ISTAMET XR (CP) TABLET 7'S

How ISTAMET XR (CP) TABLET 7'S Works

• ISTAMET XR (CP) TABLET 7'S is a combination medication containing two active ingredients: Sitagliptin and Metformin Hydrochloride. These components work synergistically to improve glycemic control in adults with type 2 diabetes mellitus. To fully understand how ISTAMET XR (CP) works, it's crucial to examine the individual mechanisms of action of Sitagliptin and Metformin.
• Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that inactivates incretin hormones. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine in response to food intake. They stimulate insulin release from the pancreas and reduce glucagon secretion from the liver. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones in the body. This leads to an increase in insulin release when blood sugar is high (i.e., after a meal) and a decrease in glucagon secretion, which helps to lower blood sugar levels.
• Metformin Hydrochloride, on the other hand, is a biguanide antihyperglycemic agent. Its primary mechanism of action involves decreasing glucose production in the liver (hepatic gluconeogenesis). Metformin also improves insulin sensitivity in peripheral tissues, such as muscles, allowing them to utilize glucose more effectively. Furthermore, Metformin slows down the absorption of glucose from the intestines. Unlike some other diabetes medications, Metformin does not stimulate insulin release, which reduces the risk of hypoglycemia (low blood sugar) when used alone.
• When Sitagliptin and Metformin are combined in ISTAMET XR (CP) TABLET 7'S, they provide complementary mechanisms of action to control blood sugar levels. Sitagliptin enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner, while Metformin reduces hepatic glucose production and improves insulin sensitivity. The 'XR' in the name stands for extended-release, indicating that Metformin is released slowly over time, which helps to maintain a more consistent blood sugar level throughout the day and often reduces gastrointestinal side effects associated with immediate-release Metformin.
• In summary, ISTAMET XR (CP) TABLET 7'S effectively manages blood glucose levels by targeting multiple pathways involved in glucose regulation. It increases insulin availability, reduces glucagon secretion, decreases hepatic glucose production, and improves insulin sensitivity in peripheral tissues. This multi-faceted approach helps patients with type 2 diabetes achieve and maintain better glycemic control.
• It is important to note that ISTAMET XR (CP) TABLET 7'S should be used in conjunction with lifestyle modifications, including diet and exercise, to achieve optimal blood sugar control. Consult your healthcare provider for specific medical advice and treatment options.

Like all medicines, ISTAMET XR (CP) TABLET 7'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Metallic taste **Uncommon Side Effects (may affect up to 1 in 100 people):** * Skin rash * Itching * Urticaria (hives) * Changes in blood sugar levels (hypoglycemia or hyperglycemia) * Dizziness * Headache **Rare Side Effects (may affect up to 1 in 1,000 people):** * Lactic acidosis (symptoms include deep, rapid breathing, nausea, vomiting, stomach pain) * Abnormal liver function tests * Vitamin B12 deficiency **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Hepatitis (inflammation of the liver) * Erythema multiforme (a type of skin rash) **Other Possible Side Effects (frequency not known):** * Pancreatitis (inflammation of the pancreas) * Weight loss * Constipation * Heartburn This is not a complete list of side effects. If you experience any troublesome or persistent side effects, or if you notice any other unusual symptoms, stop taking ISTAMET XR (CP) TABLET 7'S and consult your doctor or pharmacist.

• If you miss a dose of ISTAMET XR (CP) TABLET 7'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep ISTAMET XR (CP) TAB 1X7 away from the reach of children and pets.
• Store ISTAMET XR (CP) TAB 1X7 at room temperature.

• Take ISTAMET XR (CP) TABLET 7'S exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with a full glass of water. This medication is typically taken once or twice daily with meals to help manage blood sugar levels effectively and minimize gastrointestinal side effects. Consistency in timing is key for optimal results. Missing doses can lead to fluctuations in blood sugar.
• Monitor your blood sugar regularly while taking ISTAMET XR (CP) TABLET 7'S. Keep a log of your readings and share it with your healthcare provider. This helps in tracking your progress and making necessary adjustments to your treatment plan. Understanding how your body responds to the medication and different foods is crucial for effective diabetes management. Be aware of symptoms of both high and low blood sugar.
• Maintain a healthy lifestyle while using ISTAMET XR (CP) TABLET 7'S. Follow a balanced diet that is low in sugar and refined carbohydrates, and engage in regular physical activity. Exercise improves insulin sensitivity and helps lower blood sugar levels. Consult with a registered dietitian or nutritionist to create a personalized meal plan that suits your needs and preferences. Avoid excessive alcohol consumption.
• Be aware of potential side effects of ISTAMET XR (CP) TABLET 7'S. Common side effects include nausea, diarrhea, and stomach upset. If these persist or worsen, contact your doctor. In rare cases, more serious side effects such as lactic acidosis can occur. Seek immediate medical attention if you experience symptoms like severe weakness, muscle pain, trouble breathing, or unusual sleepiness. Regular check-ups can help monitor kidney function and overall health.
• Inform your doctor about all other medications and supplements you are taking before starting ISTAMET XR (CP) TABLET 7'S. Certain medications can interact with this drug, affecting its effectiveness or increasing the risk of side effects. This includes over-the-counter drugs, herbal remedies, and vitamins. Provide a complete list to your healthcare provider to ensure safe and effective treatment. Also, keep your doctor informed about any pre-existing medical conditions, especially kidney or liver problems.

• ISTAMET XR (CP) TABLET 7'S should be taken with food to decrease the chance of stomach upset.
• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of lactic acidosis, a serious side effect.