VOLGA R 0.5/0.3MG TABLET 15'S

How VOLGA R 0.5/0.3MG TABLET 15'S Works

• VOLGA R 0.5/0.3MG TABLET 15'S is a combination medicine containing Repaglinide and Metformin. This medication is primarily used to manage type 2 diabetes mellitus, particularly in individuals whose blood sugar levels are not adequately controlled by diet and exercise alone. Understanding how each component of VOLGA R contributes to glucose regulation is crucial for appreciating its overall efficacy.
• Repaglinide, a key ingredient in VOLGA R, belongs to a class of drugs known as meglitinides. It functions as a short-acting insulin secretagogue. This means that Repaglinide stimulates the pancreas to release insulin, but only when blood glucose levels are elevated, such as after a meal. Specifically, Repaglinide works by closing ATP-sensitive potassium channels on the surface of pancreatic beta cells. This closure leads to depolarization of the beta cell membrane, causing calcium channels to open. The influx of calcium triggers the exocytosis of insulin-containing granules, thus releasing insulin into the bloodstream. Because its action is glucose-dependent, Repaglinide is less likely to cause hypoglycemia (low blood sugar) compared to longer-acting sulfonylureas, provided it is taken as directed, with meals.
• Metformin, the other crucial component of VOLGA R, operates through several distinct mechanisms to lower blood glucose. Unlike Repaglinide, Metformin does not directly stimulate insulin release. Instead, it primarily reduces glucose production in the liver (hepatic glucose output). It achieves this by inhibiting gluconeogenesis (the process by which the liver makes glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Metformin also enhances insulin sensitivity in peripheral tissues, such as muscle and fat. This allows these tissues to take up and utilize glucose more effectively from the bloodstream. Furthermore, Metformin can modestly reduce glucose absorption from the gastrointestinal tract. Together, these actions contribute to lower fasting and postprandial (after-meal) blood glucose levels.
• The synergistic action of Repaglinide and Metformin in VOLGA R provides comprehensive blood sugar control. Repaglinide swiftly addresses post-meal glucose spikes by prompting insulin release, while Metformin works continuously to reduce hepatic glucose production and improve insulin sensitivity. This dual mechanism of action helps to maintain stable blood sugar levels throughout the day, reducing the risk of both hyperglycemia (high blood sugar) and hypoglycemia. Patients taking VOLGA R should adhere to their prescribed dosage and timing, usually before meals, to optimize its effectiveness. Regular monitoring of blood glucose levels, along with dietary modifications and regular exercise, is essential for achieving optimal glycemic control and preventing long-term complications associated with diabetes.
• In summary, VOLGA R 0.5/0.3MG TABLET 15'S leverages the complementary effects of Repaglinide and Metformin to effectively manage type 2 diabetes. Repaglinide stimulates insulin release in response to elevated glucose, while Metformin reduces hepatic glucose production and improves insulin sensitivity. This combination provides a balanced approach to glucose regulation, helping patients achieve and maintain better control over their blood sugar levels.

Common side effects of VOLGA R may include nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, breast tenderness or pain, changes in menstrual periods, weight changes, mood swings, acne, and fluid retention. Uncommon side effects may include changes in libido, vaginal infections, visual disturbances, allergic reactions (rash, itching, swelling), high blood pressure, blood clots, liver problems, and gallbladder disease. This is not an exhaustive list; consult your doctor for more information.

• If you forget to take a dose of VOLGA R 0.5/0.3MG TABLET 15'S, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

• Keep VOLGA R 0.5/0.3MG TAB 1X15 away from the reach of children and pets.
• Store VOLGA R 0.5/0.3MG TAB 1X15 at room temperature.

• Take VOLGA R 0.5/0.3MG TABLET 15'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider. Consistency is key for optimal results in managing your condition. Setting a daily reminder can help you remember to take your tablet at the same time each day.
• Inform your doctor about all other medications, supplements, or herbal products you are currently taking. Drug interactions can affect how VOLGA R 0.5/0.3MG TABLET 15'S works and may increase the risk of side effects. A comprehensive list of your medications will help your doctor make informed decisions about your treatment plan. Don't forget to mention any over-the-counter medications you use regularly.
• Be aware of potential side effects. While VOLGA R 0.5/0.3MG TABLET 15'S is generally safe, some people may experience side effects such as nausea, headache, or dizziness. If you experience any persistent or bothersome side effects, contact your doctor immediately. Knowing what to expect can help you manage any discomfort and ensure your well-being.
• Follow any dietary or lifestyle recommendations provided by your doctor. Certain foods or activities may affect how VOLGA R 0.5/0.3MG TABLET 15'S works. A healthy diet and regular exercise can complement the effects of the medication and improve your overall health. Discuss any specific concerns or questions with your doctor or a registered dietitian.
• Store VOLGA R 0.5/0.3MG TABLET 15'S in a cool, dry place away from direct sunlight and moisture. Proper storage helps maintain the effectiveness of the medication. Keep it out of reach of children and pets to prevent accidental ingestion. Check the expiration date before using and discard any expired medication safely.

• VOLGA R 0.5/0.3MG TABLET 15'S does not typically have significant interactions with food. It can be taken with or without food. However, it is advisable to take it at the same time each day to maintain consistent blood levels. If you experience stomach upset, taking it with food might help.
• Avoid grapefruit and grapefruit juice while taking VOLGA R 0.5/0.3MG TABLET 15'S as they can increase the levels of the medication in your blood, potentially leading to increased side effects. Consult your doctor for further guidance.