MEXATE 5MG TABLET 10'S
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MEXATE 5MG TABLET 10'S
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MEXATE 5MG TABLET 10'S

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MEXATE 5MG TABLET 10'S

By ZYDUS LIFESCIENCES LIMITED

MRP

97.52

₹82.89

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Product DetailsArrow

About MEXATE 5MG TABLET 10'S

  • MEXATE 5MG TABLET 10'S is a medication prescribed for the treatment of various cancers affecting different parts of the body, including the breasts, head, neck, lungs, blood, bone, lymph nodes, and uterus. It is also utilized in the management of rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease. This versatile medication can be administered independently or in conjunction with other drugs, depending on the specific condition and the doctor's recommendations.
  • It is crucial to adhere strictly to your doctor's instructions regarding the dosage and administration of MEXATE 5MG TABLET 10'S. Exceeding the prescribed dose can lead to serious and potentially harmful side effects. While the therapeutic benefits may not be immediately apparent, it is essential to continue taking the medication as directed, even if it takes several weeks or months to experience noticeable improvements. Discontinuation of the medication should only occur under the guidance and explicit instructions of your healthcare provider. Furthermore, it is strongly advised to abstain from alcohol consumption while taking this medicine, as it can significantly increase the risk of liver damage.
  • Common side effects associated with MEXATE 5MG TABLET 10'S include ulcerative stomatitis (mouth sores), hair loss, low blood cell count, elevated liver enzymes, nausea, and abdominal discomfort. To mitigate some of these side effects, your doctor may recommend folic acid supplementation. If these side effects persist or worsen, it is imperative to promptly inform your doctor. They can provide strategies for preventing or reducing these effects. This medicine can also compromise your body's ability to fight infections and may lead to complications affecting the blood, liver, or kidneys. Regular monitoring through blood tests, X-rays, and physical examinations may be conducted before and during treatment to assess for any potential issues.
  • Before initiating treatment with MEXATE 5MG TABLET 10'S, it is essential to inform your doctor about any pre-existing conditions or medical history, particularly concerning stomach, liver, or kidney problems. Additionally, disclose all medications you are currently taking, including those for treating infections. The interaction between MEXATE 5MG TABLET 10'S and other medications can be complex, so it is crucial to provide a comprehensive list to your healthcare team. This medication is generally not recommended for use during pregnancy or breastfeeding due to the potential risks to the developing baby.

Uses of MEXATE 5MG TABLET 10'S

  • Treatment of Cancer
  • Treatment of Rheumatoid arthritis
  • Treatment of Psoriasis
  • Treatment of Crohn’s disease

How MEXATE 5MG TABLET 10'S Works

  • MEXATE 5MG TABLET 10'S works by inhibiting an enzyme called dihydrofolate reductase. This enzyme is crucial for cell division and growth, so by blocking it, MEXATE 5MG TABLET 10'S effectively prevents cells from multiplying rapidly. This action also contributes to its anti-inflammatory effects.
  • In the context of cancer treatment, MEXATE 5MG TABLET 10'S stops cancer cells from producing DNA. Since DNA is essential for cell survival and replication, this action leads to the death of cancer cells. This makes MEXATE 5MG TABLET 10'S a valuable tool in chemotherapy regimens for certain types of cancer.
  • For individuals with psoriasis, MEXATE 5MG TABLET 10'S helps to manage the condition by slowing down the overproduction of skin cells, which is a hallmark of psoriasis. Additionally, it reduces inflammation in the affected areas, alleviating symptoms like redness, itching, and scaling. By targeting both cell production and inflammation, MEXATE 5MG TABLET 10'S offers comprehensive relief.
  • In treating rheumatoid arthritis and Crohn's disease, MEXATE 5MG TABLET 10'S acts as an immunosuppressant. It suppresses the immune system, preventing it from mistakenly attacking the body's own cells. This is particularly beneficial in rheumatoid arthritis, where the immune system targets the joints, causing inflammation, swelling, and stiffness. Similarly, in Crohn's disease, it reduces inflammation in the bowel, thereby alleviating the associated symptoms and preventing damage.

Side Effects of MEXATE 5MG TABLET 10'SArrow

Most side effects are temporary and generally disappear as your body adapts to the medication. However, if any side effects persist or cause concern, it is important to consult your doctor.

  • Ulcerative stomatitis
  • Nausea
  • Abdominal pain
  • Increased liver enzymes
  • Hair loss
  • Decreased blood cells (red cells, white cells, and platelets)

Safety Advice for MEXATE 5MG TABLET 10'SArrow

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Liver Function

Caution

MEXATE 5MG TABLET 10'S should be used with caution in patients with liver disease. Dose adjustment of MEXATE 5MG TABLET 10'S may be needed. Please consult your doctor.

Dosage of MEXATE 5MG TABLET 10'SArrow

  • For Children: The dosage for children is based on their body surface area (BSA) or weight. Typically, the starting dose ranges from 10 to 20 mg/m² per week, divided into several smaller doses. The dosage may be adjusted based on the child's response to treatment and any potential side effects.
  • For Adults: For adults, the dosage of MEXATE 5MG TABLET 10'S can vary depending on the condition being treated. For certain cancers, the typical starting dose ranges from 10 to 25 mg/m² per week, divided into several smaller doses. In the case of rheumatoid arthritis, the initial dosage is often lower, usually starting with 7.5 mg per week, which may be increased gradually.

How to store MEXATE 5MG TABLET 10'S?Arrow

  • Keep MEXATE 5MG TAB 1X10 away from the reach of children and pets.
  • Store MEXATE 5MG TAB 1X10 at room temperature.

Benefits of MEXATE 5MG TABLET 10'SArrow

  • **Treatment of Cancer:** MEXATE 5MG TABLET 10'S works by inhibiting the growth of cancer cells. It's prescribed for various cancers, including acute leukemias, non-Hodgkin’s lymphoma, and solid tumors in the breast, lung, bladder, head, neck, cervix, ovaries, and testicles. It can be used alone or with other medications. It is important to consult your doctor about the potential risks and benefits of this strong medication. Avoid alcohol during treatment and stay hydrated by drinking plenty of water. Regular monitoring and dosage adjustments are essential for managing side effects and ensuring treatment effectiveness. Follow your doctor's instructions carefully.
  • **Treatment of Rheumatoid Arthritis:** MEXATE 5MG TABLET 10'S is an antimetabolite used for severe rheumatoid arthritis when other treatments haven't been effective. It's not a first-line treatment. It reduces the body's immune system, alleviating swelling, pain, and stiffness, thus improving joint function. Take it exactly as prescribed for optimal benefit. Do not exceed the recommended dose. It may take several months to see full results, requiring patience and consistent adherence to the treatment plan. Regular check-ups are necessary to monitor its effectiveness and adjust the dosage if needed.
  • **Treatment of Psoriasis:** MEXATE 5MG TABLET 10'S, an antimetabolite, treats severe psoriasis when other treatments fail. Psoriasis causes rapid skin cell growth, and MEXATE 5MG TABLET 10'S slows this down. Consult your doctor about the risks and benefits of this potent medicine. Take it exactly as prescribed for the best outcome and don't take more than you should. It may take several months to work fully. Avoid alcohol and drink plenty of water. It's crucial to follow your doctor's guidance and report any side effects promptly. Consistent monitoring is important to manage the condition effectively.
  • **Treatment of Crohn’s Disease:** Crohn’s disease is a chronic inflammatory condition of the intestines, characterized by diarrhea and abdominal pain. MEXATE 5MG TABLET 10'S reduces inflammation, relieves symptoms, and prevents recurrence. Regular monitoring by your doctor is important to assess the effectiveness of the treatment and manage any potential side effects. Lifestyle adjustments, such as dietary changes, may also be recommended to help manage the condition alongside medication.

How to use MEXATE 5MG TABLET 10'SArrow

  • Always adhere to your doctor's instructions regarding the dosage and duration of MEXATE 5MG TABLET 10'S. It's crucial to take this medication precisely as prescribed to achieve the best possible outcome and minimize the risk of side effects. Avoid altering the dosage or frequency of administration without consulting your healthcare provider.
  • Swallow the tablet whole with a glass of water. Avoid chewing, crushing, or breaking it, as this can affect how the medication is absorbed into your system. If you have difficulty swallowing pills, discuss this with your doctor or pharmacist; they may be able to offer alternative formulations or techniques to make it easier.
  • MEXATE 5MG TABLET 10'S can be taken either with or without food. However, for optimal results and to maintain a consistent level of the medication in your body, it's best to take it at a fixed time each day. Choose a time that easily fits into your daily routine, such as morning or evening, and stick to it as closely as possible.
  • If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you have any concerns about missed doses, consult your doctor or pharmacist.
  • Continue taking MEXATE 5MG TABLET 10'S for the full duration prescribed by your doctor, even if you start to feel better. Stopping the medication prematurely may lead to a relapse of your condition.

Quick Tips for MEXATE 5MG TABLET 10'SArrow

  • Stay well-hydrated by drinking plenty of fluids while taking MEXATE 5MG TABLET 10'S. Adequate hydration can help minimize potential side effects and support overall well-being during your treatment.
  • If your doctor recommends it, take folic acid supplements. Folic acid can help reduce some of the side effects associated with MEXATE 5MG TABLET 10'S, making your treatment more comfortable.
  • It's important to be patient, as MEXATE 5MG TABLET 10'S may take several weeks or even months to show its full effects. Continue taking the medication exactly as prescribed by your doctor, even if you don't notice immediate improvement. Consistency is key to achieving the best results.
  • Your doctor may order regular blood tests to monitor your kidney function, liver function, and blood cell levels while you are taking MEXATE 5MG TABLET 10'S. These tests help ensure your safety and allow your doctor to adjust your treatment plan if necessary.
  • Avoid consuming alcohol while taking MEXATE 5MG TABLET 10'S, as it can increase the risk of side effects and potentially interfere with the medication's effectiveness. Limiting alcohol intake will help you minimize any unwanted complications.
  • MEXATE 5MG TABLET 10'S can be harmful to an unborn baby. If you are a woman of childbearing age, use effective contraception to avoid pregnancy during treatment and for at least 6 months after your last dose. Discuss your family planning goals with your doctor.
  • In addition to these tips, maintain a healthy lifestyle, including a balanced diet and regular exercise, to support your overall health and well-being during your treatment with MEXATE 5MG TABLET 10'S. Always consult with your doctor or pharmacist if you have any concerns or questions about your medication.

FAQs

Can MEXATE 5MG TABLET 10'S cause mouth ulcers?Arrow

Yes, MEXATE 5MG TABLET 10'S can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.

Why do I have to take folic acid with MEXATE 5MG TABLET 10'S?Arrow

Folic acid is required to make new cells in the body and MEXATE 5MG TABLET 10'S decreases the folic acid levels in the body. Folic acid can help reduce some of the common side effects of MEXATE 5MG TABLET 10'S such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems.

Why do I need to take regular blood tests while taking MEXATE 5MG TABLET 10'S?Arrow

Regular blood tests will help your doctor to check your response to MEXATE 5MG TABLET 10'S and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also order additional tests depending on the results.

Can MEXATE 5MG TABLET 10'S use make me more prone to infections?Arrow

MEXATE 5MG TABLET 10'S may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports which suggest occurrence of serious lung infections with MEXATE 5MG TABLET 10'S use. If you have an active infection, MEXATE 5MG TABLET 10'S should be used with extreme caution.

Can MEXATE 5MG TABLET 10'S affect fertility?Arrow

Yes, MEXATE 5MG TABLET 10'S may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry, these effects are reversible and disappear once the therapy is discontinued.

What to do if I am planning to become pregnant and my husband is taking MEXATE 5MG TABLET 10'S?Arrow

You should avoid pregnancy if your husband is taking MEXATE 5MG TABLET 10'S. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.

References

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Methotrexate [Prescribing Information]. Eatontown, NJ: West-Ward Pharmaceuticals Corp.; 2020. (online) Available from:

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Methotrexate [Product Label]. New York, NY: Pfizer Inc.; 2022. (online) Available from:

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Methotrexate [Drug Label]. Sandton, South Africa: Pfizer Laboratories (Pty) Ltd.; 2022 (online) Available from:

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Walfish AE, Companioni RA. Drugs for Inflammatory Bowel Disease. [Updated Sep. 2022]. (online) Available from:

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Crohn's & Colitis, UK. Methotrexate [Information Sheet]. (online) Available from:

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CiplaMed. Methotrexate [Prescribing Information]. [Last Reviewed: Feb 2019]. (online) Available from:

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