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Composition
Content Reviewed By:
Dr. Sanjay Mehta
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

General Safety and Monitoring
Use under medical supervisionBefore starting Nogacid, alarm features such as unintentional weight loss, recurrent vomiting, dysphagia, gastrointestinal bleeding, or anemia should be evaluated, as they may indicate serious underlying disease requiring further investigation.
This medicine can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and NOGACID 20MG CAPSULE 15'S decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
You should not take it if you are taking a medicine containing atazanavir and nelfinavir (used for HIV infection). Let your doctor know if you are suffering from any liver problems, persistent diarrhea or vomiting, black stools (blood-stained stools), unusual weight loss, trouble swallowing, stomach pain or indigestion. Tell your doctor about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you have or ever had an allergic skin reaction with this medicine. It should not be given to children who are less than 1 year of age or whose body weight is less than 10 kgs. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine to avoid harmful effects on the baby.
Yes, it may cause diarrhea as a side effect in some people. This is usually not bothersome, but if you experience persistent watery stools that do not go away, along with stomach cramps and fever, get medical help immediately.
Take it for as long as advised by your doctor. The duration may vary depending on your condition. Do not stop taking this medicine without talking to your doctor.
It can cause osteoporosis (thinning of bones) as it decreases the calcium absorption leading to calcium deficiency. This leads to an increased risk of bone fractures on long-term use, like hip, wrist or spine fractures. Inform your doctor if you have osteoporosis or if you are taking corticosteroids (these can increase the risk of osteoporosis) before starting your therapy. Consult your doctor on ways to prevent this. Your doctor may advise you calcium or vitamin D supplements to reduce the risk.
If used for more than 3 months, certain long term side effects may be seen. The most important of these is low magnesium levels in your blood which may make you feel tired, confused, dizzy, shaky, or dizzy. You may also have muscle twitches or irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures (due to decreased calcium levels in the blood), especially hip, wrist, or spine, stomach infections, and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally, you may also have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas), or nerve problems such as numbness, tingling, and problem in walking.
It may cause vitamin B12 and vitamin C deficiency. When taken orally, vitamin B12 requires an acidic environment for its absorption from the stomach while this medicine causes a decrease in gastric acid secretion. You may need to take vitamin B12 supplements along with it. The clinical significance of the decrease in vitamin C levels is not known, so vitamin C supplementation is not recommended.
Patients with cardiac disease can take this medicine as prescribed by the doctor. However, it can interact with certain drugs (e.g clopidogrel, digoxin) which might be used by a patient with an underlying cardiac disease. Patients taking these medicines together need to be monitored closely by a doctor.
Nogacid tablet, containing omeprazole, is mainly used to treat acid‑related disorders such as gastroesophageal reflux disease (GERD), erosive esophagitis, gastric and duodenal ulcers, and conditions with excessive acid production like Zollinger–Ellison syndrome. It may also be used, in combination with antibiotics, to treat Helicobacter pylori–associated peptic ulcers and to prevent NSAID‑associated gastric damage in high‑risk patients, as decided by a doctor.
Nogacid contains omeprazole, a proton pump inhibitor. It selectively blocks the H+/K+ ATPase enzyme (proton pump) in the gastric parietal cells, which is the final step in acid secretion. By inhibiting this pump, Nogacid significantly reduces both basal and stimulated gastric acid production, thereby relieving symptoms of acid reflux and allowing healing of ulcers and erosive lesions in the stomach and esophagus.
No, Nogacid is not a simple antacid. Antacids neutralize existing stomach acid and provide short‑term, rapid relief. Nogacid is a proton pump inhibitor that reduces the production of acid at its source. Its onset of action is slower, and it is intended for regular use over a prescribed period to control acid secretion and promote healing, rather than for immediate relief of occasional heartburn.
Some people may notice improvement in heartburn and acid reflux symptoms within a few days of starting Nogacid, but maximum benefit often occurs after several days to 1–2 weeks of continuous use. Ulcer healing typically requires a longer course, as advised by the doctor. If symptoms persist or worsen despite treatment, or if new alarm symptoms appear, medical review is necessary.
Nogacid should ideally be taken under medical supervision. Short‑term use of omeprazole‑containing products is sometimes allowed for self‑medication in certain countries, but persistent or recurrent symptoms, especially in older adults, require evaluation to exclude serious conditions such as malignancy or complicated ulcer disease. Do not use Nogacid for prolonged periods or repeatedly without professional advice.
Commonly reported side effects include headache, abdominal pain, bloating, nausea, vomiting, diarrhea, constipation, and flatulence. Most are mild and transient. Less common but more serious adverse effects include severe allergic reactions, severe diarrhea (possibly due to Clostridioides difficile infection), low magnesium, vitamin B12 deficiency with long‑term use, and increased fracture risk. Any persistent, severe, or unusual symptoms should be reported to a healthcare professional promptly.
Omeprazole has been used in pregnancy when clinically indicated, and available data do not suggest a major increase in risk of congenital malformations. However, Nogacid should be used during pregnancy only if the potential benefit justifies any potential risk, and always under the guidance of a doctor. Non‑pharmacological measures and safer alternatives may be considered first, depending on the severity of symptoms.
Omeprazole is excreted into breast milk in small amounts. Available evidence suggests that the risk to a breastfed infant is likely low, but data are limited. Use of Nogacid during breastfeeding should be based on a careful benefit–risk assessment by the treating physician. If used, the lowest effective dose for the shortest necessary duration is generally recommended, and the infant should be monitored for gastrointestinal disturbances.
Yes. Nogacid can interact with several medicines. By reducing stomach acidity, it may affect the absorption of drugs that require an acidic environment, such as ketoconazole or certain antivirals. Omeprazole also influences hepatic enzymes (particularly CYP2C19), which can alter blood levels of drugs like clopidogrel, phenytoin, diazepam, and some antiretrovirals. It can also affect warfarin and other anticoagulants. Always inform your doctor and pharmacist about all medicines, supplements, and herbal products you are taking before starting Nogacid.
Long‑term use of proton pump inhibitors, including Nogacid, should be carefully justified and regularly reviewed. Prolonged therapy has been associated with potential risks such as vitamin B12 deficiency, hypomagnesemia, increased risk of bone fractures (especially in older adults or those on high doses), possible increased risk of certain infections (e.g., Clostridioides difficile‑associated diarrhea, some respiratory infections), and, in some studies, kidney‑related adverse effects. Long‑term treatment should be at the lowest effective dose, with periodic reassessment by a healthcare professional.
If you miss a dose of Nogacid, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. If you frequently forget doses, discuss this with your doctor or pharmacist so they can help you find a dosing strategy that works for you.
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