NEVELOL AM TABLET 10'S

How NEVELOL AM TABLET 10'S Works

• NEVELOL AM TABLET 10'S is a combination medication designed to manage hypertension (high blood pressure) effectively. It combines two active ingredients: Nebivolol and Amlodipine, each working through different mechanisms to lower blood pressure and protect the cardiovascular system.
• Nebivolol is a beta-blocker with a unique mechanism of action. Unlike traditional beta-blockers, Nebivolol selectively blocks beta-1 adrenergic receptors in the heart. This selectivity reduces heart rate and force of contraction, lowering cardiac output and blood pressure. Additionally, Nebivolol stimulates the release of nitric oxide (NO) from the cells lining blood vessels (endothelium). Nitric oxide is a potent vasodilator, meaning it widens blood vessels, further reducing blood pressure and improving blood flow. This dual action of reducing cardiac output and increasing vasodilation makes Nebivolol particularly effective in managing hypertension and improving overall cardiovascular function. Furthermore, the nitric oxide component offers additional benefits such as protecting the endothelium and improving blood vessel health.
• Amlodipine, on the other hand, is a calcium channel blocker. It works by blocking the entry of calcium into the smooth muscle cells of blood vessels and heart muscle. By reducing calcium influx into vascular smooth muscle, Amlodipine causes these muscles to relax, leading to vasodilation and a decrease in blood pressure. In the heart, Amlodipine's action reduces the force of contraction and lowers the heart's oxygen demand. This is particularly beneficial in patients with angina (chest pain) as it helps to reduce the frequency and severity of angina attacks. The combined effect of vasodilation and reduced cardiac workload contributes significantly to Amlodipine's efficacy in treating hypertension and preventing cardiovascular events.
• When Nebivolol and Amlodipine are combined in NEVELOL AM TABLET 10'S, they provide complementary mechanisms to control blood pressure. Nebivolol reduces cardiac output and increases vasodilation through nitric oxide release, while Amlodipine directly relaxes blood vessels by blocking calcium channels. This synergistic action results in more effective blood pressure control compared to using either medication alone. The combination helps to achieve target blood pressure levels, reducing the risk of serious complications such as heart attack, stroke, kidney damage, and other cardiovascular diseases.
• In summary, NEVELOL AM TABLET 10'S works by combining the beta-1 receptor blocking and nitric oxide enhancing effects of Nebivolol with the calcium channel blocking action of Amlodipine. This dual mechanism effectively lowers blood pressure, reduces cardiac workload, improves blood vessel function, and protects against cardiovascular events, making it a valuable treatment option for individuals with hypertension.

Common side effects of NEVELOL AM Tablet may include headache, dizziness, fatigue, sleepiness, palpitations, nausea, flushing (sense of warmth in the face, ears, neck and trunk), ankle swelling, constipation and abdominal pain. Uncommon side effects include: slow heart rate, low blood pressure, difficulty breathing (bronchospasm), leg pain, asthenia (weakness), limb discomfort, impotence (inability to maintain erection), dyspnea (shortness of breath), dyspepsia (indigestion), vomiting, rhinitis (stuffy nose), diarrhea, depression, visual disturbances, muscle cramps, pruritus (itching), rash, increased sweating, and worsening of psoriasis. Rare side effects include: nightmares, fainting, confusion. Very rare side effects include: a skin disease involving scaling (psoriasis), Raynaud's phenomenon (numbness and paleness in fingers and toes), dry eyes and hair loss. Other side effects may include: Allergic reaction, Angioedema, Increased blood sugar, Increased cholesterol, Joint pain, Muscle pain, Weight gain.

• If you miss a dose of NEVELOL AM TABLET, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep NEVELOL AM TAB 1X10 away from the reach of children and pets.
• Store NEVELOL AM TAB 1X10 at room temperature.

• Take NEVELOL AM TABLET 10'S exactly as prescribed by your doctor. Do not change the dose or stop taking the medication without consulting your physician, as this can lead to serious heart problems.
• NEVELOL AM TABLET 10'S is typically taken once daily. It's best to take it at the same time each day to maintain a consistent level of medication in your body. This helps in managing your blood pressure and heart rate effectively.
• Monitor your blood pressure and heart rate regularly while taking NEVELOL AM TABLET 10'S. Keep a record of your readings and share them with your doctor during your check-ups. This will help your doctor to adjust your dosage if needed.
• Be aware of potential side effects, such as dizziness, fatigue, or swelling in your ankles or feet. If you experience any bothersome or persistent side effects, contact your doctor immediately for guidance.
• Avoid consuming large amounts of grapefruit or grapefruit juice while taking NEVELOL AM TABLET 10'S, as it can interact with the medication and increase the risk of side effects. Also, inform your doctor about all other medications, supplements, and herbal products you are taking to prevent any potential drug interactions.

• NEVELOL AM TABLET 10'S can be taken with or without food, but it is important to take it at the same time each day.
• Avoid consuming high amounts of potassium-rich foods (e.g., bananas, spinach) as this medication can affect potassium levels.
• Grapefruit and grapefruit juice may interact with amlodipine, potentially increasing the drug's levels in your blood. Discuss with your doctor whether it's safe for you to consume grapefruit products while taking this medication.
• If you experience stomach upset, taking it with food may help.