WOSULIN 50/50 PENFILL 3 ML

How WOSULIN 50/50 PENFILL 3 ML Works

• WOSULIN 50/50 PENFILL 3 ML is a premixed insulin formulation containing both rapid-acting and intermediate-acting human insulin. This combination helps to manage blood sugar levels effectively throughout the day by addressing both prandial (meal-related) and basal (background) insulin needs. The rapid-acting component, also known as soluble insulin, starts working quickly after injection to cover the rise in blood glucose levels that occur after eating. It helps to lower blood sugar soon after a meal and prevents hyperglycemia.
• The intermediate-acting component, also known as Isophane insulin, has a longer duration of action. After injection, Isophane insulin is absorbed more slowly into the bloodstream, providing a sustained release of insulin over several hours. This helps to control blood sugar levels between meals and during the night, preventing hypoglycemia or hyperglycemia from occurring when you are not eating. The action of the intermediate-acting insulin complements the rapid-acting insulin to provide a more stable and consistent blood sugar control.
• When WOSULIN 50/50 is injected, the soluble insulin part of it is readily absorbed and starts to lower blood glucose by allowing glucose to enter the cells. Insulin binds to receptors on the cell surface, which then triggers a cascade of events leading to the translocation of glucose transporters (GLUT4) to the cell membrane. These transporters then facilitate the uptake of glucose from the bloodstream into the cells, where it can be used for energy or stored as glycogen.
• The Isophane insulin component works in a similar way, but its effects are prolonged due to the way it is formulated. The protamine and zinc in the formulation cause the insulin to form crystals that are slowly dissolved after injection. As the crystals dissolve, insulin is gradually released into the bloodstream, providing a longer-lasting effect on blood sugar levels. This isophane insulin helps in suppressing hepatic glucose production and increasing peripheral glucose utilization, contributing to the overall glycemic control throughout the day and night.
• The combined action of rapid and intermediate-acting insulins in WOSULIN 50/50 mimics the way a healthy pancreas releases insulin in response to meals and between meals. By providing both immediate and sustained insulin coverage, it helps to maintain blood sugar levels within a target range, reducing the risk of both hyperglycemic and hypoglycemic episodes. Regular monitoring of blood glucose levels and adherence to a balanced diet and exercise plan are essential for achieving optimal blood sugar control with WOSULIN 50/50.

Like all medicines, Wosulin 50/50 Penfill can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms can include sweating, shakiness, dizziness, hunger, blurred vision, headache, fast heartbeat, anxiety, irritability, confusion, difficulty concentrating, slurred speech, and loss of consciousness. Severe hypoglycemia can lead to seizures and brain damage, and can be life-threatening. * Injection site reactions: Redness, swelling, itching, or pain at the injection site. * Lipodystrophy: Changes in fat tissue at the injection site (either thickening or pitting of the skin). **Uncommon side effects (may affect up to 1 in 100 people):** * Allergic reactions: These can include rash, itching, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing or swallowing. Severe allergic reactions can be life-threatening. * Edema: Swelling of the ankles and feet. **Rare side effects (may affect up to 1 in 1,000 people):** * Diabetic neuropathy (nerve damage): This can cause pain, numbness, or tingling in the hands and feet. * Visual disturbances: Changes in vision may occur temporarily when starting insulin therapy. **Very rare side effects (may affect up to 1 in 10,000 people):** * Retinopathy (eye disease): Insulin treatment can cause diabetic retinopathy to worsen. **Other possible side effects:** * Weight gain * Muscle pain * Flu-like symptoms **Important Information:** * **Always monitor your blood sugar levels regularly.** * **If you experience symptoms of low blood sugar, treat it immediately with a fast-acting source of sugar, such as glucose tablets, juice, or candy.** * **If you experience any serious side effects, such as difficulty breathing or swelling of the face, seek immediate medical attention.** * **Talk to your doctor or pharmacist if you are concerned about any side effects.**

• If you miss a dose of Wosulin 50/50, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one. Consult your doctor or pharmacist if you are unsure about what to do.

• Keep WOSULIN 50/50 PENFILL 3ML away from the reach of children and pets.
• Store WOSULIN 50/50 PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

• **Understand Your Insulin Type:** Wosulin 50/50 is a premixed insulin, containing 50% rapid-acting and 50% intermediate-acting insulin. This means it covers both your mealtime insulin needs and provides a background level of insulin. Make sure you understand how this combination works to manage your blood sugar levels throughout the day.
• **Timing is Key:** Inject Wosulin 50/50 approximately 30 minutes before a meal. This allows the rapid-acting component to start working as you eat, preventing a spike in blood sugar. Consistency in timing is crucial for optimal blood sugar control. Do not inject and skip meals, as this may cause hypoglycemia.
• **Injection Technique Matters:** Always inject Wosulin 50/50 subcutaneously (under the skin) into areas like your abdomen, thigh, or upper arm. Rotate injection sites to prevent lipodystrophy (thickening or pitting of the skin), which can affect insulin absorption. Use a new needle for each injection to ensure sterility and minimize discomfort.
• **Monitor Your Blood Sugar Regularly:** Frequent blood sugar monitoring is essential when using Wosulin 50/50. Check your blood sugar levels before meals, two hours after meals, and at bedtime to understand how the insulin is affecting you and to make necessary adjustments in consultation with your doctor. Keep a record of your readings to share with your healthcare provider.
• **Be Prepared for Hypoglycemia:** Hypoglycemia (low blood sugar) is a potential side effect of insulin therapy. Always carry a source of fast-acting sugar, such as glucose tablets or juice, to treat low blood sugar immediately. Recognize the symptoms of hypoglycemia (sweating, shakiness, confusion) and inform your family and friends how to assist you if you become hypoglycemic. It is advisable to wear a medical identification bracelet or carry a card indicating that you have diabetes and use insulin. Inform your doctor immediately if there are frequent episodes of hypoglycemia.

• WOSULIN 50/50 PENFILL 3 ML should be administered 15 minutes before or immediately after meals. Consistent timing of meals and insulin administration is crucial for maintaining stable blood sugar levels. Consult your doctor or diabetes educator for personalized dietary advice related to your insulin therapy.