NEBILONG AM TABLET 10'S

How NEBILONG AM TABLET 10'S Works

• NEBILONG AM TABLET 10'S is a combination medicine designed to manage hypertension (high blood pressure). It combines two active ingredients: Nebivolol and Amlodipine, each working through different mechanisms to lower blood pressure effectively.
• Nebivolol is a beta-blocker that works selectively on beta-1 adrenergic receptors, primarily found in the heart. By blocking these receptors, Nebivolol slows down the heart rate and reduces the force of heart contractions. This results in a decreased cardiac output, meaning the heart pumps less blood with each beat. Consequently, the overall blood pressure is reduced. Unlike some other beta-blockers, Nebivolol also stimulates the production of nitric oxide (NO) in the blood vessels. Nitric oxide is a vasodilator, meaning it helps relax and widen the blood vessels. This vasodilation further contributes to lowering blood pressure by reducing peripheral resistance, which is the resistance the heart has to pump against.
• Amlodipine, on the other hand, is a calcium channel blocker. It works by blocking the entry of calcium into the smooth muscle cells of the blood vessel walls. Calcium is essential for muscle contraction; therefore, by blocking calcium entry, Amlodipine relaxes these smooth muscle cells, leading to vasodilation. This vasodilation primarily affects the arteries, reducing the resistance against which the heart has to pump. This, in turn, lowers blood pressure. Amlodipine's effect is more pronounced in the peripheral arteries, contributing to a significant reduction in blood pressure without significantly affecting heart rate.
• The combination of Nebivolol and Amlodipine provides a synergistic effect in managing hypertension. Nebivolol reduces cardiac output and promotes vasodilation through nitric oxide, while Amlodipine directly relaxes blood vessels. This dual mechanism ensures a more comprehensive and effective control of blood pressure compared to using either medication alone. The reduced heart rate from Nebivolol can also help counteract any reflex tachycardia (increased heart rate) that might occur due to Amlodipine's vasodilation.
• In summary, NEBILONG AM TABLET 10'S works by decreasing heart rate and cardiac output (Nebivolol) and relaxing blood vessels (Nebivolol and Amlodipine), leading to a significant reduction in blood pressure and improved cardiovascular health. This combination targets multiple pathways involved in blood pressure regulation, making it an effective treatment for hypertension.

Like all medicines, Nebilong AM Tablet can cause side effects, although not everybody gets them. **Common Side Effects (may affect up to 1 in 10 people):** * Headache * Dizziness * Swelling of ankles, feet, or fingers * Fatigue * Abdominal pain * Nausea * Diarrhea * Constipation * Cold or numb feeling in your limbs * Shortness of breath * Slow heart rate * Irregular heart beat * Low blood pressure **Uncommon Side Effects (may affect up to 1 in 100 people):** * Allergic reaction such as skin rash, itching * Sleep disturbances, depression * Visual disturbances * Vertigo * Worsening of heart failure * Slow heart rate or palpitations * Difficulty breathing or wheezing * Muscle cramps * Indigestion * Flatulence * Dry mouth * Impotence * Increased sweating **Rare Side Effects (may affect up to 1 in 1,000 people):** * Fainting * Worsening of psoriasis **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Angioedema (severe allergic reaction with swelling of the face, lips, tongue, and/or throat, causing difficulty breathing or swallowing) **Other possible side effects:** * Hallucinations * Psychosis * Confusion If you experience any of these or other concerning symptoms, contact your doctor immediately.

• If you miss a dose of NEBILONG AM TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

• Keep NEBILONG AM TAB 1X10 away from the reach of children and pets.
• Store NEBILONG AM TAB 1X10 at room temperature.

• **Consistency is Key:** Take NEBILONG AM TABLET 10'S at the same time each day to maintain a steady level of medication in your body. This helps ensure its effectiveness in managing your blood pressure and heart condition. Set a daily alarm or reminder if needed to avoid missing a dose.
• **Monitor Your Blood Pressure Regularly:** Keep a log of your blood pressure readings at home and share it with your doctor during appointments. This helps your doctor assess how well the medication is working and make any necessary adjustments to your treatment plan. Regular monitoring provides valuable insights into your cardiovascular health.
• **Be Mindful of Potential Interactions:** Inform your doctor about all other medications, supplements, and herbal remedies you are taking. NEBILONG AM TABLET 10'S can interact with certain substances, potentially affecting its efficacy or increasing the risk of side effects. Avoiding drug interactions is crucial for your safety and well-being.
• **Lifestyle Matters:** Complement your medication with a healthy lifestyle. This includes a balanced diet low in sodium and saturated fats, regular physical activity (as advised by your doctor), and stress management techniques. Lifestyle changes can significantly enhance the benefits of NEBILONG AM TABLET 10'S and improve your overall cardiovascular health. Smoking cessation and moderate alcohol consumption are also important considerations.
• **Report Any Unusual Symptoms:** Contact your doctor promptly if you experience any unusual or concerning symptoms while taking NEBILONG AM TABLET 10'S, such as severe dizziness, swelling of the ankles or feet, chest pain, or difficulty breathing. Early reporting allows for timely evaluation and management of any potential side effects or complications. Never adjust the dosage without consulting your physician.
• **Storage Instructions**: Store NEBILONG AM TABLET 10'S in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. Proper storage ensures the medication remains effective and safe for consumption until its expiration date.
• **Dietary Considerations**: While taking NEBILONG AM TABLET 10'S, be mindful of your sodium intake. High sodium levels can counteract the medication's effectiveness in lowering blood pressure. Also, be cautious with grapefruit and grapefruit juice, as they can interact with the medication and increase the risk of side effects.
• **Hydration is Important**: Drink plenty of water throughout the day while taking NEBILONG AM TABLET 10'S. Staying hydrated helps maintain healthy blood volume and supports the medication's effectiveness in managing blood pressure. Aim for at least 8 glasses of water daily, unless otherwise directed by your doctor.

• NEBILONG AM TABLET 10'S may be taken with or without food. However, it is important to take the tablet at the same time each day to maintain consistent blood levels. Avoid consuming large amounts of grapefruit or grapefruit juice while taking this medication, as it can increase the levels of amlodipine in your blood, potentially leading to increased side effects. If you have any concerns, consult your doctor or pharmacist.