PREGEB NT 75MG/10MG TABLET 10'S

How PREGEB NT 75MG/10MG TABLET 10'S Works

• PREGEB NT 75MG/10MG TABLET 10'S is a combination medication designed to alleviate neuropathic pain and improve overall nerve health. Its effectiveness stems from the synergistic action of its two active ingredients: Pregabalin and Nortriptyline.
• Pregabalin, an anticonvulsant and analgesic, is the cornerstone of PREGEB NT. It primarily functions by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. These calcium channels play a crucial role in regulating the release of neurotransmitters, the chemical messengers that transmit signals between nerve cells. By binding to these channels, Pregabalin modulates calcium influx, subsequently reducing the release of excitatory neurotransmitters such as glutamate, noradrenaline, and substance P. This reduction in neurotransmitter release helps to calm overexcited nerves and reduce the sensation of pain. Essentially, Pregabalin acts as a nerve modulator, quieting down the signals that contribute to neuropathic pain. It helps to stabilize nerve activity, reducing the erratic firing that leads to pain sensations. This mechanism not only addresses the pain itself but also helps to prevent the pain signals from being amplified or misinterpreted by the brain.
• Nortriptyline, a tricyclic antidepressant (TCA), complements Pregabalin's action by addressing the underlying mood and emotional aspects often associated with chronic pain. Nortriptyline primarily works by inhibiting the reuptake of norepinephrine and serotonin in the synaptic cleft, the space between nerve cells. By blocking the reuptake of these neurotransmitters, Nortriptyline increases their concentration in the synapse, prolonging their activity. Norepinephrine and serotonin are crucial neurotransmitters involved in mood regulation, pain modulation, and overall well-being. Increasing their levels helps to elevate mood, reduce feelings of depression or anxiety that can exacerbate pain perception, and directly modulate pain pathways in the brain and spinal cord. The pain-relieving effect of Nortriptyline is also attributed to its ability to block sodium channels in nerve cells. This action helps to stabilize nerve membranes and reduce the firing of pain signals. The dual action of increasing mood-regulating neurotransmitters and directly affecting pain signals makes Nortriptyline an effective component in managing neuropathic pain.
• The combination of Pregabalin and Nortriptyline in PREGEB NT offers a multifaceted approach to neuropathic pain management. Pregabalin directly targets the nerve signals causing pain, while Nortriptyline addresses the emotional and neurological aspects that contribute to the overall pain experience. This synergistic action not only provides pain relief but also improves the patient's quality of life by addressing mood disturbances and promoting a sense of well-being. The medication effectively reduces the intensity and frequency of neuropathic pain, allowing individuals to engage in daily activities with greater comfort and ease. By targeting multiple pathways involved in pain signaling and mood regulation, PREGEB NT offers a comprehensive approach to managing the complex nature of neuropathic pain.

Common side effects of PREGEB NT may include: Sleepiness, Dizziness, Headache, Fatigue, Lack of coordination, Blurred vision, Dry mouth, Weight gain, Peripheral edema (swelling of the extremities), and Difficulty concentrating. Less common but potentially serious side effects can include: Mood changes (such as depression or anxiety), Suicidal thoughts, Allergic reactions (rash, itching, swelling), Muscle pain or weakness, Memory problems, Confusion, Difficulty speaking, Visual disturbances, Gastrointestinal issues (nausea, vomiting, constipation), Sexual dysfunction, and Increased risk of falls. In rare cases, PREGEB NT may cause serious heart problems. This is not an exhaustive list, and it's important to consult your doctor if you experience any unusual or bothersome symptoms while taking this medication.

• If you miss a dose of PREGEB NT 75MG/10MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep PREGEB NT 75/10MG TAB 1X10 away from the reach of children and pets.
• Store PREGEB NT 75/10MG TAB 1X10 at room temperature.

• **Take PREGEB NT as Prescribed:** Always follow your doctor's instructions on dosage and timing. Consistency is key for managing your condition effectively. Do not self-adjust the dosage.
• **Be Aware of Potential Side Effects:** PREGEB NT may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. Common side effects also include nausea, dry mouth, and weight gain. Contact your doctor if side effects persist or worsen.
• **Monitor Your Blood Sugar Regularly:** If you have diabetes, PREGEB NT can affect blood sugar levels. Regular monitoring is crucial. Discuss any significant changes with your doctor, who may adjust your diabetes medication accordingly.
• **Inform Your Doctor About All Medications:** Tell your doctor about all other medications, supplements, or herbal remedies you're taking. Drug interactions can alter the effectiveness of PREGEB NT or increase the risk of side effects. Pay special attention to other medications that cause sedation or affect mood.
• **Lifestyle Adjustments Can Help:** Combine PREGEB NT with healthy lifestyle choices. Regular exercise, a balanced diet, and stress management techniques can improve your overall well-being and potentially reduce the need for medication over time. Discuss appropriate lifestyle modifications with your healthcare provider.

• PREGEB NT 75MG/10MG TABLET 10'S may be taken with or without food. However, it is important to maintain consistency with how you take it each day. If you experience stomach upset, taking it with food may help.
• Avoid alcohol while taking this medication, as it can increase the risk of side effects.