ISTAMET G IR 50/1/1000MG TABLET 10'S

How ISTAMET G IR 50/1/1000MG TABLET 10'S Works

• ISTAMET G IR 50/1/1000MG TABLET 10'S is a combination medication designed to manage type 2 diabetes effectively. It combines three active ingredients: Sitagliptin, Metformin Hydrochloride, and Glimepiride, each working through different mechanisms to lower blood glucose levels.
• Sitagliptin belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). DPP-4 inhibitors work by increasing the amount of incretin hormones released in the body. Incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), are naturally produced in the intestine and released in response to food intake. These hormones have several important functions. They stimulate the pancreas to release insulin when blood sugar levels are high, helping to lower blood sugar after meals. They also reduce the amount of glucagon produced by the pancreas. Glucagon is a hormone that raises blood sugar levels by telling the liver to release stored glucose. By increasing incretin levels, Sitagliptin enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner, meaning it works best when blood sugar is elevated, reducing the risk of hypoglycemia (low blood sugar).
• Metformin Hydrochloride is a biguanide that primarily works by decreasing glucose production in the liver. The liver is a major source of glucose in the body, and in people with type 2 diabetes, the liver often produces too much glucose. Metformin reduces hepatic glucose production by inhibiting gluconeogenesis (the process of making glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, Metformin improves insulin sensitivity in peripheral tissues such as muscle and fat. This means that the body's cells are more responsive to insulin, allowing them to take up glucose from the bloodstream more effectively. Metformin may also slow down the absorption of glucose from the intestines after a meal. Unlike some other diabetes medications, Metformin does not stimulate insulin secretion, so it does not usually cause hypoglycemia when used alone. However, when combined with other drugs like sulfonylureas (such as Glimepiride) or insulin, the risk of hypoglycemia may increase.
• Glimepiride is a sulfonylurea that works by stimulating the pancreas to release more insulin. Sulfonylureas bind to receptors on the surface of pancreatic beta cells, which are the cells responsible for producing and releasing insulin. This binding triggers a cascade of events that leads to the opening of calcium channels and the influx of calcium into the beta cells. The increased calcium levels stimulate the release of insulin. Glimepiride is considered a second-generation sulfonylurea, which means it is more potent and has a longer duration of action compared to older sulfonylureas. While Glimepiride is effective at lowering blood sugar, it carries a higher risk of hypoglycemia compared to Metformin or Sitagliptin, especially if meals are skipped or if it is used in combination with other medications that lower blood sugar. The combination of Sitagliptin, Metformin, and Glimepiride in ISTAMET G IR 50/1/1000MG TABLET 10'S provides a comprehensive approach to managing blood sugar levels in people with type 2 diabetes. By targeting different pathways involved in glucose metabolism, this medication helps to improve glycemic control and reduce the risk of diabetes-related complications. It is important to take this medication exactly as prescribed by your doctor and to follow a healthy diet and exercise plan to maximize its benefits.
• In summary, ISTAMET G IR combines Sitagliptin to enhance insulin release and suppress glucagon, Metformin to reduce liver glucose production and improve insulin sensitivity, and Glimepiride to directly stimulate insulin release from the pancreas. This triple-action approach provides comprehensive glycemic control for individuals with type 2 diabetes.

The following side effects may occur while using ISTAMET G IR 50/1/1000MG TABLET 10'S: * **Common Side Effects:** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Metallic taste * Headache * Dizziness * Weakness * Hypoglycemia (low blood sugar), especially when used with other diabetes medications * **Uncommon Side Effects:** * Rash * Itching * Urticaria (hives) * Constipation * Flatulence * Heartburn * Upper respiratory tract infection * Back pain * Joint pain * Anemia * **Rare Side Effects:** * Lactic acidosis (symptoms include: feeling very weak, tired or uncomfortable; unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, feeling cold, dizziness or lightheadedness, and slow or irregular heartbeat) * Vitamin B12 deficiency * Abnormal liver function tests * Severe allergic reactions (anaphylaxis) * Pancreatitis * Stevens-Johnson Syndrome (a severe skin reaction) * Decreased white blood cell count * Decreased platelet count

• If you miss a dose of ISTAMET G IR 50/1/1000MG TABLET 10'S, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep ISTAMET G IR 50/1000/1MG TAB 1X10 away from the reach of children and pets.
• Store ISTAMET G IR 50/1000/1MG TAB 1X10 at room temperature.

• Take ISTAMET G IR 50/1/1000MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medicine without consulting your healthcare provider. Consistent adherence to the prescribed regimen is crucial for effective blood sugar control. For optimal absorption, take this medication with food.
• Monitor your blood sugar levels regularly as directed by your doctor or diabetes educator. Keeping a log of your blood sugar readings can help you and your doctor assess how well the medication is working and make necessary adjustments to your treatment plan. Regular monitoring helps in early detection of hypo or hyperglycemia.
• Be aware of the symptoms of hypoglycemia (low blood sugar), such as shakiness, sweating, rapid heartbeat, blurred vision, and confusion. Carry a source of fast-acting sugar, like glucose tablets or fruit juice, with you at all times to treat hypoglycemia promptly. Inform your family and friends about how to recognize and treat hypoglycemia.
• Inform your doctor about all other medications, supplements, and herbal products you are taking. Some medications can interact with ISTAMET G IR 50/1/1000MG TABLET 10'S, potentially affecting its efficacy or increasing the risk of side effects. This includes over-the-counter drugs as well. Always maintain an updated list of all medicines.
• Maintain a healthy lifestyle by following a balanced diet and engaging in regular physical activity. A healthy diet, rich in fiber and low in processed sugars, along with regular exercise, can significantly improve blood sugar control and overall health. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Weight management through diet and exercise further enhances the medicine effectiveness.
• Stay hydrated by drinking plenty of water throughout the day. Adequate hydration is important for overall health and can also help prevent certain side effects associated with ISTAMET G IR 50/1/1000MG TABLET 10'S. It also aids in kidney function and helps in flushing out excess glucose.
• Attend all scheduled appointments with your doctor and diabetes educator. Regular check-ups are essential for monitoring your progress, adjusting your treatment plan as needed, and addressing any concerns or questions you may have. These appointments also include periodic assessment of kidney and liver function.
• Store ISTAMET G IR 50/1/1000MG TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Proper storage helps maintain the medication's effectiveness. Keep out of reach of children.
• Be cautious while driving or operating heavy machinery, especially when starting this medication or after a dosage change. ISTAMET G IR 50/1/1000MG TABLET 10'S can sometimes cause dizziness or low blood sugar, which can impair your ability to perform these activities safely. If you experience any such symptoms, avoid driving or operating machinery.
• Report any unusual side effects or concerns to your doctor promptly. While ISTAMET G IR 50/1/1000MG TABLET 10'S is generally safe and effective, some individuals may experience side effects. Prompt reporting allows your doctor to assess the situation and make appropriate adjustments to your treatment.

• ISTAMET G IR 50/1/1000MG TABLET 10'S can be taken with or without food, but it is generally recommended to take it with meals to reduce the risk of gastrointestinal side effects like nausea, vomiting, or diarrhea. Consistent timing with meals can also help maintain stable blood sugar levels. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of hypoglycemia (low blood sugar).