precautions.
If you have a known allergy to human insulin or any component of Insugen R, you must inform your doctor before starting treatment. Signs of an allergic reaction can include redness, swelling, or itching at the injection site, rash, difficulty breathing, wheezing, or swelling of the face, lips, tongue, or throat. Local injection site reactions are relatively common and often mild, but severe or generalized allergic reactions require urgent medical attention. Your doctor will decide whether Insugen R is appropriate for you or if an alternative treatment is needed.
The most common side effect of Insugen R, as with all insulin preparations, is hypoglycemia (low blood sugar). Symptoms may include sweating, trembling, hunger, palpitations, headache, dizziness, irritability, or confusion. Severe hypoglycemia can lead to loss of consciousness or seizures and is a medical emergency. Other possible side effects include injection site reactions such as pain, redness, or swelling, and, rarely, changes in fat tissue at the injection site (lipodystrophy) if the same site is used repeatedly. To reduce risks, follow your doctor’s instructions on dosing, meal planning, and physical activity, rotate injection sites, and monitor your blood glucose regularly. Always carry a source of fast-acting carbohydrate and inform those close to you about how to help in case of severe hypoglycemia.
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BIOCON BIOPHARMACEUTICALS PRIVATE LIMITED
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India

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