PELODOX 20MG/10ML INJECTION

How PELODOX 20MG/10ML INJECTION Works

• PELODOX 20MG/10ML INJECTION contains Pemetrexed, a chemotherapy medication that belongs to the class of antifolate drugs. It works by disrupting the processes necessary for cancer cells to grow and multiply. To understand how it works, we need to delve into the specifics of cellular metabolism and DNA synthesis.
• Cancer cells, like all cells, require certain building blocks to create new DNA and RNA, the genetic materials essential for cell division and proliferation. These building blocks are called nucleotides. The synthesis of nucleotides requires folate, a type of B vitamin. Folate is converted into various coenzymes that are crucial for several metabolic pathways involved in nucleotide synthesis. Pemetrexed acts as an inhibitor of several key enzymes that are involved in folate metabolism.
• Specifically, Pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). Thymidylate synthase is an enzyme essential for creating thymidine, one of the building blocks of DNA. Dihydrofolate reductase is necessary for regenerating tetrahydrofolate, a coenzyme required for several metabolic reactions, including those involving thymidylate synthase and glycinamide ribonucleotide formyltransferase. Glycinamide ribonucleotide formyltransferase is another enzyme involved in purine synthesis, which is essential for both DNA and RNA production.
• By inhibiting these enzymes, Pemetrexed effectively blocks the production of the nucleotides that cancer cells need to replicate their DNA and RNA. This disruption slows down and eventually halts the growth and spread of cancerous cells. Because cancer cells divide more rapidly than most healthy cells, they are more susceptible to the effects of Pemetrexed. However, Pemetrexed can also affect healthy cells that divide quickly, such as those in the bone marrow, digestive tract, and hair follicles, leading to some of the common side effects associated with chemotherapy.
• In summary, PELODOX 20MG/10ML INJECTION, through its active ingredient Pemetrexed, targets and inhibits key enzymes involved in folate metabolism and nucleotide synthesis. This process deprives cancer cells of the necessary building blocks for DNA and RNA replication, ultimately leading to the cessation of their growth and proliferation. The selective toxicity towards rapidly dividing cells makes it an effective chemotherapeutic agent, albeit one with potential side effects due to its impact on healthy, rapidly dividing cells as well.
• It's crucial to remember that the specific mechanism and effectiveness can vary based on the type of cancer, the individual patient, and other factors. Healthcare professionals will consider these factors when prescribing and monitoring the treatment.
• Furthermore, pretreatment with folic acid and vitamin B12 is often recommended to reduce the severity of side effects. These vitamins help to support normal cell function and mitigate the impact of Pemetrexed on healthy cells. These supplements are essential for minimizing toxicity and improving the patient's overall tolerance of the treatment.

Possible side effects of PELODOX 20MG/10ML INJECTION may include: Common side effects: Nausea, Vomiting, Diarrhea, Constipation, Abdominal pain, Loss of appetite, Fatigue, Weakness, Headache, Dizziness, Hair loss, Skin rash, Mouth sores, Changes in taste, Injection site reactions (pain, swelling, redness). Uncommon side effects: Fever, Chills, Sore throat, Cough, Shortness of breath, Chest pain, Swelling of the ankles or feet, Weight gain, Muscle pain, Joint pain, Numbness or tingling in the hands or feet, Vision changes, Hearing changes, Anxiety, Depression, Difficulty sleeping, Allergic reactions (hives, itching, swelling of the face, lips, tongue, or throat), Increased risk of infection, Bleeding or bruising more easily than usual, Changes in blood counts, Liver problems, Kidney problems, Heart problems. Rare side effects: Severe allergic reactions (anaphylaxis), Blood clots, Stroke, Seizures, Coma. This is not an exhaustive list. If you experience any unusual symptoms, consult your doctor immediately.

• If you miss a scheduled dose of PELODOX 20MG/10ML INJECTION, contact your doctor or healthcare provider immediately for instructions. Do not attempt to self-administer a double dose to make up for the missed one. The healthcare provider will determine the appropriate course of action based on your specific situation and treatment plan.

• Keep PELODOX 20MG INJ 10ML away from the reach of children and pets.
• Store PELODOX 20MG INJ 10ML in a refrigerator (2 - 8°C). Do not freeze.

• **Communicate Your Medical History:** Before receiving PELODOX, inform your doctor about all your existing medical conditions, especially any heart, kidney, or liver problems. This helps ensure safe and effective treatment.
• **Be Aware of Potential Side Effects:** PELODOX, like many medications, can cause side effects. Common ones include nausea, vomiting, and headache. Report any severe or persistent side effects to your healthcare provider immediately. Also, be vigilant for signs of allergic reactions like rash, itching, or swelling.
• **Understand the Administration Route:** PELODOX is administered intravenously (IV) by a healthcare professional. Do not attempt to self-administer this medication. Ask your doctor or nurse if you have any questions about the injection process.
• **Avoid Alcohol and Certain Medications:** Alcohol and certain medications can interact with PELODOX. Discuss your current medications and alcohol consumption with your doctor to avoid potential adverse interactions.
• **Follow Post-Injection Instructions:** Your doctor will provide specific instructions after the injection. These might include monitoring your symptoms, attending follow-up appointments, and reporting any changes in your condition. Adhering to these instructions is crucial for optimal recovery.
• **Stay Hydrated:** Maintain adequate hydration before and after the injection, unless your doctor advises otherwise. This can help minimize some potential side effects.
• **Inform about Pregnancy/Breastfeeding:** If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your doctor before receiving PELODOX. It's important to weigh the potential risks and benefits in these situations.

• While using PELODOX 20MG/10ML INJECTION, it's generally recommended to maintain your regular dietary habits unless your doctor advises otherwise. There are no known specific food interactions that significantly alter the drug's effectiveness or safety. However, always inform your doctor about any dietary restrictions or supplements you are taking.