XIGDUO XR 10/1000MG TABLET 7'S

How XIGDUO XR 10/1000MG TABLET 7'S Works

• XIGDUO XR 10/1000MG TABLET 7'S is a combination medication containing dapagliflozin and metformin hydrochloride, both of which work through different mechanisms to help lower blood sugar levels in individuals with type 2 diabetes. Dapagliflozin belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 inhibitors work in the kidneys by blocking the reabsorption of glucose back into the bloodstream. This allows excess glucose to be excreted in the urine, thereby lowering blood sugar levels. By reducing glucose reabsorption, dapagliflozin promotes glycosuria (glucose in the urine) and helps to reduce overall blood glucose levels, particularly after meals.
• Metformin, on the other hand, is a biguanide that primarily works by decreasing glucose production in the liver and improving the body's sensitivity to insulin. It reduces hepatic glucose production by inhibiting gluconeogenesis (the process by which the liver makes glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, metformin increases insulin sensitivity in peripheral tissues, such as muscle, allowing cells to utilize glucose more effectively. This dual action helps to lower both fasting and postprandial (after-meal) blood sugar levels.
• When combined in XIGDUO XR, dapagliflozin and metformin provide complementary mechanisms of action. Dapagliflozin reduces glucose reabsorption in the kidneys, while metformin reduces glucose production in the liver and improves insulin sensitivity. This synergistic effect leads to better blood sugar control compared to using either medication alone. The extended-release (XR) formulation of XIGDUO XR allows for a slower release of the medication into the body, providing a more consistent and prolonged effect on blood sugar levels throughout the day. This can help to improve glycemic control and reduce the frequency of dosing.
• Furthermore, XIGDUO XR offers additional benefits beyond blood sugar control. Dapagliflozin has been shown to have positive effects on weight loss and blood pressure, which are common comorbidities in individuals with type 2 diabetes. By promoting glucose excretion, dapagliflozin can lead to a reduction in body weight. Additionally, it may have a mild diuretic effect, which can help to lower blood pressure. Metformin has also been associated with modest weight loss and cardiovascular benefits. The combination of these two medications in XIGDUO XR can therefore provide a comprehensive approach to managing type 2 diabetes and reducing the risk of associated complications.

The following side effects may occur while taking XIGDUO XR 10/1000MG TABLET 7'S. This is not an exhaustive list, and it's important to consult with your doctor if you experience any unusual or severe symptoms. **Common Side Effects:** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Metallic taste * Headache * Weakness * Upper respiratory tract infection * Urinary tract infection * Hypoglycemia (low blood sugar), especially when used with other diabetes medications **Uncommon Side Effects:** * Lactic acidosis (a serious metabolic condition) * Vitamin B12 deficiency * Skin rash * Itching * Urticaria (hives) * Increased risk of bone fractures * Joint pain * Pancreatitis (inflammation of the pancreas) * Kidney problems * Genital fungal infections (in both men and women) * Fournier's gangrene (a rare but serious infection of the genitals and perineum) * Dehydration * Dizziness **Rare Side Effects:** * Severe allergic reactions (anaphylaxis) * Liver problems **Important Considerations:** * This is not a complete list of side effects. Other side effects may occur. * Tell your doctor right away if you have any side effects. * Some side effects, such as lactic acidosis, can be very serious and require immediate medical attention. * The risk of some side effects, such as hypoglycemia, may be increased when XIGDUO XR is taken with other diabetes medications. * The frequency and severity of side effects can vary from person to person.

• If you miss a dose of XIGDUO XR 10/1000MG TABLET 7'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep XIGDUO XR 10/1000MG TAB 1X7 away from the reach of children and pets.
• Store XIGDUO XR 10/1000MG TAB 1X7 at room temperature.

• **Take XIGDUO XR 10/1000MG TABLET 7'S as prescribed by your doctor:** Always follow your doctor's instructions regarding dosage and timing. Do not exceed the recommended dose or discontinue the medication without consulting your healthcare provider. Consistent adherence to the prescribed regimen is crucial for optimal blood sugar control and to minimize potential side effects. Skipping doses or altering the dosage without medical advice can negatively impact your blood sugar levels and overall health.
• **Take XIGDUO XR 10/1000MG TABLET 7'S with food:** To minimize potential stomach upset and improve absorption of the medication, take XIGDUO XR with a meal. This helps to regulate the release of the medication and ensures a more consistent effect on your blood sugar levels. Taking it on an empty stomach can sometimes lead to nausea or other gastrointestinal discomfort. Choose a meal that's balanced and contains carbohydrates, protein and healthy fats for best results.
• **Monitor your blood sugar regularly while taking XIGDUO XR 10/1000MG TABLET 7'S:** Regularly check your blood glucose levels as directed by your doctor. This helps you and your doctor to assess how well the medication is working and make any necessary adjustments to your treatment plan. Keep a log of your blood sugar readings and share it with your healthcare provider during your appointments. This information is valuable for managing your diabetes effectively.
• **Stay hydrated while on XIGDUO XR 10/1000MG TABLET 7'S:** Drink plenty of water throughout the day to help your kidneys function properly and to prevent dehydration, especially during physical activity or hot weather. Adequate hydration is important for overall health and can also help to minimize certain side effects associated with XIGDUO XR. Aim for at least eight glasses of water per day, unless your doctor advises otherwise.
• **Be aware of potential side effects:** Be aware of potential side effects such as nausea, diarrhea, or low blood sugar (hypoglycemia). If you experience any persistent or severe side effects, contact your doctor immediately. Hypoglycemia can occur if you skip meals, exercise strenuously, or take other medications that lower blood sugar. Learn the symptoms of hypoglycemia and how to treat it promptly (e.g., by consuming glucose tablets or juice). Discuss any concerns you have about side effects with your doctor.
• **Inform your doctor about all other medications:** Before starting XIGDUO XR, inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. Some medications can interact with XIGDUO XR and affect its effectiveness or increase the risk of side effects. Your doctor needs a complete picture of your medication history to ensure your safety and optimize your treatment plan.
• **Maintain a healthy lifestyle:** Combine XIGDUO XR with a healthy lifestyle, including a balanced diet and regular exercise. This synergistic approach will help you achieve better blood sugar control and reduce your risk of diabetes-related complications. Work with a registered dietitian or certified diabetes educator to develop a personalized meal plan and exercise routine that suits your needs and preferences. Aim for at least 150 minutes of moderate-intensity exercise per week.

• XIGDUO XR 10/1000MG TABLET 7'S should be taken with food to help decrease the chance of an upset stomach.
• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of lactic acidosis.
• While taking this medication, maintain a consistent carbohydrate intake. Consult your doctor or dietician for specific dietary advice tailored to your condition.