PREGALIN NT TABLET 10'S

How PREGALIN NT TABLET 10'S Works

• PREGALIN NT TABLET 10'S is a combination medication formulated to alleviate neuropathic pain and manage certain types of seizures. Its effectiveness stems from the synergistic action of its two active ingredients: Pregabalin and Nortriptyline.
• Pregabalin, an anticonvulsant and analgesic, primarily functions by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. These calcium channels play a crucial role in regulating the release of neurotransmitters, chemical messengers responsible for transmitting signals between nerve cells. By binding to the alpha2-delta subunit, Pregabalin modulates calcium influx into nerve terminals, subsequently reducing the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. This reduction in neurotransmitter release helps to calm overactive nerves and reduce the sensation of pain.
• Specifically, in the context of neuropathic pain, Pregabalin's mechanism of action helps to dampen the amplified pain signals that arise from damaged or dysfunctional nerves. It does not heal the nerve damage itself, but rather modulates the way the brain perceives pain signals originating from those damaged nerves. This makes it effective in managing conditions like diabetic neuropathy, postherpetic neuralgia, and fibromyalgia.
• Nortriptyline, a tricyclic antidepressant (TCA), contributes to pain relief through a different mechanism. It primarily works by inhibiting the reuptake of neurotransmitters, specifically norepinephrine and serotonin, in the synaptic cleft – the space between nerve cells. By blocking the reuptake of these neurotransmitters, Nortriptyline increases their concentration in the synaptic cleft, allowing them to bind to receptors on the postsynaptic neuron for a longer duration.
• The increased levels of norepinephrine and serotonin in the synaptic cleft have several effects that contribute to pain relief. Norepinephrine is involved in the modulation of pain pathways in the spinal cord and brain. By increasing norepinephrine levels, Nortriptyline helps to enhance the descending inhibitory pathways that suppress pain signals. Serotonin, on the other hand, plays a role in regulating mood and sleep. Its increased availability can help alleviate the mood disturbances and sleep problems that often accompany chronic pain conditions. Nortriptyline also possesses some antihistaminic and anticholinergic properties, which may contribute to its overall therapeutic effect.
• The combination of Pregabalin and Nortriptyline in PREGALIN NT TABLET 10'S offers a dual-pronged approach to managing neuropathic pain. Pregabalin targets the overexcited nerves to reduce pain signaling at its source, while Nortriptyline modulates neurotransmitter levels to enhance pain inhibition and improve mood and sleep. This synergistic action provides more comprehensive pain relief than either drug alone. It's important to note that the full therapeutic effect of PREGALIN NT TABLET 10'S may take several weeks to manifest, as the body adjusts to the medication and neurotransmitter levels gradually stabilize. Patients should adhere to their prescribed dosage and consult their healthcare provider for any concerns or adjustments.

Common side effects of Pregalin NT Tablet may include: Drowsiness, dizziness, headache, blurred vision, uncoordinated body movements, memory impairment, increased appetite, weight gain, constipation, trouble in passing urine, erectile dysfunction, decreased sexual desire, swelling of hands and feet, fatigue. Uncommon side effects may include: Changes in heart rhythm, reduced blood platelets, muscle damage, allergic reactions (skin rash, itching, hives), anxiety, depression, confusion, nervousness, agitation, panic attacks, difficulty concentrating, sleep disturbances, speech problems, tremors, jerky movements, vertigo, ringing in ears (tinnitus), double vision, dry eyes, increased sweating, muscle cramps, joint pain, back pain, neck pain, breast enlargement in men (gynecomastia). Rare side effects may include: Liver problems, kidney problems, Stevens-Johnson syndrome (severe skin reaction), angioedema (swelling of face, lips, tongue, or throat), suicidal thoughts.

• If you miss a dose of Pregalin NT Tablet 10's, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep PREGALIN NT TAB 1X10 away from the reach of children and pets.
• Store PREGALIN NT TAB 1X10 at room temperature.

• Take PREGALIN NT TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. This medication works best when taken consistently.
• Be aware that PREGALIN NT TABLET 10'S may cause drowsiness or dizziness. Avoid driving, operating heavy machinery, or performing other tasks that require alertness until you know how the medication affects you. Inform your doctor if these side effects are severe or persistent.
• If you have diabetes, monitor your blood sugar levels regularly while taking PREGALIN NT TABLET 10'S, as it may affect glucose control. Report any significant changes in blood sugar levels to your doctor.
• Inform your doctor about all other medications, supplements, and herbal products you are taking, as they may interact with PREGALIN NT TABLET 10'S. This is especially important if you are taking other medications for pain, anxiety, or sleep disorders.
• Do not abruptly stop taking PREGALIN NT TABLET 10'S, as this may lead to withdrawal symptoms. Consult your doctor for a gradual tapering schedule when discontinuing the medication. Common withdrawal symptoms may include insomnia, headache, nausea, anxiety, and seizures.
• PREGALIN NT TABLET 10'S can be taken with or without food. If you experience stomach upset, taking it with food may help. Maintain a healthy diet and lifestyle while on this medication to support overall well-being and manage your condition effectively.
• Store PREGALIN NT TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Properly dispose of any unused medication according to local regulations.

• PREGALIN NT TABLET 10'S can be taken with or without food. However, it is advisable to take it at a fixed time to maintain consistent levels of the medicine in your body. This helps ensure the medicine works effectively. There are no specific food items to avoid unless your doctor has advised you otherwise based on your individual health condition.