SITAGLO M TABLET 15'S

How SITAGLO M TABLET 15'S Works

• SITAGLO M TABLET 15'S is a combination medication designed to manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients: sitagliptin and metformin, each working through different mechanisms to achieve optimal glycemic control.
• Sitagliptin belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). DPP-4 is an enzyme that inactivates incretin hormones. Incretins are hormones released by the intestine in response to food intake. They stimulate the release of insulin from the pancreas and reduce the secretion of glucagon from the liver. By inhibiting DPP-4, sitagliptin increases the levels of active incretin hormones in the body. This results in increased insulin release when blood sugar is high (e.g., after a meal) and decreased glucagon secretion, which reduces glucose production by the liver. In simpler terms, sitagliptin helps your body to better utilize the insulin it produces and reduces the amount of sugar produced by the liver when it's not needed.
• Metformin, on the other hand, is a biguanide that works primarily by reducing glucose production in the liver and improving insulin sensitivity in the body's tissues (muscle and fat). It does not directly stimulate insulin release, which minimizes the risk of hypoglycemia (low blood sugar) when used alone. Metformin's mechanism of action is complex and not fully understood, but it is believed to involve several pathways. It decreases hepatic glucose production by inhibiting gluconeogenesis (the process of making glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Metformin also increases insulin sensitivity by increasing glucose uptake and utilization in peripheral tissues. This means that your muscles and fat cells are better able to use the insulin available to take up glucose from the bloodstream.
• The combined action of sitagliptin and metformin addresses multiple aspects of type 2 diabetes. Sitagliptin enhances insulin secretion and suppresses glucagon secretion in a glucose-dependent manner, while metformin reduces hepatic glucose production and improves insulin sensitivity. Together, they provide a more comprehensive approach to blood sugar control than either drug alone. This synergistic effect helps to lower both fasting and postprandial (after-meal) blood sugar levels.
• In summary, SITAGLO M TABLET 15'S works by: 1. Increasing the amount of insulin released after meals. 2. Reducing the amount of sugar produced by the liver. 3. Helping the body use insulin more effectively. This combination helps to maintain stable blood sugar levels throughout the day, reducing the risk of complications associated with diabetes.

The following side effects may occur while taking SITAGLO M TABLET 15'S: * **Common Side Effects:** Nausea, Vomiting, Diarrhea, Abdominal pain, Loss of appetite, Metallic taste, Hypoglycemia (low blood sugar), Headache, Upper respiratory tract infection. * **Uncommon Side Effects:** Constipation, Flatulence, Skin reactions (rash, itching, hives), Dizziness, Sleepiness, Edema (swelling), Weakness, Abnormal kidney function tests. * **Rare Side Effects:** Lactic acidosis (a serious metabolic problem), Pancreatitis (inflammation of the pancreas), Severe allergic reactions (anaphylaxis), Liver problems (hepatitis), Bullous pemphigoid (a skin disorder), Acute kidney injury.

• If you miss a dose of SITAGLO M TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep SITAGLO M 50/500MG TAB 1X10 away from the reach of children and pets.
• Store SITAGLO M 50/500MG TAB 1X10 at room temperature.

• Take Sitaglo M Tablet 15'S as prescribed by your doctor. It's usually taken with meals to minimize stomach upset. Swallow the tablet whole with a glass of water and do not crush, chew, or break it.
• Sitaglo M Tablet 15'S helps control blood sugar levels. It works best when combined with a healthy diet and regular exercise. Continue following your diet and exercise plan even while taking this medication.
• Monitor your blood sugar levels regularly as advised by your doctor or diabetes educator. Keep a record of your readings and share them with your healthcare provider during your appointments. This helps in assessing the effectiveness of the medication and adjusting the dosage if needed.
• Be aware of the symptoms of low blood sugar (hypoglycemia) such as sweating, shaking, dizziness, rapid heartbeat, hunger, blurred vision, or tingling lips. If you experience any of these symptoms, consume a quick source of sugar like glucose tablets, honey, or fruit juice and inform your doctor immediately.
• Inform your doctor about all other medications, supplements, or herbal products you are taking, including over-the-counter medicines. Some medications can interact with Sitaglo M Tablet 15'S and affect its efficacy or increase the risk of side effects. Common side effects include nausea, vomiting, diarrhea, stomach pain, and loss of appetite. If these side effects persist or worsen, consult your doctor.

• SITAGLO M TABLET 15'S can be taken with or without food, but it is generally recommended to take it with meals to help reduce the risk of gastrointestinal side effects like nausea or upset stomach.
• Consistent timing with meals can also help maintain stable blood sugar levels.
• Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of hypoglycemia (low blood sugar).