XSULIN 30/70 PENFILL 3 ML

How XSULIN 30/70 PENFILL 3 ML Works

• XSULIN 30/70 PENFILL 3 ML is a premixed insulin formulation containing 30% soluble insulin and 70% isophane insulin. This combination provides both a rapid onset and an intermediate duration of action, mimicking the natural insulin release pattern of the pancreas. The soluble insulin component quickly lowers blood glucose levels after injection, while the isophane insulin provides a longer-lasting effect to control blood sugar between meals and overnight.
• Insulin, in general, works by allowing glucose from the blood to enter cells, providing them with the energy they need to function properly. In individuals with diabetes, the pancreas either doesn't produce enough insulin (Type 1 diabetes) or the body doesn't respond properly to the insulin that is produced (Type 2 diabetes). XSULIN 30/70 PENFILL 3 ML helps to compensate for this deficiency by providing an external source of insulin.
• Specifically, the soluble insulin component acts rapidly. After injection, it is quickly absorbed into the bloodstream, facilitating the uptake of glucose by cells. This helps to reduce elevated blood sugar levels resulting from food intake. The isophane insulin component is formulated to be absorbed more slowly. This is achieved by modifying the insulin molecule to form a suspension of crystals. These crystals gradually dissolve, releasing insulin into the bloodstream over a prolonged period, thus maintaining a stable background level of insulin and helping to control blood glucose levels between meals and during the night. The 30/70 ratio is carefully chosen to provide optimal blood sugar control throughout the day, minimizing both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar).
• The premixed nature of XSULIN 30/70 PENFILL 3 ML simplifies insulin therapy, as it reduces the need for multiple injections of different insulin types. However, it's crucial to administer the injection about 30 minutes before a meal to allow the soluble insulin component to start working when food is ingested. The dosage is individualized based on the patient's needs, considering factors such as blood glucose levels, diet, and activity level. Regular monitoring of blood glucose levels is essential to ensure optimal control and to adjust the insulin dosage as needed. This also allows to identify the ideal injection timing with respect to meals.
• It is crucial to understand that consistent administration, adherence to a proper diet, and regular exercise are essential components of effective diabetes management when using XSULIN 30/70 PENFILL 3 ML. Working closely with your healthcare provider is paramount to determine the appropriate dosage, injection timing, and overall treatment plan for your individual needs. Furthermore, patients should be educated about recognizing and managing the symptoms of both hyperglycemia and hypoglycemia to ensure their safety and well-being.

Like all medicines, XSULIN 30/70 Penfill can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms can include cold sweat, cool pale skin, headache, rapid heartbeat, feeling sick, feeling very hungry, temporary vision changes, drowsiness, unusual tiredness or weakness, nervousness or tremor, feeling anxious, feeling confused, difficulty in concentrating. * Local reactions at the injection site: Redness, pain, itching, swelling, or inflammation at the injection site. **Uncommon Side Effects (may affect up to 1 in 100 people):** * Lipodystrophy: ( pitting in the skin or thickened skin) If you inject insulin too often at the same place, the fatty tissue may either shrink (lipoatrophy) or thicken (lipohypertrophy). * Allergic reactions: Generalized allergic reactions are potentially serious. Symptoms may include rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening. * Edema: Swelling of ankles and feet due to fluid retention. **Rare Side Effects (may affect up to 1 in 1,000 people):** * Diabetic retinopathy (eye disease): Changes in your vision may occur because of improvement in blood sugar control. However, intensification of insulin therapy with abrupt improvement in blood sugar control may be associated with temporary worsening of diabetic retinopathy. **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Painful neuropathy: If your blood sugar control improves very fast it may cause a nerve related pain. This is usually reversible. **Other Possible Side Effects:** * Weight gain * Injection site reactions such as bruising, bleeding, or infection. **If you experience any of the following, seek immediate medical attention:** * Signs of a severe allergic reaction * Severe hypoglycemia causing unconsciousness or seizures

• If you miss a dose of XSULIN 30/70, administer it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not administer a double dose to make up for a missed one.
• Consult your doctor or pharmacist if you are unsure about what to do after missing a dose.

• Keep XSULIN 30/70 PENFILL 3ML away from the reach of children and pets.
• Store XSULIN 30/70 PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

• **Understand Your Insulin:** XSULIN 30/70 is a premixed insulin containing 30% rapid-acting and 70% intermediate-acting insulin. This means it provides both immediate and sustained blood sugar control. Always consult your doctor to understand if this type of insulin is right for your specific needs and how it fits into your overall diabetes management plan. Understanding the specific components ensures you are managing your blood glucose levels effectively throughout the day.
• **Proper Storage is Key:** Store your XSULIN 30/70 penfill in the refrigerator (2°C to 8°C or 36°F to 46°F) until you are ready to use it. Once in use, the pen can be stored at room temperature (below 30°C or 86°F) for up to 28 days. Avoid direct sunlight or heat exposure, and never freeze insulin. Proper storage ensures the insulin remains effective and safe to use. Always check the expiration date before each use.
• **Administer Correctly:** Always use a new needle for each injection to maintain sterility and prevent infection. Prime the pen before each injection by dialing up 2 units and expelling the insulin to ensure the needle is clear and the pen is working correctly. Inject the insulin into the subcutaneous tissue (fatty layer under the skin) of your abdomen, thigh, or upper arm. Rotate injection sites to prevent lipodystrophy (lumps or pits in the skin).
• **Monitor Blood Glucose Regularly:** Consistently monitor your blood glucose levels as directed by your healthcare provider. Keep a log of your readings, noting the time of day, meal times, and insulin dosages. This information will help you and your doctor adjust your insulin regimen as needed. Understanding how XSULIN 30/70 affects your blood sugar levels at different times is crucial for effective diabetes management. Be prepared to adjust your diet and activity levels as well.
• **Be Aware of Hypoglycemia:** Hypoglycemia (low blood sugar) is a potential side effect of insulin therapy. Symptoms include shakiness, sweating, dizziness, confusion, and hunger. Always carry a fast-acting source of glucose, such as glucose tablets, juice, or hard candy, to treat hypoglycemia immediately. If you experience frequent or severe hypoglycemic episodes, consult your doctor to adjust your insulin dosage or meal plan. Make sure family and friends know how to recognize and treat hypoglycemia.

• XSULIN 30/70 PENFILL 3 ML should be administered 15 minutes before or immediately after a meal. Consistent timing with meals is crucial for managing blood sugar levels effectively.
• Be mindful of carbohydrate intake and balance it with your insulin dosage to avoid hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar).
• Consult your doctor or diabetes educator for personalized dietary advice tailored to your insulin regimen.