JODAPA S 10/100MG TABLET 10'S

How JODAPA S 10/100MG TABLET 10'S Works

• JODAPA S 10/100MG TABLET 10'S is a combination medicine containing two active ingredients: Dapagliflozin and Sitagliptin. These medications work through different but complementary mechanisms to lower blood sugar levels in individuals with type 2 diabetes. Dapagliflozin belongs to a class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors, while Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
• Dapagliflozin primarily works in the kidneys. In healthy individuals, the kidneys filter glucose from the blood, and then reabsorb it back into the bloodstream. Dapagliflozin inhibits the SGLT2 protein in the kidneys, which is responsible for reabsorbing glucose. By blocking this protein, Dapagliflozin reduces the reabsorption of glucose, leading to more glucose being excreted in the urine. This process effectively lowers blood sugar levels. The excretion of glucose also results in a loss of calories, which can contribute to modest weight loss. Beyond glucose control, Dapagliflozin has also demonstrated cardiovascular benefits in clinical trials, potentially reducing the risk of heart failure and other cardiovascular events in certain patients.
• Sitagliptin, on the other hand, works by enhancing the body's own ability to lower blood sugar. It inhibits the DPP-4 enzyme, which is responsible for breaking down incretin hormones. Incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), are released by the intestine in response to food intake. These hormones stimulate the pancreas to release insulin and also reduce the secretion of glucagon, a hormone that raises blood sugar levels. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones in the body. This results in increased insulin secretion and decreased glucagon secretion in a glucose-dependent manner, meaning that these effects are more pronounced when blood sugar levels are high. This helps to lower blood sugar levels after meals and throughout the day. The combined action of Dapagliflozin and Sitagliptin provides a dual approach to managing blood sugar levels in type 2 diabetes, addressing both glucose reabsorption in the kidneys and incretin hormone activity in the body.
• In summary, JODAPA S works by reducing glucose reabsorption in the kidneys through Dapagliflozin and enhancing incretin hormone activity through Sitagliptin, leading to improved blood sugar control in individuals with type 2 diabetes. Always use this medication as directed by your healthcare provider.

Like all medicines, JODAPA S 10/100MG TABLET 10'S can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Nausea * Diarrhea * Headache * Dizziness * Fatigue * Muscle pain or cramps * Upper respiratory tract infection * Back pain * Increased sweating **Uncommon Side Effects (may affect up to 1 in 100 people):** * Skin rash or itching * Indigestion or heartburn * Constipation * Weakness * Swelling in the extremities (edema) * Difficulty sleeping (insomnia) * Anxiety * Blurred vision * Dry mouth * Changes in taste * Increased liver enzymes (detected in blood tests) **Rare Side Effects (may affect up to 1 in 1,000 people):** * Severe allergic reaction (anaphylaxis) – seek immediate medical attention * Muscle damage or breakdown (rhabdomyolysis) – can cause kidney problems * Liver problems (hepatitis, jaundice) * Kidney problems * Low blood sugar (hypoglycemia) * Nerve problems (peripheral neuropathy) – causing numbness, tingling, or pain in the hands or feet **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) – seek immediate medical attention * Pancreatitis (inflammation of the pancreas) * Changes in blood cell counts **Other Potential Side Effects (frequency not known):** * Increased cholesterol levels * Erectile dysfunction This is not a complete list of side effects. If you experience any unusual symptoms, consult your doctor or pharmacist.

• If you miss a dose of JODAPA S 10/100MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep JODAPA S 10/100MG TAB 1X10 away from the reach of children and pets.
• Store JODAPA S 10/100MG TAB 1X10 at room temperature.

• Take JODAPA S 10/100MG TABLET 10'S exactly as prescribed by your doctor. Do not change the dosage or stop taking it without consulting them, even if you feel better. This ensures the medication works effectively and prevents potential complications.
• JODAPA S 10/100MG TABLET 10'S is typically taken once daily, preferably in the morning. Maintaining a consistent time each day helps maintain steady blood sugar levels and improves adherence to the treatment plan.
• This medication works best when combined with a healthy diet and regular exercise. Focus on consuming balanced meals with controlled carbohydrates and engage in physical activity for at least 30 minutes most days of the week to maximize its benefits in managing your diabetes.
• Inform your doctor about all other medications, supplements, and herbal products you are currently taking before starting JODAPA S 10/100MG TABLET 10'S. This helps prevent potential drug interactions and ensures your safety.
• Monitor your blood sugar levels regularly as directed by your healthcare provider. This will help you and your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. Report any unusual symptoms or side effects to your doctor promptly.
• Stay well-hydrated by drinking plenty of water throughout the day. Adequate hydration supports kidney function and helps your body process the medication effectively. Limit sugary drinks and opt for water or unsweetened beverages.
• Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, dizziness, and confusion. Carry a source of fast-acting sugar, like glucose tablets or juice, with you at all times to treat hypoglycemia promptly. Discuss with your doctor how to manage low blood sugar episodes effectively.
• Store JODAPA S 10/100MG TABLET 10'S at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Proper storage ensures the medication remains effective until its expiration date.

• JODAPA S 10/100MG TABLET 10'S is generally safe to take with or without food. However, it's best to follow your doctor's instructions regarding timing and meals. Consistent timing, relative to meals, may help maintain steady blood sugar levels. Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of side effects.