PANGRAF 0.25MG CAPSULE 10'S
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PANGRAF 0.25MG CAPSULE 10'S
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PANGRAF 0.25MG CAPSULE 10'S

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PANGRAF 0.25MG CAPSULE 10'S

By PANACEA BIOTEC LIMITED

MRP

154.38

₹131.22

15 % OFF

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CAPSULE

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Product DetailsArrow

About PANGRAF 0.25MG CAPSULE 10'S

  • PANGRAF 0.25MG CAPSULE 10'S contains the active substance Tacrolimus. It is an immunosuppressant that belongs to the class of medications called calcineurin inhibitors. This capsule is used along with other medications to prevent organ transplant rejection in people receiving liver, kidney, heart, or other transplants. It is also indicated to control your body’s immune response, enabling it to accept the transplanted organ. This medication works by suppressing the activity of certain immune cells that could otherwise attack the transplanted organ, leading to rejection.
  • Do not take this PANGRAF 0.25MG CAPSULE 10'S if you are allergic to tacrolimus or any of the other ingredients of this medicine. Report to your physician if you are allergic to any antibiotic group. Inform your doctor if you have or had a liver or heart disease before initiating the treatment. It's crucial to discuss your complete medical history with your doctor before starting this medication to ensure it's safe and appropriate for you. This includes any pre-existing conditions, allergies, and other medications you are taking.
  • Notify your physician immediately if you develop fever, bruising under the skin (which may appear as red dots), unexplained tiredness, confusion, yellowing of the skin or eyes, reduced urine output, vision loss, and seizures after taking this medicine. These symptoms could indicate serious side effects that require immediate medical attention. Regular monitoring and communication with your healthcare provider are essential while taking this medication.
  • Limit exposure to sunlight and UV light while consuming PANGRAF 0.25MG CAPSULE 10'S by wearing appropriate protective clothing and sunscreen with a high sun protection factor. This is because of the potential risk of malignant skin changes with immunosuppressive therapy. This medicine may cause diarrhea; inform your physician if you have diarrhea for over a day. If you need to receive any vaccinations, consult your doctor once before receiving them. Live vaccines may be contraindicated while on this medication due to the suppressed immune system.

Uses of PANGRAF 0.25MG CAPSULE 10'S

  • Prevents organ transplant rejections. This means the medicine helps your body from rejecting a newly transplanted organ.

How PANGRAF 0.25MG CAPSULE 10'S Works

  • PANGRAF 0.25MG CAPSULE 10'S works by inhibiting the activity of calcineurin, an enzyme involved in the activation of T cells. By suppressing T-cell activation, it helps in reducing the immune response and preventing organ rejection in transplant recipients.
  • PANGRAF 0.25MG CAPSULE 10'S exerts its therapeutic effects by selectively inhibiting the activity of calcineurin, an enzyme responsible for the activation of T cells. T cells play a crucial role in the immune response, including the rejection of transplanted organs. By inhibiting calcineurin, PANGRAF 0.25MG CAPSULE 10'S blocks the signaling pathway that leads to the production of cytokines and other molecules involved in the immune response. This effectively suppresses the immune system, reducing the activity of T cells and preventing them from attacking the transplanted organ. In the case of topical use, PANGRAF 0.25MG CAPSULE 10'S penetrates the skin and inhibits the activation of immune cells in the skin, reducing inflammation and symptoms associated with conditions like atopic dermatitis. However, it is important to note that the precise mechanism of action of PANGRAF 0.25MG CAPSULE 10'S in skin disorders is not fully understood.

Side Effects of PANGRAF 0.25MG CAPSULE 10'SArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

  • Swelling in the arm or leg
  • Hair loss
  • Itchy skin
  • Constipation, diarrhea
  • Nausea, vomiting
  • Anemia
  • Headache
  • Cough
  • Increased or decreased heartbeats
  • GI bleeding
  • Liver Injury
  • Seizure
  • Acute kidney failure
  • Lung infection or respiratory problems

Safety Advice for PANGRAF 0.25MG CAPSULE 10'SArrow

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Pregnancy

CONSULT YOUR DOCTOR

Based on animal studies, PANGRAF 0.25MG CAPSULE 10'S can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy or planning to get pregnant before initiating the treatment.

Dosage of PANGRAF 0.25MG CAPSULE 10'SArrow

  • Your doctor will determine the appropriate dosage and duration of treatment with PANGRAF 0.25MG CAPSULE 10'S based on your specific medical condition, its severity, and other individual factors. It is crucial to always take PANGRAF 0.25MG CAPSULE 10'S exactly as prescribed by your healthcare provider.
  • To ensure optimal absorption and effectiveness, avoid opening, breaking, crushing, or chewing the capsules. Swallow each capsule whole with a sufficient amount of water. For best results, administer PANGRAF 0.25MG CAPSULE 10'S on an empty stomach, ideally at least one hour before a meal or two to three hours after eating.
  • Consistency in timing is important for maintaining stable drug levels in your system. If you have any questions or concerns regarding the dosage schedule or administration of PANGRAF 0.25MG CAPSULE 10'S, do not hesitate to consult your doctor or pharmacist for clarification. Never adjust the dosage on your own without professional guidance, as this could affect the medication's effectiveness and potentially lead to adverse effects.
  • Adhering to your doctor's instructions and maintaining open communication with your healthcare team will help ensure the most effective and safest use of PANGRAF 0.25MG CAPSULE 10'S.

How to store PANGRAF 0.25MG CAPSULE 10'S?Arrow

  • Keep PANGRAF 0.25MG CAP 1X10 away from the reach of children and pets.
  • Store PANGRAF 0.25MG CAP 1X10 at room temperature.

Benefits of PANGRAF 0.25MG CAPSULE 10'SArrow

  • PANGRAF 0.25MG CAPSULE 10'S is a potent immunosuppressant that works by specifically targeting and suppressing the activity of T-lymphocytes, which are crucial components of the immune system. The medication inhibits T-lymphocyte activation and proliferation, effectively dampening the body's immune response.
  • Furthermore, PANGRAF 0.25MG CAPSULE 10'S also affects the T-helper-cell-dependent B-cell response, another critical aspect of the adaptive immune system. By suppressing this response, the medication further reduces the likelihood of the immune system attacking the body's own tissues.
  • The mechanism of action involves PANGRAF 0.25MG CAPSULE 10'S binding to an intracellular protein called FKBP-12. This binding results in the formation of a complex known as tacrolimus-FKBP. This complex then inhibits the activity of calcineurin phosphatase, an enzyme essential for T-cell activation.
  • By inhibiting calcineurin, PANGRAF 0.25MG CAPSULE 10'S effectively blocks the signaling pathways required for T-cell development and function. This leads to a significant reduction in the formation of active T cells, which ultimately suppresses the overall immune response and prevents rejection of transplanted organs or tissues, or helps manage autoimmune disorders.

How to use PANGRAF 0.25MG CAPSULE 10'SArrow

  • Your doctor will determine the appropriate dosage and duration of treatment with PANGRAF 0.25MG CAPSULE 10'S based on your specific medical condition, its severity, and other relevant factors. It is crucial to strictly adhere to your doctor's instructions regarding the use of this medication.
  • Always take PANGRAF 0.25MG CAPSULE 10'S exactly as prescribed by your healthcare provider. Do not alter the dosage or frequency of administration without consulting your doctor first.
  • These capsules should be swallowed whole with a glass of water. Avoid opening, breaking, crushing, or chewing them, as this could affect how the medication is absorbed by your body. To ensure optimal absorption, take PANGRAF 0.25MG CAPSULE 10'S on an empty stomach, either at least 1 hour before a meal or 2 to 3 hours after eating.
  • Consistency is key when taking PANGRAF 0.25MG CAPSULE 10'S. Try to take it at the same time each day to maintain a steady level of medication in your system. If you have any questions or concerns about how to take this medication, please consult your doctor or pharmacist for clarification.

FAQs

What if I missed a dose of PANGRAF 0.25MG CAPSULE 10'S?Arrow

Try to take it as soon as possible, you remember. If it is time for the next dose, skip the missed dose and follow the regular schedule. Do not double the dose to make up for the forgotten dose.

What should you not use with PANGRAF 0.25MG CAPSULE 10'S?Arrow

Avoid taking mycophenolic acid-containing products, nelfinavir, sirolimus, cyclosporine, antibiotics, and antiviral medications. Inform your healthcare provider about any prescription medicines, over-the-counter medications, or vitamin or herbal supplements you have taken before the treatment.

How long do I need to take PANGRAF 0.25MG CAPSULE 10'S after a transplant?Arrow

The duration of PANGRAF 0.25MG CAPSULE 10'S treatment after a transplant can vary depending on various factors, including the type of organ transplant and the individual's response to the medication. In most cases, PANGRAF 0.25MG CAPSULE 10'S is taken long-term to prevent organ rejection, but the healthcare professional will determine the specific duration.

Can PANGRAF 0.25MG CAPSULE 10'S increase the risk of infections?Arrow

Yes, PANGRAF 0.25MG CAPSULE 10'S can suppress the immune system, which may increase the risk of infections. It is important to take precautions to minimize the risk of infections, such as practicing good hygiene, avoiding close contact with individuals who are sick, and getting recommended vaccinations.

Can PANGRAF 0.25MG CAPSULE 10'S affect kidney function?Arrow

PANGRAF 0.25MG CAPSULE 10'S must be cautiously administered in patients with kidney diseases because it can potentially affect kidney function. Regular monitoring of kidney function through blood tests is typically done to detect any changes or potential complications. Inform your physician if you have kidney problems before initiating the therapy

Should I follow any dietary restrictions while taking PANGRAF 0.25MG CAPSULE 10'S?Arrow

PANGRAF 0.25MG CAPSULE 10'S can interact with certain foods and beverages, particularly grapefruit and grapefruit juice, which may increase the levels of this medicine in the blood. Discussing dietary restrictions and potential interactions with your healthcare provider is important. 

What are the potential drug interactions of PANGRAF 0.25MG CAPSULE 10'S?Arrow

PANGRAF 0.25MG CAPSULE 10'S can interact with many medications. Inform your healthcare provider about all the medications you are taking so they can monitor potential interactions and adjust your treatment as needed.

What advice should I follow while taking PANGRAF 0.25MG CAPSULE 10'S?Arrow

Do not eat grapefruit or drink grapefruit juice while you are using PANGRAF 0.25MG CAPSULE 10'S. Do not drink alcohol while you are using this medicine. This medicine may interfere with the vaccine. Ask your healthcare professional before getting a flu shot or other vaccines. You must take this medicine as a long-term treatment to prevent rejection of your transplanted organ. Do not stop taking this medicine without informing your doctor. Your doctor may advise you to take certain tests to monitor the effectiveness and side effects of the therapy. Keep all your appointments regularly.

What is PANGRAF 0.25MG CAPSULE 10'S made of?Arrow

TACROLIMUS is the molecule/combination used for making PANGRAF 0.25MG CAPSULE 10'S.

For what conditions is PANGRAF 0.25MG CAPSULE 10'S prescribed?Arrow

PANGRAF 0.25MG CAPSULE 10'S is prescribed for conditions related to Nephrology and Infectious Disease.

References

Book Icon

Prograf 0.5mg Hard Capsules - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published December 2022.

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Highlights Of Prescribing Information, Prograf ® (Tacrolimus) Capsules PROGRAF ® (Tacrolimus) Injection, (for Intravenous Use).

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Ratings & Review

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Chirag Patel

Reviewed on 01-02-2024

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(5/5)

वेरी गुड एक्सीलेंट

bhavtosh vyas

Reviewed on 31-01-2024

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(5/5)

medkart pharmacy medicine is very nice 👍

Sagar Christian

Reviewed on 27-11-2023

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(5/5)

Good place to buy generic medicines

Patel Jinal

Reviewed on 24-05-2023

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(5/5)

Medicines available at good discounted rates and it really help the pockets of the customer...even they help in getting medicines when you order and give your number ..

Pashupati Nath Pandey

Reviewed on 03-02-2024

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(5/5)


Marketer / Manufacturer Details

PANACEA BIOTEC LIMITED

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India

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PANGRAF 0.25MG CAPSULE 10'S

MRP

154.38

₹131.22

15 % OFF

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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