XSULIN 50/50 PENFIL 3 ML

How XSULIN 50/50 PENFIL 3 ML Works

• XSULIN 50/50 Penfil 3 ml is a pre-mixed insulin formulation containing both rapid-acting and intermediate-acting insulin. This combination allows for better blood sugar control throughout the day. The rapid-acting insulin (usually Insulin Lispro or Aspart, in a 50% concentration in XSULIN 50/50) starts working quickly, typically within 10-20 minutes after injection. It helps to cover the rise in blood sugar levels that occur after meals. This component mimics the bolus insulin that a healthy pancreas produces in response to food.
• The intermediate-acting insulin (NPH insulin, also at a 50% concentration in XSULIN 50/50) has a slower onset of action, usually within 1-2 hours, and its effects last for up to 24 hours. This provides a background level of insulin to help control blood sugar levels between meals and during the night. Think of this as mimicking the basal insulin that a healthy pancreas produces to keep blood sugar levels stable even when you are not eating.
• When you inject XSULIN 50/50 Penfil, the rapid-acting insulin immediately begins to lower your blood sugar after a meal. Simultaneously, the intermediate-acting insulin is released more slowly into your bloodstream, providing a sustained effect that helps to maintain blood sugar control over a longer period. This dual action helps to manage both post-meal glucose spikes and overall baseline glucose levels. The pre-mixed nature of XSULIN 50/50 simplifies insulin administration, as it reduces the need for multiple injections of different types of insulin. It aims to replicate the natural insulin release pattern of a healthy pancreas, offering a balanced approach to glucose management. Regular monitoring of blood sugar levels is crucial to optimize the dosage and timing of XSULIN 50/50, as individual responses to insulin can vary.

Like all medicines, XSULIN 50/50 PENFIL 3 ML can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms can include sweating, shakiness, anxiety, rapid heartbeat, dizziness, hunger, blurred vision, headache, and confusion. Severe hypoglycemia can lead to unconsciousness and, in rare cases, be fatal. * Injection site reactions: Redness, swelling, itching, or pain at the injection site. * Lipodystrophy: Changes in fat tissue at the injection site (either thickening or pitting of the skin). **Uncommon side effects (may affect up to 1 in 100 people):** * Allergic reactions: Skin rash, itching, hives. * Edema: Swelling of the ankles and feet. **Rare side effects (may affect up to 1 in 1,000 people):** * Severe allergic reaction (anaphylaxis): Symptoms can include difficulty breathing, wheezing, rapid heartbeat, sweating, and loss of consciousness. **Seek immediate medical attention.** **Very rare side effects (may affect up to 1 in 10,000 people):** * Visual Disturbances: Changes in vision may occur at the start of insulin treatment **Other possible side effects:** * Weight gain: Insulin can cause weight gain. * Peripheral neuropathy: Nerve damage causing pain, numbness, and tingling in the hands and feet. **Important Considerations:** * This is not an exhaustive list. Tell your doctor or pharmacist if you notice any other side effects. * The risk of side effects can be minimized by following your doctor's instructions carefully regarding dosage, diet, and exercise. * Regularly rotate injection sites to help prevent lipodystrophy.

• If you miss a dose of XSULIN 50/50, inject your dose as soon as you remember, but ensure there is a gap of at least 3 hours to the next dose.If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.Do not inject a double dose to make up for a missed one, as this can increase your risk of hypoglycemia (low blood sugar).

• Keep XSULIN 50/50 PENFIL 3ML away from the reach of children and pets.
• Store XSULIN 50/50 PENFIL 3ML in a refrigerator (2 - 8°C). Do not freeze.

• **Understand Your Insulin:** XSULIN 50/50 is a pre-mixed insulin containing both rapid-acting and intermediate-acting insulin. This means it's designed to control blood sugar levels both at mealtime and between meals. Make sure you understand the proportions and how they work to manage your diabetes effectively. Speak to your doctor about what target blood glucose range is ideal for you.
• **Proper Storage is Key:** Always store your XSULIN 50/50 Penfill in the refrigerator (2°C to 8°C or 36°F to 46°F) until you are ready to use it. Do not freeze. Once in use, the Penfill can be stored at room temperature (below 30°C or 86°F) for up to 28 days. Discard it after 28 days, even if there is insulin left. Protect from direct heat and light. Always use a new needle for each injection to maintain sterility and prevent contamination.
• **Master the Injection Technique:** Inject XSULIN 50/50 subcutaneously (under the skin) as instructed by your doctor or diabetes educator. Rotate injection sites within the same general area (e.g., abdomen, thigh, or upper arm) to prevent lipohypertrophy (lumps under the skin). Ensure you prime the pen before each injection to remove any air bubbles and ensure accurate dosing. Pinch up the skin before injecting to avoid injecting into the muscle.
• **Timing is Everything:** Administer XSULIN 50/50 approximately 15 minutes before a meal. This allows the rapid-acting component to start working when you begin eating. Consistent timing helps to better control post-meal blood sugar spikes. Discuss your eating schedule with your doctor to determine the optimal injection timing for your individual needs.
• **Monitor Blood Glucose Regularly:** Regular blood glucose monitoring is essential for managing diabetes. Check your blood sugar levels before meals, two hours after meals, and at bedtime, or as directed by your doctor. Keep a log of your blood sugar readings and share it with your healthcare team to help them adjust your insulin dosage if needed. Be aware of the signs and symptoms of hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar), and know how to treat them.
• **Be Prepared for Emergencies:** Always carry a source of fast-acting carbohydrates, such as glucose tablets or juice, to treat hypoglycemia. Wear a medical identification bracelet or necklace to alert others that you have diabetes in case of an emergency. Have a glucagon emergency kit available and ensure your family and close friends know how to administer it in case you are unable to treat yourself.
• **Diet and Exercise Matter:** Insulin is most effective when combined with a healthy diet and regular exercise. Work with a registered dietitian or certified diabetes educator to develop a meal plan that fits your lifestyle and helps you manage your blood sugar levels. Aim for at least 150 minutes of moderate-intensity exercise per week.
• **Travel Smart with Insulin:** When traveling, carry your XSULIN 50/50 Penfill in your carry-on luggage to avoid exposure to extreme temperatures in the cargo hold. Bring a copy of your prescription in case you need to replace your insulin. Pack extra supplies, such as needles, syringes, and blood glucose monitoring equipment, in case of delays. Consult your doctor about adjusting your insulin dosage for different time zones.
• **Recognize and Report Side Effects:** Be aware of potential side effects of insulin, such as hypoglycemia, weight gain, and injection site reactions. Report any persistent or bothersome side effects to your doctor. Do not adjust your insulin dosage without consulting your healthcare team.
• **Stay Educated:** Diabetes management is an ongoing process. Attend diabetes education classes, join support groups, and stay informed about the latest advances in diabetes care. Knowledge is power when it comes to managing your diabetes effectively.

• XSULIN 50/50 PENFIL 3 ML should be administered 15 minutes before or soon after starting a meal.
• Consistent timing of meals and insulin administration is crucial for maintaining stable blood sugar levels.
• Consult your doctor or diabetes educator for personalized advice on how XSULIN 50/50 PENFIL 3 ML interacts with your specific dietary needs.