INSUGEN 50/50 PENFILL 3 ML

How INSUGEN 50/50 PENFILL 3 ML Works

• INSUGEN 50/50 is a premixed insulin formulation containing two types of insulin: rapid-acting (soluble) insulin and intermediate-acting isophane insulin. This combination helps to manage blood sugar levels effectively throughout the day. The rapid-acting component starts working quickly to cover insulin needs at meal times, while the intermediate-acting component provides a longer-lasting background insulin coverage. The soluble insulin works by allowing the body to use sugar from carbohydrates in your food. By facilitating the entry of glucose into cells, insulin lowers blood glucose levels after meals. It helps in converting glucose to glycogen which is stored in liver. This prevents excess glucose from remaining in the bloodstream.
• The isophane insulin component is designed to release insulin more gradually. This slower release helps to control blood sugar levels between meals and during the night. Isophane insulin is a modified form of insulin that is combined with protamine and zinc to delay its absorption. This delayed absorption results in a longer duration of action, providing a basal level of insulin to keep blood sugar levels stable over a longer period. The combined action of rapid and intermediate acting insulins mimics the natural insulin release of the body and provides better glycemic control.
• When INSUGEN 50/50 is injected subcutaneously (under the skin), the soluble insulin component is rapidly absorbed into the bloodstream, initiating its glucose-lowering effect within 30 minutes. The isophane insulin is absorbed more slowly, with its effect lasting up to 24 hours. The precise timing and dosage of INSUGEN 50/50 are determined by your healthcare provider based on your individual needs, including your diet, activity level, and blood sugar levels. It is crucial to follow their instructions carefully to achieve optimal blood sugar control and minimize the risk of hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar). Regular blood glucose monitoring is also essential to assess the effectiveness of the insulin and make any necessary adjustments to your treatment plan in consultation with your doctor.
• In summary, INSUGEN 50/50 works by providing a dual action of rapid and intermediate insulin release, closely mimicking the body's natural insulin response. The rapid-acting component addresses mealtime glucose spikes, while the intermediate-acting component provides basal insulin coverage for sustained blood sugar control. This combination helps individuals with diabetes maintain stable blood sugar levels throughout the day, reducing the risk of diabetes-related complications. Remember to always use INSUGEN 50/50 as prescribed by your doctor, and consult them if you have any questions or concerns about your diabetes management plan.

Like all medicines, INSUGEN 50/50 PENFILL can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms can include sweating, shaking, dizziness, rapid heartbeat, hunger, blurred vision, headache, and mood changes. Severe hypoglycemia can lead to unconsciousness and, in rare cases, be fatal. * Local injection site reactions: Redness, swelling, itching, or pain at the injection site. **Uncommon side effects (may affect up to 1 in 100 people):** * Lipodystrophy: This occurs when subcutaneous fat either shrinks (lipoatrophy) or thickens (lipohypertrophy) at the injection site. Rotating injection sites can help prevent this. * Allergic reactions: Skin rash, itching, hives. **Rare side effects (may affect up to 1 in 1,000 people):** * Systemic allergic reaction: This is a serious, potentially life-threatening allergic reaction that can include difficulty breathing, wheezing, rapid heartbeat, sweating, and a drop in blood pressure. Seek immediate medical attention if you experience these symptoms. **Very rare side effects (may affect up to 1 in 10,000 people):** * Visual disturbances: Changes in vision may occur temporarily at the start of insulin treatment. * Edema: Swelling of ankles and feet may occur due to fluid retention. **Other possible side effects:** * Weight gain: Insulin can cause weight gain. * Peripheral neuropathy (nerve damage): Improved blood sugar control can sometimes temporarily worsen nerve pain in people with diabetic neuropathy.

• If you miss a dose of INSUGEN 50/50, inject it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not inject a double dose to make up for the missed one.
• It is important to maintain consistent blood sugar levels, so try to avoid missing doses. If you frequently miss doses, talk to your doctor about strategies to help you remember.

• Keep INSUGEN 50/50 PENFILL 3ML away from the reach of children and pets.
• Store INSUGEN 50/50 PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

• **Understand Your Insulin Type:** INSUGEN 50/50 is a premixed insulin, containing both rapid-acting and intermediate-acting insulin. This means it helps control blood sugar levels after meals and between meals. Make sure you understand how each component works and how it affects your blood sugar at different times of the day. Consistent timing of meals is crucial for managing blood sugar effectively with this type of insulin. Consult your doctor or diabetes educator for personalized guidance on how to best utilize INSUGEN 50/50.
• **Proper Storage is Key:** Always store your INSUGEN 50/50 penfill in the refrigerator (2°C to 8°C or 36°F to 46°F) until you are ready to use it. Avoid freezing it. Once in use, the pen can be stored at room temperature (below 30°C or 86°F) for up to 28 days, protected from direct heat and light. Discard the pen after 28 days, even if it still contains insulin. Proper storage ensures the insulin remains effective and safe.
• **Master the Injection Technique:** Use a new needle for each injection to ensure sterility and reduce the risk of lipohypertrophy (lumps under the skin). Rotate injection sites (abdomen, thigh, upper arm) to prevent skin thickening or pitting. Inject the insulin into the subcutaneous tissue (the layer of fat just under the skin) at a 90-degree angle, unless your doctor advises otherwise. Pinching the skin can help ensure you inject into the correct layer. If you experience pain or bleeding, adjust your technique and consult your healthcare provider.
• **Monitor Your Blood Sugar Regularly:** Frequent blood sugar monitoring is essential when using INSUGEN 50/50. Check your blood sugar levels before meals and at bedtime, and occasionally two hours after meals, to understand how the insulin is affecting your blood sugar. Keep a log of your blood sugar readings and share it with your doctor during appointments. This information will help them adjust your insulin dosage as needed to achieve optimal blood sugar control.
• **Recognize and Treat Hypoglycemia:** Be aware of the signs and symptoms of hypoglycemia (low blood sugar), such as sweating, shaking, dizziness, hunger, and confusion. Carry a fast-acting source of glucose, such as glucose tablets or fruit juice, with you at all times. If you experience hypoglycemia, treat it immediately by consuming 15-20 grams of fast-acting carbohydrates. Check your blood sugar again after 15 minutes, and repeat treatment if needed. Inform your family and friends about how to recognize and treat hypoglycemia in case you are unable to do so yourself. Talk to your doctor about creating a hypoglycemia action plan.
• **Be Prepared for Travel:** When traveling with INSUGEN 50/50, always carry it in your carry-on luggage to prevent it from being exposed to extreme temperatures in the cargo hold. Bring a copy of your prescription and a letter from your doctor stating that you require insulin. Pack extra insulin and supplies in case of delays or lost luggage. If traveling across time zones, consult your doctor about how to adjust your insulin dosage and timing.
• **Consistency is Key:** To get the most out of INSUGEN 50/50, consistency in your daily routine is very important. This includes the timing of your meals, insulin injections, and physical activity. Try to eat your meals at the same times each day and inject your insulin at the prescribed time before meals. Regular physical activity can also help improve your blood sugar control. However, it is important to monitor your blood sugar closely during and after exercise, as exercise can sometimes cause blood sugar to drop. Talk to your doctor about how to adjust your insulin dosage or carbohydrate intake based on your activity level.

• INSUGEN 50/50 PENFILL 3 ML should be administered 15 minutes before or soon after starting a meal.
• It is important to maintain a consistent meal schedule and carbohydrate intake while using this medication.
• Consult your doctor or dietician for personalized dietary advice to manage blood sugar levels effectively.