PREGAVYOM NT TABLET 10'S

How PREGAVYOM NT TABLET 10'S Works

• PREGAVYOM NT TABLET 10'S is a multifaceted medication designed to alleviate neuropathic pain and improve overall nerve health. Its efficacy stems from the synergistic action of its three key ingredients: Pregabalin, Nortriptyline, and Methylcobalamin. Understanding how each component works is crucial to appreciating the therapeutic benefits of this tablet.
• Pregabalin, an anticonvulsant and analgesic, plays a pivotal role in managing neuropathic pain. It primarily functions by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. These channels are crucial for regulating the influx of calcium into nerve cells, which in turn influences the release of neurotransmitters. By binding to this subunit, Pregabalin modulates calcium influx, thereby reducing the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. These neurotransmitters are heavily involved in the transmission of pain signals. By reducing their release, Pregabalin effectively dampens the pain signals sent to the brain, providing significant pain relief. Furthermore, Pregabalin's action is selective, meaning it targets the overactive nerve cells responsible for neuropathic pain without significantly affecting normal nerve function. This targeted approach minimizes the risk of widespread side effects, making it a well-tolerated option for many patients.
• Nortriptyline, a tricyclic antidepressant (TCA), contributes to pain relief through a different mechanism. TCAs like Nortriptyline primarily work by inhibiting the reuptake of certain neurotransmitters, specifically norepinephrine and serotonin, in the synaptic cleft. The synaptic cleft is the space between nerve cells where neurotransmitters are released to transmit signals. By blocking the reuptake of norepinephrine and serotonin, Nortriptyline increases the concentration of these neurotransmitters in the synaptic cleft. Elevated levels of these neurotransmitters can enhance pain modulation pathways in the brain and spinal cord. Norepinephrine, in particular, plays a crucial role in descending pain pathways, which help to inhibit pain signals. Serotonin also contributes to mood regulation and pain modulation. The combined effect of increased norepinephrine and serotonin levels can lead to a reduction in pain perception and an improvement in mood, which is often affected by chronic pain conditions. Additionally, Nortriptyline has some antihistaminic and anticholinergic properties, which may contribute to its overall therapeutic effect, though these effects can also contribute to some of its side effects.
• Methylcobalamin, a form of Vitamin B12, is essential for nerve health and regeneration. It plays a vital role in several key metabolic processes within nerve cells. Methylcobalamin is crucial for the synthesis of myelin, the protective sheath that surrounds nerve fibers. Myelin ensures efficient nerve impulse transmission. Damage to the myelin sheath, which is common in neuropathic conditions, can lead to impaired nerve function and increased pain sensitivity. By promoting myelin synthesis, Methylcobalamin helps to repair and maintain the integrity of nerve fibers, thereby improving nerve conduction and reducing pain. Additionally, Methylcobalamin is involved in the synthesis of neurotransmitters and the regeneration of damaged nerve tissue. It acts as a cofactor for methionine synthase, an enzyme that converts homocysteine to methionine, which is then used to produce S-adenosylmethionine (SAMe). SAMe is involved in numerous biochemical reactions, including the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine. By supporting these processes, Methylcobalamin contributes to overall nerve health, reduces nerve damage, and supports the function of the other two medications in the tablet.
• In summary, PREGAVYOM NT TABLET 10'S combines the analgesic effects of Pregabalin and Nortriptyline with the neuroprotective properties of Methylcobalamin. Pregabalin reduces the release of excitatory neurotransmitters, Nortriptyline enhances pain modulation pathways, and Methylcobalamin supports nerve regeneration and function. Together, these three ingredients provide comprehensive relief from neuropathic pain and promote overall nerve health, improving the quality of life for individuals suffering from nerve-related pain conditions.

Common side effects of Pregavyom NT Tablet may include: Dizziness, Sleepiness, Tiredness, Uncoordinated body movements, Dryness in mouth, Increased heart rate, Blurred vision, Constipation, Difficulty in urination, Weight gain, Orthostatic hypotension (sudden lowering of blood pressure on standing), Peripheral edema (swelling of the extremities). Uncommon side effects may include: Memory impairment, Difficulty in concentration, Confusion, Tremors, Visual disturbances, Changes in taste, Speech disorder, Muscle pain or weakness, Sexual dysfunction, Anxiety, Mood changes, Increased sweating, Ringing in ears (tinnitus), Gastrointestinal disturbances such as nausea, vomiting, diarrhea, or abdominal pain. Rare side effects may include: Liver problems, Blood disorders, Severe allergic reactions, Suicidal thoughts.

• If you miss a dose of PREGAVYOM NT TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep PREGAVYOM NT TAB 1X10 away from the reach of children and pets.
• Store PREGAVYOM NT TAB 1X10 at room temperature.

• Take PREGAVYOM NT TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them. Consistent timing helps maintain steady blood levels of the medication for optimal effectiveness in managing neuropathic pain and improving mood.
• Inform your doctor about all other medications, supplements, and herbal products you are currently taking. Drug interactions can alter how PREGAVYOM NT TABLET 10'S works and increase the risk of side effects. This includes over-the-counter medications as well.
• Be patient and consistent with your treatment. It may take several weeks to experience the full benefits of PREGAVYOM NT TABLET 10'S. Do not get discouraged if you don't see immediate results. Continue taking the medication as directed and attend all follow-up appointments.
• Monitor yourself for potential side effects, such as drowsiness, dizziness, blurred vision, or gastrointestinal issues. If you experience any bothersome or persistent side effects, contact your doctor promptly. Do not drive or operate heavy machinery until you know how this medicine affects you.
• Store PREGAVYOM NT TABLET 10'S in a cool, dry place, away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage helps maintain the medication's effectiveness and prevents accidental ingestion.

• PREGAVYOM NT TABLET 10'S can be taken with or without food, but it is best to take it at a fixed time. Taking it with food may help to reduce stomach upset. Avoid alcohol while taking this medication as it can increase drowsiness and other side effects.
• High-fat meals may delay the absorption of PREGAVYOM NT TABLET 10'S.